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Select item 112923641.

Dynamic stem–loop extension by Pol θ and templated insertion during DNA repair

Denisse Carvajal-Maldonado, Yuzhen Li, Mark Returan, April M. Averill, Sylvie Doublié, Richard D. Wood

J Biol Chem. 2024 Jul; 300(7): 107461. Published online 2024 Jun 12. doi: 10.1016/j.jbc.2024.107461

PMCID:: PMC11292364

Abstract Article PDF–3.1M

Select item 111168702.

Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model

Zhenqiang Sun, Yanxin Xu, Bo Shao, Pengyuan Dang, Shengyun Hu, Haifeng Sun, Chen Chen, Chaoguan Wang, Jinbo Liu, Yang Liu, Junhong Hu

J Immunother Cancer. 2024; 12(5): e008491. Published online 2024 May 23. doi: 10.1136/jitc-2023-008491

PMCID:: PMC11116870

Abstract Article PDF–15M

Select item 110800513.

Melanoma-Derived DNA Polymerase Theta Variants Exhibit Altered DNA Polymerase Activity

Corey Thomas, Lisbeth Avalos-Irving, Jorge Victorino, Sydney Green, Morgan Andrews, Naisha Rodrigues, Sarah Ebirim, Ayden Mudd, Jamie B. Towle-Weicksel

Biochemistry. 2024 May 7; 63(9): 1107–1117. Published online 2024 Apr 26. doi: 10.1021/acs.biochem.3c00670

PMCID:: PMC11080051

Abstract Article PDF–4.6M

Select item 109951934.

POLQ inhibition attenuates the stemness and ferroptosis resistance in gastric cancer cells via downregulation of dihydroorotate dehydrogenase

Yanmei Peng, Wenbo Zheng, Yuehong Chen, Xuetao Lei, Zhijing Yang, Yuxuan Yang, Weiqi Liang, Kai Sun, Guoxin Li, Jiang Yu

Cell Death Dis. 2024 Apr; 15(4): 248. Published online 2024 Apr 4. doi: 10.1038/s41419-024-06618-5

PMCID:: PMC10995193

Abstract Article PDF–15M

Select item 108109385.

The m⁶A demethylase FTO targets POLQ to promote ccRCC cell proliferation and genome stability maintenance

Yichen He, Yimeng Chen, Zhengsheng Li, Changping Wu

J Cancer Res Clin Oncol. 2024; 150(2): 30. Published online 2024 Jan 25. doi: 10.1007/s00432-023-05541-0

PMCID:: PMC10810938

Abstract Article PDF–10M

Select item 105615586.

RHINO directs MMEJ to repair DNA breaks in mitosis

Alessandra Brambati, Olivia Sacco, Sarina Porcella, Joshua Heyza, Mike Kareh, Jens C. Schmidt, Agnel Sfeir

Science. Author manuscript; available in PMC 2023 Oct 9.

Published in final edited form as: Science. 2023 Aug 11; 381(6658): 653–660. Published online 2023 Jul 13. doi: 10.1126/science.adh3694

PMCID:: PMC10561558

Abstract Article PDF–2.2M

Select item 104996037.

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis

Camille Gelot, Marton Tibor Kovacs, Simona Miron, Emilie Mylne, Alexis Haan, Liza Boeffard-Dosierre, Rania Ghouil, Tatiana Popova, Florent Dingli, Damarys Loew, Josée Guirouilh-Barbat, Elaine Del Nery, Sophie Zinn-Justin, Raphael Ceccaldi

Nature. 2023; 621(7978): 415–422. Published online 2023 Sep 6. doi: 10.1038/s41586-023-06506-6

Correction in:: Nature. 2024; 626(7999): E13.

PMCID:: PMC10499603

Abstract Article PDF–13M

Select item 102431168.

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification

Camila M. Aprosoff, Boris J.A. Dyakov, Vivian H.W. Cheung, Cassandra J. Wong, Mikaela Palandra, Anne-Claude Gingras, Haley D.M. Wyatt

J Proteome Res. 2023 Jun 2; 22(6): 1660–1681. Published online 2023 Apr 18. doi: 10.1021/acs.jproteome.2c00706

PMCID:: PMC10243116

Abstract Article PDF–13M

Select item 91197369.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 910630310.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 846385511.

DNA polymerase θ promotes CAG•CTG repeat expansions in Huntington’s disease via insertion sequences of its catalytic domain

Kara Y. Chan, Xueying Li, Janice Ortega, Liya Gu, Guo-Min Li

J Biol Chem. 2021 Oct; 297(4): 101144. Published online 2021 Aug 30. doi: 10.1016/j.jbc.2021.101144

PMCID:: PMC8463855

Abstract Article PDF–1.9M

Select item 833695912.

