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Select item 111432361.

ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression

Huan Zhang, Yan Sun, Zhaokai Wang, Xiaoju Huang, Lu Tang, Ke Jiang, Xin Jin

Nat Commun. 2024; 15: 4642. Published online 2024 May 31. doi: 10.1038/s41467-024-49105-3

PMCID:: PMC11143236

Abstract Article PDF–6.8M

Select item 109902772.

ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication

Guy J. Pearson, Harriet V. Mears, Malgorzata Broncel, Ambrosius P. Snijders, David L. V. Bauer, Jeremy G. Carlton

Sci Adv. 2024 Apr 5; 10(14): eadl5012. Published online 2024 Apr 3. doi: 10.1126/sciadv.adl5012

PMCID:: PMC10990277

Abstract Article PDF–3.9M

Select item 109168663.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 103459634.

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

Amr El Zawily, Frederick S. Vizeacoumar, Renuka Dahiya, Sara L. Banerjee, Kalpana K. Bhanumathy, Hussain Elhasasna, Glinton Hanover, Jessica C. Sharpe, Malkon G. Sanchez, Paul Greidanus, R. Greg Stacey, Kyung-Mee Moon, Ilya Alexandrov, Juha P. Himanen, Dimitar B. Nikolov, Humphrey Fonge, Aaron P. White, Leonard J. Foster, Bingcheng Wang, Behzad M. Toosi, Nicolas Bisson, Tajib A. Mirzabekov, Franco J. Vizeacoumar, Andrew Freywald

Clin Cancer Res. 2023 Jul 14; 29(14): 2686–2701. Published online 2023 Mar 28. doi: 10.1158/1078-0432.CCR-22-2535

PMCID:: PMC10345963

Abstract Article PDF–13M

Select item 88515155.

Bivalent recognition of fatty acyl-CoA by a human integral membrane palmitoyltransferase

Chul-Jin Lee, Robyn Stix, Mitra S. Rana, Flowreen Shikwana, R. Elliot Murphy, Rodolfo Ghirlando, José D. Faraldo-Gómez, Anirban Banerjee

Proc Natl Acad Sci U S A. 2022 Feb 15; 119(7): e2022050119. Published online 2022 Feb 9. doi: 10.1073/pnas.2022050119

PMCID:: PMC8851515

Abstract Article PDF–1.8M

Select item 86830796.

S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca²⁺ signaling by Jurkat T cell receptors at the immune synapse

Amado Carreras-Sureda, Laurence Abrami, Kim Ji-Hee, Wen-An Wang, Christopher Henry, Maud Frieden, Monica Didier, F Gisou van der Goot, Nicolas Demaurex

eLife. 2021; 10: e72051. Published online 2021 Dec 16. doi: 10.7554/eLife.72051

PMCID:: PMC8683079

Abstract Article PDF–4.2M

Select item 85529077.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 85138538.

The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation

Jordan M. Meyers, Muthukumar Ramanathan, Ronald L. Shanderson, Aimee Beck, Laura Donohue, Ian Ferguson, Margaret G. Guo, Deepti S. Rao, Weili Miao, David Reynolds, Xue Yang, Yang Zhao, Yen-Yu Yang, Catherine Blish, Yinsheng Wang, Paul A. Khavari

PLoS Pathog. 2021 Oct; 17(10): e1009412. Published online 2021 Oct 1. doi: 10.1371/journal.ppat.1009412

PMCID:: PMC8513853

Abstract Article PDF–4.1M

Select item 84921729.

Regulation of EGFR signalling by palmitoylation and its role in tumorigenesis

Yasmin A. Kadry, Jia-Ying Lee, Eric S. Witze

Open Biol. 2021 Oct; 11(10): 210033. Published online October 6, 2021. doi: 10.1098/rsob.210033

PMCID:: PMC8492172

Abstract Article PDF–729K

Select item 848608310.

