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Items: 1 to 20 of 45

1.
HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2
Peiyi Yin, Yongbin Wu, Xiang Long, Shuqiang Zhu, Shiwei Chen, Feng Lu, Kun Lin, Jianjun Xu
Aging (Albany NY) 2023 Dec 15; 15(23): 13888–13900. Published online 2023 Dec 6. doi: 10.18632/aging.205272
PMCID:
PMC10756096
AbstractArticlePDF–1.3M
2.
Structural Basis for the Enzymatic Activity of the HACE1 HECT‐Type E3 Ligase Through N‐Terminal Helix Dimerization
Sunil Singh, Satoru Machida, Nikhil Kumar Tulsian, Yeu Khai Choong, Joel Ng, Srihari Shankar, Yaochen Liu, Krisha Vashdev Chandiramani, Jian Shi, J Sivaraman
Adv Sci (Weinh) 2023 Sep; 10(27): 2207672. Published online 2023 Aug 3. doi: 10.1002/advs.202207672
PMCID:
PMC10520629
AbstractArticlePDF–3.7M
3.
CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR
Xiaolong Wang, Tong Chen, Chen Li, Wenhao Li, Xianyong Zhou, Yaming Li, Dan Luo, Ning Zhang, Bing Chen, Lijuan Wang, Wenjing Zhao, Shanji Fu, Qifeng Yang
J Hematol Oncol. 2022; 15: 122. Published online 2022 Aug 29. doi: 10.1186/s13045-022-01345-w
PMCID:
PMC9425971
AbstractArticlePDF–19M
4.
Ubiquitylation of cyclin C by HACE1 regulates cisplatin‐associated sensitivity in gastric cancer
Hong‐yue Jiang, Ying‐ling Chen, Xing‐xing Xu, Chuan‐yin Li, Yun Chen, Dong‐ping Li, Xiao‐qing Zeng, Hong Gao
Clin Transl Med. 2022 Mar; 12(3): e770. Published online 2022 Mar 28. doi: 10.1002/ctm2.770
PMCID:
PMC8958351
AbstractArticlePDF–3.6M
5.
HACE1 negatively regulates neuroinflammation through ubiquitylating and degrading Rac1 in Parkinson’s disease models
Cai-xia Zang, Lu Wang, Han-yu Yang, Jun-mei Shang, Hui Liu, Zi-hong Zhang, Cheng Ju, Fang-yu Yuan, Fang-yuan Li, Xiu-qi Bao, Dan Zhang
Acta Pharmacol Sin. 2022 Feb; 43(2): 285–294. Published online 2021 Sep 30. doi: 10.1038/s41401-021-00778-2
PMCID:
PMC8792019
AbstractArticlePDF–3.2M
6.
HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells
Chenxing Da, Jun Pu, Zhe Liu, Jing Wei, Yiping Qu, Yongxing Wu, Bingyin Shi, Jian Yang, Nongyue He, Peng Hou
Signal Transduct Target Ther. 2021; 6: 399. Published online 2021 Nov 24. doi: 10.1038/s41392-021-00793-z
PMCID:
PMC8611003
AbstractArticlePDF–3.4M
7.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
8.
HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner
Busra Turgu, Fan Zhang, Amal El-Naggar, Gian Luca Negri, Melanie Kogler, Luigi Tortola, Fraser Johnson, Tony Ng, Amy Li, Donald Yapp, William Lockwood, Daniel Martinez, John M. Maris, Mads Daugaard, Josef M. Penninger, Christopher S. Hughes, Poul H. Sorensen
Oncogene. 2021; 40(11): 1988–2001. Published online 2021 Feb 18. doi: 10.1038/s41388-021-01680-1
PMCID:
PMC7979542
AbstractArticlePDF–4.1M
9.
meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes
Diana M. Ciuculete, Sarah Voisin, Lara Kular, Jörgen Jonsson, Mathias Rask-Andersen, Jessica Mwinyi, Helgi B. Schiöth
Clin Epigenetics. 2020; 12: 99. Published online 2020 Jul 2. doi: 10.1186/s13148-020-00884-8
PMCID:
PMC7333393
AbstractArticlePDF–1.4M
10.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
11.
HACE1, an E3 Ubiquitin Protein Ligase, Mitigates Kaposi’s Sarcoma-Associated Herpesvirus Infection-Induced Oxidative Stress by Promoting Nrf2 Activity
Binod Kumar, Arunava Roy, Kumari Asha, Neelam Sharma-Walia, Mairaj Ahmed Ansari, Bala Chandran
J Virol. 2019 May 1; 93(9): e01812-18. Prepublished online 2019 Feb 20. Published online 2019 Apr 17. doi: 10.1128/JVI.01812-18
PMCID:
PMC6475796
AbstractArticlePDF–4.5M
12.
HACE1 is a potential tumor suppressor in osteosarcoma
Amal M El-Naggar, Paul W. Clarkson, Gian Luca Negri, Busra Turgu, Fan Zhang, Michael S. Anglesio, Poul H. Sorensen
Cell Death Dis. 2019 Jan; 10(1): 21. Published online 2019 Jan 8. doi: 10.1038/s41419-018-1276-4
PMCID:
PMC6325116
AbstractArticlePDF–3.2M
13.
