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Select item 111515701.

Increased expression of REG3A promotes tumorigenic behavior in triple negative breast cancer cells

Xiaoxia Jin, Shuyun Yang, Xiaoyun Lu, Xudong Chen, Wencheng Dai

Breast Cancer Res. 2024; 26: 92. Published online 2024 Jun 5. doi: 10.1186/s13058-024-01845-2

PMCID:: PMC11151570

Abstract Article PDF–16M

Select item 111075862.

PAP/REG3A favors perineural invasion in pancreatic adenocarcinoma and serves as a prognostic marker

Jérémy Nigri, Meritxell Gironella, Christian Bressy, Elena Vila-Navarro, Julie Roques, Sophie Lac, Caroline Bontemps, Coraline Kozaczyk, Jérôme Cros, Daniel Pietrasz, Raphaël Maréchal, Jean-Luc Van Laethem, Juan Iovanna, Jean-Baptiste Bachet, Emma Folch-Puy, Richard Tomasini

Cell Mol Life Sci. 2017 Nov; 74(22): 4231–4243. Published online 2017 Jun 27. doi: 10.1007/s00018-017-2579-9

PMCID:: PMC11107586

Abstract Article PDF–2.1M

Select item 96335593.

The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance, glucose levels, and gut function

Jae Hoon Shin, Nadejda Bozadjieva-Kramer, Yikai Shao, Sally Lyons-Abbott, Alan C. Rupp, Darleen A. Sandoval, Randy J. Seeley

Cell Metab. Author manuscript; available in PMC 2023 Nov 1.

Published in final edited form as: Cell Metab. 2022 Nov 1; 34(11): 1765–1778.e6. Published online 2022 Oct 13. doi: 10.1016/j.cmet.2022.09.024

PMCID:: PMC9633559

Abstract Article PDF–2.2M

Select item 91319174.

Regenerating islet-derived protein 3-α is a prognostic biomarker for gastrointestinal chronic graft-versus-host disease

Brittany Paige DePriest, Hong Li, Alan Bidgoli, Lynn Onstad, Daniel Couriel, Stephanie J. Lee, Sophie Paczesny

Blood Adv. 2022 May 24; 6(10): 2981–2986. Published online 2022 May 13. doi: 10.1182/bloodadvances.2021005420

PMCID:: PMC9131917

Abstract Article PDF–839K

Select item 88254095.

The regenerating protein 3A: a crucial molecular with dual roles in cancer

Liying Wang, Yanchun Quan, Yanxi Zhu, Xiaoli Xie, Zhiqiang Wang, Long Wang, Xiuhong Wei, Fengyuan Che

Mol Biol Rep. 2022; 49(2): 1491–1500. Published online 2021 Nov 23. doi: 10.1007/s11033-021-06904-x

PMCID:: PMC8825409

Abstract Article PDF–993K

Select item 88066396.

Reg3A (regenerating family member 3 alpha) acts as a tumor suppressor by targeting DMBT1 (deleted in malignant brain tumors 1) in gastric cancer

Liang Wang, Hongfang Tuo, Zhe Song, Wei Li, Yanhui Peng

Bioengineered. 2021; 12(1): 7644–7655. Published online 2021 Oct 4. doi: 10.1080/21655979.2021.1981800

PMCID:: PMC8806639

Abstract Article PDF–3.3M

Select item 87164197.

Antimicrobial Protein REG3A and Signaling Networks are Predictive of Stroke Outcomes

Madison Sands, Jacqueline A. Frank, Benton Maglinger, Christopher J. McLouth, Amanda L. Trout, Jadwiga Turchan-Cholewo, Ann M. Stowe, Justin F. Fraser, Keith R. Pennypacker

J Neurochem. Author manuscript; available in PMC 2023 Jan 1.

Published in final edited form as: J Neurochem. 2022 Jan; 160(1): 100–112. Published online 2021 Oct 14. doi: 10.1111/jnc.15520

PMCID:: PMC8716419

Abstract Article PDF–980K

Select item 84902008.

