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Items: 1 to 20 of 25

1.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
2.
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization
Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti
Science. Author manuscript; available in PMC 2022 Sep 11.
Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983
PMCID:
PMC9119736
AbstractArticlePDF–3.3M
3.
Reciprocal interaction between SIRT6 and APC/C regulates genomic stability
Helin Wang, Kangze Feng, Qingtao Wang, Haiteng Deng
Sci Rep. 2021; 11: 14253. Published online 2021 Jul 9. doi: 10.1038/s41598-021-93684-w
PMCID:
PMC8270898
AbstractArticlePDF–2.6M
4.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
5.
Recessive, Deleterious Variants in SMG8 Expand the Role of Nonsense-Mediated Decay in Developmental Disorders in Humans
Fatema Alzahrani, Hiroyuki Kuwahara, Yongkang Long, Mohammed Al-Owain, Mohamed Tohary, Moeenaldeen AlSayed, Mohammed Mahnashi, Lana Fathi, Maha Alnemer, Mohamed H. Al-Hamed, Gabrielle Lemire, Kym M. Boycott, Mais Hashem, Wenkai Han, Almundher Al-Maawali, Feisal Al Mahrizi, Khalid Al-Thihli, Xin Gao, Fowzan S. Alkuraya
Am J Hum Genet. 2020 Dec 3; 107(6): 1178–1185. Published online 2020 Nov 25. doi: 10.1016/j.ajhg.2020.11.007
PMCID:
PMC7820624
AbstractArticlePDF–1.6M
6.
Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM
Andres López-Perrote, Nele Hug, Ana González-Corpas, Carlos F Rodríguez, Marina Serna, Carmen García-Martín, Jasminka Boskovic, Rafael Fernandez-Leiro, Javier F Caceres, Oscar Llorca
eLife. 2020; 9: e63042. Published online 2020 Nov 18. doi: 10.7554/eLife.63042
PMCID:
PMC7707835
AbstractArticlePDF–2.9M
7.
Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism
Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat
Nat Metab. Author manuscript; available in PMC 2020 Dec 1.
Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z
PMCID:
PMC7566881
AbstractArticlePDF–4.8M
8.
Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity
Lukas M Langer, Yair Gat, Fabien Bonneau, Elena Conti
eLife. 2020; 9: e57127. Published online 2020 May 29. doi: 10.7554/eLife.57127
PMCID:
PMC7334022
AbstractArticlePDF–3.4M
9.
Targeting RICTOR sensitizes SMAD4-negative colon cancer to irinotecan
Chen Khuan Wong, Arthur William Lambert, Sait Ozturk, Panagiotis Papageorgis, Delia Lopez, Ning Shen, Zaina Sen, Hamid Mostafavi Abdolmaleky, Balázs Győrffy, Hui Feng, Sam Thiagalingam
Mol Cancer Res. Author manuscript; available in PMC 2020 Sep 1.
Published in final edited form as: Mol Cancer Res. 2020 Mar; 18(3): 414–423. Published online 2020 Jan 13. doi: 10.1158/1541-7786.MCR-19-0525
PMCID:
PMC7115128
AbstractArticlePDF–1.6M
10.
Cryo-EM structure of SMG1–SMG8–SMG9 complex
Li Zhu, Liang Li, Yilun Qi, Zishuo Yu, Yanhui Xu
Cell Res. 2019 Dec; 29(12): 1027–1034. Published online 2019 Nov 15. doi: 10.1038/s41422-019-0255-3
PMCID:
PMC6951342
AbstractArticlePDF–4.4M
11.
The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis
Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino
Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9
PMCID:
PMC6778137
AbstractArticlePDF–7.8M
12.
PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling
Adnan Shami Shah, Alex G. Batrouni, Dongsung Kim, Amith Punyala, Wendy Cao, Chun Han, Michael L. Goldberg, Marcus B. Smolka, Jeremy M. Baskin
Cell Rep. Author manuscript; available in PMC 2019 Jun 26.
