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Select item 109062211.

S-nitrosylation attenuates pregnane X receptor hyperactivity and acetaminophen-induced liver injury

Qi Cui, Tingting Jiang, Xinya Xie, Haodong Wang, Lei Qian, Yanyan Cheng, Qiang Li, Tingxu Lu, Qinyu Yao, Jia Liu, Baochang Lai, Chang Chen, Lei Xiao, Nanping Wang

JCI Insight. 2024 Jan 23; 9(2): e172632. Published online 2024 Jan 23. doi: 10.1172/jci.insight.172632

PMCID:: PMC10906221

Abstract Article PDF–3.0M

Select item 105803512.

Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO‐1 pathway

Li‐Na Xuan, Zhen‐Xin Hu, Zhen‐Fu Jiang, Cong Zhang, Xiao‐Wan Sun, Wen‐Hua Ming, Hui‐Tao Liu, Rong‐Fang Qiao, Lin‐Jie Shen, Shao‐Bo Liu, Guan‐Yu Wang, Lin Wen, Zhi‐Lin Luan, Jian Yin

CNS Neurosci Ther. 2023 Nov; 29(11): 3460–3478. Published online 2023 Jun 2. doi: 10.1111/cns.14279

PMCID:: PMC10580351

Abstract Article PDF–82M

Select item 104157983.

Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice

Mikko Karpale, Outi Kummu, Olli Kärkkäinen, Marko Lehtonen, Juha Näpänkangas, Uta M. Herfurth, Albert Braeuning, Jaana Rysä, Jukka Hakkola

Mol Metab. 2023 Oct; 76: 101779. Published online 2023 Jul 17. doi: 10.1016/j.molmet.2023.101779

PMCID:: PMC10415798

Abstract Article PDF–6.0M

Select item 100804764.

The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability

Scott Peng, Megan S. Grace, Arisbel B. Gondin, Jeffri S. Retamal, Larissa Dill, William Darby, Nigel W. Bunnett, Fe C. Abogadie, Simona E. Carbone, Tara Tigani, Thomas P. Davis, Daniel P. Poole, Nicholas A. Veldhuis, Peter McIntyre

Lab Invest. Author manuscript; available in PMC 2023 Apr 7.

Published in final edited form as: Lab Invest. 2020 Aug; 100(8): 1057–1067. Published online 2020 Apr 27. doi: 10.1038/s41374-020-0430-7

PMCID:: PMC10080476

Abstract Article PDF–2.2M

Select item 99963685.

Oral arsenic administration to humanizedUDP-glucuronosyltransferase1 neonatal mice induces UGT1A1 through a dependence on Nrf2 and PXR

Xiaojing Yang, André A. Weber, Elvira Mennillo, Miles Paszek, Samantha Wong, Sabrina Le, Jia Ying Ashley Teo, Max Chang, Christopher W. Benner, Robert H. Tukey, Shujuan Chen

J Biol Chem. 2023 Mar; 299(3): 102955. Published online 2023 Jan 30. doi: 10.1016/j.jbc.2023.102955

PMCID:: PMC9996368

Abstract Article PDF–2.2M

Select item 98832976.

The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and Fibrosis

Kyle L. Flannigan, Kristoff M. Nieves, Holly E. Szczepanski, Alex Serra, Joshua W. Lee, Laurie A. Alston, Hena Ramay, Sridhar Mani, Simon A. Hirota

Cell Mol Gastroenterol Hepatol. 2023; 15(3): 765–795. Published online 2022 Oct 26. doi: 10.1016/j.jcmgh.2022.10.014

PMCID:: PMC9883297

Abstract Article PDF–10M

Select item 92330687.

Mice blocking Ser347 phosphorylation of pregnane x receptor develop hepatic fasting-induced steatosis and hypertriglyceridemia

Kosuke Yokobori, Artiom Gruzdev, Masahiko Negishi

Biochem Biophys Res Commun. Author manuscript; available in PMC 2023 Jul 30.

