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Select item 108418131.

IntS6 and the Integrator phosphatase module tune the efficiency of select premature transcription termination events

Rina Fujiwara, Si-Nan Zhai, Dongming Liang, Aayushi P. Shah, Matthew Tracey, Xu-Kai Ma, Christopher J. Fields, María Saraí Mendoza-Figueroa, Michele C. Meline, Deirdre C. Tatomer, Li Yang, Jeremy E. Wilusz

Mol Cell. Author manuscript; available in PMC 2024 Dec 21.

Published in final edited form as: Mol Cell. 2023 Dec 21; 83(24): 4445–4460.e7. Published online 2023 Nov 22. doi: 10.1016/j.molcel.2023.10.035

PMCID:: PMC10841813

Abstract Article PDF–3.4M

Select item 99385902.

Proximity labeling reveals a new in vivo network of interactors for the histone demethylase KDM5

Matanel Yheskel, Simone Sidoli, Julie Secombe

Epigenetics Chromatin. 2023; 16: 8. Published online 2023 Feb 18. doi: 10.1186/s13072-023-00481-y

PMCID:: PMC9938590

Abstract Article PDF–4.8M

Select item 86452073.

In vivo proximity biotin ligation identifies the interactome of Egalitarian, a Dynein cargo adaptor

Frederick C. Baker, Hannah Neiswender, Rajalakshmi Veeranan-Karmegam, Graydon B. Gonsalvez

Development. 2021 Nov 15; 148(22): dev199935. Published online 2021 Nov 18. doi: 10.1242/dev.199935

PMCID:: PMC8645207

Abstract Article

Select item 85678404.

The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

Stephin J. Vervoort, Sarah A. Welsh, Jennifer R. Devlin, Elisa Barbieri, Deborah A. Knight, Sarah Offley, Stefan Bjelosevic, Matteo Costacurta, Izabela Todorovski, Conor J. Kearney, Jarrod J. Sandow, Zheng Fan, Benjamin Blyth, Victoria McLeod, Joseph H.A. Vissers, Karolina Pavic, Ben P. Martin, Gareth Gregory, Elena Demosthenous, Magnus Zethoven, Isabella Y. Kong, Edwin D. Hawkins, Simon J. Hogg, Madison J. Kelly, Andrea Newbold, Kaylene J. Simpson, Otto Kauko, Kieran F. Harvey, Michael Ohlmeyer, Jukka Westermarck, Nathanael Gray, Alessandro Gardini, Ricky W. Johnstone

Cell. Author manuscript; available in PMC 2022 Jun 10.

Published in final edited form as: Cell. 2021 Jun 10; 184(12): 3143–3162.e32. Published online 2021 May 17. doi: 10.1016/j.cell.2021.04.022

PMCID:: PMC8567840

Abstract Article PDF–2.8M

Select item 76609705.

Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination

Kai-Lieh Huang, David Jee, Chad B. Stein, Nathan D. Elrod, Telmo Henriques, Lauren G. Mascibroda, David Baillat, William K. Russell, Karen Adelman, Eric J. Wagner

Mol Cell. Author manuscript; available in PMC 2021 Oct 15.

Published in final edited form as: Mol Cell. 2020 Oct 15; 80(2): 345–358.e9. Published online 2020 Sep 22. doi: 10.1016/j.molcel.2020.08.016

PMCID:: PMC7660970

Abstract Article PDF–3.3M

Select item 69615786.

CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans

Ping Wei, Wen Xue, Yun Zhao, Guang Ning, Jiwu Wang

Genome Res. 2020 Jan; 30(1): 95–106. doi: 10.1101/gr.250811.119

PMCID:: PMC6961578

Abstract Article PDF–3.6M

Select item 68244657.

The Integrator complex cleaves nascent mRNAs to attenuate transcription

Deirdre C. Tatomer, Nathan D. Elrod, Dongming Liang, Mei-Sheng Xiao, Jeffrey Z. Jiang, Michael Jonathan, Kai-Lieh Huang, Eric J. Wagner, Sara Cherry, Jeremy E. Wilusz

Genes Dev. 2019 Nov 1; 33(21-22): 1525–1538. doi: 10.1101/gad.330167.119

PMCID:: PMC6824465

Abstract Article PDF–4.0M

Select item 59346448.

Integrator subunit 4 is a ‘Symplekin-like’ scaffold that associates with INTS9/11 to form the Integrator cleavage module

Todd R Albrecht, Sergey P Shevtsov, Yixuan Wu, Lauren G Mascibroda, Natoya J Peart, Kai-Lieh Huang, Iain A Sawyer, Liang Tong, Miroslav Dundr, Eric J Wagner

Nucleic Acids Res. 2018 May 4; 46(8): 4241–4255. Published online 2018 Feb 20. doi: 10.1093/nar/gky100

PMCID:: PMC5934644

Abstract Article PDF–9.0M

Select item 57078059.

Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species

Piero Sanfilippo, Jiayu Wen, Eric C. Lai

Genome Biol. 2017; 18: 229. Published online 2017 Nov 30. doi: 10.1186/s13059-017-1358-0

PMCID:: PMC5707805

Abstract Article PDF–3.2M

Select item 568900210.

