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Select item 111588441.

EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth

Megumi Iiizumi, Masayo Hosokawa, Akio Takehara, Suyoun Chung, Toru Nakamura, Toyomasa Katagiri, Hidetoshi Eguchi, Hiroaki Ohigashi, Osamu Ishikawa, Yusuke Nakamura, Hidewaki Nakagawa

Cancer Sci. 2006 Nov; 97(11): 1211–1216. Published online 2006 Sep 5. doi: 10.1111/j.1349-7006.2006.00313.x

PMCID:: PMC11158844

Abstract Article PDF–225K

Select item 103459632.

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

Amr El Zawily, Frederick S. Vizeacoumar, Renuka Dahiya, Sara L. Banerjee, Kalpana K. Bhanumathy, Hussain Elhasasna, Glinton Hanover, Jessica C. Sharpe, Malkon G. Sanchez, Paul Greidanus, R. Greg Stacey, Kyung-Mee Moon, Ilya Alexandrov, Juha P. Himanen, Dimitar B. Nikolov, Humphrey Fonge, Aaron P. White, Leonard J. Foster, Bingcheng Wang, Behzad M. Toosi, Nicolas Bisson, Tajib A. Mirzabekov, Franco J. Vizeacoumar, Andrew Freywald

Clin Cancer Res. 2023 Jul 14; 29(14): 2686–2701. Published online 2023 Mar 28. doi: 10.1158/1078-0432.CCR-22-2535

PMCID:: PMC10345963

Abstract Article PDF–13M

Select item 100729063.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 98886814.

Suppression of KSHV lytic replication and primary effusion lymphoma by selective RNF5 inhibition

Xiaojuan Li, Fan Wang, Xiaolin Zhang, Qinqin Sun, Ersheng Kuang

PLoS Pathog. 2023 Jan; 19(1): e1011103. Published online 2023 Jan 19. doi: 10.1371/journal.ppat.1011103

PMCID:: PMC9888681

Abstract Article PDF–5.6M

Select item 92792855.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 91714116.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 85529077.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 83641818.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 82608799.

A cancer mutation promotes EphA4 oligomerization and signaling by altering the conformation of the SAM domain

Taylor P. Light, Maricel Gomez-Soler, Zichen Wang, Kelly Karl, Elmer Zapata-Mercado, Marina P. Gehring, Bernhard C. Lechtenberg, Taras V. Pogorelov, Kalina Hristova, Elena B. Pasquale

J Biol Chem. 2021 Jul; 297(1): 100876. Published online 2021 Jun 15. doi: 10.1016/j.jbc.2021.100876

PMCID:: PMC8260879

Abstract Article PDF–4.2M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 798062711.

Exosomal miR-106b-5p derived from melanoma cell promotes primary melanocytes epithelial-mesenchymal transition through targeting EphA4

Wenkang Luan, Yuting Ding, Haolan Xi, Hongru Ruan, Feng Lu, Shaojun Ma, Jinlong Wang

J Exp Clin Cancer Res. 2021; 40: 107. Published online 2021 Mar 19. doi: 10.1186/s13046-021-01906-w

PMCID:: PMC7980627

Abstract Article PDF–12M

Select item 692775412.

Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong

eLife. 2019; 8: e50223. Published online 2019 Nov 19. doi: 10.7554/eLife.50223

PMCID:: PMC6927754

Abstract Article PDF–5.1M

Select item 684406813.

Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage

Elizabeth A. Kowalski, Jiang Chen, Amanda Hazy, Lauren E. Fritsch, Erwin Kristobal Gudenschwager-Basso, Michael Chen, Xia Wang, Yun Qian, Mingjun Zhou, Matthew Byerly, Alicia M. Pickrell, John B. Matson, Irving Coy Allen, Michelle H. Theus

J Neuroinflammation. 2019; 16: 210. Published online 2019 Nov 11. doi: 10.1186/s12974-019-1605-2

PMCID:: PMC6844068

Abstract Article PDF–3.1M

Select item 678266114.

Ephrin-A Binding and EphA Receptor Expression Delineate the Matrix Compartment of the Striatum

L. Scott Janis, Robert M. Cassidy, Lawrence F. Kromer

J Neurosci. 1999 Jun 15; 19(12): 4962–4971. doi: 10.1523/JNEUROSCI.19-12-04962.1999

PMCID:: PMC6782661

Abstract Article PDF–1.0M

Select item 642983015.

Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer

Sean P. Kennedy, Jeremy Z. R. Han, Neil Portman, Max Nobis, Jordan F. Hastings, Kendelle J. Murphy, Sharissa L. Latham, Antonia L. Cadell, Dushan Miladinovic, Gabriella R. Marriott, Yolande E. I. O’Donnell, Robert F. Shearer, James T. Williams, Amaya Garcia Munoz, Thomas R. Cox, D. Neil Watkins, Darren N. Saunders, Paul Timpson, Elgene Lim, Walter Kolch, David R. Croucher

Breast Cancer Res. 2019; 21: 43. Published online 2019 Mar 21. doi: 10.1186/s13058-019-1127-y

PMCID:: PMC6429830

Abstract Article PDF–3.1M

Select item 638658816.

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001

PMCID:: PMC6386588

Abstract Article PDF–1.7M

Select item 638128417.

Ephrin Receptor A4 is a New Kaposi’s Sarcoma-Associated Herpesvirus Virus Entry Receptor

Jia Chen, Xianming Zhang, Samantha Schaller, Theodore S. Jardetzky, Richard Longnecker

mBio. 2019 Jan-Feb; 10(1): e02892-18. Published online 2019 Feb 19. doi: 10.1128/mBio.02892-18

PMCID:: PMC6381284

Abstract Article PDF–1.7M

Select item 586483218.

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations

Xiaonan Liu, Kari Salokas, Fitsum Tamene, Yaming Jiu, Rigbe G. Weldatsadik, Tiina Öhman, Markku Varjosalo

Nat Commun. 2018; 9: 1188. Published online 2018 Mar 22. doi: 10.1038/s41467-018-03523-2

PMCID:: PMC5864832

Abstract Article PDF–4.5M

Select item 583915819.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

Select item 571604420.

SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration

Timothy Y. Huang, Yingjun Zhao, Lu-lin Jiang, Xiaoguang Li, Yan Liu, Yu Sun, Juan C. Piña-Crespo, Bing Zhu, Eliezer Masliah, Thomas E. Willnow, Elena B. Pasquale, Huaxi Xu

J Exp Med. 2017 Dec 4; 214(12): 3669–3685. doi: 10.1084/jem.20171413

PMCID:: PMC5716044

Abstract Article PDF–1.9M

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