Uncovering and deciphering the pro-invasive role of HACE1 in melanoma cells
Najla El-Hachem, Nadia Habel, Tanesha Naiken, Hanene Bzioueche, Yann Cheli, Guillaume E. Beranger, Emilie Jaune, Florian Rouaud, Nicolas Nottet, Frédéric Reinier, Céline Gaudel, Pascale Colosetti, Corine Bertolotto, Robert Ballotti
Cell Death Differ. 2018 Nov; 25(11): 2010–2022. Published online 2018 Mar 7. doi: 10.1038/s41418-018-0090-y
PMCID:
PMC6219503
AbstractArticlePDF–3.7M
14.
Overexpression of HACE1 in gastric cancer inhibits tumor aggressiveness by impeding cell proliferation and migration
Ying‐ling Chen, Dong‐ping Li, Hong‐yue Jiang, Yang Yang, Li‐li Xu, Shun‐cai Zhang, Hong Gao
Cancer Med. 2018 Jun; 7(6): 2472–2484. Published online 2018 Apr 19. doi: 10.1002/cam4.1496
PMCID:
PMC6010910
AbstractArticlePDF–1.2M
15.
Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination
Maria I. Acosta, Serge Urbach, Anne Doye, Yuen-Wai Ng, Jérôme Boudeau, Amel Mettouchi, Anne Debant, Edward Manser, Orane Visvikis, Emmanuel Lemichez
Sci Rep. 2018; 8: 1410. Published online 2018 Jan 23. doi: 10.1038/s41598-018-19471-2
PMCID:
PMC5780496
AbstractArticlePDF–2.8M
16.
Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation
Emilie Andrio, Romain Lotte, Daniel Hamaoui, Jacqueline Cherfils, Anne Doye, Mads Daugaard, Poul H. Sorensen, Frédéric Bost, Raymond Ruimy, Amel Mettouchi, Emmanuel Lemichez
Sci Rep. 2017; 7: 44779. Published online 2017 Mar 20. doi: 10.1038/srep44779
PMCID:
PMC5357957
AbstractArticlePDF–1.6M
17.
A cascading activity-based probe sequentially targets E1–E2–E3 ubiquitin enzymes
Monique P.C. Mulder, Katharina Witting, Ilana Berlin, Jonathan N. Pruneda, Kuen-Phon Wu, Jer-Gung Chang, Remco Merkx, Johanna Bialas, Marcus Groettrup, Alfred C.O. Vertegaal, Brenda A. Schulman, David Komander, Jacques Neefjes, Farid El Oualid, Huib Ovaa
Nat Chem Biol. Author manuscript; available in PMC 2017 Jan 1.
Published in final edited form as: Nat Chem Biol. 2016 Jul; 12(7): 523–530. Published online 2016 May 16. doi: 10.1038/nchembio.2084
PMCID:
PMC5108872
AbstractArticlePDF–2.4M
18.
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes
Wei Zhang, Kuen-Phon Wu, Maria A. Sartori, Hari B. Kamadurai, Alban Ordureau, Chong Jiang, Peter Y. Mercredi, Ryan Murchie, Jicheng Hu, Avinash Persaud, Manjeet Mukherjee, Nan Li, Anne Doye, John R. Walker, Yi Sheng, Zhenyue Hao, Yanjun Li, Kevin R. Brown, Emmanuel Lemichez, Junjie Chen, Yufeng Tong, J. Wade Harper, Jason Moffat, Daniela Rotin, Brenda A. Schulman, Sachdev S. Sidhu
Mol Cell. Author manuscript; available in PMC 2017 Apr 7.
Published in final edited form as: Mol Cell. 2016 Apr 7; 62(1): 121–136. Published online 2016 Mar 3. doi: 10.1016/j.molcel.2016.02.005
PMCID:
PMC4988125
AbstractArticlePDF–1.2M
19.
Monoubiquitination of syntaxin 5 regulates Golgi membrane dynamics during the cell cycle
Shijiao Huang, Danming Tang, Yanzhuang Wang
Dev Cell. Author manuscript; available in PMC 2017 Jul 11.
Published in final edited form as: Dev Cell. 2016 Jul 11; 38(1): 73–85. doi: 10.1016/j.devcel.2016.06.001
PMCID:
PMC4942811
AbstractArticlePDF–2.4M
20.
HACE1 Negatively Regulates Virus-Triggered Type I IFN Signaling by Impeding the Formation of the MAVS-TRAF3 Complex
He-Ting Mao, Yan Wang, Juan Cai, Jun-Ling Meng, Yu Zhou, Yu Pan, Xiao-Ping Qian, Yu Zhang, Jun Zhang
Viruses. 2016 May; 8(5): 146. Published online 2016 May 21. doi: 10.3390/v8050146
PMCID:
PMC4885101
AbstractArticlePDF–3.2M

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