Published in final edited form as: Cell Rep. 2019 May 14; 27(7): 2157–2170.e8. doi: 10.1016/j.celrep.2019.04.060
PMCID:
PMC6594551
AbstractArticlePDF–1.4M
13.
Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function
Jan B Heidelberger, Andrea Voigt, Marina E Borisova, Giuseppe Petrosino, Stefanie Ruf, Sebastian A Wagner, Petra Beli
EMBO Rep. 2018 Apr; 19(4): e44754. Published online 2018 Feb 21. doi: 10.15252/embr.201744754
PMCID:
PMC5891417
AbstractArticlePDF–1.0M
14.
SUMO targets the APC/C to regulate transition from metaphase to anaphase
Karolin Eifler, Sabine A. G. Cuijpers, Edwin Willemstein, Jonne A. Raaijmakers, Dris El Atmioui, Huib Ovaa, René H. Medema, Alfred C. O. Vertegaal
Nat Commun. 2018; 9: 1119. Published online 2018 Mar 16. doi: 10.1038/s41467-018-03486-4
PMCID:
PMC5856775
AbstractArticlePDF–1.8M
15.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
16.
Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein
Yingjie Xu, Wen Yang, Jinjun Shi, Bruce R. Zetter
J Mol Cell Biol. 2016 Jun; 8(3): 282–285. Published online 2016 Jul 7. doi: 10.1093/jmcb/mjw018
PMCID:
PMC5525133
ArticlePDF–1.9M
17.
The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation
Roberto Melero, Nele Hug, Andrés López-Perrote, Akio Yamashita, Javier F. Cáceres, Oscar Llorca
Nat Commun. 2016; 7: 10585. Published online 2016 Feb 4. doi: 10.1038/ncomms10585
PMCID:
PMC4743010
AbstractArticlePDF–3.3M
18.
The BioPlex Network: A Systematic Exploration of the Human Interactome
Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2016 Jul 16.
Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043
PMCID:
PMC4617211
AbstractArticlePDF–2.2M
19.
Inhibition of SMG-8, a subunit of SMG-1 kinase, ameliorates nonsense-mediated mRNA decay-exacerbated mutant phenotypes without cytotoxicity
Fusako Usuki, Akio Yamashita, Tadafumi Shiraishi, Atsushi Shiga, Osamu Onodera, Itsuro Higuchi, Shigeo Ohno
Proc Natl Acad Sci U S A. 2013 Sep 10; 110(37): 15037–15042. Published online 2013 Aug 27. doi: 10.1073/pnas.1300654110
PMCID:
PMC3773753
AbstractArticlePDF–1.0M
20.
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia
Alexander P. Reiner, Jaana Hartiala, Tanja Zeller, Joshua C. Bis, Josée Dupuis, Myriam Fornage, Jens Baumert, Marcus E. Kleber, Philipp S. Wild, Stephan Baldus, Suzette J. Bielinski, João D. Fontes, Thomas Illig, Brendan J. Keating, Leslie A. Lange, Francisco Ojeda, Martina Müller-Nurasyid, Thomas F. Munzel, Bruce M. Psaty, Kenneth Rice, Jerome I. Rotter, Renate B. Schnabel, W.H. Wilson Tang, Barbara Thorand, Jeanette Erdmann, CARDIoGRAM Consortium, David R. Jacobs, Jr, James G. Wilson, Wolfgang Koenig, Russell P. Tracy, Stefan Blankenberg, Winfried März, Myron D. Gross, Emelia J. Benjamin, Stanley L. Hazen, Hooman Allayee
Hum Mol Genet. 2013 Aug 15; 22(16): 3381–3393. Published online 2013 Apr 24. doi: 10.1093/hmg/ddt189
PMCID:
PMC3723315
AbstractArticlePDF–914K

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