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Select item 111623321.

A synthetic cationic helical polypeptide as a multipotent innate immune activator for cancer immunotherapy

DaeYong Lee, Kristin Huntoon, Yifan Wang, Minjeong Kang, Yifei Lu, Seong Dong Jeong, Todd M. Link, Thomas D. Gallup, Yaqing Qie, Xuefeng Li, Yifan Ma, Shiyan Dong, Benjamin R. Schrank, Adam Grippin, Abin Antony, Jonghoon Ha, Mengyu Chang, Yi An, Liang Wang, Dadi Jiang, Jing Li, Albert C. Koong, John A. Tainer, Wen Jiang, Betty Y.S. Kim

Nat Biomed Eng. Author manuscript; available in PMC 2024 Jun 9.

Published in final edited form as: Nat Biomed Eng. 2024 May; 8(5): 593–610. Published online 2024 Apr 19. doi: 10.1038/s41551-024-01194-7

PMCID:: PMC11162332

Abstract Article PDF–7.0M

Select item 110990162.

Zebularine potentiates anti-tumor immunity by inducing tumor immunogenicity and improving antigen processing through cGAS-STING pathway

Yong Zhang, Heng Zhao, Weili Deng, Junzhong Lai, Kai Sang, Qi Chen

Commun Biol. 2024; 7: 587. Published online 2024 May 16. doi: 10.1038/s42003-024-06271-w

PMCID:: PMC11099016

Abstract Article PDF–5.8M

Select item 110777653.

FGF21 attenuates neuroinflammation following subarachnoid hemorrhage through promoting mitophagy and inhibiting the cGAS-STING pathway

Yue Ma, Zhiqin Liu, Lele Deng, Jingjing Du, Zenghui Fan, Tian Ma, Jing Xiong, Xue Xiuyun, Naibing Gu, Zhengli Di, Yu Zhang

J Transl Med. 2024; 22: 436. Published online 2024 May 8. doi: 10.1186/s12967-024-05239-y

PMCID:: PMC11077765

Abstract Article PDF–13M

Select item 109590754.

Candida albicans extracellular vesicles trigger type I IFN signalling via cGAS and STING

Hannah Brown Harding, Geneva N. Kwaku, Christopher M. Reardon, Nida S. Khan, Daniel Zamith-Miranda, Robert Zarnowski, Jenny M. Tam, Collins K. Bohaen, Lauren Richey, Kenta Mosallanejad, Arianne J. Crossen, Jennifer L. Reedy, Rebecca A. Ward, Diego A. Vargas-Blanco, Kyle J. Basham, Roby P. Bhattacharyya, Jeniel E. Nett, Michael K. Mansour, Frank L. van de Veerdonk, Vinod Kumar, Jonathan C. Kagan, David R. Andes, Joshua D. Nosanchuk, Jatin M. Vyas

Nat Microbiol. Author manuscript; available in PMC 2024 Mar 22.

Published in final edited form as: Nat Microbiol. 2024 Jan; 9(1): 95–107. Published online 2024 Jan 2. doi: 10.1038/s41564-023-01546-0

PMCID:: PMC10959075

Abstract Article PDF–3.2M

Select item 109176605.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108829376.

Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages

Stoyan Tankov, Marija Petrovic, Marc Lecoultre, Felipe Espinoza, Nadia El-Harane, Viviane Bes, Sylvie Chliate, Darel Martinez Bedoya, Olivier Jordan, Gerrit Borchard, Denis Migliorini, Valérie Dutoit, Paul R. Walker

Cell Commun Signal. 2024; 22: 144. Published online 2024 Feb 22. doi: 10.1186/s12964-024-01523-y

PMCID:: PMC10882937

Abstract Article PDF–3.3M

Select item 108633227.

Engineering cGAS-agonistic oligonucleotides as therapeutics for cancer immunotherapy

Shurong Zhou, Ting Su, Furong Cheng, Janet Cole, Xiang Liu, Bei Zhang, Shaheer Alam, Jinze Liu, Guizhi Zhu

Mol Ther Nucleic Acids. 2024 Mar 12; 35(1): 102126. Published online 2024 Jan 24. doi: 10.1016/j.omtn.2024.102126

PMCID:: PMC10863322

Abstract Article PDF–2.4M

Select item 107306958.