S-acylation controls SARS-CoV-2 membrane lipid organization and enhances infectivity

Francisco S. Mesquita, Laurence Abrami, Oksana Sergeeva, Priscilla Turelli, Enya Qing, Béatrice Kunz, Charlène Raclot, Jonathan Paz Montoya, Luciano A. Abriata, Tom Gallagher, Matteo Dal Peraro, Didier Trono, Giovanni D’Angelo, F. Gisou van der Goot

Dev Cell. 2021 Oct 25; 56(20): 2790–2807.e8. Published online 2021 Oct 1. doi: 10.1016/j.devcel.2021.09.016

PMCID:: PMC8486083

Abstract Article PDF–6.9M

Select item 837982211.

S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity

Robbins Puthenveetil, Cheng Man Lun, R. Elliot Murphy, Liam B. Healy, Geraldine Vilmen, Eric T. Christenson, Eric O. Freed, Anirban Banerjee

J Biol Chem. 2021 Oct; 297(4): 101112. Published online 2021 Aug 21. doi: 10.1016/j.jbc.2021.101112

PMCID:: PMC8379822

Abstract Article PDF–2.7M

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 794912413.

Metallo-β-lactamase domain-containing protein 2 is S-palmitoylated and exhibits acyl-CoA hydrolase activity

Martin Ian P. Malgapo, Jenelle M. Safadi, Maurine E. Linder

J Biol Chem. 2021 Jan-Jun; 296: 100106. Published online 2020 Dec 3. doi: 10.1074/jbc.RA120.015701

PMCID:: PMC7949124

Abstract Article PDF–2.9M

Select item 764232714.

A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

Dick J. H. van den Boomen, Agata Sienkiewicz, Ilana Berlin, Marlieke L. M. Jongsma, Daphne M. van Elsland, J. Paul Luzio, Jacques J. C. Neefjes, Paul J. Lehner

Nat Commun. 2020; 11: 5559. Published online 2020 Nov 3. doi: 10.1038/s41467-020-19032-0

PMCID:: PMC7642327

Abstract Article PDF–12M

Select item 703671115.

DHHC20 Palmitoyl-Transferase Reshapes the Membrane to Foster Catalysis

Robyn Stix, James Song, Anirban Banerjee, José D. Faraldo-Gómez

Biophys J. 2020 Feb 25; 118(4): 980–988. Published online 2019 Nov 14. doi: 10.1016/j.bpj.2019.11.003

PMCID:: PMC7036711

Abstract Article PDF–3.0M

Select item 638658816.

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001

PMCID:: PMC6386588

Abstract Article PDF–1.7M

Select item 631707817.

Fatty acyl recognition and transfer by an integral membrane S-acyltransferase

Mitra S. Rana, Pramod Kumar, Chul-Jin Lee, Raffaello Verardi, Kanagalaghatta R. Rajashankar, Anirban Banerjee

Science. Author manuscript; available in PMC 2019 Jan 3.

Published in final edited form as: Science. 2018 Jan 12; 359(6372): eaao6326. doi: 10.1126/science.aao6326

PMCID:: PMC6317078

Abstract Article PDF–2.3M

Select item 612890518.

Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability

Hema Adhikari, Christopher M. Counter

Nat Commun. 2018; 9: 3646. Published online 2018 Sep 7. doi: 10.1038/s41467-018-05692-6

PMCID:: PMC6128905

Abstract Article PDF–2.2M

Select item 586483219.

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations

Xiaonan Liu, Kari Salokas, Fitsum Tamene, Yaming Jiu, Rigbe G. Weldatsadik, Tiina Öhman, Markku Varjosalo

Nat Commun. 2018; 9: 1188. Published online 2018 Mar 22. doi: 10.1038/s41467-018-03523-2

PMCID:: PMC5864832

Abstract Article PDF–4.5M

Select item 576695820.

The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity

Temet M. McMichael, Lizhi Zhang, Mahesh Chemudupati, Jocelyn C. Hach, Adam D. Kenney, Howard C. Hang, Jacob S. Yount

J Biol Chem. 2017 Dec 29; 292(52): 21517–21526. Published online 2017 Oct 27. doi: 10.1074/jbc.M117.800482

PMCID:: PMC5766958

Abstract Article PDF–1.6M

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