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Items: 1 to 20 of 307

1.
Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer
Taijin Lan, Sara Arastu, Jarrick Lam, Hyungsin Kim, Wenping Wang, Samuel Wang, Vrushank Bhatt, Eduardo Cararo Lopes, Zhixian Hu, Michael Sun, Xuefei Luo, Jonathan M. Ghergurovich, Xiaoyang Su, Joshua D. Rabinowitz, Eileen White, Jessie Yanxiang Guo
Nat Commun. 2024; 15: 5857. Published online 2024 Jul 12. doi: 10.1038/s41467-024-50157-8
PMCID:
PMC11245543
AbstractArticlePDF–3.3M
2.
MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma
Yu Qian, Ana Galan-Cobo, Irene Guijarro, Minghao Dang, David Molkentine, Alissa Poteete, Fahao Zhang, Qi Wang, Jing Wang, Edwin Parra, Apekshya Panda, Jacy Fang, Ferdinandos Skoulidis, Ignacio I. Wistuba, Svena Verma, Taha Merghoub, Jedd D. Wolchok, Kwok-Kin Wong, Ralph J. DeBerardinis, John D. Minna, Natalie I. Vokes, Catherine B. Meador, Justin F. Gainor, Linghua Wang, Alexandre Reuben, John V. Heymach
Cancer Cell. Author manuscript; available in PMC 2024 Jun 7.
Published in final edited form as: Cancer Cell. 2023 Jul 10; 41(7): 1363–1380.e7. Published online 2023 Jun 15. doi: 10.1016/j.ccell.2023.05.015
PMCID:
PMC11161201
AbstractArticlePDF–1.8M
3.
Hepatocellular carcinoma development induced by conditional β‐catenin activation in Lkb1+/− mice
Hiroyuki Miyoshi, Atsuko Deguchi, Masayuki Nakau, Yasushi Kojima, Akira Mori, Masanobu Oshima, Masahiro Aoki, Makoto Mark Taketo
Cancer Sci. 2009 Nov; 100(11): 2046–2053. Published online 2009 Jul 10. doi: 10.1111/j.1349-7006.2009.01284.x
PMCID:
PMC11159713
AbstractArticlePDF–647K
4.
Palmitic Acid Exerts Anti-Tumorigenic Activities by Modulating Cellular Stress and Lipid Droplet Formation in Endometrial Cancer
Ziyi Zhao, Jiandong Wang, Weimin Kong, Meredith A. Newton, Wesley C. Burkett, Wenchuan Sun, Lindsey Buckingham, Jillian O’Donnell, Hongyan Suo, Boer Deng, Xiaochang Shen, Xin Zhang, Tianran Hao, Chunxiao Zhou, Victoria L. Bae-Jump
Biomolecules. 2024 May; 14(5): 601. Published online 2024 May 20. doi: 10.3390/biom14050601
PMCID:
PMC11117634
AbstractArticlePDF–11M
5.
NRF2 activation promotes aggressive lung cancer and associates with poor clinical outcomes
Anju Singh, Anneleen Daemen, Dorothee Nickles, Sang-Min Jeon, Oded Foreman, Kuladeep Sudini, Florian Gnad, Stephane Lajoie, Naina Gour, Wayne Mitzner, Samit Chatterjee, Eun-Ji Choi, Buvana Ravishankar, Amy Rappaport, Namrata Patil, Mark McCleland, Leisa Johnson, George Acquaah-Mensah, Edward Gabrielson, Shyam Biswal, Georgia Hatzivassiliou
Clin Cancer Res. Author manuscript; available in PMC 2024 Feb 15.
Published in final edited form as: Clin Cancer Res. 2021 Feb 1; 27(3): 877–888. Published online 2020 Oct 19. doi: 10.1158/1078-0432.CCR-20-1985
PMCID:
PMC10867786
AbstractArticlePDF–2.5M
6.
Development of a Genetically Engineered Mouse Model Recapitulating LKB1 and PTEN Deficiency in Gastric Cancer Pathogenesis
Kuan-Te Fang, Hsin Hung, Nga Yin Sadonna Lau, Jou-Hsi Chi, Deng-Chyang Wu, Kuang-Hung Cheng
Cancers (Basel) 2023 Dec; 15(24): 5893. Published online 2023 Dec 18. doi: 10.3390/cancers15245893
PMCID:
PMC10741874
AbstractArticlePDF–4.1M
7.
Fully accessible fitness landscape of oncogene-negative lung adenocarcinoma
Maryam Yousefi, Laura Andrejka, Márton Szamecz, Monte M. Winslow, Dmitri A. Petrov, Gábor Boross
Proc Natl Acad Sci U S A. 2023 Sep 19; 120(38): e2303224120. Published online 2023 Sep 11. doi: 10.1073/pnas.2303224120
PMCID:
PMC10515140
AbstractArticlePDF–646K
8.
