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Items: 1 to 20 of 459

1.
BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway
Elena Prosdocimi, Veronica Carpanese, Luca Matteo Todesca, Tatiana Varanita, Magdalena Bachmann, Margherita Festa, Daniele Bonesso, Mireia Perez-Verdaguer, Andrea Carrer, Angelo Velle, Roberta Peruzzo, Silvia Muccioli, Davide Doni, Luigi Leanza, Paola Costantini, Frank Stein, Mandy Rettel, Antonio Felipe, Michael J. Edwards, Erich Gulbins, Laura Cendron, Chiara Romualdi, Vanessa Checchetto, Ildiko Szabo
Sci Adv. 2024 Sep 6; 10(36): eadn9361. Published online 2024 Sep 4. doi: 10.1126/sciadv.adn9361
PMCID:
PMC11373599
AbstractArticlePDF–11M
2.
A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex
Marisa Bedir, Emily Outwin, Rita Colnaghi, Lydia Bassett, Iga Abramowicz, Mark O’Driscoll
EMBO Rep. 2024 Aug; 25(8): 3432–3455. Published online 2024 Jun 28. doi: 10.1038/s44319-024-00184-9
PMCID:
PMC11315929
AbstractArticlePDF–3.4M
3.
Hepatocyte-specific loss of DDB1 attenuates hepatic steatosis but aggravates liver inflammation and fibrosis in MASH
Qiuxia Gu, Yushun Chang, Yan Jin, Jing Fang, Tong Ji, Jie Lin, Xi Zhu, Binzhi Dong, Hanning Ying, Xiaoxiao Fan, Zheyong Li, Zerui Gao, Yongfen Zhu, Yifan Tong, Xiujun Cai
Hepatol Commun. 2024 Jul; 8(7): e0474. Published online 2024 Jun 27. doi: 10.1097/HC9.0000000000000474
PMCID:
PMC11213592
AbstractArticlePDF–2.2M
4.
Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson
Cell. Author manuscript; available in PMC 2024 Oct 26.
Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008
PMCID:
PMC11209935
AbstractArticlePDF–3.0M
5.
CRL4DCAF1/VprBP E3 ubiquitin ligase controls ribosome biogenesis, cell proliferation, and development
Xiao-Ran Han, Naoya Sasaki, Sarah C. Jackson, Pu Wang, Zhijun Li, Matthew D. Smith, Ling Xie, Xian Chen, Yanping Zhang, William F. Marzluff, Yue Xiong
Sci Adv. 2020 Dec; 6(51): eabd6078. Published online 2020 Dec 18. doi: 10.1126/sciadv.abd6078
PMCID:
PMC11206221
AbstractArticlePDF–2.7M
6.
The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation
Jue Zhang, Yin-Li Zhang, Long-Wen Zhao, Shuai-Bo Pi, Song-Ying Zhang, Chao Tong, Heng-Yu Fan
Cell Mol Life Sci. 2020 Jun; 77(11): 2181–2197. Published online 2019 Sep 6. doi: 10.1007/s00018-019-03280-5
PMCID:
PMC11105099
AbstractArticlePDF–11M
7.
The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions
Dimitriya H Garvanska, R Elias Alvarado, Filip Oskar Mundt, Richard Lindqvist, Josephine Kerzel Duel, Fabian Coscia, Emma Nilsson, Kumari Lokugamage, Bryan A Johnson, Jessica A Plante, Dorothea R Morris, Michelle N Vu, Leah K Estes, Alyssa M McLeland, Jordyn Walker, Patricia A Crocquet-Valdes, Blanca Lopez Mendez, Kenneth S Plante, David H Walker, Melanie Bianca Weisser, Anna K Överby, Matthias Mann, Vineet D Menachery, Jakob Nilsson
EMBO Rep. 2024 Feb; 25(2): 902–926. Published online 2024 Jan 2. doi: 10.1038/s44319-023-00043-z
PMCID:
PMC10897489
AbstractArticlePDF–8.2M
8.
Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7
Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537
PMCID:
PMC10850818
AbstractArticlePDF–2.7M
9.
The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg
Science. Author manuscript; available in PMC 2023 Oct 31.
Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021
PMCID:
PMC10617673
AbstractArticlePDF–3.6M
10.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
11.
MLF2 Negatively Regulates P53 and Promotes Colorectal Carcinogenesis
Debao Fang, Hao Hu, Kailiang Zhao, Aman Xu, Changjun Yu, Yong Zhu, Ning Yu, Bo Yao, Suyun Tang, Xianning Wu, Yide Mei
Adv Sci (Weinh) 2023 Sep; 10(26): 2303336. Published online 2023 Jul 12. doi: 10.1002/advs.202303336
PMCID:
PMC10502657
AbstractArticlePDF–3.4M
12.
Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex
Islam E. Elkholi, Jonathan Boulais, Marie-Pier Thibault, Hong-Duc Phan, Amélie Robert, Lien B. Lai, Denis Faubert, Matthew J. Smith, Venkat Gopalan, Jean-Franҫois Côté
J Biol Chem. 2023 Sep; 299(9): 105123. Published online 2023 Aug 1. doi: 10.1016/j.jbc.2023.105123
PMCID:
PMC10480535
AbstractArticlePDF–2.4M
13.
The CUL4B‐based E3 ubiquitin ligase regulates mitosis and brain development by recruiting phospho‐specific DCAFs
Anna Stier, Samuel Gilberto, Weaam I Mohamed, Lars N Royall, Jonne Helenius, Ivan Mikicic, Tatjana Sajic, Petra Beli, Daniel J Müller, Sebastian Jessberger, Matthias Peter
EMBO J. 2023 Sep; 42(17): e112847. Published online 2023 Jun 27. doi: 10.15252/embj.2022112847
PMCID:
PMC10476281
AbstractArticlePDF–2.6M
14.
High-sensitivity profiling of SARS-CoV-2 noncoding region–host protein interactome reveals the potential regulatory role of negative-sense viral RNA
Liuyiqi Jiang, Mu Xiao, Qing-Qing Liao, Luqian Zheng, Chunyan Li, Yuemei Liu, Bing Yang, Aiming Ren, Chao Jiang, Xin-Hua Feng
mSystems. 2023 Jul-Aug; 8(4): e00135-23. Published online 2023 Jun 14. doi: 10.1128/msystems.00135-23
PMCID:
PMC10469612
AbstractArticlePDF–4.0M
15.
C9orf72 protein quality control by UBR5‐mediated heterotypic ubiquitin chains
Julia Jülg, Dieter Edbauer, Christian Behrends
EMBO Rep. 2023 Aug; 24(8): e55895. Published online 2023 Jun 15. doi: 10.15252/embr.202255895
PMCID:
PMC10398660
AbstractArticlePDF–2.4M
16.
HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
Julie K. Monda, Xuezhen Ge, Moritz Hunkeler, Katherine A. Donovan, Michelle W. Ma, Cyrus Y. Jin, Marilyn Leonard, Eric S. Fischer, Eric J. Bennett
Cell Rep. Author manuscript; available in PMC 2023 Jun 19.
Published in final edited form as: Cell Rep. 2023 May 30; 42(5): 112496. Published online 2023 May 9. doi: 10.1016/j.celrep.2023.112496
PMCID:
PMC10279472
AbstractArticlePDF–2.9M
17.
Ring finger protein 12 activates AKT signalling to promote the progression of liver cancer by interacting with EGFR
Chengpeng Yu, Dean Rao, Tiantian Wang, Jiaqi Sheng, Enjun Lv, Long Zhang, Xun Lu, Jingjing Yu, Huifang Liang, Jia Song, Wenjie Huang
J Cell Mol Med. 2023 Jun; 27(11): 1523–1538. Published online 2023 May 2. doi: 10.1111/jcmm.17757
PMCID:
PMC10243154
AbstractArticlePDF–51M
18.
De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity
Jingwei Liu, Tingting Zhou, Xiang Dong, Qiqiang Guo, Lixia Zheng, Xiaoxun Wang, Naijin Zhang, Danni Li, Ling Ren, Fei Yi, Ying Zhang, Ziwei Li, Xiwen Wang, Chengsi Deng, Chunlu Li, Hongde Xu, Yi Guan, Xiaoman Li, Yang Yu, Wendong Guo, Zhuo Wang, Bo Jiang, Xuan Wu, Ning Bai, Yanling Feng, Mengtao Ma, Qingquan Kong, Jiayi Wei, Zhenshuang Wang, Hao Li, Songming Lu, Liangzi Cao, Yutong Xiao, Xiaoyu Song, Zhenning Wang, Chengzhong Xing, Liu Cao
Oncogene. 2023; 42(22): 1843–1856. Published online 2023 Apr 20. doi: 10.1038/s41388-023-02667-w
PMCID:
PMC10238270
AbstractArticlePDF–6.2M
19.
TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing
Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan
Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233
PMCID:
PMC10237422
AbstractArticlePDF–23M
20.
The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing
Yingxiao Chen, Yanping Li, Roselyn S Dai, Jonathan C Savage, Ujwal Shinde, John Klimek, Larry L David, Emma A Young, Markus Hafner, Rosalie C Sears, Xiao-Xin Sun, Mu-Shui Dai
Nucleic Acids Res. 2023 May 8; 51(8): 3934–3949. Published online 2023 Mar 13. doi: 10.1093/nar/gkad140
PMCID:
PMC10164564
AbstractArticlePDF–3.8M

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