Tumour-Derived Reg3A Educates Dendritic Cells to Promote Pancreatic Cancer Progression

Jie Guo, Mengfan Liao, Xianmin Hu, Jun Wang

Mol Cells. 2021 Sep 30; 44(9): 647–657. Published online 2021 Sep 10. doi: 10.14348/molcells.2021.0145

PMCID:: PMC8490200

Abstract Article PDF–4.2M

Select item 83738919.

Secretome screening reveals immunomodulating functions of IFNα-7, PAP and GDF-7 on regulatory T-cells

Mei Ding, Rajneesh Malhotra, Tomas Ottosson, Magnus Lundqvist, Aman Mebrahtu, Johan Brengdahl, Ulf Gehrmann, Elisabeth Bäck, Douglas Ross-Thriepland, Ida Isaksson, Björn Magnusson, Kris F. Sachsenmeier, Hanna Tegel, Sophia Hober, Mathias Uhlén, Lorenz M. Mayr, Rick Davies, Johan Rockberg, Lovisa Holmberg Schiavone

Sci Rep. 2021; 11: 16767. Published online 2021 Aug 18. doi: 10.1038/s41598-021-96184-z

PMCID:: PMC8373891

Abstract Article PDF–3.6M

Select item 818475510.

REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway

Huairong Zhang, Andrea Liliam Gomez Corredor, Julia Messina-Pacheco, Qing Li, George Zogopoulos, Nancy Kaddour, Yifan Wang, Bing-yin Shi, Alex Gregorieff, Jun-li Liu, Zu-hua Gao

Commun Biol. 2021; 4: 688. Published online 2021 Jun 7. doi: 10.1038/s42003-021-02193-z

PMCID:: PMC8184755

Abstract Article PDF–7.7M

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 807608412.

Blood Biomarkers of Intestinal Epithelium Damage Regenerating Islet-derived Protein 3α and Trefoil Factor 3 Are Persistently Elevated in Patients with Alcoholic Hepatitis

Jing Yang, Fahim Syed, Ying Xia, Arun Sanyal, Vijay Shah, Naga Chalasani, Xiaoqun Zheng, Qigui Yu, Yongliang Lou, Wei Li

Alcohol Clin Exp Res. Author manuscript; available in PMC 2022 Apr 1.

Published in final edited form as: Alcohol Clin Exp Res. 2021 Apr; 45(4): 720–731. Published online 2021 Mar 11. doi: 10.1111/acer.14579

PMCID:: PMC8076084

Abstract Article PDF–1.2M

Select item 807262713.

Myocardial Accumulations of Reg3A, Reg3γ and Oncostatin M Are Associated with the Formation of Granulomata in Patients with Cardiac Sarcoidosis

Praveen Gajawada, Ayse Cetinkaya, Susanne von Gerlach, Natalia Kubin, Heiko Burger, Michael Näbauer, Carola Grinninger, Andreas Rolf, Markus Schönburg, Yeong-Hoon Choi, Thomas Kubin, Manfred Richter

Int J Mol Sci. 2021 Apr; 22(8): 4148. Published online 2021 Apr 16. doi: 10.3390/ijms22084148

PMCID:: PMC8072627

Abstract Article PDF–53M

Select item 687751314.

LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription

Hamed Yari, Lei Jin, Liu Teng, Yufang Wang, Yongyan Wu, Guang Zhi Liu, Wei Gao, Jin Liang, Yanfeng Xi, Yu Chen Feng, Chunming Zhang, Yuan Yuan Zhang, Hessam Tabatabaee, Ting La, Rui Hong Yang, Fu Hua Wang, Xu Guang Yan, Margaret Farrelly, Rodney Scott, Tao Liu, Rick F. Thorne, Su Tang Guo, Xu Dong Zhang

Nat Commun. 2019; 10: 5334. Published online 2019 Nov 25. doi: 10.1038/s41467-019-13313-z

PMCID:: PMC6877513

Abstract Article PDF–2.4M

Select item 639553015.

