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Select item 112971461.

Phospholipase C-β3 is dispensable for vascular constriction but indispensable for vascular hyperplasia

Seo Yeon Jin, Jung Min Ha, Hye Jin Kum, Ji Soo Ma, Hong Koo Ha, Sang Heon Song, Yong Ryoul Yang, Ho Lee, Yoon Soo Bae, Masahiro Yamamoto, Pann-Ghill Suh, Sun Sik Bae

Exp Mol Med. 2024 Jul; 56(7): 1620–1630. Published online 2024 Jul 1. doi: 10.1038/s12276-024-01271-6

PMCID:: PMC11297146

Abstract Article PDF–4.7M

Select item 108406922.

A regulatory node involving Gα_q, PLCβ, and RGS proteins modulates platelet reactivity to critical agonists

Shuchi Gupta, Matthew Cooper, Xuefei Zhao, Yanki Yarman, Hannah Thomson, Daniel DeHelian, Lawrence F. Brass, Peisong Ma

J Thromb Haemost. Author manuscript; available in PMC 2024 Dec 1.

Published in final edited form as: J Thromb Haemost. 2023 Dec; 21(12): 3633–3639. Published online 2023 Aug 30. doi: 10.1016/j.jtha.2023.08.022

PMCID:: PMC10840692

Abstract Article PDF–754K

Select item 89576053.

Novel role of pre-replication complex component cell division cycle 6 in retinal neovascularization

Raj Kumar, Gadiparthi N. Rao

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2022 Apr; 42(4): 407–427. Published online 2022 Mar 3. doi: 10.1161/ATVBAHA.121.317182

PMCID:: PMC8957605

Abstract Article PDF–4.8M

Select item 85775594.

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle

Qian Wang, Wendy Wing Sze Yue, Zheng Jiang, Tian Xue, Shin H. Kang, Dwight E. Bergles, Katsuhiko Mikoshiba, Stefan Offermanns, King-Wai Yau

Curr Biol. Author manuscript; available in PMC 2021 Nov 9.

Published in final edited form as: Curr Biol. 2017 Jun 19; 27(12): 1791–1800.e5. Published online 2017 Jun 1. doi: 10.1016/j.cub.2017.05.022

PMCID:: PMC8577559

Abstract Article PDF–1.7M

Select item 79387705.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 74258666.

A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli

Debarghya Dutta Banik, Eric D. Benfey, Laura E. Martin, Kristen E. Kay, Gregory C. Loney, Amy R. Nelson, Zachary C. Ahart, Barrett T. Kemp, Bailey R. Kemp, Ann-Marie Torregrossa, Kathryn F. Medler

PLoS Genet. 2020 Aug; 16(8): e1008925. Published online 2020 Aug 13. doi: 10.1371/journal.pgen.1008925

PMCID:: PMC7425866

Abstract Article PDF–3.3M

Select item 69775437.

Frontline Science: TNF‐α and GM‐CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K‐γ, and neutrophil proinflammatory responses

Sabine Suire, Fernando C. Baltanas, Anne Segonds‐Pichon, Keith Davidson, Eugenio Santos, Phillip T. Hawkins, Len R. Stephens

J Leukoc Biol. 2019 Oct; 106(4): 815–822. Published online 2019 Feb 5. doi: 10.1002/JLB.2HI0918-359RR

PMCID:: PMC6977543

Abstract Article PDF–1.0M

Select item 66927708.

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics

Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea

Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253

PMCID:: PMC6692770

Abstract Article PDF–7.7M

Select item 63099009.

Protective roles of adenosine A₁, A_2A, and A₃ receptors in skeletal muscle ischemia and reperfusion injury

Jingang Zheng, Rubio Wang, Edward Zambraski, Dan Wu, Kenneth A. Jacobson, Bruce T. Liang

Am J Physiol Heart Circ Physiol. Author manuscript; available in PMC 2018 Dec 28.

Published in final edited form as: Am J Physiol Heart Circ Physiol. 2007 Dec; 293(6): H3685–H3691. Published online 2007 Oct 5. doi: 10.1152/ajpheart.00819.2007

PMCID:: PMC6309900

Abstract Article PDF–935K

Select item 620330410.

Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically-Photosensitive Retinal Ganglion Cells

Zheng Jiang, Wendy W.S. Yue, Lujing Chen, Yanghui Sheng, King-Wai Yau

Cell. Author manuscript; available in PMC 2019 Oct 18.

Published in final edited form as: Cell. 2018 Oct 18; 175(3): 652–664.e12. Published online 2018 Sep 27. doi: 10.1016/j.cell.2018.08.055

PMCID:: PMC6203304

Abstract Article PDF–1.2M

Select item 555517711.

