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Items: 1 to 20 of 306

1.
Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation
Jian-Xin Lin, Meili Ge, Cheng-yu Liu, Ronald Holewinski, Thorkell Andresson, Zu-Xi Yu, Tesfay Gebregiorgis, Rosanne Spolski, Peng Li, Warren J. Leonard
Nat Commun. 2024; 15: 7372. Published online 2024 Aug 27. doi: 10.1038/s41467-024-50925-6
PMCID:
PMC11349758
AbstractArticlePDF–3.5M
2.
USP28 protects development of inflammation in mouse intestine by regulating STAT5 phosphorylation and IL22 production in T lymphocytes
Gwenaëlle Le Menn, Keela Pikkarainen, Daniela Mennerich, Dominika Miroszewska, Thomas Kietzmann, Zhi Chen
Front Immunol. 2024; 15: 1401949. Published online 2024 Jul 15. doi: 10.3389/fimmu.2024.1401949
PMCID:
PMC11284026
AbstractArticlePDF–4.1M
3.
Physiological significance of STAT proteins: investigations through gene disruption in vivo
D. E. Levy
Cell Mol Life Sci. 1999 Sep; 55(12): 1559–1567. doi: 10.1007/s000180050395
PMCID:
PMC11146878
AbstractPDF–86K
4.
JAK-STAT signaling maintains homeostasis in T cells and macrophages
Nikolaus Fortelny, Matthias Farlik, Victoria Fife, Anna-Dorothea Gorki, Caroline Lassnig, Barbara Maurer, Katrin Meissl, Marlies Dolezal, Laura Boccuni, Aarathy Ravi Sundar Jose Geetha, Mojoyinola Joanna Akagha, Anzhelika Karjalainen, Stephen Shoebridge, Asma Farhat, Ulrike Mann, Rohit Jain, Shweta Tikoo, Nina Zila, Wolfgang Esser-Skala, Thomas Krausgruber, Katarzyna Sitnik, Thomas Penz, Anastasiya Hladik, Tobias Suske, Sophie Zahalka, Martin Senekowitsch, Daniele Barreca, Florian Halbritter, Sabine Macho-Maschler, Wolfgang Weninger, Heidi A. Neubauer, Richard Moriggl, Sylvia Knapp, Veronika Sexl, Birgit Strobl, Thomas Decker, Mathias Müller, Christoph Bock
Nat Immunol. 2024; 25(5): 847–859. Published online 2024 Apr 24. doi: 10.1038/s41590-024-01804-1
PMCID:
PMC11065702
AbstractArticlePDF–10M
5.
Stromal STAT5-Mediated Trophic Activity Regulates Hematopoietic Niche Factors
Zhengqi Wang, Grace Emmel, Hong Seo Lim, Wandi Zhu, Astrid Kosters, Eliver E B Ghosn, Peng Qiu, Kevin D Bunting
Stem Cells. 2023 Oct; 41(10): 944–957. Published online 2023 Jul 19. doi: 10.1093/stmcls/sxad055
PMCID:
PMC11009694
AbstractArticlePDF–24M
6.
Adipocyte STAT5 (signal transducer and activator of transcription 5) is not required for glucocorticoid-induced metabolic dysfunction
Innocence Harvey, Allison J. Richard, Tamra M. Mendoza, Jacqueline M. Stephens
Am J Physiol Endocrinol Metab. 2023 Nov 1; 325(5): E438–E447. Published online 2023 Sep 13. doi: 10.1152/ajpendo.00116.2023
PMCID:
PMC10864007
AbstractArticle
7.
Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells towards durable effector-like states during chronic antigen exposure
Jean-Christophe Beltra, Mohamed S. Abdel-Hakeem, Sasikanth Manne, Zhen Zhang, Hua Huang, Makoto Kurachi, Leon Su, Lora Picton, Shin Foong Ngiow, Yuki Muroyama, Valentina Casella, Yinghui J. Huang, Josephine R. Giles, Divij Mathew, Jonathan Belman, Max Klapholz, Hélène Decaluwe, Alexander C. Huang, Shelley L. Berger, K. Christopher Garcia, E. John Wherry
Immunity. Author manuscript; available in PMC 2024 Dec 12.