Transcription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster

Xiaochuan Liu, Jaime Freitas, Dinghai Zheng, Marta S. Oliveira, Mainul Hoque, Torcato Martins, Telmo Henriques, Bin Tian, Alexandra Moreira

RNA. 2017 Dec; 23(12): 1807–1816. doi: 10.1261/rna.062661.117

PMCID:: PMC5689002

Abstract Article PDF–4.0M

Select item 498142411.

Comparative Genomic Analyses Provide New Insights into the Evolutionary Dynamics of Heterochromatin in Drosophila

Ruggiero Caizzi, Roberta Moschetti, Lucia Piacentini, Laura Fanti, Renè Massimiliano Marsano, Patrizio Dimitri

PLoS Genet. 2016 Aug; 12(8): e1006212. Published online 2016 Aug 11. doi: 10.1371/journal.pgen.1006212

PMCID:: PMC4981424

Abstract Article PDF–6.5M

Select item 488965812.

mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster

Gildas Lepennetier, Francesco Catania

G3 (Bethesda) 2016 Jun; 6(6): 1617–1626. Published online 2016 Mar 28. doi: 10.1534/g3.116.029231

PMCID:: PMC4889658

Abstract Article PDF–1.5M

Select item 478811613.

Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet

Ibrahim Ömer Çiçek, Samir Karaca, Marko Brankatschk, Suzanne Eaton, Henning Urlaub, Halyna R. Shcherbata

Genetics. 2016 Mar; 202(3): 1167–1183. Published online 2016 Jan 22. doi: 10.1534/genetics.115.185371

PMCID:: PMC4788116

Abstract Article PDF–4.7M

Select item 473800514.

Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes

Sadhna Phanse, Cuihong Wan, Blake Borgeson, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Bezginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. Malty, Mihail Sarov, Jack Greenblatt, Mohan Babu, W. Brent Derry, Elisabeth R. Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili

Data Brief. 2016 Mar; 6: 715–721. Published online 2015 Dec 12. doi: 10.1016/j.dib.2015.11.062

PMCID:: PMC4738005

Abstract Article PDF–205K

Select item 460746315.

Modulation of Heterochromatin by Male Specific Lethal Proteins and roX RNA in Drosophila melanogaster Males

S. Kiran Koya, Victoria H. Meller

PLoS One. 2015; 10(10): e0140259. Published online 2015 Oct 15. doi: 10.1371/journal.pone.0140259

PMCID:: PMC4607463

Abstract Article PDF–720K

Select item 452833016.

Gene Model Annotations for Drosophila melanogaster: The Rule-Benders

Madeline A. Crosby, L. Sian Gramates, Gilberto dos Santos, Beverley B. Matthews, Susan E. St. Pierre, Pinglei Zhou, Andrew J. Schroeder, Kathleen Falls, David B. Emmert, Susan M. Russo, William M. Gelbart, the FlyBase Consortium

G3 (Bethesda) 2015 Aug; 5(8): 1737–1749. Published online 2015 Jun 24. doi: 10.1534/g3.115.018937

PMCID:: PMC4528330

Abstract Article PDF–2.2M

Select item 452832917.

Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data

Beverley B. Matthews, Gilberto dos Santos, Madeline A. Crosby, David B. Emmert, Susan E. St. Pierre, L. Sian Gramates, Pinglei Zhou, Andrew J. Schroeder, Kathleen Falls, Victor Strelets, Susan M. Russo, William M. Gelbart, the FlyBase Consortium

G3 (Bethesda) 2015 Aug; 5(8): 1721–1736. Published online 2015 Jun 24. doi: 10.1534/g3.115.018929

PMCID:: PMC4528329

Abstract Article PDF–4.9M

Select item 435288718.

The Release 6 reference sequence of the Drosophila melanogaster genome

Roger A. Hoskins, Joseph W. Carlson, Kenneth H. Wan, Soo Park, Ivonne Mendez, Samuel E. Galle, Benjamin W. Booth, Barret D. Pfeiffer, Reed A. George, Robert Svirskas, Martin Krzywinski, Jacqueline Schein, Maria Carmela Accardo, Elisabetta Damia, Giovanni Messina, María Méndez-Lago, Beatriz de Pablos, Olga V. Demakova, Evgeniya N. Andreyeva, Lidiya V. Boldyreva, Marco Marra, A. Bernardo Carvalho, Patrizio Dimitri, Alfredo Villasante, Igor F. Zhimulev, Gerald M. Rubin, Gary H. Karpen, Susan E. Celniker

Genome Res. 2015 Mar; 25(3): 445–458. doi: 10.1101/gr.185579.114

PMCID:: PMC4352887

Abstract Article PDF–1022K

Select item 401229719.

Tau promotes neurodegeneration through global chromatin relaxation

Bess Frost, Martin Hemberg, Jada Lewis, Mel B. Feany

Nat Neurosci. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: Nat Neurosci. 2014 Mar; 17(3): 357–366. Published online 2014 Jan 26. doi: 10.1038/nn.3639

PMCID:: PMC4012297

Abstract Article PDF–1.5M

Select item 384078920.

Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster

Joshua G Dunn, Catherine K Foo, Nicolette G Belletier, Elizabeth R Gavis, Jonathan S Weissman

eLife. 2013; 2: e01179. Published online 2013 Dec 3. doi: 10.7554/eLife.01179

Correction in:: eLife. 2014; 3: e03178.

PMCID:: PMC3840789

Abstract Article PDF–4.2M

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