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Select item 114064211.

Knockdown of cullin 3 inhibits progressive phenotypes and increases chemosensitivity in cholangiocarcinoma cells

Kandawasri Pratummanee, Kankamol Kerdkumthong, Sittiruk Roytrakul, Phonprapavee Tantimetta, Phanthipha Runsaeng, Sompop Saeheng, Sumalee Obchoei

Mol Med Rep. 2024 Nov; 30(5): 198. Published online 2024 Sep 3. doi: 10.3892/mmr.2024.13322

PMCID:: PMC11406421

Abstract Article PDF–9.3M

Select item 112969142.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 112379303.

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein

Xiao Tang, Yang Liu, Jinhui Wang, Teng Long, Bobo Wing Yee Mok, Yan Huang, Ziqing Peng, Qinyu Jia, Chengxi Liu, Pui-Kin So, Sirius Pui-Kam Tse, Cheuk Hei NG, Shiyi Liu, Fei Sun, Shaojun Tang, Zhong-Ping Yao, Honglin Chen, Yusong Guo

J Biol Chem. 2024 Jun; 300(6): 107390. Published online 2024 May 21. doi: 10.1016/j.jbc.2024.107390

PMCID:: PMC11237930

Abstract Article PDF–3.8M

Select item 112139334.

Prognostic potential of CUL3 ligase with differential roles in luminal A and basal type breast cancer tumors

Vasiliki Pantazi, Vanda Miklós, Paul Smith, Orsolya Oláh-Németh, Gabriella Pankotai-Bodó, Divya Teja Dondapati, Ferhan Ayaydin, Vincenzo D’Angiolella, Tibor Pankotai

Sci Rep. 2024; 14: 14912. Published online 2024 Jun 28. doi: 10.1038/s41598-024-65692-z

PMCID:: PMC11213933

Abstract Article PDF–9.8M

Select item 112099355.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111094836.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 109210667.

Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex

Andreas Damianou, Zhu Liang, Frederik Lassen, Iolanda Vendrell, George Vere, Svenja Hester, Philip D Charles, Adan Pinto-Fernandez, Alberto Santos, Roman Fischer, Benedikt M Kessler

Life Sci Alliance. 2024 May; 7(5): e202302245. Published online 2024 Mar 7. doi: 10.26508/lsa.202302245

PMCID:: PMC10921066

Abstract Article PDF–3.2M

Select item 108832808.

Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation

Chop Yan Lee, Dalmira Hubrich, Julia K Varga, Christian Schäfer, Mareen Welzel, Eric Schumbera, Milena Djokic, Joelle M Strom, Jonas Schönfeld, Johanna L Geist, Feyza Polat, Toby J Gibson, Claudia Isabelle Keller Valsecchi, Manjeet Kumar, Ora Schueler-Furman, Katja Luck

Mol Syst Biol. 2024 Feb; 20(2): 75–97. Published online 2024 Jan 15. doi: 10.1038/s44320-023-00005-6

PMCID:: PMC10883280

Abstract Article PDF–3.4M

Select item 107002189.

BCLAF1-induced HIF-1α accumulation under normoxia enhances PD-L1 treatment resistances via BCLAF1-CUL3 complex

Bowen Yao, Ye Lu, Yazhao Li, Yixue Bai, Xinyu Wei, Yuanyuan Yang, Demao Yao

Cancer Immunol Immunother. 2023 Dec; 72(12): 4279–4292. Published online 2023 Oct 31. doi: 10.1007/s00262-023-03563-8

PMCID:: PMC10700218

Abstract Article PDF–7.4M

Select item 1056462210.

Structural and biochemical characterization establishes a detailed understanding of KEAP1-CUL3 complex assembly

Roslin J. Adamson, N Connor Payne, Sergio G. Bartual, Ralph Mazitschek, Alex N. Bullock

Free Radic Biol Med. 2023 Aug 1; 204: 215–225. doi: 10.1016/j.freeradbiomed.2023.04.021

PMCID:: PMC10564622

Abstract Article PDF–5.7M

Select item 1041393311.

