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Items: 1 to 20 of 182

1.
BTK drives neutrophil activation for sterilizing antifungal immunity
Jigar V. Desai, Marissa A. Zarakas, Andrew L. Wishart, Mark Roschewski, Mariano A. Aufiero, Agnes Donkò, Gustaf Wigerblad, Neta Shlezinger, Markus Plate, Matthew R. James, Jean K. Lim, Gulbu Uzel, Jenna R.E. Bergerson, Ivan Fuss, Robert A. Cramer, Luis M. Franco, Emily S. Clark, Wasif N. Khan, Daisuke Yamanaka, Georgios Chamilos, Jamel El-Benna, Mariana J. Kaplan, Louis M. Staudt, Thomas L. Leto, Steven M. Holland, Wyndham H. Wilson, Tobias M. Hohl, Michail S. Lionakis
J Clin Invest. 2024 Jun 17; 134(12): e176142. Published online 2024 May 2. doi: 10.1172/JCI176142
PMCID:
PMC11178547
AbstractArticlePDF–2.3M
2.
In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function
H. Yesid Estupiñán, Thibault Bouderlique, Chenfei He, Anna Berglöf, Andrea Cappelleri, Nicolai Frengen, Rula Zain, Mikael C. I. Karlsson, Robert Månsson, C. I. Edvard Smith
Blood Adv. 2024 Apr 23; 8(8): 1981–1990. Published online 2024 Mar 22. doi: 10.1182/bloodadvances.2024012706
PMCID:
PMC11024922
AbstractArticlePDF–4.1M
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
Bruton’s tyrosine kinase-bearing B cells and microglia in neuromyelitis optica spectrum disorder
Ye Liu, Zhenning Huang, Tian-Xiang Zhang, Bin Han, Guili Yang, Dongmei Jia, Li Yang, Qiang Liu, Alexander Y. L. Lau, Friedemann Paul, Alexei Verkhratsky, Fu-Dong Shi, Chao Zhang
J Neuroinflammation. 2023; 20: 309. Published online 2023 Dec 21. doi: 10.1186/s12974-023-02997-2
PMCID:
PMC10740299
AbstractArticlePDF–9.5M
5.
Bruton's Tyrosine Kinase in Neutrophils Is Crucial for Host Defense against Klebsiella pneumoniae
Zhe Liu, Alexander P.N.A. De Porto, Regina De Beer, Joris J.T.H. Roelofs, Onno J. De Boer, Sandrine Florquin, Cornelis Van't Veer, Rudi W. Hendriks, Tom Van der Poll, Alex F. De Vos
J Innate Immun. 2023 Jan-Dec; 15(1): 1–15. Published online 2022 May 10. doi: 10.1159/000524583
PMCID:
PMC10643901
AbstractArticlePDF–1.0M
6.
B cell receptor signaling in germinal centers prolongs survival and primes B cells for selection
Spencer T. Chen, Thiago Y. Oliveira, Anna Gazumyan, Melissa Cipolla, Michel C. Nussenzweig
Immunity. Author manuscript; available in PMC 2023 Aug 14.
Published in final edited form as: Immunity. 2023 Mar 14; 56(3): 547–561.e7. Published online 2023 Mar 6. doi: 10.1016/j.immuni.2023.02.003
PMCID:
PMC10424567
AbstractArticlePDF–3.0M
7.
Bruton's TK regulates myeloid cell recruitment during acute inflammation
Gareth S. D. Purvis, Haidee Aranda‐Tavio, Keith M. Channon, David R. Greaves
Br J Pharmacol. 2022 Jun; 179(11): 2754–2770. Published online 2022 Mar 15. doi: 10.1111/bph.15778
PMCID:
PMC9361009
AbstractArticlePDF–12M
8.
Bruton's tyrosine kinase inhibition induces rewiring of proximal and distal B‐cell receptor signaling in mice
Jasper Rip, Marjolein J. W. de Bruijn, Stefan F. H. Neys, Simar Pal Singh, Jonas Willar, Jennifer A. C. van Hulst, Rudi W. Hendriks, Odilia B. J. Corneth
Eur J Immunol. 2021 Sep; 51(9): 2251–2265. Published online 2021 Aug 16. doi: 10.1002/eji.202048968
PMCID:
PMC9291019
AbstractArticlePDF–1.8M
9.
Bruton’s Tyrosine Kinase Supports Gut Mucosal Immunity and Commensal Microbiome Recognition in Autoimmune Arthritis
Rachel H. Bonami, Christina E. Thurman, Sonam Verma, Camille S. Westlake, Lindsay E. Nyhoff, Bridgette B. Barron, Andrea Reboldi, Peggy L. Kendall
Front Immunol. 2022; 13: 748284. Published online 2022 Mar 29. doi: 10.3389/fimmu.2022.748284
PMCID:
PMC9002138
AbstractArticlePDF–22M
10.
DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis
Yanchuan Li, Xiaoping Xie, Zuliang Jie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, Sung Yun Jung, Natalia Baran, Marina Y. Konopleva, Xuhong Cheng, Shao-Cong Sun
Blood. 2021 Dec 9; 138(23): 2360–2371. doi: 10.1182/blood.2021011247
PMCID:
PMC8832461
AbstractArticle
11.