Published in final edited form as: Biochem Biophys Res Commun. 2022 Jul 30; 615: 75–80. Published online 2022 May 18. doi: 10.1016/j.bbrc.2022.05.055

PMCID:: PMC9233068

Abstract Article PDF–1.2M

Select item 91353268.

Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature

Sarah Kim, Sora Choi, Moumita Dutta, Jeffrey O. Asubonteng, Marianne Polunas, Michael Goedken, Frank J. Gonzalez, Julia Yue Cui, Maxwell A. Gyamfi

Biochem Pharmacol. Author manuscript; available in PMC 2022 Nov 1.

Published in final edited form as: Biochem Pharmacol. 2021 Nov; 193: 114698. Published online 2021 Jul 23. doi: 10.1016/j.bcp.2021.114698

PMCID:: PMC9135326

Abstract Article PDF–4.7M

Select item 89977069.

Pregnane X Receptor Mediates Atherosclerosis Induced by Dicyclohexyl Phthalate in LDL Receptor-Deficient Mice

Jingwei Liu, Rebecca Hernandez, Xiuchun Li, Zhaojie Meng, Hong Chen, Changcheng Zhou

Cells. 2022 Apr; 11(7): 1125. Published online 2022 Mar 26. doi: 10.3390/cells11071125

PMCID:: PMC8997706

Abstract Article PDF–5.7M

Select item 886211710.

CAR directs T cell adaptation to bile acids in the small intestine

Mei Lan Chen, Xiangsheng Huang, Hongtao Wang, Courtney Hegner, Yujin Liu, Jinsai Shang, Amber Eliason, Huitian Diao, HaJeung Park, Blake Frey, Guohui Wang, Sarah A. Mosure, Laura A. Solt, Douglas J. Kojetin, Alex Rodriguez-Palacios, Deborah A. Schady, Casey T. Weaver, Matthew E. Pipkin, David D. Moore, Mark S. Sundrud

Nature. Author manuscript; available in PMC 2022 Feb 22.

Published in final edited form as: Nature. 2021 May; 593(7857): 147–151. Published online 2021 Apr 7. doi: 10.1038/s41586-021-03421-6

PMCID:: PMC8862117

Abstract Article PDF–4.8M

Select item 872431811.

PXR mediates mifepristone-induced hepatomegaly in mice

Xin-peng Yao, Ting-ying Jiao, Yi-ming Jiang, Shi-cheng Fan, Ying-yuan Zhao, Xiao Yang, Yue Gao, Fei Li, Yan-ying Zhou, Pan-pan Chen, Min Huang, Hui-chang Bi

Acta Pharmacol Sin. 2022 Jan; 43(1): 146–156. Published online 2021 Mar 29. doi: 10.1038/s41401-021-00633-4

PMCID:: PMC8724318

Abstract Article PDF–4.0M

Select item 863490312.

Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice

Yipeng Sui, Zhaojie Meng, Jianzhong Chen, Jingwei Liu, Rebecca Hernandez, Miko B. Gonzales, Taesik Gwag, Andrew J. Morris, Changcheng Zhou

Environ Health Perspect. 2021 Dec; 129(12): 127001. Published online 2021 Dec 1. doi: 10.1289/EHP9262

PMCID:: PMC8634903

Abstract Article PDF–2.5M

Select item 861949113.

Indole-3-Propionic Acid, a Functional Metabolite of Clostridium sporogenes, Promotes Muscle Tissue Development and Reduces Muscle Cell Inflammation

Lei Du, Renli Qi, Jing Wang, Zuohua Liu, Zhenlong Wu

Int J Mol Sci. 2021 Nov; 22(22): 12435. Published online 2021 Nov 18. doi: 10.3390/ijms222212435

PMCID:: PMC8619491

Abstract Article PDF–2.7M

Select item 805922514.

