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Select item 112362931.

SIGLEC15, negatively correlated with PD-L1 in HCC, could induce CD8+ T cell apoptosis to promote immune evasion

Zheng Chen, Mincheng Yu, Bo Zhang, Lei Jin, Qiang Yu, Shuang Liu, Binghai Zhou, Jiuliang Yan, Wentao Zhang, Xiaoqiang Li, Yongfeng Xu, Yongsheng Xiao, Jian Zhou, Jia Fan, Mien-Chie Hung, Qinghai Ye, Hui Li, Lei Guo

Oncoimmunology. 2024; 13(1): 2376264. Published online 2024 Jul 9. doi: 10.1080/2162402X.2024.2376264

PMCID:: PMC11236293

Abstract Article PDF–5.3M

Select item 109401582.

Siglec-15 on macrophages suppress the immune microenvironment in patients with PD-L1 negative non-metastasis lung adenocarcinoma

Ziqi Huang, Yan Guo, Baihui Li, Meng Shen, Yeran Yi, Li Li, Xiaohe Zhao, Lili Yang

Cancer Gene Ther. 2024; 31(3): 427–438. Published online 2023 Dec 11. doi: 10.1038/s41417-023-00713-z

PMCID:: PMC10940158

Abstract Article PDF–4.9M

Select item 104838523.

Non-spatial and spatial heterogeneity revealed a suppressive immune feature of Siglec-15 in lung adenocarcinomas

Baihui Li, Yan Guo, Yeran Yi, Ziqi Huang, Yulin Ren, Hao Wang, Lili Yang

J Transl Med. 2023; 21: 599. Published online 2023 Sep 6. doi: 10.1186/s12967-023-04489-6

PMCID:: PMC10483852

Abstract Article PDF–6.8M

Select item 103514254.

Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia

Claire E. Pillsbury, Jodi Dougan, Jennifer L. Rabe, Jairo A. Fonseca, Chengjing Zhou, Alyssa N. Evans, Hasan Abukharma, Ona Ichoku, Gloria Gonzalez-Flamenco, Sunita I. Park, Ahmed Aljudi, Deborah DeRyckere, Sharon M. Castellino, Sarwish Rafiq, Solomon Langermann, Linda N. Liu, Curtis J. Henry, Christopher C. Porter

Cancer Res Commun. 2023 Jul; 3(7): 1248–1259. Published online 2023 Jul 17. doi: 10.1158/2767-9764.CRC-23-0056

PMCID:: PMC10351425

Abstract Article PDF–4.4M

Select item 102662075.

Siglec15 is a prognostic indicator and a potential tumor-related macrophage regulator that is involved in the suppressive immunomicroenvironment in gliomas

Jinchao Wang, Linzong Xu, Qian Ding, Xiaoru Li, Kai Wang, Shangchen Xu, Bin Liu

Front Immunol. 2023; 14: 1065062. Published online 2023 May 30. doi: 10.3389/fimmu.2023.1065062

PMCID:: PMC10266207

Abstract Article PDF–9.5M

Select item 102643976.

Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b

Maria Pia Lenza, Leire Egia-Mendikute, Asier Antoñana-Vildosola, Cátia O. Soares, Helena Coelho, Francisco Corzana, Alexandre Bosch, Prodhi Manisha, Jon Imanol Quintana, Iker Oyenarte, Luca Unione, María Jesús Moure, Mikel Azkargorta, Unai Atxabal, Klaudia Sobczak, Felix Elortza, James D. Sutherland, Rosa Barrio, Filipa Marcelo, Jesús Jiménez-Barbero, Asis Palazon, June Ereño-Orbea

Nat Commun. 2023; 14: 3496. Published online 2023 Jun 13. doi: 10.1038/s41467-023-39119-8

PMCID:: PMC10264397

Abstract Article PDF–3.6M

Select item 102061447.

Dynamic change in Siglec-15 expression in peritumoral macrophages confers an immunosuppressive microenvironment and poor outcome in glioma

Quan Chen, Bingkun Chen, Chunhua Wang, Li Hu, Qiongwen Wu, Yanyang Zhu, Qiuyu Zhang

Front Immunol. 2023; 14: 1159085. Published online 2023 May 10. doi: 10.3389/fimmu.2023.1159085

PMCID:: PMC10206144

Abstract Article PDF–12M

Select item 98961568.

Significance of Siglec‐15 expression in colorectal cancer: association with advanced disease stage and fewer tumor‐infiltrating lymphocytes

Zhao Lu, Pu Cheng, Fei Huang, Jiyun Li, Bingzhi Wang, Shuangmei Zou, Zhaoxu Zheng, Chunwei Peng

J Pathol Clin Res. 2023 Mar; 9(2): 121–128. Published online 2022 Nov 24. doi: 10.1002/cjp2.303

PMCID:: PMC9896156

Abstract Article PDF–889K

Select item 98216069.

Transcriptional Regulation of Siglec-15 by ETS-1 and ETS-2 in Hepatocellular Carcinoma Cells

Kaiqin Sheng, Yuecheng Wu, Hanbin Lin, Menghan Fang, Chaorong Xue, Xu Lin, Xinjian Lin

Int J Mol Sci. 2023 Jan; 24(1): 792. Published online 2023 Jan 2. doi: 10.3390/ijms24010792

PMCID:: PMC9821606

Abstract Article PDF–3.5M

Select item 968251110.

