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Select item 112091021.

Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in Metabolic-Associated Fatty Liver Disease and COVID-19 Outcomes

Mykhailo Buchynskyi, Valentyn Oksenych, Iryna Kamyshna, Ihor Vorobets, Iryna Halabitska, Oleksandr Kamyshnyi

Viruses. 2024 Jun; 16(6): 985. Published online 2024 Jun 19. doi: 10.3390/v16060985

PMCID:: PMC11209102

Abstract Article PDF–1.9M

Select item 111363252.

Lipid sensing and lipid sensors: Bile acids and their signaling pathways: eclectic regulators of diverse cellular functions

E. Scotti, F. Gilardi, C. Godio, E. Gers, J. Krneta, N. Mitro, E. De Fabiani, D. Caruso, M. Crestani

Cell Mol Life Sci. 2007 Oct; 64(19-20): 2477. Published online 2007 Sep 17. doi: 10.1007/s00018-007-7280-y

PMCID:: PMC11136325

Abstract PDF–850K

Select item 111136433.

Farnesoid X receptor alpha: a molecular link between bile acids and steroid signaling?

Marine Baptissart, Aurelie Vega, Emmanuelle Martinot, Silvère Baron, Jean-Marc A. Lobaccaro, David H. Volle

Cell Mol Life Sci. 2013 Dec; 70(23): 4511–4526. Published online 2013 Jun 20. doi: 10.1007/s00018-013-1387-0

PMCID:: PMC11113643

Abstract Article PDF–551K

Select item 110275194.

NR1H4 disease: rapidly progressing neonatal intrahepatic cholestasis and early death

Zhong-Die Li, Yu-Chuan Li, Jing-Zhao, Jian-She Wang, Xin-Bao Xie

Orphanet J Rare Dis. 2024; 19: 171. Published online 2024 Apr 19. doi: 10.1186/s13023-024-03166-1

PMCID:: PMC11027519

Abstract Article PDF–1.1M

Select item 108946655.

Farnesoid X receptor prevents neutrophil extracellular traps via reduced sphingosine-1-phosphate in chronic kidney disease

Bryce A. Jones, Komuraiah Myakala, Mahilan Guha, Shania Davidson, Sharmila Adapa, Isabel Lopez Santiago, Isabel Schaffer, Yang Yue, Jeremy C. Allegood, L. Ashley Cowart, Xiaoxin X. Wang, Avi Z. Rosenberg, Moshe Levi

Am J Physiol Renal Physiol. 2023 Dec 1; 325(6): F792–F810. Published online 2023 Oct 12. doi: 10.1152/ajprenal.00292.2023

PMCID:: PMC10894665

Abstract Article

Select item 108878466.

Farnesoid X receptor enhances epithelial ACE2 expression and inhibits virally induced IL-6 secretion: implications for intestinal symptoms of SARS-CoV-2

Jessica S. Smyth, Jennifer K. Truong, Anuradha Rao, Ruxian Lin, Jennifer Foulke-Abel, Luciano Adorini, Mark Donowitz, Paul A. Dawson, Stephen J. Keely

Am J Physiol Gastrointest Liver Physiol. 2023 Nov 1; 325(5): G446–G452. Published online 2023 Sep 12. doi: 10.1152/ajpgi.00099.2023

PMCID:: PMC10887846

Abstract Article

Select item 106161977.

Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis

Juliane Tschuck, Lea Theilacker, Ina Rothenaigner, Stefanie A. I. Weiß, Banu Akdogan, Van Thanh Lam, Constanze Müller, Roman Graf, Stefanie Brandner, Christian Pütz, Tamara Rieder, Philippe Schmitt-Kopplin, Michelle Vincendeau, Hans Zischka, Kenji Schorpp, Kamyar Hadian

Nat Commun. 2023; 14: 6908. Published online 2023 Oct 30. doi: 10.1038/s41467-023-42702-8

PMCID:: PMC10616197

Abstract Article PDF–2.3M

Select item 102782998.