The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

Sharon Ann Barretto, Frederic Lasserre, Marine Huillet, Marion Régnier, Arnaud Polizzi, Yannick Lippi, Anne Fougerat, Elodie Person, Sandrine Bruel, Colette Bétoulières, Claire Naylies, Céline Lukowicz, Sarra Smati, Laurence Guzylack, Maïwenn Olier, Vassilia Théodorou, Laila Mselli-Lakhal, Daniel Zalko, Walter Wahli, Nicolas Loiseau, Laurence Gamet-Payrastre, Hervé Guillou, Sandrine Ellero-Simatos

Microbiome. 2021; 9: 93. Published online 2021 Apr 20. doi: 10.1186/s40168-021-01050-9

PMCID:: PMC8059225

Abstract Article PDF–10M

Select item 797284615.

Eurotium cristatum Fermented Loose Dark Tea Ameliorates Cigarette Smoke-Induced Lung Injury by MAPK Pathway and Enhances Hepatic Metabolic Detoxification by PXR/AhR Pathway in Mice

Xiang-Xiang Huang, Shuai Xu, Li-Jun Yu, Yu-Fei Zhou, Ying Zhou, Zhong-Hua Liu

Oxid Med Cell Longev. 2021; 2021: 6635080. Published online 2021 Mar 10. doi: 10.1155/2021/6635080

PMCID:: PMC7972846

Abstract Article PDF–3.5M

Select item 760252816.

PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice

Maya Okamura, Ryota Shizu, Taiki Abe, Susumu Kodama, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari

Cells. 2020 Oct; 9(10): 2296. Published online 2020 Oct 15. doi: 10.3390/cells9102296

PMCID:: PMC7602528

Abstract Article PDF–2.0M

Select item 749762217.

Dexamethasone-Induced Liver Enlargement Is Related to PXR/YAP Activation and Lipid Accumulation but Not Hepatocyte Proliferation

Tingying Jiao, Xinpeng Yao, Yingyuan Zhao, Yanying Zhou, Yue Gao, Shicheng Fan, Panpan Chen, Xuan Li, Yiming Jiang, Xiao Yang, Frank J. Gonzalez, Min Huang, Huichang Bi

Drug Metab Dispos. 2020 Sep; 48(9): 830–839. Published online 2020 Sep. doi: 10.1124/dmd.120.000061

Correction in:: Drug Metab Dispos. 2020 Sep; 48(9): 840.

PMCID:: PMC7497622

Abstract Article PDF–1.5M

Select item 740718218.

Toxicoproteomic Profiling of hPXR Transgenic Mice Treated with Rifampicin and Isoniazid

Christopher Trent Brewer, Kiran Kodali, Jing Wu, Timothy I. Shaw, Junmin Peng, Taosheng Chen

Cells. 2020 Jul; 9(7): 1654. Published online 2020 Jul 9. doi: 10.3390/cells9071654

PMCID:: PMC7407182

Abstract Article PDF–1.9M

Select item 727452519.

Microbial bile acid metabolites modulate gut RORγ⁺ regulatory T cell homeostasis

Xinyang Song, Ximei Sun, Sungwhan F. Oh, Meng Wu, Yanbo Zhang, Wen Zheng, Naama Geva-Zatorsky, Ray Jupp, Diane Mathis, Christophe Benoist, Dennis L. Kasper

Nature. Author manuscript; available in PMC 2020 Jun 5.

Published in final edited form as: Nature. 2020 Jan; 577(7790): 410–415. Published online 2019 Dec 25. doi: 10.1038/s41586-019-1865-0

PMCID:: PMC7274525

Abstract Article PDF–5.1M

Select item 726384320.

Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis

Kang Ho Kim, Jong Min Choi, Feng Li, Armando Arizpe, Clavia Ruth Wooton-Kee, Sayeepriyadarshini Anakk, Sung Yun Jung, Milton J Finegold, David D Moore

Endocrinology. 2018 Jun; 159(6): 2435–2446. Published online 2018 Apr 26. doi: 10.1210/en.2018-00110

PMCID:: PMC7263843

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