Bruton’s tyrosine kinase drives neuroinflammation and anxiogenic behavior in mouse models of stress
Simantini Ghosh, Zaidan Mohammed, Itender Singh
J Neuroinflammation. 2021; 18: 289. Published online 2021 Dec 11. doi: 10.1186/s12974-021-02322-9
PMCID:
PMC8665324
AbstractArticlePDF–2.1M
12.
Knockout of Bruton’s tyrosine kinase in macrophages attenuates diabetic nephropathy in streptozotocin-induced mice
Zhe Fan, Yuanyuan Li, Lingling Xia, Yonggui Wu
Am J Transl Res. 2021; 13(11): 12352–12363. Published online 2021 Nov 15.
PMCID:
PMC8661227
AbstractArticlePDF–1.7M
13.
Inhibition of a BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage inflammatory dendritic cells and enhances anti-tumor T cell immunity
Madhav D. Sharma, Rafal Pacholczyk, Huidong Shi, Zuzana J. Berrong, Yousef Zakharia, Austin Greco, Chang-Sheng S. Chang, Sudharshan Eathiraj, Eugene Kennedy, Thomas Cash, Roni J. Bollag, Ravindra Kolhe, Ramses Sadek, Tracy L. McGaha, Paulo Rodriguez, Jessica Mandula, Bruce R. Blazar, Theodore S. Johnson, David H. Munn
Immunity. Author manuscript; available in PMC 2022 Oct 12.
Published in final edited form as: Immunity. 2021 Oct 12; 54(10): 2354–2371.e8. Published online 2021 Oct 5. doi: 10.1016/j.immuni.2021.09.005
PMCID:
PMC8516719
AbstractArticlePDF–1.6M
14.
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity
Zsófia Agnes Bittner, Xiao Liu, Maria Mateo Tortola, Ana Tapia-Abellán, Sangeetha Shankar, Liudmila Andreeva, Matthew Mangan, Marianne Spalinger, Hubert Kalbacher, Peter Düwell, Marta Lovotti, Karlotta Bosch, Sabine Dickhöfer, Ana Marcu, Stefan Stevanović, Franziska Herster, Yamel Cardona Gloria, Tzu-Hsuan Chang, Francesca Bork, Carsten L. Greve, Markus W. Löffler, Olaf-Oliver Wolz, Nadine A. Schilling, Jasmin B. Kümmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Oliver Hantschel, Michael Scharl, Hao Wu, Eicke Latz, Alexander N.R. Weber
J Exp Med. 2021 Nov 1; 218(11): e20201656. Published online 2021 Sep 23. doi: 10.1084/jem.20201656
PMCID:
PMC8480672
AbstractArticlePDF–6.7M
15.
Bruton’s Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia
Alexander P. de Porto, Zhe Liu, Regina de Beer, Sandrine Florquin, Joris J. T. H. Roelofs, Onno J. de Boer, Joke M. M. den Haan, Rudi W. Hendriks, Cornelis van ‘t Veer, Tom van der Poll, Alex F. de Vos
Front Immunol. 2021; 12: 723967. Published online 2021 Sep 6. doi: 10.3389/fimmu.2021.723967
PMCID:
PMC8450579
AbstractArticlePDF–1.7M
16.
Bruton's tyrosine kinase regulates macrophage-induced inflammation in the diabetic kidney via NLRP3 inflammasome activation
Jing Zhao, Juan Chen, Yuan-Yuan Li, Ling-Ling Xia, Yong-Gui Wu
Int J Mol Med. 2021 Sep; 48(3): 177. Published online 2021 Jul 16. doi: 10.3892/ijmm.2021.5010
PMCID:
PMC8354311
AbstractArticlePDF–3.6M
17.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
18.
T-cell expression of Bruton’s tyrosine kinase promotes autoreactive T-cell activation and exacerbates aplastic anemia
Simo Xia, Xiang Liu, Xuetao Cao, Sheng Xu
Cell Mol Immunol. 2020 Oct; 17(10): 1042–1052. Published online 2019 Aug 20. doi: 10.1038/s41423-019-0270-9
PMCID:
PMC7608443
AbstractArticlePDF–3.0M
19.
X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure
Caroline E. O'Riordan, Gareth S. D. Purvis, Debora Collotta, Nadine Krieg, Bianka Wissuwa, Madeeha H. Sheikh, Gustavo Ferreira Alves, Shireen Mohammad, Lauren A. Callender, Sina M. Coldewey, Massimo Collino, David R. Greaves, Christoph Thiemermann
Front Immunol. 2020; 11: 581758. Published online 2020 Oct 7. doi: 10.3389/fimmu.2020.581758
PMCID:
PMC7580254
AbstractArticlePDF–2.3M
20.
Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β–mediated colitis
Liming Mao, Atsushi Kitani, Eitaro Hiejima, Kim Montgomery-Recht, Wenchang Zhou, Ivan Fuss, Adrian Wiestner, Warren Strober
J Clin Invest. 2020 Apr 1; 130(4): 1793–1807. Published online 2020 Mar 3. doi: 10.1172/JCI128322
PMCID:
PMC7108929
AbstractArticlePDF–2.0M

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