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Select item 116076321.

Hypoxia‐inducible factor‐1α can reverse the Adriamycin resistance of breast cancer adjuvant chemotherapy by upregulating transferrin receptor and activating ferroptosis

Xiaojie Yu, Qingqun Guo, Haojie Zhang, Xiaohong Wang, Yong Han, Zhenlin Yang

FASEB J. 2024 Aug 15; 38(15): e23876. Published online 2024 Aug 9. doi: 10.1096/fj.202401119R

PMCID:: PMC11607632

Abstract Article PDF–52M

Select item 115340362.

Impact of Hypoxia and the Levels of Transcription Factor HIF-1α and JMJD1A on Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma Cell Lines

ARMIN VON FOURNIER, CHRISTIAN WILHELM, CLARA TIRTEY, MANUEL STÖTH, TOTTA EHRET KASEMO, STEPHAN HACKENBERG, AGMAL SCHERZAD

Cancer Genomics Proteomics. 2024 Nov-Dec; 21(6): 591–607. Published online 2024 Nov 3. doi: 10.21873/cgp.20476

PMCID:: PMC11534036

Abstract Article PDF–5.0M

Select item 115144503.

A transcription-independent role for HIF-1α in modulating microprocessor assembly

Jie-Ning Li, Ming-Yang Wang, Jhen-Wei Ruan, Yu-Jhen Lyu, Yi-Hsiu Weng, Pownraj Brindangnanam, Mohane Selvaraj Coumar, Pai-Sheng Chen

Nucleic Acids Res. 2024 Oct 28; 52(19): 11806–11821. Published online 2024 Sep 25. doi: 10.1093/nar/gkae792

PMCID:: PMC11514450

Abstract Article PDF–3.7M

Select item 115133204.

β₂-integrins control HIF1α activation in human neutrophils

Lovis Kling, Claudia Eulenberg-Gustavus, Uwe Jerke, Anthony Rousselle, Kai-Uwe Eckardt, Adrian Schreiber, Ralph Kettritz

Front Immunol. 2024; 15: 1406967. Published online 2024 Oct 14. doi: 10.3389/fimmu.2024.1406967

PMCID:: PMC11513320

Abstract Article PDF–4.3M

Select item 115070675.

Pilot Study on the Effect of Patient Condition and Clinical Parameters on Hypoxia-Induced Factor Expression: HIF1A, EPAS1 and HIF3A in Human Colostrum Cells

Julia Zarychta, Adrian Kowalczyk, Karolina Słowik, Dominika Przywara, Alicja Petniak, Adrianna Kondracka, Monika Wójtowicz-Marzec, Patrycja Słyk-Gulewska, Anna Kwaśniewska, Janusz Kocki, Paulina Gil-Kulik

Int J Mol Sci. 2024 Oct; 25(20): 11042. Published online 2024 Oct 14. doi: 10.3390/ijms252011042

PMCID:: PMC11507067

Abstract Article PDF–902K

Select item 114882356.

MiR-1307-5p enhances fibroblast transdifferentiation to exacerbate chronic obstructive pulmonary disease through regulating FBXL16/HIF1α axis

Li-peng Yao, Zheng-kai Wang, Xin-qing Jiang, Beier Jiang, Si-jia Chen, Zhi-dan Hua, Dan-dan Gao, Quan Zheng, Sheng-mei Zhu, Mao-xiang Qian, Feng Zhang, Li-feng Xu, Cheng-shui Chen, Fang Lu

Respir Res. 2024; 25: 376. Published online 2024 Oct 17. doi: 10.1186/s12931-024-03007-6

PMCID:: PMC11488235

Abstract Article PDF–7.4M

Select item 114632457.

Clinical implications of activation of the LIMD1-VHL-HIF1α pathway during head-&-neck squamous cell carcinoma development

Debalina Mukhopadhyay, Balarko Chakraborty, Shreya Sarkar, Neyaz Alam, Chinmay Kumar Panda

Indian J Med Res. 2024 May; 159(5): 479–493. Published online 2024 Aug 3. doi: 10.25259/ijmr_1262_22

PMCID:: PMC11463245

Abstract Article PDF–2.5M

Select item 114434538.

CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A

Dandan Feng, Jie Gao, Ruiqiong Liu, Wei Liu, Tianyang Gao, Yunkai Yang, Die Zhang, Tianshu Yang, Xin Yin, Hefen Yu, Wei Huang, Yan Wang

Protein Cell. 2024 Oct; 15(10): 744–765. Published online 2024 Mar 13. doi: 10.1093/procel/pwae010

PMCID:: PMC11443453

Abstract Article PDF–42M

Select item 114252309.

DDR1 Drives Malignant Progression of Gastric Cancer by Suppressing HIF‐1α Ubiquitination and Degradation

Zhewei Wei, Jin Li, Li Zhong, Dongjie Yang, Wuguo Li, Wei Chen, Hao Zhou, Yulong He, Wu Song, Boyan Wang, Leli Zeng

Adv Sci (Weinh) 2024 Sep; 11(35): 2308395. Published online 2024 Jul 18. doi: 10.1002/advs.202308395

PMCID:: PMC11425230

Abstract Article PDF–11M

Select item 1137221710.

