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Select item 115396191.

SARS-CoV-2 nucleocapsid protein interaction with YBX1 displays oncolytic properties through PKM mRNA destabilization

Xin Chen, Baohong Jiang, Yu Gu, Zhaoyang Yue, Ying Liu, Zhiwei Lei, Ge Yang, Minhua Deng, Xuelong Zhang, Zhen Luo, Yongkui Li, Qiwei Zhang, Xuepei Zhang, Jianguo Wu, Chunyu Huang, Pan Pan, Fangjian Zhou, Ning Wang

Mol Cancer. 2024; 23: 248. Published online 2024 Nov 6. doi: 10.1186/s12943-024-02153-1

PMCID:: PMC11539619

Abstract Article PDF–11M

Select item 114472562.

Cell fixation improves performance of in situ crosslinking mass spectrometry while preserving cellular ultrastructure

Andrew R. M. Michael, Bruno C. Amaral, Kallie L. Ball, Kristen H. Eiriksson, David C. Schriemer

Nat Commun. 2024; 15: 8537. Published online 2024 Oct 2. doi: 10.1038/s41467-024-52844-y

PMCID:: PMC11447256

Abstract Article PDF–2.8M

Select item 114027763.

Deciphering the interaction between PKM2 and the built-in thermodynamic properties of the glycolytic pathway in cancer cells

Chengmeng Jin, Wei Hu, Yuqi Wang, Hao Wu, Siying Zeng, Minfeng Ying, Xun Hu

J Biol Chem. 2024 Sep; 300(9): 107648. Published online 2024 Aug 8. doi: 10.1016/j.jbc.2024.107648

PMCID:: PMC11402776

Abstract Article PDF–5.2M

Select item 113735994.

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway

Elena Prosdocimi, Veronica Carpanese, Luca Matteo Todesca, Tatiana Varanita, Magdalena Bachmann, Margherita Festa, Daniele Bonesso, Mireia Perez-Verdaguer, Andrea Carrer, Angelo Velle, Roberta Peruzzo, Silvia Muccioli, Davide Doni, Luigi Leanza, Paola Costantini, Frank Stein, Mandy Rettel, Antonio Felipe, Michael J. Edwards, Erich Gulbins, Laura Cendron, Chiara Romualdi, Vanessa Checchetto, Ildiko Szabo

Sci Adv. 2024 Sep 6; 10(36): eadn9361. Published online 2024 Sep 4. doi: 10.1126/sciadv.adn9361

PMCID:: PMC11373599

Abstract Article PDF–11M

Select item 112969145.

DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples

Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang

J Proteome Res. Author manuscript; available in PMC 2024 Aug 3.

Published in final edited form as: J Proteome Res. 2024 Aug 2; 23(8): 3269–3279. Published online 2024 Feb 9. doi: 10.1021/acs.jproteome.3c00832

PMCID:: PMC11296914

Abstract Article PDF–1.7M

Select item 112099356.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111197967.

Immunoglobulin Superfamily Containing Leucine-Rich Repeat (ISLR) Serves as a Redox Sensor That Modulates Antioxidant Capacity by Suppressing Pyruvate Kinase Isozyme M2 Activity

Tongtong Wang, Meijing Chen, Yang Su, Yuying Zhang, Chang Liu, Miaomiao Lan, Lei Li, Fan Liu, Na Li, Yingying Yu, Lei Xiong, Kun Wang, Jin Liu, Qing Xu, Yue Hu, Yuxin Jia, Yuxin Cao, Jingwen Pan, Qingyong Meng

Cells. 2024 May; 13(10): 838. Published online 2024 May 14. doi: 10.3390/cells13100838

PMCID:: PMC11119796

Abstract Article PDF–7.2M

Select item 111049588.

FA-SAT ncRNA interacts with PKM2 protein: depletion of this complex induces a switch from cell proliferation to apoptosis

Daniela Ferreira, Ana Escudeiro, Filomena Adega, Sandra I. Anjo, Bruno Manadas, Raquel Chaves

Cell Mol Life Sci. 2020 Apr; 77(7): 1371–1386. Published online 2019 Jul 25. doi: 10.1007/s00018-019-03234-x

PMCID:: PMC11104958

Abstract Article PDF–2.9M

Select item 111002179.

Endothelial EGLN3-PKM2 signaling induces the formation of acute astrocytic barrier to alleviate immune cell infiltration after subarachnoid hemorrhage

Mingxu Duan, Xufang Ru, Jiru Zhou, Yuanshu Li, Peiwen Guo, Wenbo Kang, Wenyan Li, Zhi Chen, Hua Feng, Yujie Chen

Fluids Barriers CNS. 2024; 21: 42. Published online 2024 May 16. doi: 10.1186/s12987-024-00550-8

PMCID:: PMC11100217

Abstract Article PDF–23M

Select item 1103666810.

CircPHGDH downregulation decreases papillary thyroid cancer progression through miR-122-5p/PKM2 axis

Jiying Shen, Zhirong Ma, Jin Yang, Tianzhen Qu, Yu Xia, Yingjie Xu, Ming Zhou, Weiwei Liu

BMC Cancer. 2024; 24: 511. Published online 2024 Apr 23. doi: 10.1186/s12885-024-12199-5

PMCID:: PMC11036668

Abstract Article PDF–6.8M

Select item 1093040511.

