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Select item 112062211.

CRL4^DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development

Xiao-Ran Han, Naoya Sasaki, Sarah C. Jackson, Pu Wang, Zhijun Li, Matthew D. Smith, Ling Xie, Xian Chen, Yanping Zhang, William F. Marzluff, Yue Xiong

Sci Adv. 2020 Dec; 6(51): eabd6078. Published online 2020 Dec 18. doi: 10.1126/sciadv.abd6078

PMCID:: PMC11206221

Abstract Article PDF–2.7M

Select item 109052762.

CUL4A Ubiquitin Ligase Is an Independent Predictor of Overall Survival in Pancreatic Adenocarcinoma

PANAGIOTIS TAVLAS, SOFIA NIKOU, CHRISTINA GERAMOUTSOU, PINELOPI BOSGANA, SPYRIDON CHAMPERIS TSANIRAS, MARIA MELACHRINOU, IOANNIS MAROULIS, VASILIKI BRAVOU

Cancer Genomics Proteomics. 2024 Mar-Apr; 21(2): 166–177. Published online 2024 Mar 3. doi: 10.21873/cgp.20438

PMCID:: PMC10905276

Abstract Article PDF–5.4M

Select item 105658763.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 104805354.

Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex

Islam E. Elkholi, Jonathan Boulais, Marie-Pier Thibault, Hong-Duc Phan, Amélie Robert, Lien B. Lai, Denis Faubert, Matthew J. Smith, Venkat Gopalan, Jean-Franҫois Côté

J Biol Chem. 2023 Sep; 299(9): 105123. Published online 2023 Aug 1. doi: 10.1016/j.jbc.2023.105123

PMCID:: PMC10480535

Abstract Article PDF–2.4M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101580296.

S100 Calcium Binding Protein A16 Promotes Cell Proliferation by triggering LATS1 ubiquitin degradation mediated by CUL4A ligase to inhibit Hippo pathway in Glioma development

Yifang Hu, Rihua Zhang, Shan Lu, Wensong Zhang, Dan Wang, Yaoqi Ge, Feng Jiang, Xiaoxuan Qin, Yun Liu

Int J Biol Sci. 2023; 19(7): 2034–2052. Published online 2023 Apr 2. doi: 10.7150/ijbs.79924

PMCID:: PMC10158029

Abstract Article PDF–7.9M

Select item 101200837.

ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1

Benjamin Mayro, Jacob P. Hoj, Christian G. Cerda-Smith, Haley M. Hutchinson, Michael W. Caminear, Hannah L. Thrash, Peter S. Winter, Suzanne E. Wardell, Donald P. McDonnell, Colleen Wu, Kris C. Wood, Ann Marie Pendergast

Proc Natl Acad Sci U S A. 2023 Apr 18; 120(16): e2210418120. Published online 2023 Apr 11. doi: 10.1073/pnas.2210418120

PMCID:: PMC10120083

Abstract Article PDF–4.2M

Select item 101196028.

Latent CSN-CRL complexes are crucial for curcumin-induced apoptosis and recruited during adipogenesis to lipid droplets via small GTPase RAB18

Dawadschargal Dubiel, Jing Wang, Roland Hartig, Supattra Chaithongyot, Wolfgang Dubiel, Michael Naumann

iScience. 2023 Apr 21; 26(4): 106468. Published online 2023 Mar 22. doi: 10.1016/j.isci.2023.106468

PMCID:: PMC10119602

Abstract Article PDF–6.6M

Select item 100796829.

Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy

Jingjie Yi, Omid Tavana, Huan Li, Donglai Wang, Richard J. Baer, Wei Gu

Nat Commun. 2023; 14: 1941. Published online 2023 Apr 6. doi: 10.1038/s41467-023-37617-3

PMCID:: PMC10079682

Abstract Article PDF–3.3M

Select item 996974110.

Molecular double clips within RepID WD40 domain control chromatin binding and CRL4-substrate assembly

Dong-Kyu Kim, Christophe E. Redon, Mirit I. Aladjem, Hyong Kyu Kim, Sang-Min Jang

Biochem Biophys Res Commun. Author manuscript; available in PMC 2023 Feb 27.