Published in final edited form as: Immunity. 2023 Dec 12; 56(12): 2699–2718.e11. doi: 10.1016/j.immuni.2023.11.005
PMCID:
PMC10752292
AbstractArticlePDF–3.6M
8.
Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms
Elodie Grockowiak, Claudia Korn, Justyna Rak, Veronika Lysenko, Adrien Hallou, Francesca M. Panvini, Matthew Williams, Claire Fielding, Zijian Fang, Eman Khatib-Massalha, Andrés García-García, Juan Li, Reema A. Khorshed, Sara González-Antón, E. Joanna Baxter, Anjali Kusumbe, Bridget S. Wilkins, Anna Green, Benjamin D. Simons, Claire N. Harrison, Anthony R. Green, Cristina Lo Celso, Alexandre P. A. Theocharides, Simón Méndez-Ferrer
Nat Cancer. 2023; 4(8): 1193–1209. Published online 2023 Aug 7. doi: 10.1038/s43018-023-00607-x
PMCID:
PMC10447237
AbstractArticlePDF–18M
9.
The Kruppel-like factor 4-signal transducer and activator of transcription 5A axis promotes pancreatic fibrosis in mice with caerulein-induced chronic pancreatitis
Xiaoxiang Wang, Lan Yu, Yao Chen, Xing Xiong, Hongmei Ran
Exp Anim. 2023; 72(3): 379–388. Published online 2023 Mar 23. doi: 10.1538/expanim.22-0147
PMCID:
PMC10435357
AbstractArticlePDF–6.0M
10.
Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death in alcohol-induced steatohepatitis
Haibo Dong, Wei Zhong, Wenliang Zhang, Liuyi Hao, Wei Guo, Ruichao Yue, Xinguo Sun, Zhaoli Sun, Ramon Bataller, Zhanxiang Zhou
Metabolism. Author manuscript; available in PMC 2023 Jun 7.
Published in final edited form as: Metabolism. 2023 Jan; 138: 155334. Published online 2022 Oct 28. doi: 10.1016/j.metabol.2022.155334
PMCID:
PMC10245388
AbstractArticlePDF–3.0M
11.
Tetramerization of STAT5 regulates monocyte differentiation and the dextran sulfate sodium-induced colitis in mice
Kelly L. Monaghan, Wen Zheng, Halima Akhter, Lei Wang, Amanda G. Ammer, Peng Li, Jian-Xin Lin, Gangqing Hu, Warren J. Leonard, Edwin C. K. Wan
Front Immunol. 2023; 14: 1117828. Published online 2023 Apr 20. doi: 10.3389/fimmu.2023.1117828
PMCID:
PMC10157487
AbstractArticlePDF–18M
12.
CSF2RB overexpression promotes the protective effects of mesenchymal stromal cells against ischemic heart injury
Tingting Qi, Xiaoming Xu, Yongzhen Guo, Yunlong Xia, Lu Peng, Congye Li, Fengyue Ding, Chao Gao, Miaomiao Fan, Min Yu, Huishou Zhao, Yuan He, Wenli Li, Chunxu Hai, Erhe Gao, Xing Zhang, Feng Gao, Yanhong Fan, Wenjun Yan, Ling Tao
Theranostics. 2023; 13(6): 1759–1773. Published online 2023 Mar 13. doi: 10.7150/thno.81336
PMCID:
PMC10091875
AbstractArticlePDF–7.4M
13.
PRL2 phosphatase enhances oncogenic FLT3 signaling via dephosphorylation of the E3 ubiquitin ligase CBL at tyrosine 371
Hongxia Chen, Yunpeng Bai, Michihiro Kobayashi, Shiyu Xiao, Wenjie Cai, Sergio Barajas, Sisi Chen, Jinmin Miao, Frederick Nguele Meke, Sasidhar Vemula, James P. Ropa, James M. Croop, H. Scott Boswell, Jun Wan, Yuzhi Jia, Huiping Liu, Loretta S. Li, Jessica K. Altman, Elizabeth A. Eklund, Peng Ji, Wei Tong, Hamid Band, Danny T. Huang, Leonidas C. Platanias, Zhong-Yin Zhang, Yan Liu
Blood. 2023 Jan 19; 141(3): 244–259. Published online 2022 Oct 11. doi: 10.1182/blood.2022016580
Correction in:
Blood. 2024 Jan 25; 143(4): 376.