Regulon analysis identifies protective FXR and CREB5 in proximal tubules in early diabetic kidney disease

Wanting Shi, Weibo Le, Qiaoli Tang, Shaolin Shi, Jingsong Shi

BMC Nephrol. 2023; 24: 180. Published online 2023 Jun 19. doi: 10.1186/s12882-023-03239-6

PMCID:: PMC10278299

Abstract Article PDF–4.4M

Select item 99816149.

The role of the farnesoid X receptor in kidney health and disease: a potential therapeutic target in kidney diseases

Dong-Hyun Kim, Jung Sun Park, Hoon-In Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim

Exp Mol Med. 2023 Feb; 55(2): 304–312. Published online 2023 Feb 3. doi: 10.1038/s12276-023-00932-2

PMCID:: PMC9981614

Abstract Article PDF–871K

Select item 970189610.

CEBPB regulates the bile acid receptor FXR to accelerate colon cancer progression by modulating aerobic glycolysis

Zhengrong Wang, Jinghuan Pang, Lingyan Wang, Qinhui Dong, Dan Jin

J Clin Lab Anal. 2022 Nov; 36(11): e24703. Published online 2022 Sep 21. doi: 10.1002/jcla.24703

PMCID:: PMC9701896

Abstract Article PDF–7.0M

Select item 969594711.

The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity

Magdalena Rausch, Sophia L. Samodelov, Michele Visentin, Gerd A. Kullak-Ublick

Int J Mol Sci. 2022 Nov; 23(22): 13967. Published online 2022 Nov 12. doi: 10.3390/ijms232213967

PMCID:: PMC9695947

Abstract Article PDF–1.4M

Select item 962992512.

Transcription Factor FXR Activates DHRS9 to Inhibit the Cell Oxidative Phosphorylation and Suppress Colon Cancer Progression

Jinlai Zhao, Yigang Wang, Yang Wang, Jianchao Gao, Haichao Yang, Xiaotang Wu, Hua Li

Anal Cell Pathol (Amst) 2022; 2022: 8275574. Published online 2022 Oct 26. doi: 10.1155/2022/8275574

PMCID:: PMC9629925

Abstract Article PDF–2.5M

Select item 945430313.

Reduced peroxisome proliferator-activated receptor-α and bile acid nuclear receptor NR1H4/FXR may affect the hepatic immune microenvironment of biliary atresia

Yingxuan Ma, Li Lu, Kezhe Tan, Zhi Li, Ting Guo, Yibo Wu, Wei Wu, Lulu Zheng, Feilong Fan, Jiayu Mo, Zhenhua Gong

Front Immunol. 2022; 13: 875593. Published online 2022 Aug 25. doi: 10.3389/fimmu.2022.875593

PMCID:: PMC9454303

Abstract Article PDF–14M

Select item 924113414.

Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes

Dong-Hyun Kim, Hoon-In Choi, Jung Sun Park, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim

Redox Biol. 2022 Aug; 54: 102382. Published online 2022 Jun 23. doi: 10.1016/j.redox.2022.102382

PMCID:: PMC9241134

Abstract Article PDF–20M

Select item 917431215.

Farnesoid X receptor functions in cervical cancer via the p14^ARF-mouse double minute 2-p53 pathway

Xiaohua Huang, Bin Wang, Huimin Shen, Danmei Huang, Ganggang Shi

Mol Biol Rep. 2022; 49(5): 3617–3625. Published online 2022 Mar 28. doi: 10.1007/s11033-022-07201-x

PMCID:: PMC9174312

Abstract Article PDF–2.1M

Select item 910387716.

Enhancement of Farnesoid X Receptor Inhibits Migration, Adhesion and Angiogenesis through Proteasome Degradation and VEGF Reduction in Bladder Cancers

Chien-Rui Lai, Hisao-Hsien Wang, Hsin-Han Chang, Yu-Ling Tsai, Wen-Chiuan Tsai, Chen-Ray Lee, Chih-Ying Changchien, Yu-Chen Cheng, Sheng-Tang Wu, Ying Chen

Int J Mol Sci. 2022 May; 23(9): 5259. Published online 2022 May 9. doi: 10.3390/ijms23095259