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Select item 91197361.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 88646952.

Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications

Antonieta L. Salguero, Maggie Chen, Aaron T. Balana, Nam Chu, Hanjie Jiang, Brad A. Palanski, Hwan Bae, Katharine M. Wright, Sara Nathan, Heng Zhu, Sandra B. Gabelli, Matthew R. Pratt, Philip A. Cole

ACS Chem Biol. Author manuscript; available in PMC 2022 Feb 23.

Published in final edited form as: ACS Chem Biol. 2022 Jan 21; 17(1): 68–76. Published online 2021 Dec 23. doi: 10.1021/acschembio.1c00632

PMCID:: PMC8864695

Abstract Article PDF–1.1M

Select item 87768533.

PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40

Tianhua Zhang, Yuzhen Wang, Hongjiu Yu, Ting Zhang, Lianying Guo, Jie Xu, Xiaoqing Wei, Ning Wang, Yingjie Wu, Xiuli Wang, Lin Huang

Cell Death Dis. 2022 Jan; 13(1): 68. Published online 2022 Jan 20. doi: 10.1038/s41419-022-04499-0

PMCID:: PMC8776853

Abstract Article PDF–7.9M

Select item 85138534.

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation

Jordan M. Meyers, Muthukumar Ramanathan, Ronald L. Shanderson, Aimee Beck, Laura Donohue, Ian Ferguson, Margaret G. Guo, Deepti S. Rao, Weili Miao, David Reynolds, Xue Yang, Yang Zhao, Yen-Yu Yang, Catherine Blish, Yinsheng Wang, Paul A. Khavari

PLoS Pathog. 2021 Oct; 17(10): e1009412. Published online 2021 Oct 1. doi: 10.1371/journal.ppat.1009412

PMCID:: PMC8513853

Abstract Article PDF–4.1M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80007856.

Dual Specificity Kinase DYRK3 Promotes Aggressiveness of Glioblastoma by Altering Mitochondrial Morphology and Function

Kyeongmin Kim, Sungmin Lee, Hyunkoo Kang, Eunguk Shin, Hae Yu Kim, HyeSook Youn, BuHyun Youn

Int J Mol Sci. 2021 Mar; 22(6): 2982. Published online 2021 Mar 15. doi: 10.3390/ijms22062982

PMCID:: PMC8000785

Abstract Article PDF–6.3M

Select item 79484527.

A conserved acetylation switch enables pharmacological control of tubby-like protein stability

Evan M. Kerek, Kevin H. Yoon, Shu Y. Luo, Jerry Chen, Robert Valencia, Olivier Julien, Andrew J. Waskiewicz, Basil P. Hubbard

J Biol Chem. 2021 Jan-Jun; 296: 100073. Published online 2020 Nov 23. doi: 10.1074/jbc.RA120.015839

PMCID:: PMC7948452

Abstract Article PDF–3.6M

Select item 74835588.

PRAS40 phosphorylation correlates with insulin-like growth factor-1 receptor-induced resistance to epidermal growth factor receptor inhibition in head and neck cancer cells

Michael I. Dougherty, Christine E. Lehman, Adam Spencer, Rolando E Mendez, Abel P. David, Linnea E. Taniguchi, Julie Wulfkuhle, Emmanuel F. Petricoin, Daniel Gioeli, Mark J. Jameson

Mol Cancer Res. Author manuscript; available in PMC 2021 Mar 1.

Published in final edited form as: Mol Cancer Res. 2020 Sep; 18(9): 1392–1401. Published online 2020 May 28. doi: 10.1158/1541-7786.MCR-19-0592

PMCID:: PMC7483558

Abstract Article PDF–1.2M

Select item 73220679.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 701646510.

MELK is Upregulated in Advanced Clear Cell Renal Cell Carcinoma and Promotes Disease Progression by Phosphorylating PRAS40

Han Zhang, Pengtao Wei, Wenwei Lv, Xingtao Han, Jinhui Yang, Shuaifeng Qin, Yue Zhang

Cell Transplant. 2019 Dec; 28(1 Suppl): 37S–50S. Published online 2019 Dec 8. doi: 10.1177/0963689719890860

PMCID:: PMC7016465

Abstract Article PDF–3.0M

Select item 695077911.

PRAS40 hyperexpression promotes hepatocarcinogenesis

Zhaolai Qi, Ting Zhang, Lei Song, Hongyong Fu, Haifeng Luo, Jie Wu, Shuyun Zhao, Tianhua Zhang, Lianying Guo, Lingling Jin, He Zhang, Gena Huang, Tonghui Ma, Yingjie Wu, Lin Huang

EBioMedicine. 2020 Jan; 51: 102604. Published online 2020 Jan 3. doi: 10.1016/j.ebiom.2019.102604

Correction in:: EBioMedicine. 2020 Oct; 60: 103001.