Expression and function of Siglec-15 in RLPS and its correlation with PD-L1: Bioinformatics Analysis and Clinicopathological Evidence

Lixuan Cui, Xiuyun Tian, Liang Yan, Xiaoya Guan, Bin Dong, Min Zhao, Ang Lv, Daoning Liu, Jianhui Wu, Chunyi Hao

Int J Med Sci. 2022; 19(13): 1977–1988. Published online 2022 Oct 31. doi: 10.7150/ijms.77193

PMCID:: PMC9682511

Abstract Article PDF–1.6M

Select item 960007711.

Siglec-15 as a New Perspective Therapy Target in Human Giant Cell Tumor of Bone

Mengke Fan, Guochuan Zhang, Mingfang Xie, Xinbo Liu, Qi Zhang, Ling Wang

Curr Oncol. 2022 Oct; 29(10): 7655–7671. Published online 2022 Oct 13. doi: 10.3390/curroncol29100605

PMCID:: PMC9600077

Abstract Article PDF–3.8M

Select item 950018812.

Unveiling the molecular features, relevant immune and clinical characteristics of SIGLEC15 in thyroid cancer

Xiaofeng Hou, Chao Chen, Xiabin Lan, Xiaodong He

Front Immunol. 2022; 13: 975787. Published online 2022 Sep 9. doi: 10.3389/fimmu.2022.975787

PMCID:: PMC9500188

Abstract Article PDF–24M

Select item 923677413.

Siglec-15 Silencing Inhibits Cell Proliferation and Promotes Cell Apoptosis by Inhibiting STAT1/STAT3 Signaling in Anaplastic Thyroid Carcinoma

Xiaofeng Hou, Chao Chen, Xiaodong He, Xiabin Lan

Dis Markers. 2022; 2022: 1606404. Published online 2022 Jun 20. doi: 10.1155/2022/1606404

PMCID:: PMC9236774

Abstract Article PDF–3.4M

Select item 921353314.

Prognostic value of PD-L1 and Siglec-15 expression in patients with nasopharyngeal carcinoma

Ju Zhao, Hanshan Yang, Hui Hu, Chao Liu, Min Wei, Yumei Zhao, Yudan Chen, Yongxia Cui, Ping Chen, Kang Xiong, Yun Lu, Hongru Yang, Linglin Yang

Sci Rep. 2022; 12: 10401. Published online 2022 Jun 21. doi: 10.1038/s41598-022-13997-2

PMCID:: PMC9213533

Abstract Article PDF–1.2M

Select item 897727315.

Analysis of a novel immune checkpoint, Siglec‐15, in pancreatic ductal adenocarcinoma

Xianlong Chen, Shengwei Mo, Yue Zhang, Heng Ma, Zhaohui Lu, Shuangni Yu, Jie Chen

J Pathol Clin Res. 2022 May; 8(3): 268–278. Published online 2022 Jan 27. doi: 10.1002/cjp2.260

PMCID:: PMC8977273

Abstract Article PDF–3.9M

Select item 888526416.

Long Noncoding RNA TUG1 Inhibits Tumor Progression through Regulating Siglec-15-Related Anti-Immune Activity in Hepatocellular Carcinoma

Yanyi Ren, Jiayi Lyu, Yaoguang Guo, Yuan Yao, Lin Hu

J Immunol Res. 2022; 2022: 9557859. Published online 2022 Feb 21. doi: 10.1155/2022/9557859

PMCID:: PMC8885264

Abstract Article PDF–5.3M

Select item 857768317.

Siglec-15 promotes progression of clear renal cell carcinoma

Wen-Bo Yang, Cai-Peng Qin, Yi-Qing Du, Song-Chen Han, Tao Xu

Chin Med J (Engl) 2021 Nov 5; 134(21): 2635–2637. Published online 2021 Sep 22. doi: 10.1097/CM9.0000000000001752

PMCID:: PMC8577683

Article PDF–179K

Select item 796726518.

Immunopositivity for Siglec-15 in gastric cancer and its association with clinical and pathological parameters

Michael Williams Leal Quirino, Michelly Cristiny Pereira, Maria de Fátima Deodato de Souza, Ivan da Rocha Pitta, Antônio Felix da Silva Filho, Mário S. de Souza Albuquerque, Amanda Pinheiro de Barros Albuquerque, Mário Rino Martins, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo

Eur J Histochem. 2021 Jan 20; 65(1): 3174. Published online 2021 Mar 4. doi: 10.4081/ejh.2021.3174

PMCID:: PMC7967265

Abstract Article PDF–1.2M

Select item 784767519.

Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer

Jiao Hu, Anze Yu, Belaydi Othmane, Dongxu Qiu, Huihuang Li, Chao Li, Peihua Liu, Wenbiao Ren, Minfeng Chen, Guanghui Gong, Xi Guo, Huihui Zhang, Jinbo Chen, Xiongbing Zu

Theranostics. 2021; 11(7): 3089–3108. Published online 2021 Jan 1. doi: 10.7150/thno.53649

PMCID:: PMC7847675

Abstract Article PDF–6.3M

Select item 780661120.

Sialic acid-binding immunoglobulin-like lectin-15 expression on peritumoral macrophages is a favorable prognostic factor for primary central nervous system lymphoma patients

Hirotaka Fudaba, Yasutomo Momii, Taisei Hirakawa, Kouhei Onishi, Daigo Asou, Wataru Matsushita, Yukari Kawasaki, Kenji Sugita, Minoru Fujiki

Sci Rep. 2021; 11: 1206. Published online 2021 Jan 13. doi: 10.1038/s41598-020-79742-9

PMCID:: PMC7806611

Abstract Article PDF–1.5M

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