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Items: 1 to 20 of 29

1.
The factor inhibiting HIF regulates T cell differentiation and anti-tumour efficacy
David Bargiela, Pedro P. Cunha, Pedro Veliça, Lena C. M. Krause, Madara Brice, Laura Barbieri, Milos Gojkovic, Iosifina P. Foskolou, Helene Rundqvist, Randall S. Johnson
Front Immunol. 2024; 15: 1293723. Published online 2024 Apr 16. doi: 10.3389/fimmu.2024.1293723
PMCID:
PMC11058823
AbstractArticlePDF–3.2M
2.
Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment
Jingyi Ma, Khatoun Al Moussawi, Hantao Lou, Hok Fung Chan, Yihua Wang, Joseph Chadwick, Chansavath Phetsouphanh, Elizabeth A. Slee, Shan Zhong, Thomas M. Leissing, Andrew Roth, Xiao Qin, Shuo Chen, Jie Yin, Indrika Ratnayaka, Yang Hu, Pakavarin Louphrasitthiphol, Lewis Taylor, Paulo J. G. Bettencourt, Mary Muers, David R. Greaves, Helen McShane, Robert Goldin, Elizabeth J. Soilleux, Mathew L. Coleman, Peter J. Ratcliffe, Xin Lu
Proc Natl Acad Sci U S A. 2024 Mar 5; 121(10): e2309957121. Published online 2024 Feb 29. doi: 10.1073/pnas.2309957121
PMCID:
PMC10927516
AbstractArticlePDF–4.9M
3.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
4.
Essential role of Mg2+ in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes
Neha Gupta, Cristina Soriano-Úbeda, Paula Stein, Virginia Savy, Brian N. Papas, Goli Ardestani, Ingrid Carvacho, Dominique Alfandari, Carmen J. Williams, Rafael A. Fissore
Cell Rep. Author manuscript; available in PMC 2024 Feb 5.
Published in final edited form as: Cell Rep. 2023 Oct 31; 42(10): 113232. Published online 2023 Oct 11. doi: 10.1016/j.celrep.2023.113232
PMCID:
PMC10842026
AbstractArticlePDF–3.0M
5.
Hydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics
Francesca Ferrante, Benedetto Daniele Giaimo, Tobias Friedrich, Toshiya Sugino, Daniel Mertens, Sabrina Kugler, Bernd Martin Gahr, Steffen Just, Leiling Pan, Marek Bartkuhn, Michael Potente, Franz Oswald, Tilman Borggrefe
Cell Death Dis. 2022 Jul; 13(7): 600. Published online 2022 Jul 12. doi: 10.1038/s41419-022-05052-9
PMCID:
PMC9276811
AbstractArticlePDF–1.8M
6.
Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia
Ann-Helen Rosendahl, Mia Monnius, Anu Laitala, Antti Railo, Ilkka Miinalainen, Ritva Heljasvaara, Joni M. Mäki, Johanna Myllyharju
J Biol Chem. 2022 Apr; 298(4): 101787. Published online 2022 Mar 2. doi: 10.1016/j.jbc.2022.101787
PMCID:
PMC8988008
AbstractArticlePDF–6.1M
7.
The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism
Amalia Ruiz-Serrano, Christina N. Boyle, Josep M. Monné Rodríguez, Julia Günter, Agnieszka E. Jucht, Svende Pfundstein, Andreas M. Bapst, Thomas A. Lutz, Roland H. Wenger, Carsten C. Scholz
Int J Mol Sci. 2022 Feb; 23(3): 1536. Published online 2022 Jan 28. doi: 10.3390/ijms23031536
PMCID:
PMC8836018
AbstractArticlePDF–3.1M
8.
FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling
Zuo-lin Li, Bin Wang, Lin-li Lv, Tao-tao Tang, Yi Wen, Jing-yuan Cao, Xiao-xiao Zhu, Song-tao Feng, Steven D. Crowley, Bi-cheng Liu
Acta Pharmacol Sin. 2021 Dec; 42(12): 2106–2119. Published online 2021 Mar 3. doi: 10.1038/s41401-021-00617-4
PMCID:
PMC8633347
AbstractArticlePDF–8.2M
9.
Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice
Feng Zhang, Xiong Zhao, Runmin Jiang, Yuying Wang, Xinli Wang, Yu Gu, Longyong Xu, Jing Ye, Charlie Degui Chen, Shuangping Guo, Dawei Zhang, Daqing Zhao
Front Cell Dev Biol. 2021; 9: 642931. Published online 2021 Jul 21. doi: 10.3389/fcell.2021.642931
PMCID:
PMC8333871
AbstractArticlePDF–1.4M
10.
miR-212 promotes renal interstitial fibrosis by inhibiting hypoxia-inducible factor 1-α inhibitor
Yun Zhang, Guo-Xin Zhang, Li-Shuang Che, Shu-Han Shi, Yue-Ting Li
Mol Med Rep. 2021 Mar; 23(3): 189. Published online 2021 Jan 6. doi: 10.3892/mmr.2021.11828
PMCID:
PMC7809912
AbstractArticlePDF–9.2M
11.