The heterotrimeric G protein Gβ₁ interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein–coupled receptor signaling in platelets

Subhashree Pradhan, Tanvir Khatlani, Angus C. Nairn, K. Vinod Vijayan

J Biol Chem. 2017 Aug 11; 292(32): 13133–13142. Published online 2017 Jun 14. doi: 10.1074/jbc.M117.796656

PMCID:: PMC5555177

Abstract Article PDF–1.4M

Select item 472228512.

Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo

Helena Block, Anika Stadtmann, Daniel Riad, Jan Rossaint, Charlotte Sohlbach, Giulia Germena, Dianqing Wu, Scott I. Simon, Klaus Ley, Alexander Zarbock

Blood. 2016 Jan 21; 127(3): 314–324. Prepublished online 2015 Oct 14. doi: 10.1182/blood-2015-06-651034

PMCID:: PMC4722285

Abstract Article

Select item 443012613.

Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation

W. K. Eddie Ip, Ruslan Medzhitov

Nat Commun. Author manuscript; available in PMC 2015 Nov 11.

Published in final edited form as: Nat Commun. 2015; 6: 6931. Published online 2015 May 11. doi: 10.1038/ncomms7931

PMCID:: PMC4430126

Abstract Article PDF–2.0M

Select item 432998614.

Critical Role for Mast Cell Stat5 Activity in Skin Inflammation

Tomoaki Ando, Wenbin Xiao, Peisong Gao, Siavash Namiranian, Kenji Matsumoto, Yoshiaki Tomimori, Hong Hong, Hirotaka Yamashita, Miho Kimura, Jun-ichi Kashiwakura, Tissa R. Hata, Kenji Izuhara, Michael F. Gurish, Axel Roers, Nicholas M. Rafaels, Kathleen C. Barnes, Colin Jamora, Yuko Kawakami, Toshiaki Kawakami

Cell Rep. Author manuscript; available in PMC 2015 Feb 16.

Published in final edited form as: Cell Rep. 2014 Jan 30; 6(2): 366–376. Published online 2014 Jan 9. doi: 10.1016/j.celrep.2013.12.029

PMCID:: PMC4329986

Abstract Article PDF–3.2M

Select item 363221915.

Implantation failure in mice with a disruption in Phospholipase C beta 1 gene: lack of embryonic attachment, aberrant steroid hormone signalling and defective endocannabinoid metabolism

Panayiotis Filis, Peter C. Kind, Norah Spears

Mol Hum Reprod. 2013 May; 19(5): 290–301. Published online 2013 Jan 7. doi: 10.1093/molehr/gas067

PMCID:: PMC3632219

Abstract Article PDF–1.3M

Select item 344777716.

Revealing the role of phospholipase Cβ3 in the regulation of VEGF-induced vascular permeability

Luke H. Hoeppner, Kathryn N. Phoenix, Karl J. Clark, Resham Bhattacharya, Xun Gong, Tracey E. Sciuto, Pawan Vohra, Sandip Suresh, Santanu Bhattacharya, Ann M. Dvorak, Stephen C. Ekker, Harold F. Dvorak, Kevin P. Claffey, Debabrata Mukhopadhyay

Blood. 2012 Sep 13; 120(11): 2167–2173. Prepublished online 2012 Jun 6. doi: 10.1182/blood-2012-03-417824

PMCID:: PMC3447777

Abstract Article

Select item 340001817.

GPCR activation of Ras and PI3Kγ in neutrophils depends on PLCβ2/β3 and the RasGEF RasGRP4

Sabine Suire, Charlotte Lécureuil, Karen E Anderson, George Damoulakis, Izabella Niewczas, Keith Davidson, Hervé Guillou, Dingxin Pan, Jonathan Clark, Phillip T Hawkins, Len Stephens

EMBO J. 2012 Jul 18; 31(14): 3118–3129. Published online 2012 Jun 22. doi: 10.1038/emboj.2012.167

PMCID:: PMC3400018

Abstract Article PDF–968K

Select item 324193018.

A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis

Wenwen Tang, Yong Zhang, Wenwen Xu, T. Kendall Harden, John Sondek, Le Sun, Lin Li, Dianqing Wu

Dev Cell. Author manuscript; available in PMC 2012 Dec 13.

Published in final edited form as: Dev Cell. 2011 Dec 13; 21(6): 1038–1050. doi: 10.1016/j.devcel.2011.10.023

PMCID:: PMC3241930

Abstract Article PDF–4.2M

Select item 322886119.

PLCβ is Critical for T-cell Chemotaxis

Tami L. Bach, Qing-Min Chen, Wesley T. Kerr, John K. Choi, Dianqing Wu, Gary A. Koretzky, Sally Zigmond, Charles S. Abrams

J Immunol. Author manuscript; available in PMC 2011 Dec 1.

Published in final edited form as: J Immunol. 2007 Aug 15; 179(4): 2223–2227. doi: 10.4049/jimmunol.179.4.2223

PMCID:: PMC3228861

Abstract Article PDF–2.9M

Select item 317805920.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

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