Structure and Function of RhoBTB1 Required for Substrate Specificity and Cullin-3 Ubiquitination

Gaurav Kumar, Shi Fang, Daria Golosova, Ko-Ting Lu, Daniel T Brozoski, Ibrahim Vazirabad, Curt D Sigmund

Function (Oxf) 2023; 4(5): zqad034. Published online 2023 Jul 3. doi: 10.1093/function/zqad034

PMCID:: PMC10413933

Abstract Article PDF–1.4M

Select item 1039866012.

C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains

Julia Jülg, Dieter Edbauer, Christian Behrends

EMBO Rep. 2023 Aug; 24(8): e55895. Published online 2023 Jun 15. doi: 10.15252/embr.202255895

PMCID:: PMC10398660

Abstract Article PDF–2.4M

Select item 1037198713.

A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development

Anthony J. Asmar, Shaun R. Abrams, Jenny Hsin, Jason C. Collins, Rita M. Yazejian, Youmei Wu, Jean Cho, Andrew D. Doyle, Samhitha Cinthala, Marleen Simon, Richard H. van Jaarsveld, David B. Beck, Laura Kerosuo, Achim Werner

Nat Commun. 2023; 14: 4499. Published online 2023 Jul 26. doi: 10.1038/s41467-023-40223-y

PMCID:: PMC10371987

Abstract Article PDF–3.9M

Select item 1034867414.

Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase

Wentong Jiang, Wei Wang, Yinfei Kong, Sanduo Zheng

Sci Adv. 2023 Jul; 9(28): eadg8369. Published online 2023 Jul 14. doi: 10.1126/sciadv.adg8369

PMCID:: PMC10348674

Abstract Article PDF–2.3M

Select item 1033005815.

Renal effects of Cullin 3 mutations causing Familial Hyperkalemic Hypertension

Ryan J. Cornelius, Yujiro Maeoka, James A. McCormick

Curr Opin Nephrol Hypertens. Author manuscript; available in PMC 2024 Jul 1.

Published in final edited form as: Curr Opin Nephrol Hypertens. 2023 Jul 1; 32(4): 335–343. Published online 2023 Apr 12. doi: 10.1097/MNH.0000000000000891

PMCID:: PMC10330058

Abstract Article PDF–902K

Select item 1030785216.

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility

Juan Gu, Pingyang Ke, Haokun Guo, Jing Liu, Yan Liu, Xin Tian, Zhuo Huang, Xin Xu, Demei Xu, Yuanlin Ma, Xuefeng Wang, Fei Xiao

Cell Death Differ. 2023 Jul; 30(7): 1726–1741. Published online 2023 May 4. doi: 10.1038/s41418-023-01174-5

PMCID:: PMC10307852

Abstract Article PDF–8.8M

Select item 1028411717.

Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry

Fenglong Jiao, Leah J. Salituro, Clinton Yu, Craig B. Gutierrez, Scott D. Rychnovsky, Lan Huang

Anal Chem. Author manuscript; available in PMC 2023 Jun 21.

Published in final edited form as: Anal Chem. 2023 Jan 31; 95(4): 2532–2539. Published online 2023 Jan 18. doi: 10.1021/acs.analchem.2c04986

PMCID:: PMC10284117

Abstract Article PDF–2.5M

Select item 1028208718.

USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice

Changzhou Cai, Huailu Ma, Jin Peng, Xiang Shen, Xinghua Zhen, Chaohui Yu, Pumin Zhang, Feng Ji, Jiewei Wang

Nat Commun. 2023; 14: 3648. Published online 2023 Jun 20. doi: 10.1038/s41467-023-39412-6

PMCID:: PMC10282087

Abstract Article PDF–2.8M

Select item 1024019919.

UBAP2L‐dependent coupling of PLK1 localization and stability during mitosis

Lucile Guerber, Aurore Vuidel, Yongrong Liao, Charlotte Kleiss, Erwan Grandgirard, Izabela Sumara, Evanthia Pangou

EMBO Rep. 2023 Jun; 24(6): e56241. Published online 2023 Apr 11. doi: 10.15252/embr.202256241

PMCID:: PMC10240199

Abstract Article PDF–4.9M

Select item 1023742220.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

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