Analysis of BMT CTN-0201 and −0901 samples did not reproduce the reported association between recipient REG3A rs7588571 and chronic GVHD

Armin Rashidi, Ryan Shanley, Claudio Anasetti, Edmund K. Waller, Bart L. Scott, Bruce R. Blazar, Daniel J. Weisdorf

Bone Marrow Transplant. Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: Bone Marrow Transplant. 2019 Mar; 54(3): 490–493. Published online 2018 Aug 31. doi: 10.1038/s41409-018-0331-1

PMCID:: PMC6395530

Article PDF–98K

Select item 620540416.

Survival signal REG3α prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease

Dongchang Zhao, Yeung-Hyen Kim, Seihwan Jeong, Joel K. Greenson, Mohammed S. Chaudhry, Matthias Hoepting, Erik R. Anderson, Marcel R.M. van den Brink, Jonathan U. Peled, Antonio L.C. Gomes, Ann E. Slingerland, Michael J. Donovan, Andrew C. Harris, John E. Levine, Umut Ozbek, Lora V. Hooper, Thaddeus S. Stappenbeck, Aaron Ver Heul, Ta-Chiang Liu, Pavan Reddy, James L.M. Ferrara

J Clin Invest. 2018 Nov 1; 128(11): 4970–4979. Published online 2018 Sep 24. doi: 10.1172/JCI99261

PMCID:: PMC6205404

Abstract Article PDF–4.4M

Select item 612875517.

Recipient single nucleotide polymorphisms in Paneth cell antimicrobial peptide genes and acute graft-versus-host disease: Analysis of BMT CTN-0201 and -0901 samples

Armin Rashidi, Ryan Shanley, Sophia L. Yohe, Bharat Thyagarajan, Julie Curtsinger, Claudio Anasetti, Edmund K. Waller, Bart L. Scott, Bruce R. Blazar, Daniel J. Weisdorf

Br J Haematol. Author manuscript; available in PMC 2019 Sep 1.

Published in final edited form as: Br J Haematol. 2018 Sep; 182(6): 887–894. Published online 2018 Jul 13. doi: 10.1111/bjh.15492

PMCID:: PMC6128755

Abstract Article PDF–465K

Select item 607772218.

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Tengfei Xiao, Wei Li, Xiaoqing Wang, Han Xu, Jixin Yang, Qiu Wu, Ying Huang, Joseph Geradts, Peng Jiang, Teng Fei, David Chi, Chongzhi Zang, Qi Liao, Jonathan Rennhack, Eran Andrechek, Nanlin Li, Simone Detre, Mitchell Dowsett, Rinath M. Jeselsohn, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2018 Jul 31; 115(31): 7869–7878. Published online 2018 Jul 9. doi: 10.1073/pnas.1722617115

PMCID:: PMC6077722

Abstract Article PDF–2.4M

Select item 588180619.

REG3A overexpression suppresses gastric cancer cell invasion, proliferation and promotes apoptosis through PI3K/Akt signaling pathway

Yan-Song Qiu, Guang-Jun Liao, Ning-Ning Jiang

Int J Mol Med. 2018 Jun; 41(6): 3167–3174. Published online 2018 Feb 28. doi: 10.3892/ijmm.2018.3520

PMCID:: PMC5881806

Abstract Article PDF–1.9M

Select item 562639620.

IL-22 induces Reg3γ and inhibits allergic inflammation in house dust mite–induced asthma models

Takashi Ito, Koichi Hirose, Aiko Saku, Kenta Kono, Hiroaki Takatori, Tomohiro Tamachi, Yoshiyuki Goto, Jean-Christophe Renauld, Hiroshi Kiyono, Hiroshi Nakajima

J Exp Med. 2017 Oct 2; 214(10): 3037–3050. doi: 10.1084/jem.20162108

PMCID:: PMC5626396

Abstract Article PDF–2.0M

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