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Select item 104447841.

Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence

Aina Lluch, Jessica Latorre, Angela Serena-Maione, Isabel Espadas, Estefanía Caballano-Infantes, José M. Moreno-Navarrete, Núria Oliveras-Cañellas, Wifredo Ricart, María M. Malagón, Alejandro Martin-Montalvo, Walter Birchmeier, Witold Szymanski, Johannes Graumann, María Gómez-Serrano, Elena Sommariva, José M. Fernández-Real, Francisco J. Ortega

Nat Commun. 2023; 14: 5106. Published online 2023 Aug 22. doi: 10.1038/s41467-023-40596-0

PMCID:: PMC10444784

Abstract Article PDF–5.1M

Select item 94746272.

Loss of nuclear envelope integrity and increased oxidant production cause DNA damage in adult hearts deficient in PKP2: a molecular substrate of ARVC

Marta Pérez-Hernández, Chantal J.M. van Opbergen, Navratan Bagwan, Christoffer Rasmus Vissing, Grecia M. Marrón-Liñares, Mingliang Zhang, Estefania Torres Vega, Andrea Sorrentino, Lylia Drici, Karolina Sulek, Ruxu Zhai, Finn B. Hansen, Alex Hørby Christensen, Søren Boesgaard, Finn Gustafsson, Kasper Rossing, Eric M. Small, Michael J. Davies, Eli Rothenberg, Priscila Sato, Marina Cerrone, Thomas Hartvig Lindkær Jensen, Klaus Qvortrup, Henning Bundgaard, Mario Delmar, Alicia Lundby

Circulation. Author manuscript; available in PMC 2023 Sep 13.

Published in final edited form as: Circulation. 2022 Sep 13; 146(11): 851–867. Published online 2022 Aug 12. doi: 10.1161/CIRCULATIONAHA.122.060454

PMCID:: PMC9474627

Abstract Article PDF–3.2M

Select item 91332203.

Progressive Reduction in Right Ventricular Contractile Function Due to Altered Actin Expression in an Aging Mouse Model of Arrhythmogenic Cardiomyopathy

Emmanuel M. Camors, Alyson H. Roth, Joseph R. Alef, Ryan D. Sullivan, Jason N. Johnson, Enkhsaikhan Purevjav, Jeffrey A. Towbin

Circulation. Author manuscript; available in PMC 2023 May 24.

Published in final edited form as: Circulation. 2022 May 24; 145(21): 1609–1624. Published online 2022 Apr 19. doi: 10.1161/CIRCULATIONAHA.120.049261

PMCID:: PMC9133220

Abstract Article PDF–1.9M

Select item 90861824.

Exercise causes arrhythmogenic remodeling of intracellular calcium dynamics in Plakophilin-2 deficient hearts

Chantal JM van Opbergen, Navratan Bagwan, Svetlana R Maurya, Joon-Chul Kim, Abigail N Smith, Daniel J Blackwell, Jeffrey N Johnston, Björn C Knollmann, Marina Cerrone, Alicia Lundby, Mario Delmar

Circulation. Author manuscript; available in PMC 2023 May 10.

Published in final edited form as: Circulation. 2022 May 10; 145(19): 1480–1496. Published online 2022 May 1. doi: 10.1161/CIRCULATIONAHA.121.057757

PMCID:: PMC9086182

Abstract Article PDF–3.8M

Select item 89346885.

Role of plakophilin-2 expression on exercise-related progression of arrhythmogenic right ventricular cardiomyopathy: a translational study

Marina Cerrone, Grecia M Marrón-Liñares, Chantal J M van Opbergen, Sarah Costa, Mimount Bourfiss, Marta Pérez-Hernández, Florencia Schlamp, Fabian Sanchis-Gomar, Kabir Malkani, Kamelia Drenkova, Mingliang Zhang, Xianming Lin, Adriana Heguy, Birgitta K Velthuis, Niek H J Prakken, Andre LaGerche, Hugh Calkins, Cynthia A James, Anneline S J M Te Riele, Mario Delmar

Eur Heart J. 2022 Mar 21; 43(12): 1251–1264. Published online 2021 Nov 19. doi: 10.1093/eurheartj/ehab772

Correction in:: Eur Heart J. 2022 Mar 21; 43(12): 1250.

PMCID:: PMC8934688

Abstract Article PDF–2.5M

Select item 88033376.

Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor

Lisa M. Godsel, Quinn R. Roth-Carter, Jennifer L. Koetsier, Lam C. Tsoi, Amber L. Huffine, Joshua A. Broussard, Gillian N. Fitz, Sarah M. Lloyd, Junghun Kweon, Hope E. Burks, Marihan Hegazy, Saki Amagai, Paul W. Harms, Xianying Xing, Joseph Kirma, Jodi L. Johnson, Gloria Urciuoli, Lynn T. Doglio, William R. Swindell, Rajeshwar Awatramani, Eli Sprecher, Xiaomin Bao, Eran Cohen-Barak, Caterina Missero, Johann E. Gudjonsson, Kathleen J. Green

J Clin Invest. 2022 Feb 1; 132(3): e144363. Published online 2022 Feb 1. doi: 10.1172/JCI144363

PMCID:: PMC8803337

Abstract Article PDF–3.6M

Select item 81774417.

Beneficial effect of voluntary physical exercise in Plakophilin2 transgenic mice

Karin P. Hammer, Julian Mustroph, Teresa Stauber, Walter Birchmeier, Stefan Wagner, Lars S. Maier

PLoS One. 2021; 16(6): e0252649. Published online 2021 Jun 4. doi: 10.1371/journal.pone.0252649

PMCID:: PMC8177441

Abstract Article PDF–2.8M

Select item 81596918.

Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy

Yan Liang, Robert C. Lyon, Jason Pellman, William H. Bradford, Stephan Lange, Julius Bogomolovas, Nancy D. Dalton, Yusu Gu, Marcus Bobar, Mong-Hong Lee, Tomoo Iwakuma, Vishal Nigam, Angeliki Asimaki, Melvin Scheinman, Kirk L. Peterson, Farah Sheikh

J Clin Invest. 2021 Jun 1; 131(11): e137689. Published online 2021 Jun 1. doi: 10.1172/JCI137689

PMCID:: PMC8159691

Abstract Article PDF–13M

Select item 78496099.

Transcriptomic Coupling of PKP2 With Inflammatory and Immune Pathways Endogenous to Adult Cardiac Myocytes

Marta Pérez-Hernández, Grecia M. Marrón-Liñares, Florencia Schlamp, Adriana Heguy, Chantal J. M. van Opbergen, Valeria Mezzano, Mingliang Zhang, Feng-Xia Liang, Marina Cerrone, Mario Delmar

Front Physiol. 2020; 11: 623190. Published online 2021 Jan 18. doi: 10.3389/fphys.2020.623190

PMCID:: PMC7849609

Abstract Article PDF–3.1M

Select item 695292610.

Knock Down of Plakophillin 2 Dysregulates Adhesion Pathway through Upregulation of miR200b and Alters the Mechanical Properties in Cardiac Cells

Luca Puzzi, Daniele Borin, Priyatansh Gurha, Raffaella Lombardi, Valentina Martinelli, Marek Weiss, Laura Andolfi, Marco Lazzarino, Luisa Mestroni, Ali J. Marian, Orfeo Sbaizero

Cells. 2019 Dec; 8(12): 1639. Published online 2019 Dec 14. doi: 10.3390/cells8121639

PMCID:: PMC6952926

Abstract Article PDF–5.1M

Select item 674715611.

Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards Stress

Chantal J.M. van Opbergen, Maartje Noorman, Anna Pfenniger, Jaël S. Copier, Sarah H. Vermij, Zhen Li, Roel van der Nagel, Mingliang Zhang, Jacques M.T. de Bakker, Aaron M. Glass, Peter J. Mohler, Steven M. Taffet, Marc A. Vos, Harold V.M. van Rijen, Mario Delmar, Toon A.B. van Veen

Int J Mol Sci. 2019 Sep; 20(17): 4076. Published online 2019 Aug 21. doi: 10.3390/ijms20174076

PMCID:: PMC6747156

Abstract Article PDF–4.3M

Select item 674660812.

Disruption of Ca²⁺_i homeostasis and Cx43 hemichannel function in the right ventricle precedes overt arrhythmogenic cardiomyopathy in PKP2-deficient mice

Joon-Chul Kim, Marta Pérez-Hernández, Francisco J Alvarado, Svetlana R Maurya, Jerome Montnach, Yandong Yin, Mingliang Zhang, Xianming Lin, Carolina Vasquez, Adriana Heguy, Feng-Xia Liang, Sun-Hee Woo, Gregory E Morely, Eli Rothenberg, Alicia Lundby, Hector H Valdivia, Marina Cerrone, Mario Delmar

Circulation. Author manuscript; available in PMC 2020 Sep 17.

Published in final edited form as: Circulation. 2019 Sep 17; 140(12): 1015–1030. Published online 2019 Jul 18. doi: 10.1161/CIRCULATIONAHA.119.039710

PMCID:: PMC6746608

Abstract Article PDF–4.1M

Select item 552463713.

Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm

Marina Cerrone, Jerome Montnach, Xianming Lin, Yan-Ting Zhao, Mingliang Zhang, Esperanza Agullo-Pascual, Alejandra Leo-Macias, Francisco J. Alvarado, Igor Dolgalev, Thomas V. Karathanos, Kabir Malkani, Chantal J.M. Van Opbergen, Joanne J.A. van Bavel, Hua-Qian Yang, Carolina Vasquez, David Tester, Steven Fowler, Fengxia Liang, Eli Rothenberg, Adriana Heguy, Gregory E. Morley, William A. Coetzee, Natalia A. Trayanova, Michael J. Ackerman, Toon A.B. van Veen, Hector H. Valdivia, Mario Delmar

Nat Commun. 2017; 8: 106. Published online 2017 Jul 24. doi: 10.1038/s41467-017-00127-0

PMCID:: PMC5524637

Abstract Article PDF–4.1M

Select item 533336114.

Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth

Chiara V. Ragni, Nicolas Diguet, Jean-François Le Garrec, Marta Novotova, Tatiana P. Resende, Sorin Pop, Nicolas Charon, Laurent Guillemot, Lisa Kitasato, Caroline Badouel, Alexandre Dufour, Jean-Christophe Olivo-Marin, Alain Trouvé, Helen McNeill, Sigolène M Meilhac

Nat Commun. 2017; 8: 14582. Published online 2017 Feb 27. doi: 10.1038/ncomms14582

PMCID:: PMC5333361

Abstract Article PDF–2.6M

Select item 501049015.

Knock Down of Plakophilin 2 Downregulates miR-184 Through CpG Hypermethylation and Suppression of the E2F1 Pathway and Leads to Enhanced Adipogenesis In Vitro

Priyatansh Gurha, Xiaofan Chen, Raffaella Lombardi, James T. Willerson, AJ Marian

Circ Res. Author manuscript; available in PMC 2017 Sep 2.

Published in final edited form as: Circ Res. 2016 Sep 2; 119(6): 731–750. Published online 2016 Jul 28. doi: 10.1161/CIRCRESAHA.116.308422

PMCID:: PMC5010490

Abstract Article PDF–2.9M

Select item 475471616.

Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes

Adi D. Dubash, Chen Y. Kam, Brian A. Aguado, Dipal M. Patel, Mario Delmar, Lonnie D. Shea, Kathleen J. Green

J Cell Biol. 2016 Feb 15; 212(4): 425–438. doi: 10.1083/jcb.201507018

PMCID:: PMC4754716

Abstract Article PDF–2.3M

Select item 431955917.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Abstract Article PDF–3.0M

Select item 395443018.

Missense Mutations in Plakophilin-2 Cause Sodium Current Deficit and Associate with a Brugada Syndrome Phenotype

Marina Cerrone, Xianming Lin, Mingliang Zhang, Esperanza Agullo-Pascual, Anna Pfenniger, Halina Chkourko Gusky, Valeria Novelli, Changsung Kim, Tiara Tirasawasdichai, Daniel P Judge, Eli Rothenberg, Huei-Sheng Vincent Chen, Carlo Napolitano, Silvia Priori, Mario Delmar

Circulation. Author manuscript; available in PMC 2015 Mar 11.

Published in final edited form as: Circulation. 2014 Mar 11; 129(10): 1092–1103. Published online 2013 Dec 18. doi: 10.1161/CIRCULATIONAHA.113.003077

PMCID:: PMC3954430

Abstract Article PDF–5.0M

Select item 391664919.

Novel Protein Interactions with Endoglin and Activin Receptor-like Kinase 1: Potential Role in Vascular Networks

Guoxiong Xu, Miriam Barrios-Rodiles, Mirjana Jerkic, Andrei L. Turinsky, Robert Nadon, Sonia Vera, Despina Voulgaraki, Jeffrey L. Wrana, Mourad Toporsian, Michelle Letarte

Mol Cell Proteomics. 2014 Feb; 13(2): 489–502. Published online 2013 Dec 7. doi: 10.1074/mcp.M113.033464

PMCID:: PMC3916649

Abstract Article PDF–4.1M

Select item 384511620.

Genetic variants related to gap junctions and hormone secretion influence conception rates in cows

Mayumi Sugimoto, Shinji Sasaki, Yusaku Gotoh, Yuuki Nakamura, Yoshito Aoyagi, Takayoshi Kawahara, Yoshikazu Sugimoto

Proc Natl Acad Sci U S A. 2013 Nov 26; 110(48): 19495–19500. Published online 2013 Nov 11. doi: 10.1073/pnas.1309307110

PMCID:: PMC3845116

Abstract Article PDF–1.4M

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