磷酸化PKM2调控糖尿病内皮依赖性血管舒张功能

鲁斌, 唐磊, 李乐, 周晓煜, 冷一平, 全承炫

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023 May 28; 48(5): 663–670. Chinese. doi: 10.11817/j.issn.1672-7347.2023.220541

PMCID:: PMC10930405

Abstract Article PDF–1.4M

Select item 1090799912.

PKM2 promotes lymphatic metastasis of hypopharyngeal carcinoma via regulating epithelial-mesenchymal transition: an experimental research

Xin Zhou, Yanshi Li, Min Pan, Tao Lu, Chuan Liu, Zhihai Wang, Fengxiang Tang, Guohua Hu

Diagn Pathol. 2024; 19: 48. Published online 2024 Mar 2. doi: 10.1186/s13000-024-01474-5

PMCID:: PMC10907999

Abstract Article PDF–12M

Select item 1088027313.

Long noncoding RNA TMPO-AS1 accelerates glycolysis by regulating the miR-1270/PKM2 axis in colorectal cancer

Yingmin Jin, Aimin Jiang, Liying Sun, Yue Lu

BMC Cancer. 2024; 24: 238. Published online 2024 Feb 21. doi: 10.1186/s12885-024-11964-w

PMCID:: PMC10880273

Abstract Article PDF–4.9M

Select item 1087890014.

RBMX通过下调PKM2抑制膀胱癌细胞的增殖、迁移、侵袭和糖酵解

颜秋霞, 曾鹏, 黄树强, 谭翠钰, 周秀琴, 乔静, 赵晓英, 冯玲, 朱振杰, 张国志, 胡鸿, 陈彩蓉

Nan Fang Yi Ke Da Xue Xue Bao. 2024 Jan 20; 44(1): 9–16. Chinese. doi: 10.12122/j.issn.1673-4254.2024.01.02

PMCID:: PMC10878900

Abstract Article PDF–2.9M

Select item 1076495815.

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence

Jiang Ren, Shuai Wang, Zhi Zong, Ting Pan, Sijia Liu, Wei Mao, Huizhe Huang, Xiaohua Yan, Bing Yang, Xin He, Fangfang Zhou, Long Zhang

Nat Commun. 2024; 15: 244. Published online 2024 Jan 4. doi: 10.1038/s41467-023-44502-6

PMCID:: PMC10764958

Abstract Article PDF–4.4M

Select item 1073173016.

Elevated plasma pyruvate kinase M2 concentrations are associated with the clinical severity and prognosis of coronary artery disease

Zi-wen Zhao, Yi-wei Xu, Xin-tao Zhang, Hang-hao Ma, Jing-kun Zhang, Xue Wu, Yu Huang

Biochem Med (Zagreb) 2024 Feb 15; 34(1): 010704. Published online 2023 Dec 15. doi: 10.11613/BM.2024.010704

PMCID:: PMC10731730

Abstract Article PDF–211K

Select item 1073023917.

GLUT-1/PKM2 loop dysregulation in patients with non-ST-segment elevation myocardial infarction promotes metainflammation

Francesco Canonico, Daniela Pedicino, Anna Severino, Ramona Vinci, Davide Flego, Eugenia Pisano, Alessia d’Aiello, Pellegrino Ciampi, Myriana Ponzo, Alice Bonanni, Astrid De Ciutiis, Sara Russo, Marianna Di Sario, Giulia Angelini, Piotr Szczepaniak, Alfonso Baldi, Boguslaw Kapelak, Karol Wierzbicki, Rocco A Montone, Domenico D’Amario, Massimo Massetti, Tomasz J Guzik, Filippo Crea, Giovanna Liuzzo

Cardiovasc Res. 2023 Nov; 119(16): 2653–2662. Published online 2022 Dec 13. doi: 10.1093/cvr/cvac184

PMCID:: PMC10730239

Abstract Article PDF–531K

Select item 1072184718.

PKM2 is a potential prognostic biomarker and related to immune infiltration in lung cancer

Lan Yin, Jiaying Shi, Jingfei Zhang, Xinyu Lin, Wenhao Jiang, Yingchuan Zhu, Yue Song, Yilu Lu, Yongxin Ma

Sci Rep. 2023; 13: 22243. Published online 2023 Dec 14. doi: 10.1038/s41598-023-49558-4

PMCID:: PMC10721847

Abstract Article PDF–11M

Select item 1070602319.

Pyruvate Kinase Differentially Alters Metabolic Signatures during Head and Neck Carcinogenesis

Pei-Chun Huang, Ching-Wen Chang, Yu-Cheng Lin, Chang-Yi Chen, Tsai-Ying Chen, Lu-Te Chuang, Chung-Ji Liu, Chien-Ling Huang, Wan-Chun Li

Int J Mol Sci. 2023 Dec; 24(23): 16639. Published online 2023 Nov 23. doi: 10.3390/ijms242316639

PMCID:: PMC10706023

Abstract Article PDF–3.6M

Select item 1065756320.

Transcription factor LHX9 (LIM Homeobox 9) enhances pyruvate kinase PKM2 activity to induce glycolytic metabolic reprogramming in cancer stem cells, promoting gastric cancer progression

Hongying Zhao, Rongke Jiang, Zhijing Feng, Xue Wang, Chunmei Zhang

J Transl Med. 2023; 21: 833. Published online 2023 Nov 18. doi: 10.1186/s12967-023-04658-7

PMCID:: PMC10657563

Abstract Article PDF–2.4M

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