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Select item 109725951.

High-mobility group box 1 increases platelet surface P2Y₁₂ and platelet activation in sickle cell disease

Deirdre Nolfi-Donegan, Gowtham K. Annarapu, Claudette St. Croix, Michael Calderon, Cheryl A. Hillery, Sruti Shiva

JCI Insight. 2024 Mar 8; 9(5): e174575. Published online 2024 Mar 8. doi: 10.1172/jci.insight.174575

PMCID:: PMC10972595

Abstract Article PDF–1.9M

Select item 105217892.

Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y₁₂ and Link to Residual Platelet Reactivity

Marta Brambilla, Alessia Becchetti, Gian Enrico Rovati, Nicola Cosentino, Maria Conti, Paola Canzano, Peter L.A. Giesen, Alessia Loffreda, Alice Bonomi, Marco Cattaneo, Erica De Candia, Gian Marco Podda, Daniela Trabattoni, Pablo Josè Werba, Jeness Campodonico, Christian Pinna, Giancarlo Marenzi, Elena Tremoli, Marina Camera

Arterioscler Thromb Vasc Biol. 2023 Oct; 43(10): 2042–2057. Published online 2023 Aug 17. doi: 10.1161/ATVBAHA.123.319099

PMCID:: PMC10521789

Abstract Article PDF–1.9M

Select item 99846423.

P2Y12 receptor gene polymorphisms are associated with epilepsy

Qi Wang, Nan-Rui Shi, Peng Lv, Juan Liu, Ji-Zhou Zhang, Bin-Lu Deng, Yan-Qin Zuo, Jie Yang, Xin Wang, Xiang Chen, Xiu-Min Hu, Ting-Ting Liu, Jie Liu

Purinergic Signal. 2023 Mar; 19(1): 155–162. Published online 2022 Feb 17. doi: 10.1007/s11302-022-09848-4

PMCID:: PMC9984642

Abstract Article PDF–546K

Select item 98938394.

Correlation P2Y12 Genetic Polymorphism As Risk Factor of Clopidogrel Resistance in Indonesian Stroke Patients

Rakhmad Hidayat, Al Rasyid, Salim Harris, Alida Harahap, Herqutanto, Melva Louisa, Erlin Listiyaningsih, Aldy Safruddin Rambe, Tonny Loho

Vasc Health Risk Manag. 2023; 19: 53–61. Published online 2023 Jan 29. doi: 10.2147/VHRM.S386107

PMCID:: PMC9893839

Abstract Article PDF–1.2M

Select item 98678625.

Association between P2Y1 and P2Y12 polymorphisms and acute myocardial infarction and ADP-induced platelet aggregation

Chunyan Su, Zhishan Zhang, Jintu Chen, Mengcha Tian, Conglian Wu, Tao Zhang

BMC Cardiovasc Disord. 2023; 23: 41. Published online 2023 Jan 21. doi: 10.1186/s12872-023-03075-4

PMCID:: PMC9867862

Abstract Article PDF–767K

Select item 98016276.

Influence of genetic polymorphisms in P2Y12 receptor signaling pathway on antiplatelet response to clopidogrel in coronary heart disease

Yan-Jiao Zhang, Dong-Jie Li, Zhong-Yi Li, Xiao-Lei Hu, He Li, Qi-Lin Ma, Xiao-Ping Chen

BMC Cardiovasc Disord. 2022; 22: 575. Published online 2022 Dec 30. doi: 10.1186/s12872-022-02988-w

PMCID:: PMC9801627

Abstract Article PDF–1.4M

Select item 94495907.

Inhibiting P2Y12 receptor relieves LPS‐induced inflammation and endothelial dysfunction

Xiuxia Han

Immun Inflamm Dis. 2022 Oct; 10(10): e697. Published online 2022 Sep 7. doi: 10.1002/iid3.697

PMCID:: PMC9449590

Abstract Article PDF–2.0M

Select item 90036558.

Single-nucleotide polymorphisms of the SLC17A9 and P2RY12 genes are significantly associated with phantom tooth pain

Moe Soeda, Seii Ohka, Daisuke Nishizawa, Junko Hasegawa, Kyoko Nakayama, Yuko Ebata, Ken-ichi Fukuda, Kazutaka Ikeda

Mol Pain. 2022; 18: 17448069221089592. Published online 2022 Apr 8. doi: 10.1177/17448069221089592

PMCID:: PMC9003655

Abstract Article PDF–990K

Select item 82341749.

The Molecular Aspects of Disturbed Platelet Activation through ADP/P2Y₁₂ Pathway in Multiple Sclerosis

Angela Dziedzic, Elzbieta Miller, Joanna Saluk-Bijak, Marta Niwald, Michal Bijak

Int J Mol Sci. 2021 Jun; 22(12): 6572. Published online 2021 Jun 18. doi: 10.3390/ijms22126572

PMCID:: PMC8234174

Abstract Article PDF–3.4M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 807866311.

The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis

Shulan Pi, Ling Mao, Jiefang Chen, Hanqing Shi, Yuxiao Liu, Xiaoqing Guo, Yuanyuan Li, Lian Zhou, Hui He, Cheng Yu, Jianyong Liu, Yiping Dang, Yuanpeng Xia, Quanwei He, Huijuan Jin, Yanan Li, Yu Hu, Yiliang Miao, Zhenyu Yue, Bo Hu

Autophagy. 2021; 17(4): 980–1000. Published online 2020 Mar 19. doi: 10.1080/15548627.2020.1741202

PMCID:: PMC8078663

Abstract Article PDF–11M

Select item 799370912.

