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Select item 103459631.

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2–Bispecific Antibody for Combination Cancer Therapy

Amr El Zawily, Frederick S. Vizeacoumar, Renuka Dahiya, Sara L. Banerjee, Kalpana K. Bhanumathy, Hussain Elhasasna, Glinton Hanover, Jessica C. Sharpe, Malkon G. Sanchez, Paul Greidanus, R. Greg Stacey, Kyung-Mee Moon, Ilya Alexandrov, Juha P. Himanen, Dimitar B. Nikolov, Humphrey Fonge, Aaron P. White, Leonard J. Foster, Bingcheng Wang, Behzad M. Toosi, Nicolas Bisson, Tajib A. Mirzabekov, Franco J. Vizeacoumar, Andrew Freywald

Clin Cancer Res. 2023 Jul 14; 29(14): 2686–2701. Published online 2023 Mar 28. doi: 10.1158/1078-0432.CCR-22-2535

PMCID:: PMC10345963

Abstract Article PDF–13M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 98514483.

Integrin α7 Mutations Are Associated With Adult‐Onset Cardiac Dysfunction in Humans and Mice

Enrico Bugiardini, Andreia M. Nunes, Ariany Oliveira‐Santos, Marisela Dagda, Tatiana M. Fontelonga, Pamela Barraza‐Flores, Alan M. Pittman, Jasper M. Morrow, Matthew Parton, Henry Houlden, Perry M. Elliott, Petros Syrris, Roderick P. Maas, Mohammed M. Akhtar, Benno Küsters, Joost Raaphorst, Meyke Schouten, Erik‐Jan Kamsteeg, Baziel van Engelen, Michael G. Hanna, Rahul Phadke, Luis R. Lopes, Emma Matthews, Dean J. Burkin

J Am Heart Assoc. 2022 Dec; 11(23): e026494. Published online 2022 Dec 6. doi: 10.1161/JAHA.122.026494

PMCID:: PMC9851448

Abstract Article PDF–15M

Select item 93054624.

ITGA7, CD133, ALDH1 are inter‐correlated, and linked with poor differentiation, lymph node metastasis as well as worse survival in surgical cervical cancer

Na Yuan, Lei Wang, Qiang Xi, Niandong Zou, Xianyu Zhang, Xiurong Lu, Zhilin Zhang

J Obstet Gynaecol Res. 2022 Apr; 48(4): 1011–1018. Published online 2022 Feb 22. doi: 10.1111/jog.15163

PMCID:: PMC9305462

Abstract Article PDF–940K

Select item 92316235.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 86577706.

Decrease in ITGA7 Levels Is Associated with an Increase in α-Synuclein Levels in an MPTP-Induced Parkinson’s Disease Mouse Model and SH-SY5Y Cells

Sangeun Han, Min Hyung Seo, Sabina Lim, Sujung Yeo

Int J Mol Sci. 2021 Dec; 22(23): 12616. Published online 2021 Nov 23. doi: 10.3390/ijms222312616

PMCID:: PMC8657770

Abstract Article PDF–3.6M

Select item 85529077.

SARS‐CoV‐2–host proteome interactions for antiviral drug discovery

Xiaonan Liu, Sini Huuskonen, Tuomo Laitinen, Taras Redchuk, Mariia Bogacheva, Kari Salokas, Ina Pöhner, Tiina Öhman, Arun Kumar Tonduru, Antti Hassinen, Lisa Gawriyski, Salla Keskitalo, Maria K Vartiainen, Vilja Pietiäinen, Antti Poso, Markku Varjosalo

Mol Syst Biol. 2021 Nov; 17(11): e10396. Published online 2021 Oct 28. doi: 10.15252/msb.202110396

PMCID:: PMC8552907

Abstract Article PDF–3.9M

Select item 84765068.

Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response

Noha Gwili, Stacey J. Jones, Waleed Al Amri, Ian M. Carr, Sarah Harris, Brian V. Hogan, William E. Hughes, Baek Kim, Fiona E. Langlands, Rebecca A. Millican-Slater, Arindam Pramanik, James L. Thorne, Eldo T. Verghese, Geoff Wells, Mervat Hamza, Layla Younis, Nevine M. F. El Deeb, Thomas A. Hughes

Br J Cancer. 2021 Sep 28; 125(7): 983–993. Published online 2021 Jul 12. doi: 10.1038/s41416-021-01484-w

PMCID:: PMC8476506

Abstract Article PDF–2.3M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 717131310.

Predictive value of integrin α7 for acute myeloid leukemia risk and its correlation with prognosis in acute myeloid leukemia patients

Mingyue Zeng, Siruiyun Ding, Hui Zhang, Qianqian Huang, yi Ren, Pengxiang Guo

J Clin Lab Anal. 2020 Apr; 34(4): e23151. Published online 2019 Dec 19. doi: 10.1002/jcla.23151

PMCID:: PMC7171313

Abstract Article PDF–685K

Select item 697740211.