GRB2 enforces homology-directed repair initiation by MRE11

Zu Ye, Shengfeng Xu, Yin Shi, Albino Bacolla, Aleem Syed, Davide Moiani, Chi-Lin Tsai, Qiang Shen, Guang Peng, Paul G. Leonard, Darin E. Jones, Bin Wang, John A. Tainer, Zamal Ahmed

Sci Adv. 2021 Aug; 7(32): eabe9254. Published online 2021 Aug 4. doi: 10.1126/sciadv.abe9254

PMCID:: PMC8336959

Abstract Article PDF–6.7M

Select item 822481813.

A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors

Jia Zhou, Camille Gelot, Constantia Pantelidou, Adam Li, Hatice Yücel, Rachel E. Davis, Anniina Farkkila, Bose Kochupurakkal, Aleem Syed, Geoffrey I. Shapiro, John A. Tainer, Brian S. J. Blagg, Raphael Ceccaldi, Alan D. D’Andrea

Nat Cancer. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: Nat Cancer. 2021 Jun; 2(6): 598–610. Published online 2021 Jun 17. doi: 10.1038/s43018-021-00203-x

PMCID:: PMC8224818

Abstract Article PDF–5.0M

Select item 821165314.

Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance

Diana Zatreanu, Helen M. R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert A. Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall M. B. Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luned M. Badder, Daniela Novo, Eleanor G. Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Katherine Ewings, Wojciech Krajewski, Ellen MacDonald, Hollie McCarron, Leon Pang, Chris Pedder, Laurent Rigoreau, Martin Swarbrick, Ed Wheatley, Simon Willis, Ai Ching Wong, Andre Nussenzweig, Marcel Tijsterman, Andrew Tutt, Simon J. Boulton, Geoff S. Higgins, Stephen J. Pettitt, Graeme C. M. Smith, Christopher J. Lord

Nat Commun. 2021; 12: 3636. Published online 2021 Jun 17. doi: 10.1038/s41467-021-23463-8

PMCID:: PMC8211653

Abstract Article PDF–31M

Select item 819548515.

Polθ reverse transcribes RNA and promotes RNA-templated DNA repair

Gurushankar Chandramouly, Jiemin Zhao, Shane McDevitt, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Taylor Treddinick, Felicia Wednesday Lopezcolorado, Tatiana Kent, Labiba A. Siddique, Joseph Mallon, Jacklyn Huhn, Zainab Shoda, Ekaterina Kashkina, Alessandra Brambati, Jeremy M. Stark, Xiaojiang S. Chen, Richard T. Pomerantz

Sci Adv. 2021 Jun; 7(24): eabf1771. Published online 2021 Jun 11. doi: 10.1126/sciadv.abf1771

PMCID:: PMC8195485

Abstract Article PDF–1.7M

Select item 816503016.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 808071017.

Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining

Tzah Feldman, Akhiad Bercovich, Yoni Moskovitz, Noa Chapal-Ilani, Amanda Mitchell, Jessie J. F. Medeiros, Tamir Biezuner, Nathali Kaushansky, Mark D. Minden, Vikas Gupta, Michael Milyavsky, Zvi Livneh, Amos Tanay, Liran I. Shlush

Nat Commun. 2021; 12: 2455. Published online 2021 Apr 28. doi: 10.1038/s41467-021-22803-y

PMCID:: PMC8080710

Abstract Article PDF–1.1M

Select item 806935518.

Translesion Synthesis or Repair by Specialized DNA Polymerases Limits Excessive Genomic Instability upon Replication Stress

Domenico Maiorano, Jana El Etri, Camille Franchet, Jean-Sébastien Hoffmann

Int J Mol Sci. 2021 Apr; 22(8): 3924. Published online 2021 Apr 10. doi: 10.3390/ijms22083924

PMCID:: PMC8069355

Abstract Article PDF–2.9M

Select item 801772019.

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M. Miller Jenkins, Yves Pommier

Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2015654118. Published online 2021 Feb 3. doi: 10.1073/pnas.2015654118

PMCID:: PMC8017720

Abstract Article PDF–1.9M

Select item 750276520.

POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks

Luther Davis, Kevin J. Khoo, Yinbo Zhang, Nancy Maizels

Proc Natl Acad Sci U S A. 2020 Sep 15; 117(37): 22900–22909. Published online 2020 Sep 1. doi: 10.1073/pnas.2008073117

PMCID:: PMC7502765

Abstract Article PDF–1.4M

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