PMCID:
PMC9936309
AbstractArticle
14.
An OGT-STAT5 Axis in Regulatory T Cells Controls Energy and Iron Metabolism
Zengdi Zhang, Oscar C. Salgado, Bing Liu, Zahra Moazzami, Kristin A. Hogquist, Michael A. Farrar, Hai-Bin Ruan
Front Immunol. 2022; 13: 874863. Published online 2022 Jul 8. doi: 10.3389/fimmu.2022.874863
PMCID:
PMC9304952
AbstractArticlePDF–8.3M
15.
An engineered IL-2 partial agonist promotes CD8+ T cell stemness
Fei Mo, Zhiya Yu, Peng Li, Jangsuk Oh, Rosanne Spolski, Liang Zhao, Caleb R. Glassman, Tori N. Yamamoto, Yun Chen, Filip M. Golebiowski, Dalton Hermans, Sonia S. Majri, Lora K. Picton, Wei Liao, Min Ren, Xiaoxuan Zhuang, Suman Mitra, Jian-Xin Lin, Luca Gattinoni, Jonathan D. Powell, Nicholas P. Restifo, K. Christopher Garcia, Warren J. Leonard
Nature. Author manuscript; available in PMC 2022 Jun 7.
Published in final edited form as: Nature. 2021 Sep; 597(7877): 544–548. Published online 2021 Sep 15. doi: 10.1038/s41586-021-03861-0
PMCID:
PMC9172917
AbstractArticlePDF–2.5M
16.
Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis
Allison J. Richard, Hardy Hang, Timothy D. Allerton, Peng Zhao, Tamra Mendoza, Sujoy Ghosh, Carrie M. Elks, Jacqueline M. Stephens
Front Endocrinol (Lausanne) 2022; 13: 812802. Published online 2022 Apr 7. doi: 10.3389/fendo.2022.812802
PMCID:
PMC9022209
AbstractArticlePDF–4.7M
17.
PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development
Diego Y. Grinman, Kata Boras-Granic, Farzin M. Takyar, Pamela Dann, Julie R. Hens, Christina Marmol, Jongwon Lee, Jungmin Choi, Lewis A. Chodosh, Martin E. Garcia Sola, John J. Wysolmerski
Breast Cancer Res. 2022; 24: 30. Published online 2022 Apr 19. doi: 10.1186/s13058-022-01523-1
PMCID:
PMC9020078
AbstractArticlePDF–11M
18.
The PAX5‐JAK2 translocation acts as dual‐hit mutation that promotes aggressive B‐cell leukemia via nuclear STAT5 activation
Sabine Jurado, Anna S Fedl, Markus Jaritz, Daniela Kostanova‐Poliakova, Stephen G Malin, Charles G Mullighan, Sabine Strehl, Maria Fischer, Meinrad Busslinger
EMBO J. 2022 Apr; 41(7): e108397. Published online 2022 Feb 14. doi: 10.15252/embj.2021108397
PMCID:
PMC8982625
AbstractArticlePDF–2.4M
19.
Intrinsic IL-2 Production by Effector CD8 T Cells Affects IL-2 Signaling and Promotes Fate Decisions, Stemness, and Protection
Shannon M. Kahan, Rakesh K. Bakshi, Jennifer T. Ingram, R. Curtis Hendrickson, Elliot J. Lefkowitz, David K. Crossman, Laurie E. Harrington, Casey T. Weaver, Allan J. Zajac
Sci Immunol. Author manuscript; available in PMC 2023 Feb 11.
Published in final edited form as: Sci Immunol. 2022 Feb 11; 7(68): eabl6322. Published online 2022 Feb 11. doi: 10.1126/sciimmunol.abl6322
PMCID:
PMC8923238
AbstractArticlePDF–3.1M
20.
Growth hormone receptor contributes to the activation of STAT5 in the hypothalamus of pregnant mice
Frederick Wasinski, Pryscila D.S. Teixeira, Edward O. List, John J. Kopchick, Jose Donato, Jr.
Neurosci Lett. Author manuscript; available in PMC 2022 Mar 14.
Published in final edited form as: Neurosci Lett. 2022 Jan 23; 770: 136402. Published online 2021 Dec 17. doi: 10.1016/j.neulet.2021.136402
PMCID:
PMC8919473
AbstractArticlePDF–861K

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