Airway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling

Zhangchu Jin, Zhehua Shao, Shiyi Yang, Anyi Guo, Yinling Han, Yinfang Wu, Yun Zhao, Yanping Wu, Jiaxin Shen, Min Zhang, Xueqin Zhan, Wenqi Diao, Songmin Ying, Chao Zhang, Wen Li, Huahao Shen, Zhihua Chen, Fugui Yan

Cell Death Dis. 2023 Dec; 14(12): 844. Published online 2023 Dec 19. doi: 10.1038/s41419-023-06364-0

PMCID:: PMC10730695

Abstract Article PDF–4.7M

Select item 106655219.

Megakaryocytes possess a STING pathway that is transferred to platelets to potentiate activation

Firas El-Mortada, Karima Landelouci, Samuel Bertrand-Perron, Félix-Antoine Aubé, Amélie Poirier, Amel Bidias, Georges Jourdi, Mélanie Welman, Michael P Gantier, Justin R Hamilton, Benjamin Kile, Marie Lordkipanidzé, Geneviève Pépin

Life Sci Alliance. 2024 Feb; 7(2): e202302211. Published online 2023 Nov 22. doi: 10.26508/lsa.202302211

PMCID:: PMC10665521

Abstract Article PDF–1.9M

Select item 1065467310.

Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells

Hannah E. Meibers, Kathrynne A. Warrick, Andrew VonHandorf, Charles N. Vallez, Kiana Kawarizadeh, Irene Saha, Omer Donmez, Viral G. Jain, Leah C. Kottyan, Matthew T. Weirauch, Chandrashekhar Pasare

Cell Rep. Author manuscript; available in PMC 2023 Nov 17.

Published in final edited form as: Cell Rep. 2023 Oct 31; 42(10): 113180. Published online 2023 Oct 3. doi: 10.1016/j.celrep.2023.113180

PMCID:: PMC10654673

Abstract Article PDF–2.8M

Select item 1058468911.

Fanconi anemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mouse development

Nazareno Bona, Gerry P. Crossan

Nat Struct Mol Biol. 2023; 30(10): 1434–1445. Published online 2023 Aug 14. doi: 10.1038/s41594-023-01067-8

PMCID:: PMC10584689

Abstract Article PDF–9.2M

Select item 1054280712.

A possible role for proinflammatory activation via cGAS-STING pathway in atherosclerosis induced by accumulation of DNA double-strand breaks

Chiemi Sakai, Keitaro Ueda, Kohei Goda, Rikuto Fujita, Junji Maeda, Shinya Nakayama, Yusuke Sotomaru, Satoshi Tashiro, Masao Yoshizumi, Takafumi Ishida, Mari Ishida

Sci Rep. 2023; 13: 16470. Published online 2023 Sep 30. doi: 10.1038/s41598-023-43848-7

PMCID:: PMC10542807

Abstract Article PDF–3.9M

Select item 1053137113.

High-Intensity Interval Training Ameliorates High-Fat Diet-Induced Metabolic Disorders via the Cyclic GMP-AMP Synthase-Stimulator of Interferon Gene Signaling Pathway

Zhiwen Hu, Xi Li, Yangjun Yang, Zhe Zhang, Shuzhe Ding

Int J Mol Sci. 2023 Sep; 24(18): 13840. Published online 2023 Sep 8. doi: 10.3390/ijms241813840

PMCID:: PMC10531371

Abstract Article PDF–1.6M

Select item 1050647414.

TLR2 is non-redundant in the population and subpopulation responses to Mycobacterium tuberculosis in macrophages and in vivo

Charul Jani, Sydney L. Solomon, Joshua M. Peters, Stephanie C. Pringle, Amelia E. Hinman, Julie Boucau, Bryan D. Bryson, Amy K. Barczak

mSystems. 2023 Jul-Aug; 8(4): e00052-23. Published online 2023 Jul 13. doi: 10.1128/msystems.00052-23

PMCID:: PMC10506474

Abstract Article PDF–2.5M

Select item 1043566815.

Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production

Andrew D. Hildreth, Eddie T. Padilla, Rana Yakhshi Tafti, Akshara R. Legala, Timothy E. O’Sullivan

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Feb 28; 42(2): 112141. Published online 2023 Feb 18. doi: 10.1016/j.celrep.2023.112141

PMCID:: PMC10435668

Abstract Article PDF–2.5M

Select item 1041245416.

cGAS–STING drives ageing-related inflammation and neurodegeneration

Muhammet F. Gulen, Natasha Samson, Alexander Keller, Marius Schwabenland, Chong Liu, Selene Glück, Vivek V. Thacker, Lucie Favre, Bastien Mangeat, Lona J. Kroese, Paul Krimpenfort, Marco Prinz, Andrea Ablasser

Nature. 2023; 620(7973): 374–380. Published online 2023 Aug 2. doi: 10.1038/s41586-023-06373-1

PMCID:: PMC10412454

Abstract Article PDF–27M

Select item 1037350317.

Gut lumen-leaked microbial DNA causes myocardial inflammation and impairs cardiac contractility in ageing mouse heart

Hong Gao, Ke Wang, Jorge A. Suarez, Zhongmou Jin, Karina Cunha e Rocha, Dinghong Zhang, Andrea Farrell, Tyler Truong, Yasemin Tekin, Breanna Tan, Hyun Suh Jung, Julia Kempf, Sushil K. Mahata, Wolfgang H. Dillmann, Jorge Suarez, Wei Ying

Front Immunol. 2023; 14: 1216344. Published online 2023 Jul 13. doi: 10.3389/fimmu.2023.1216344

PMCID:: PMC10373503

Abstract Article PDF–5.9M

Select item 1036039618.

Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT

Iman Al Khatib, Jingti Deng, Yuanjiu Lei, Sylvia Torres-Odio, Gladys R Rojas, Laura E Newman, Brian K Chung, Andrew Symes, Hongliang Zhang, Shar-yin N Huang, Yves Pommier, Aneal Khan, Gerald S Shadel, Andrew Phillip West, William T Gibson, Timothy E Shutt

Hum Mol Genet. 2023 Aug 1; 32(15): 2422–2440. Published online 2023 May 2. doi: 10.1093/hmg/ddad062

PMCID:: PMC10360396

Abstract Article PDF–2.4M

Select item 1035256319.

PTEN‐induced kinase 1 is associated with renal aging, via the cGAS‐STING pathway

Min Heui Ha, Man S. Kim, Hyun‐Ju An, Min‐Ji Sung, Yu Ho Lee, Dong‐Ho Yang, Sang Hyun Jung, Jihyun Baek, Yueun Choi, Deanne M. Taylor, Yuanchao Zhang, So‐Young Lee, Hye Yun Jeong

Aging Cell. 2023 Jul; 22(7): e13865. Published online 2023 May 15. doi: 10.1111/acel.13865

PMCID:: PMC10352563

Abstract Article PDF–11M

Select item 1033084320.

Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity

Yuanjiu Lei, Jordyn J. VanPortfliet, Yi-Fan Chen, Joshua D. Bryant, Ying Li, Danielle Fails, Sylvia Torres-Odio, Katherine B. Ragan, Jingti Deng, Armaan Mohan, Bing Wang, Olivia N. Brahms, Shawn D. Yates, Michael Spencer, Carl W. Tong, Marcus W. Bosenberg, Laura Ciaccia West, Gerald S. Shadel, Timothy E. Shutt, Jason W. Upton, Pingwei Li, A. Phillip West

Cell. Author manuscript; available in PMC 2024 Jul 6.

Published in final edited form as: Cell. 2023 Jul 6; 186(14): 3013–3032.e22. Published online 2023 Jun 22. doi: 10.1016/j.cell.2023.05.039

PMCID:: PMC10330843

Abstract Article PDF–4.7M

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