Citrullination modulation stabilizes HIF-1α to promote tumour progression

Rui Chen, Zhiyuan Lin, Shengqi Shen, Chuxu Zhu, Kai Yan, Caixia Suo, Rui Liu, Haoran Wei, Li Gao, Kaixiang Fan, Huafeng Zhang, Linchong Sun, Ping Gao

Nat Commun. 2024; 15: 7654. Published online 2024 Sep 3. doi: 10.1038/s41467-024-51882-w

PMCID:: PMC11372217

Abstract Article PDF–5.4M

Select item 1136475011.

Downregulation of malic enzyme 3 facilitates progression of gastric carcinoma via regulating intracellular oxidative stress and hypoxia-inducible factor-1α stabilization

Yingying Huang, Yan Yang, Xiangliu Chen, Siying Zeng, Yiran Chen, Haiyong Wang, Xiadong Lv, Xun Hu, Lisong Teng

Cell Mol Life Sci. 2024 Dec; 81(1): 375. Published online 2024 Aug 30. doi: 10.1007/s00018-024-05388-9

PMCID:: PMC11364750

Abstract Article PDF–9.3M

Select item 1134376512.

LAT1 expression in colorectal cancer cells is unresponsive to HIF-1/2α accumulation under experimental hypoxia

Ryuichi Ohgaki, Yuma Hirase, Minhui Xu, Hiroki Okanishi, Yoshikatsu Kanai

Sci Rep. 2024; 14: 19635. Published online 2024 Aug 23. doi: 10.1038/s41598-024-70603-3

PMCID:: PMC11343765

Abstract Article PDF–4.3M

Select item 1130078913.

Late stage melanoma is hallmarked by low NLGN4X expression leading to HIF1A accumulation

David Schörghofer, Laurenz Vock, Madalina A. Mirea, Oliver Eckel, Anna Gschwendtner, Jürgen Neesen, Erika Richtig, Markus Hengstschläger, Mario Mikula

Br J Cancer. 2024 Aug 24; 131(3): 468–480. Published online 2024 Jun 20. doi: 10.1038/s41416-024-02758-9

PMCID:: PMC11300789

Abstract Article PDF–3.7M

Select item 1127681014.

The Role of PTEN in Chemoresistance Mediated by the HIF-1α/YY1 Axis in Pediatric Acute Lymphoblastic Leukemia

Gabriela Antonio-Andres, Mario Morales-Martinez, Elva Jimenez-Hernandez, Sara Huerta-Yepez

Int J Mol Sci. 2024 Jul; 25(14): 7767. Published online 2024 Jul 16. doi: 10.3390/ijms25147767

PMCID:: PMC11276810

Abstract Article PDF–1.7M

Select item 1123632415.

MATN4 as a target gene of HIF-1α promotes the proliferation and metastasis of osteosarcoma

Lu Zhang, Yujie Pan, Feng Pan, Songsong Huang, Fengyan Wang, Zhirui Zeng, Houping Chen, Xiaobin Tian

Aging (Albany NY) 2024 Jun 30; 16(12): 10462–10476. Published online 2024 Jun 17. doi: 10.18632/aging.205941

PMCID:: PMC11236324

Abstract Article PDF–1.9M

Select item 1121835016.

A critical influence of HIF-1 on MMP-9 and Galectin-3 in oral lichen planus

Hala H. Hazzaa, Marwa A. M. El Shiekh, Osama Elkashty, Eman Magdy, Dalia Riad, Eman khalifa, Gasser M. Elewa, Naglaa M. Kamal

BMC Oral Health. 2024; 24: 756. Published online 2024 Jun 29. doi: 10.1186/s12903-024-04457-6

PMCID:: PMC11218350

Abstract Article PDF–1.6M

Select item 1120396617.

Understanding Hypoxia-Driven Tumorigenesis: The Interplay of HIF1A, DNA Methylation, and Prolyl Hydroxylases in Head and Neck Squamous Cell Carcinoma

Julia Ostapowicz, Kamila Ostrowska, Agnieszka A. Rawłuszko-Wieczorek, Bartosz Wojtera, Sabina Koczot, Wojciech Golusiński, Wiktoria M. Suchorska

Int J Mol Sci. 2024 Jun; 25(12): 6495. Published online 2024 Jun 12. doi: 10.3390/ijms25126495

PMCID:: PMC11203966

Abstract Article PDF–10M

Select item 1118484418.

Iron deficiency affects oxygen transport and activates HIF1 signaling pathway to regulate phenotypic transformation of VSMC in aortic dissection

Yuanyang Chen, Xu Li, Zhiwei Wang, Shun Yuan, Xiaoyan Shen, Xiaoping Xie, Kai Xing, Qingyi Zhu

Mol Med. 2024; 30: 90. Published online 2024 Jun 17. doi: 10.1186/s10020-024-00859-y

PMCID:: PMC11184844

Abstract Article PDF–6.9M

Select item 1118273419.

UCHL1-dependent control of hypoxia-inducible factor transcriptional activity during liver fibrosis

Amy Collins, Rebecca Scott, Caroline L. Wilson, Giuseppe Abbate, Gabrielle B. Ecclestone, Adam G. Albanese, Demi Biddles, Steven White, Jeremy French, John Moir, Wasfi Alrawashdeh, Colin Wilson, Sanjay Pandanaboyana, John S. Hammond, Rohan Thakkar, Fiona Oakley, Jelena Mann, Derek A. Mann, Niall S. Kenneth

Biosci Rep. 2024 Jun 26; 44(6): BSR20232147. Published online 2024 Jun 14. doi: 10.1042/BSR20232147