Published in final edited form as: Biochem Biophys Res Commun. 2021 Aug 27; 567: 208–214. Published online 2021 Jun 22. doi: 10.1016/j.bbrc.2021.06.047

PMCID:: PMC9969741

Abstract Article PDF–1.5M

Select item 995018311.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Abstract Article PDF–2.4M

Select item 979798812.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

Select item 976969813.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 972466314.

SCF^FBXW7 regulates G2‐M progression through control of CCNL1 ubiquitination

Siobhan O'Brien, Susan Kelso, Zachary Steinhart, Stephen Orlicky, Monika Mis, Yunhye Kim, Sichun Lin, Frank Sicheri, Stephane Angers

EMBO Rep. 2022 Dec; 23(12): e55044. Published online 2022 Oct 24. doi: 10.15252/embr.202255044

PMCID:: PMC9724663

Abstract Article PDF–3.3M

Select item 970808615.

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy

eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676

PMCID:: PMC9708086

Abstract Article PDF–8.5M

Select item 964056716.

LINC01468 drives NAFLD-HCC progression through CUL4A-linked degradation of SHIP2

Hongquan Wang, Yan Wang, Shihui Lai, Liang Zhao, Wenhui Liu, Shiqian Liu, Haiqiang Chen, Jinhua Wang, Guanhua Du, Bo Tang

Cell Death Discov. 2022; 8: 449. Published online 2022 Nov 7. doi: 10.1038/s41420-022-01234-8

PMCID:: PMC9640567

Abstract Article PDF–5.8M

Select item 961170517.

Lentivirus-mediated short hairpin RNA interference of CENPK inhibits growth of colorectal cancer cells with overexpression of Cullin 4A

Xian Li, Yi-Ru Han, Xuefeng Xuefeng, Yong-Xiang Ma, Guo-Sheng Xing, Zhi-Wen Yang, Zhen Zhang, Lin Shi, Xin-Lin Wu

World J Gastroenterol. 2022 Oct 7; 28(37): 5420–5443. Published online 2022 Oct 7. doi: 10.3748/wjg.v28.i37.5420

PMCID:: PMC9611705

Abstract Article PDF–27M

Select item 951327118.

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1

Amelia K. Luciano, Ekaterina D. Korobkina, Scott P. Lyons, John A. Haley, Shelagh M. Fluharty, Su Myung Jung, Arminja N. Kettenbach, David A. Guertin

J Biol Chem. 2022 Oct; 298(10): 102379. Published online 2022 Aug 13. doi: 10.1016/j.jbc.2022.102379

PMCID:: PMC9513271

Abstract Article PDF–2.7M

Select item 944012219.

Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation

María Arroyo, Florian D. Hastert, Andreas Zhadan, Florian Schelter, Susanne Zimbelmann, Cathia Rausch, Anne K. Ludwig, Thomas Carell, M. Cristina Cardoso

Nat Commun. 2022; 13: 5173. Published online 2022 Sep 2. doi: 10.1038/s41467-022-32799-8

Correction in:: Nat Commun. 2023; 14: 369.

PMCID:: PMC9440122

Abstract Article PDF–9.3M

Select item 933619620.

M⁶A RNA Methylation Regulates Histone Ubiquitination to Support Cancer Growth and Progression

Pooja Yadav, Panneerdoss Subbarayalu, Daisy Medina, Saif Nirzhor, Santosh Timilsina, Subapriya Rajamanickam, Vijay K. Eedunuri, Yogesh Gupta, Siyuan Zheng, Nourhan Abdelfattah, Yufei Huang, Ratna Vadlamudi, Robert Hromas, Paul Meltzer, Peter Houghton, Yidong Chen, Manjeet K. Rao

Cancer Res. Author manuscript; available in PMC 2022 Jul 29.

Published in final edited form as: Cancer Res. 2022 May 16; 82(10): 1872–1889. doi: 10.1158/0008-5472.CAN-21-2106