Impact of genetic variants on clinical outcome after percutaneous coronary intervention in elderly patients

Jung-Joon Cha, Jae Hyoung Park, Hyung Joon Joo, Soon Jun Hong, Tae Hoon Ahn, Byeong-Keuk Kim, WonYong Shin, Sung Gyun Ahn, JungHan Yoon, Yong Hoon Kim, Yun-Hyeong Cho, Woong Chol Kang, Weon Kim, Young-Hyo Lim, Hyeon Cheol Gwon, Woong Gil Choi, Do-Sun Lim

Aging (Albany NY) 2021 Mar 15; 13(5): 6506–6524. Published online 2021 Mar 12. doi: 10.18632/aging.202799

PMCID:: PMC7993709

Abstract Article PDF–1.3M

Select item 791597913.

Microglia and Neuroinflammation: What Place for P2RY12?

Albert Gómez Morillas, Valérie C. Besson, Dominique Lerouet

Int J Mol Sci. 2021 Feb; 22(4): 1636. Published online 2021 Feb 6. doi: 10.3390/ijms22041636

PMCID:: PMC7915979

Abstract Article PDF–1001K

Select item 745390214.

Intravascular hemolysis triggers ADP-mediated generation of platelet-rich thrombi in precapillary pulmonary arterioles

Tomasz Brzoska, Ravi Vats, Margaret F. Bennewitz, Egemen Tutuncuoglu, Simon C. Watkins, Margaret V. Ragni, Matthew D. Neal, Mark T. Gladwin, Prithu Sundd

JCI Insight. 2020 Jul 23; 5(14): e139437. Published online 2020 Jul 23. doi: 10.1172/jci.insight.139437

PMCID:: PMC7453902

Abstract Article PDF–13M

Select item 722049115.

Association of clopidogrel high on-treatment reactivity with clinical outcomes and gene polymorphism in acute ischemic stroke patients: An observational study

Hefei Fu, Pan Hu, Chunmei Ma, Fei Peng, Zhiyi He

Medicine (Baltimore) 2020 Apr; 99(15): e19472. Published online 2020 Apr 10. doi: 10.1097/MD.0000000000019472

PMCID:: PMC7220491

Abstract Article PDF–641K

Select item 708582516.

Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients

Zhouping Wang, Yufen Xu, Huazhong Zhou, Yanfei Wang, Wei Li, Zhaoliang Lu, Zhiyong Jiang, Xueping Gu, Hao Zheng, Lanlan Zeng, Ping Huang, Li Zhang, Xiaoqiong Gu

Cardiovasc Ther. 2020; 2020: 3568608. Published online 2020 Mar 10. doi: 10.1155/2020/3568608

PMCID:: PMC7085825

Abstract Article PDF–482K

Select item 701424817.

Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer’s Disease Brains

Douglas G. Walker, Tiffany M. Tang, Anarmaa Mendsaikhan, Ikuo Tooyama, Geidy E. Serrano, Lucia I. Sue, Thomas G. Beach, Lih-Fen Lue

Int J Mol Sci. 2020 Jan; 21(2): 678. Published online 2020 Jan 20. doi: 10.3390/ijms21020678

PMCID:: PMC7014248

Abstract Article PDF–6.7M

Select item 690735618.

Regulation of microglial TMEM119 and P2RY12 immunoreactivity in multiple sclerosis white and grey matter lesions is dependent on their inflammatory environment

Thecla A. van Wageningen, Eva Vlaar, Gijs Kooij, Cornelis A. M. Jongenelen, Jeroen J. G. Geurts, Anne-Marie van Dam

Acta Neuropathol Commun. 2019; 7: 206. Published online 2019 Dec 11. doi: 10.1186/s40478-019-0850-z

PMCID:: PMC6907356

Abstract Article PDF–3.2M

Select item 677989419.

ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12

Loreen Kloss, Claudia Dollt, Kai Schledzewski, Andreas Krewer, Susanne Melchers, Calin Manta, Carsten Sticht, Carolina de la Torre, Jochen Utikal, Viktor Umansky, Astrid Schmieder

Cell Death Dis. 2019 Oct; 10(10): 760. Published online 2019 Oct 7. doi: 10.1038/s41419-019-2010-6

PMCID:: PMC6779894

Abstract Article PDF–3.2M

Select item 602503920.

Clinical Relevant Polymorphisms Affecting Clopidogrel Pharmacokinetics and Pharmacodynamics: Insights from the Puerto Rico Newborn Screening Program

Dagmar F. Hernandez-Suarez, Jonnalie C. Tomassini-Fernandini, Angelica Cuevas, Anyelis N. Rosario-Berrios, Héctor J. Nuñez-Medina, Dariana Padilla-Arroyo, Nannette Rivera, Jennifer Liriano, Rocio K. Vega-Roman, Jessicca Y. Renta, Kyle Melin, Jorge Duconge

Int J Environ Res Public Health. 2018 Jun; 15(6): 1115. Published online 2018 May 30. doi: 10.3390/ijerph15061115

PMCID:: PMC6025039

Abstract Article PDF–617K

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