Integrin α7 is overexpressed and correlates with higher pathological grade, increased T stage, advanced TNM stage as well as worse survival in clear cell renal cell carcinoma patients: A retrospective study

Yue Chen, Yang Wang, Zhixing Cai, Xiaoli Fan, Yi Zhang

J Clin Lab Anal. 2020 Jan; 34(1): e23034. Published online 2019 Nov 11. doi: 10.1002/jcla.23034

PMCID:: PMC6977402

Abstract Article PDF–686K

Select item 691018712.

Integrin α7 correlates with worse clinical features and prognosis, and its knockdown inhibits cell proliferation and stemness in tongue squamous cell carcinoma

Zhiyong Lv, Ye Yang, Chunyan Yang

Int J Oncol. 2020 Jan; 56(1): 69–84. Published online 2019 Nov 29. doi: 10.3892/ijo.2019.4927

PMCID:: PMC6910187

Abstract Article PDF–1.7M

Select item 680526913.

Correlation of integrin alpha 7 with clinicopathological characteristics and survival profiles, as well as its regulatory role in cell proliferation, apoptosis, and stemness in non‐small‐cell lung cancer

Dongping Xia, Beibei Chen, Xun Yang

J Clin Lab Anal. 2019 Oct; 33(8): e22973. Published online 2019 Aug 16. doi: 10.1002/jcla.22973

PMCID:: PMC6805269

Abstract Article PDF–1.0M

Select item 680525614.

Integrin α7 high expression correlates with deteriorative tumor features and worse overall survival, and its knockdown inhibits cell proliferation and invasion but increases apoptosis in breast cancer

Xiaorong Bai, Chen Gao, Lifeng Zhang, Suisheng Yang

J Clin Lab Anal. 2019 Oct; 33(8): e22979. Published online 2019 Jul 19. doi: 10.1002/jcla.22979

PMCID:: PMC6805256

Abstract Article PDF–972K

Select item 678143015.

Perlecan regulates pericyte dynamics in the maintenance and repair of the blood–brain barrier

Kuniyuki Nakamura, Tomoko Ikeuchi, Kazuki Nara, Craig S. Rhodes, Peipei Zhang, Yuta Chiba, Saiko Kazuno, Yoshiki Miura, Tetsuro Ago, Eri Arikawa-Hirasawa, Yoh-suke Mukouyama, Yoshihiko Yamada

J Cell Biol. 2019 Oct 7; 218(10): 3506–3525. Published online 2019 Sep 20. doi: 10.1083/jcb.201807178

PMCID:: PMC6781430

Abstract Article PDF–5.3M

Select item 661633016.

Integrin α7 expression is increased in asthmatic patients and its inhibition reduces Kras protein abundance in airway smooth muscle cells

Chun Ming Teoh, Sheryl S. L. Tan, Shenna Y. Langenbach, Amanda H. Wong, Dorothy H. J. Cheong, John K. C. Tam, Chih Sheng New, Thai Tran

Sci Rep. 2019; 9: 9892. Published online 2019 Jul 9. doi: 10.1038/s41598-019-46260-2

PMCID:: PMC6616330

Abstract Article PDF–2.9M

Select item 553161117.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 515065818.

Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma

Xiao-Yan Ming, Li Fu, Li-Yi Zhang, Yan-Ru Qin, Ting-Ting Cao, Kwok Wah Chan, Stephanie Ma, Dan Xie, Xin-Yuan Guan

Nat Commun. 2016; 7: 13568. Published online 2016 Dec 7. doi: 10.1038/ncomms13568

PMCID:: PMC5150658

Abstract Article PDF–5.5M

Select item 474574819.

S100P interacts with integrin α7 and increases cancer cell migration and invasion in lung cancer

Ya-Ling Hsu, Jen-Yu Hung, Yung-Yu Liang, Yi-Shiuan Lin, Ming-Ju Tsai, Shah-Hwa Chou, Chi-Yu Lu, Po-Lin Kuo

Oncotarget. 2015 Oct 6; 6(30): 29585–29598. Published online 2015 Jul 21. doi: 10.18632/oncotarget.4987

PMCID:: PMC4745748

Abstract Article PDF–8.6M

Select item 463079720.

Human α7 Integrin Gene (ITGA7) Delivered by Adeno-Associated Virus Extends Survival of Severely Affected Dystrophin/Utrophin-Deficient Mice

Kristin N. Heller, Chrystal L. Montgomery, Kimberly M. Shontz, K. Reed Clark, Jerry R. Mendell, Louise R. Rodino-Klapac

Hum Gene Ther. 2015 Oct 1; 26(10): 647–656. Published online 2015 Jun 12. doi: 10.1089/hum.2015.062

PMCID:: PMC4630797

Abstract Article PDF–743K

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