MiR-135-5p promotes osteoblast differentiation by targeting HIF1AN in MC3T3-E1 cells
Nuo Yin, Longzhang Zhu, Liang Ding, Junjie Yuan, Li Du, Mingmang Pan, Feng Xue, Haijun Xiao
Cell Mol Biol Lett. 2019; 24: 51. Published online 2019 Aug 8. doi: 10.1186/s11658-019-0177-6
PMCID:
PMC6686269
AbstractArticlePDF–3.9M
12.
The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia
Jingwei Sim, Andrew S. Cowburn, Asis Palazon, Basetti Madhu, Petros A. Tyrakis, David Macías, David M. Bargiela, Sandra Pietsch, Michael Gralla, Colin E. Evans, Thaksaon Kittipassorn, Yu C.J. Chey, Cristina M. Branco, Helene Rundqvist, Daniel J. Peet, Randall S. Johnson
Cell Metab. 2018 Apr 3; 27(4): 898–913.e7. doi: 10.1016/j.cmet.2018.02.020
PMCID:
PMC5887987
AbstractArticlePDF–4.0M
13.
FIH-1 Disrupts an LRRK1/EGFR Complex to Positively Regulate Keratinocyte Migration
Han Peng, Nihal Kaplan, Wending Yang, Spiro Getsios, Robert M. Lavker
Am J Pathol. 2014 Dec; 184(12): 3262–3271. doi: 10.1016/j.ajpath.2014.08.014
PMCID:
PMC4258497
AbstractArticlePDF–1.6M
14.
A Gain-of-Function Mutation in Tnni2 Impeded Bone Development through Increasing Hif3a Expression in DA2B Mice
Xiaoquan Zhu, Fengchao Wang, Yanyang Zhao, Peng Yang, Jun Chen, Hanzi Sun, Lei Liu, Wenjun Li, Lin Pan, Yanru Guo, Zhaohui Kou, Yu Zhang, Cheng Zhou, Jiang He, Xue Zhang, Jianxin Li, Weitian Han, Jian Li, Guanghui Liu, Shaorong Gao, Ze Yang
PLoS Genet. 2014 Oct; 10(10): e1004589. Published online 2014 Oct 23. doi: 10.1371/journal.pgen.1004589
PMCID:
PMC4207604
AbstractArticlePDF–3.6M
15.
Regulation of IL-1β–induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways
Carsten C. Scholz, Miguel A. S. Cavadas, Murtaza M. Tambuwala, Emily Hams, Javier Rodríguez, Alex von Kriegsheim, Philip Cotter, Ulrike Bruning, Padraic G. Fallon, Alex Cheong, Eoin P. Cummins, Cormac T. Taylor
Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46): 18490–18495. Published online 2013 Oct 21. doi: 10.1073/pnas.1309718110
PMCID:
PMC3832034
AbstractArticlePDF–997K
16.
FIH-1/c-Kit Signaling: A Novel Contributor to Corneal Epithelial Glycogen Metabolism
Han Peng, Julia Katsnelson, Wending Yang, Melissa A. Brown, Robert M. Lavker
Invest Ophthalmol Vis Sci. 2013 Apr; 54(4): 2781–2786. Published online 2013 Apr 17. doi: 10.1167/iovs.12-11512
PMCID:
PMC3632267
AbstractArticlePDF–517K
17.
A conditional knockout resource for the genome–wide study of mouse gene function
William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley
Nature. Author manuscript; available in PMC 2013 Feb 14.
Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163
PMCID:
PMC3572410
AbstractArticlePDF–1.1M
18.
microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation
Han Peng, Nihal Kaplan, Robert B. Hamanaka, Julia Katsnelson, Hanz Blatt, Wending Yang, Liangliang Hao, Paul J. Bryar, Randall S. Johnson, Spiro Getsios, Navdeep S. Chandel, Robert M. Lavker
Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35): 14030–14034. Published online 2012 Aug 13. doi: 10.1073/pnas.1111292109
PMCID:
PMC3435188
AbstractArticlePDF–966K
19.
Factor Inhibiting HIF (FIH) Recognizes Distinct Molecular Features within Hypoxia-inducible Factor-α (HIF-α) versus Ankyrin Repeat Substrates
Sarah E. Wilkins, Sarah Karttunen, Rachel J. Hampton-Smith, Iain Murchland, Anne Chapman-Smith, Daniel J. Peet
J Biol Chem. 2012 Mar 16; 287(12): 8769–8781. Published online 2012 Jan 23. doi: 10.1074/jbc.M111.294678
PMCID:
PMC3308777
AbstractArticlePDF–3.7M
20.
Quantitative Mass Spectrometry Reveals Dynamics of Factor-inhibiting Hypoxia-inducible Factor-catalyzed Hydroxylation
Rachelle S. Singleton, David C. Trudgian, Roman Fischer, Benedikt M. Kessler, Peter J. Ratcliffe, Matthew E. Cockman
J Biol Chem. 2011 Sep 30; 286(39): 33784–33794. Published online 2011 Jul 30. doi: 10.1074/jbc.M111.262808
PMCID:
PMC3190818
AbstractArticlePDF–1.4M

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