PMCID:: PMC6950779

Abstract Article PDF–5.4M

Select item 685609512.

PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells

Kevin Sun Zhang, Johannes Schecker, Alexandros Krull, Eva Riechert, Lonny Jürgensen, Verena Kamuf-Schenk, Jana Burghaus, Leon Kiper, Thanh Cao Ho, Kerstin Wöltje, Verena Stangl, Hugo A. Katus, Karl Stangl, Mirko Völkers, Till F. Althoff

Sci Rep. 2019; 9: 16787. Published online 2019 Nov 14. doi: 10.1038/s41598-019-53098-1

PMCID:: PMC6856095

Abstract Article PDF–4.6M

Select item 679553613.

Architecture of human Rag GTPase heterodimers and their complex with mTORC1

Madhanagopal Anandapadamanaban, Glenn R. Masson, Olga Perisic, Alex Berndt, Jonathan Kaufman, Chris M. Johnson, Balaji Santhanam, Kacper B. Rogala, David M. Sabatini, Roger L. Williams

Science. Author manuscript; available in PMC 2020 Apr 11.

Published in final edited form as: Science. 2019 Oct 11; 366(6462): 203–210. doi: 10.1126/science.aax3939

PMCID:: PMC6795536

Abstract Article PDF–3.4M

Select item 673044814.

Neuroprotective Role of a Proline-Rich Akt Substrate in Apoptotic Neuronal Cell Death after Stroke: Relationships with Nerve Growth Factor

Atsushi Saito, Purnima Narasimhan, Takeshi Hayashi, Shuzo Okuno, Michel Ferrand-Drake, Pak H. Chan

J Neurosci. 2004 Feb 18; 24(7): 1584–1593. doi: 10.1523/JNEUROSCI.5209-03.2004

PMCID:: PMC6730448

Abstract Article PDF–606K

Select item 653228815.

Bloom Syndrome Protein Activates AKT and PRAS40 in Prostate Cancer Cells

Kun Chen, Houqiang Xu, Jiafu Zhao

Oxid Med Cell Longev. 2019; 2019: 3685817. Published online 2019 May 9. doi: 10.1155/2019/3685817

PMCID:: PMC6532288

Abstract Article PDF–3.7M

Select item 650456116.

MARK3-mediated phosphorylation of ARHGEF2 couples the actin and tubulin cytoskeletons to establish cell polarity

María-José Sandí, Christopher B. Marshall, Marc Balan, Étienne Coyaud, Ming Zhou, Daniel M. Monson, Noboru Ishiyama, Arun A. Chandrakumar, José La Rose, Amber L. Couzens, Anne-Claude Gingras, Brian Raught, Wei Xu, Mitsuhiko Ikura, Deborah K. Morrison, Robert Rottapel

Sci Signal. Author manuscript; available in PMC 2019 May 7.

Published in final edited form as: Sci Signal. 2017 Oct 31; 10(503): eaan3286. Published online 2017 Oct 31. doi: 10.1126/scisignal.aan3286

PMCID:: PMC6504561

Abstract Article PDF–3.6M

Select item 583915817.

Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells

Giorgio Giurato, Giovanni Nassa, Annamaria Salvati, Elena Alexandrova, Francesca Rizzo, Tuula A. Nyman, Alessandro Weisz, Roberta Tarallo

Sci Data. 2018; 5: 180031. Published online 2018 Mar 6. doi: 10.1038/sdata.2018.31

PMCID:: PMC5839158

Abstract Article PDF–1.9M

Select item 575007618.

Structural Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

Haijuan Yang, Xiaolu Jiang, Buren Li, Hyo J. Yang, Meredith Miller, Angela Yang, Ankita Dhar, Nikola P. Pavletich

Nature. Author manuscript; available in PMC 2018 Jun 13.

Published in final edited form as: Nature. 2017 Dec 21; 552(7685): 368–373. Published online 2017 Dec 13. doi: 10.1038/nature25023

PMCID:: PMC5750076

Abstract Article PDF–3.0M

Select item 567858119.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 559972220.

PRAS40 Connects Microenvironmental Stress Signaling to Exosome-Mediated Secretion

Jiacong Guo, Priyamvada Jayaprakash, Jian Dan, Petra Wise, Gyu-Beom Jang, Chengyu Liang, Mei Chen, David T. Woodley, Muller Fabbri, Wei Li

Mol Cell Biol. 2017 Oct 1; 37(19): e00171-17. Prepublished online 2017 Jul 3. Published online 2017 Sep 12. doi: 10.1128/MCB.00171-17

PMCID:: PMC5599722

Abstract Article PDF–3.1M

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