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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 102131582.

Mechanisms of mGluR‐dependent plasticity in hippocampal area CA2

Mahsa Samadi, Claire A. Hales, Daniel J. Lustberg, Shannon Farris, Madeleine R. Ross, Meilan Zhao, John R. Hepler, Nicholas H. Harbin, Emma S. J. Robinson, Paul J. Banks, Zafar I. Bashir, Serena M. Dudek

Hippocampus. 2023 Jun; 33(6): 730–744. Published online 2023 Mar 27. doi: 10.1002/hipo.23529

PMCID:: PMC10213158

Abstract Article PDF–3.6M

Select item 98402883.

Tyrosine phosphatase STEP₆₁ in human dementia and in animal models with amyloid and tau pathology

Deonne Taylor, Andrew Kneynsberg, Marloes van Roijen, Jürgen Götz

Mol Brain. 2023; 16: 6. Published online 2023 Jan 13. doi: 10.1186/s13041-023-00994-3

PMCID:: PMC9840288

Abstract Article PDF–1.0M

Select item 84129854.

Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP₆₁) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner

Murat S. Durakoglugil, Catherine R. Wasser, Connie H. Wong, Theresa Pohlkamp, Xunde Xian, Courtney Lane-Donovan, Katja Fritschle, Lea Naestle, Joachim Herz

J Neurosci. 2021 Sep 1; 41(35): 7340–7349. doi: 10.1523/JNEUROSCI.0388-21.2021

PMCID:: PMC8412985

Abstract Article PDF–1.9M

Select item 83264255.

Tyrosine phosphatase STEP is a key regulator of glutamate-induced prostaglandin E₂ release from neurons

Sathyanarayanan Rajagopal, Ranjana Poddar, Surojit Paul

J Biol Chem. 2021 Aug; 297(2): 100944. Published online 2021 Jul 8. doi: 10.1016/j.jbc.2021.100944

PMCID:: PMC8326425

Abstract Article PDF–1.9M

Select item 79795086.

Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP

Sathyanarayanan Rajagopal, Changjun Yang, Kelly M. DeMars, Ranjana Poddar, Eduardo Candelario-Jalil, Surojit Paul

Brain Behav Immun. Author manuscript; available in PMC 2022 Mar 1.

Published in final edited form as: Brain Behav Immun. 2021 Mar; 93: 141–155. Published online 2021 Jan 8. doi: 10.1016/j.bbi.2020.12.034

PMCID:: PMC7979508

Abstract Article PDF–3.4M

Select item 79387707.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 67261258.

Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription

Jaehong Suh, Donna M. Romano, Larissa Nitschke, Scott P. Herrick, Britt A. DiMarzio, Volodymyr Dzhala, Jun-Seok Bae, Mary K. Oram, Yuejiao Zheng, Basavaraj Hooli, Kristina Mullin, Vincenzo A. Gennarino, Wilma Wasco, Jeremy D. Schmahmann, Mark W. Albers, Huda Y. Zoghbi, Rudolph E. Tanzi

Cell. Author manuscript; available in PMC 2020 Aug 22.

Published in final edited form as: Cell. 2019 Aug 22; 178(5): 1159–1175.e17. doi: 10.1016/j.cell.2019.07.043

PMCID:: PMC6726125

Abstract Article PDF–3.5M

Select item 65792379.

STEP₆₁: A Member of a Family of Brain-Enriched PTPs Is Localized to the Endoplasmic Reticulum

Abel Bult, Feisha Zhao, Ronald Dirkx Jr., Ela Sharma, Erika Lukacsi, Michele Solimena, Janice R. Naegele, Paul J. Lombroso

J Neurosci. 1996 Dec 15; 16(24): 7821–7831. doi: 10.1523/JNEUROSCI.16-24-07821.1996

PMCID:: PMC6579237

Abstract Article PDF–1.2M

Select item 647541610.

The STEP₆₁ interactome reveals subunit-specific AMPA receptor binding and synaptic regulation

Sehoon Won, Salvatore Incontro, Yan Li, Roger A. Nicoll, Katherine W. Roche

Proc Natl Acad Sci U S A. 2019 Apr 16; 116(16): 8028–8037. Published online 2019 Apr 1. doi: 10.1073/pnas.1900878116

PMCID:: PMC6475416

Abstract Article PDF–1.7M

Select item 636241311.

Social Memory and Social Patterns Alterations in the Absence of STriatal-Enriched Protein Tyrosine Phosphatase

Gloria Blázquez, Anna Castañé, Ana Saavedra, Mercè Masana, Jordi Alberch, Esther Pérez-Navarro

Front Behav Neurosci. 2018; 12: 317. Published online 2019 Jan 25. doi: 10.3389/fnbeh.2018.00317

PMCID:: PMC6362413

Abstract Article PDF–2.6M

Select item 566820512.

Synaptic NMDA receptor activation induces ubiquitination and degradation of STEP₆₁

Jian Xu, Pradeep Kurup, Angus C. Nairn, Paul J. Lombroso

Mol Neurobiol. Author manuscript; available in PMC 2019 Apr 1.

Published in final edited form as: Mol Neurobiol. 2018 Apr; 55(4): 3096–3111. Published online 2017 May 2. doi: 10.1007/s12035-017-0555-x

PMCID:: PMC5668205

Abstract Article PDF–2.8M

Select item 539536713.

Inhibition of STEP₆₁ ameliorates deficits in mouse and hiPSC-based schizophrenia models

J Xu, B J Hartley, P Kurup, A Phillips, A Topol, M Xu, C Ononenyi, E Foscue, S-M Ho, T D Baguley, N Carty, C S Barros, U Müller, S Gupta, P Gochman, J Rapoport, J A Ellman, C Pittenger, B Aronow, A C Nairn, M W Nestor, P J Lombroso, K J Brennand

Mol Psychiatry. 2018 Feb; 23(2): 271–281. Published online 2016 Oct 18. doi: 10.1038/mp.2016.163

PMCID:: PMC5395367

Abstract Article PDF–990K

Select item 498779214.

PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP₆₁

Sehoon Won, Salvatore Incontro, Roger A. Nicoll, Katherine W. Roche

Proc Natl Acad Sci U S A. 2016 Aug 9; 113(32): E4736–E4744. Published online 2016 Jul 25. doi: 10.1073/pnas.1609702113

PMCID:: PMC4987792

Abstract Article PDF–1.5M

Select item 489288015.

STEP signaling pathway mediates psychomotor stimulation and morphine withdrawal symptoms, but not for reward, analgesia and tolerance

Yoon-Jung Kim, Young Kang, Hye-Yeon Park, Jae-Ran Lee, Dae-Yeul Yu, Takuya Murata, Yoichi Gondo, Jung Hwan Hwang, Yong-Hoon Kim, Chul-Ho Lee, Myungchull Rhee, Pyung-Lim Han, Bong-Hyun Chung, Hyun-Jun Lee, Kyoung-Shim Kim

Exp Mol Med. 2016 Feb; 48(2): e212. Published online 2016 Feb 26. doi: 10.1038/emm.2016.1

PMCID:: PMC4892880

Abstract Article PDF–1.9M

Select item 480920616.

Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition

Garikoitz Azkona, Ana Saavedra, Zigor Aira, David Aluja, Xavier Xifró, Tyler Baguley, Jordi Alberch, Jonathan A. Ellman, Paul J. Lombroso, Jon J. Azkue, Esther Pérez-Navarro

Pain. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: Pain. 2016 Feb; 157(2): 377–386. doi: 10.1097/j.pain.0000000000000329