MKP1 promotes nonalcoholic steatohepatitis by suppressing AMPK activity through LKB1 nuclear retention
Bin Qiu, Ahmed Lawan, Chrysovalantou E. Xirouchaki, Jae-Sung Yi, Marie Robert, Lei Zhang, Wendy Brown, Carlos Fernández-Hernando, Xiaoyong Yang, Tony Tiganis, Anton M. Bennett
Nat Commun. 2023; 14: 5405. Published online 2023 Sep 5. doi: 10.1038/s41467-023-41145-5
PMCID:
PMC10480499
AbstractArticlePDF–6.7M
9.
Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6
Qiming Deng, Hongxuan Li, Xiaolin Yue, Chenghu Guo, Yuanyuan Sun, Chang Ma, Jiangang Gao, Yue Wu, Bin Du, Jianmin Yang, Cheng Zhang, Wencheng Zhang
Cell Death Dis. 2023 Aug; 14(8): 542. Published online 2023 Aug 22. doi: 10.1038/s41419-023-06054-x
PMCID:
PMC10444762
AbstractArticlePDF–11M
10.
STAT3/LKB1 controls metastatic prostate cancer by regulating mTORC1/CREB pathway
Jan Pencik, Cecile Philippe, Michaela Schlederer, Emine Atas, Matteo Pecoraro, Sandra Grund-Gröschke, Wen (Jess) Li, Amanda Tracz, Isabel Heidegger, Sabine Lagger, Karolína Trachtová, Monika Oberhuber, Ellen Heitzer, Osman Aksoy, Heidi A. Neubauer, Bettina Wingelhofer, Anna Orlova, Nadine Witzeneder, Thomas Dillinger, Elisa Redl, Georg Greiner, David D’Andrea, Johnny R. Östman, Simone Tangermann, Ivana Hermanova, Georg Schäfer, Felix Sternberg, Elena E. Pohl, Christina Sternberg, Adam Varady, Jaqueline Horvath, Dagmar Stoiber, Tim I. Malcolm, Suzanne D. Turner, Eileen E. Parkes, Brigitte Hantusch, Gerda Egger, Stefan Rose-John, Valeria Poli, Suneil Jain, Chris W. D. Armstrong, Gregor Hoermann, Vincent Goffin, Fritz Aberger, Richard Moriggl, Arkaitz Carracedo, Cathal McKinney, Richard D. Kennedy, Helmut Klocker, Michael R. Speicher, Dean G. Tang, Ali A. Moazzami, David M. Heery, Marcus Hacker, Lukas Kenner
Mol Cancer. 2023; 22: 133. Published online 2023 Aug 12. doi: 10.1186/s12943-023-01825-8
PMCID:
PMC10422794
AbstractArticlePDF–3.9M
11.
LKB1 signaling is altered in skeletal muscle of a Duchenne muscular dystrophy mouse model
Brigida Boccanegra, Paola Mantuano, Elena Conte, Alessandro Giovanni Cerchiara, Lisamaura Tulimiero, Raffaella Quarta, Erika Caputo, Francesca Sanarica, Monica Forino, Valeria Spadotto, Ornella Cappellari, Gianluca Fossati, Christian Steinkühler, Annamaria De Luca
Dis Model Mech. 2023 Jul 1; 16(7): dmm049930. Published online 2023 Jul 10. doi: 10.1242/dmm.049930
PMCID:
PMC10354716
AbstractArticle
12.
Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression
Janine M. DeBlasi, Aimee Falzone, Samantha Caldwell, Nicolas Prieto-Farigua, Justin R. Prigge, Edward E. Schmidt, Iok In Christine Chio, Florian A. Karreth, Gina M. DeNicola
Cancer Res. 2023 Jun 15; 83(12): 1953–1967. Published online 2023 Apr 16. doi: 10.1158/0008-5472.CAN-22-3848
PMCID:
PMC10267679
AbstractArticlePDF–43M
13.
Tumor loss-of-function mutations in STK11/LKB1 induce cachexia
Puneeth Iyengar, Aakash Y. Gandhi, Jorge Granados, Tong Guo, Arun Gupta, Jinhai Yu, Ernesto M. Llano, Faya Zhang, Ang Gao, Asha Kandathil, Dorothy Williams, Boning Gao, Luc Girard, Venkat S. Malladi, John M. Shelton, Bret M. Evers, Raquibul Hannan, Chul Ahn, John D. Minna, Rodney E. Infante
JCI Insight. 2023 Apr 24; 8(8): e165419. Published online 2023 Apr 24. doi: 10.1172/jci.insight.165419
PMCID:
PMC10243820
AbstractArticlePDF–6.8M
14.
LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma
Benjamin D. Stein, John R. Ferrarone, Eric E. Gardner, Jae Won Chang, David Wu, Pablo E. Hollstein, Roger J. Liang, Min Yuan, Qiuying Chen, John S. Coukos, Miriam Sindelar, Bryan Ngo, Steven S. Gross, Reuben J. Shaw, Chen Zhang, John M. Asara, Raymond E. Moellering, Harold Varmus, Lewis C. Cantley
Cancer Discov. 2023 Apr 3; 13(4): 1002–1025. Published online 2023 Jan 30. doi: 10.1158/2159-8290.CD-22-0805
PMCID:
PMC10068449
AbstractArticlePDF–13M
15.
Loss of Lkb1 in CD11c+ myeloid cells protects mice from diet-induced obesity while enhancing glucose intolerance and IL-17/IFN-γ imbalance
Yunyan Sun, Bing Wang, Qianwen Hu, Haixiao Zhang, Xun Lai, Tier Wang, Chunxiao Zhao, Jiali Wang, Xi Zhang, Qing Niu, Baolin He, Erlie Jiang, Mingxia Shi, Xiaoming Feng, Yuechen Luo
Cell Mol Life Sci. 2023 Mar; 80(3): 63. Published online 2023 Feb 13. doi: 10.1007/s00018-023-04707-w
PMCID:
PMC9925521
AbstractArticlePDF–4.4M
16.
Lkb1 loss in regulatory T cells leads to dysregulation of hematopoietic stem cell expansion and differentiation in bone marrow
Jiadi Chen, Jingru Liu, Huifang Huang
FEBS Open Bio. 2023 Feb; 13(2): 270–278. Published online 2023 Jan 4. doi: 10.1002/2211-5463.13536
PMCID:
PMC9900093
AbstractArticlePDF–2.1M
17.
PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis
Jennifer L. Cotton, Kyvan Dang, Lu Hu, Yang Sun, Alka Singh, Mihir S. Rajurkar, Qi Li, Xu Wu, Junhao Mao
Cell Rep. Author manuscript; available in PMC 2022 Dec 20.
Published in final edited form as: Cell Rep. 2022 Jul 19; 40(3): 111125. doi: 10.1016/j.celrep.2022.111125
PMCID:
PMC9764383
AbstractArticlePDF–1.4M
18.
Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors
Yan Cao, Diego Fajardo, Debbie Guerrero-Given, Melanie A. Samuel, Toshihisa Ohtsuka, Shannon E. Boye, Naomi Kamasawa, Kirill A. Martemyanov
Curr Biol. Author manuscript; available in PMC 2023 Nov 21.
Published in final edited form as: Curr Biol. 2022 Nov 21; 32(22): 4783–4796.e3. Published online 2022 Sep 29. doi: 10.1016/j.cub.2022.09.016
PMCID:
PMC9691582
AbstractArticlePDF–1.7M
19.
Annexin A2/TLR2/MYD88 pathway induces arginase 1 expression in tumor-associated neutrophils
Huajia Zhang, Xiaodong Zhu, Travis J. Friesen, Jeff W. Kwak, Tatyana Pisarenko, Surapat Mekvanich, Mark A. Velasco, Timothy W. Randolph, Julia Kargl, A. McGarry Houghton
J Clin Invest. 2022 Nov 15; 132(22): e153643. Published online 2022 Nov 15. doi: 10.1172/JCI153643
PMCID:
PMC9663166
AbstractArticlePDF–20M
20.
The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
Chen-Song Zhang, Mengqi Li, Yu Wang, Xiaoyang Li, Yue Zong, Shating Long, Mingliang Zhang, Jin-Wei Feng, Xiaoyan Wei, Yan-Hui Liu, Baoding Zhang, Jianfeng Wu, Cixiong Zhang, Wenhua Lian, Teng Ma, Xiao Tian, Qi Qu, Yaxin Yu, Jinye Xiong, Dong-Tai Liu, Zhenhua Wu, Mingxia Zhu, Changchuan Xie, Yaying Wu, Zheni Xu, Chunyan Yang, Junjie Chen, Guohong Huang, Qingxia He, Xi Huang, Lei Zhang, Xiufeng Sun, Qingfeng Liu, Abdul Ghafoor, Fu Gui, Kaili Zheng, Wen Wang, Zhi-Chao Wang, Yong Yu, Qingliang Zhao, Shu-Yong Lin, Zhi-Xin Wang, Hai-Long Piao, Xianming Deng, Sheng-Cai Lin
Nat Metab. 2022; 4(10): 1369–1401. Published online 2022 Oct 10. doi: 10.1038/s42255-022-00640-7
PMCID:
PMC9584815
AbstractArticlePDF–9.0M

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