PMC Links for GEO Profiles (Select 69637707) - PMC

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 105658764.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 92792856.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 91063037.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80572589.

RhoG deficiency abrogates cytotoxicity of human lymphocytes and causes hemophagocytic lymphohistiocytosis

Artem Kalinichenko, Giovanna Perinetti Casoni, Loïc Dupré, Luca Trotta, Jakob Huemer, Donatella Galgano, Yolla German, Ben Haladik, Julia Pazmandi, Marini Thian, Özlem Yüce Petronczki, Samuel C. Chiang, Mervi Taskinen, Anne Hekkala, Saila Kauppila, Outi Lindgren, Terhi Tapiainen, Michael J. Kraakman, Kim Vettenranta, Alexis J. Lomakin, Janna Saarela, Mikko R. J. Seppänen, Yenan T. Bryceson, Kaan Boztug

Blood. 2021 Apr 15; 137(15): 2033–2045. Prepublished online 2021 Jan 29. doi: 10.1182/blood.2020008738

PMCID:: PMC8057258

Abstract Article

Select item 805356510.

Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine storms

Hui Luo, Dan Liu, Wenbing Liu, Gaoxiang Wang, Liting Chen, Yang Cao, Jia Wei, Min Xiao, Xin Liu, Gang Huang, Wei Wang, Jianfeng Zhou, Qian-fei Wang

Eur J Hum Genet. 2021 Aug; 29(8): 1312–1315. Published online 2021 Apr 19. doi: 10.1038/s41431-021-00886-x

PMCID:: PMC8053565

Abstract Article PDF–626K

Select item 768787111.

Unc-13 homolog D mediates an antiviral effect of the chromosome 19 microRNA cluster miR-517a

Kamil Krawczynski, Yingshi Ouyang, Jean-Francois Mouillet, Tianjiao Chu, Carolyn B. Coyne, Yoel Sadovsky

J Cell Sci. 2020 Mar 1; 134(5): jcs246769. Published online 2020 Nov 19. doi: 10.1242/jcs.246769

PMCID:: PMC7687871

Abstract Article

Select item 756688112.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 731020213.

Lentiviral Gene Therapy for Familial Hemophagocytic Lymphohistiocytosis Type 3, Caused by UNC13D Genetic Defects

Sarah E. Takushi, Na Yoon Paik, Andrew Fedanov, Chengyu Prince, Christopher B. Doering, H. Trent Spencer, Shanmuganathan Chandrakasan

Hum Gene Ther. June 2020; 31(11-12): 626–638. Published online 2020 Jun 12. doi: 10.1089/hum.2019.329

PMCID:: PMC7310202

Abstract Article PDF–920K

Select item 729614114.

Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets

Donatella Galgano, Tayebeh Soheili, Matthias Voss, Lamberto Torralba-Raga, Bianca Tesi, Frank Cichocki, Isabelle Andre, Jens Rettig, Marina Cavazzana, Yenan Bryceson

Front Immunol. 2020; 11: 1154. Published online 2020 Jun 9. doi: 10.3389/fimmu.2020.01154

PMCID:: PMC7296141

Abstract Article PDF–2.3M

Select item 673567515.

Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency

Jinzhong Zhang, Jing He, Jennifer L. Johnson, Gennaro Napolitano, Mahalakshmi Ramadass, Farhana Rahman, Sergio D. Catz

Autophagy. 2019; 15(10): 1738–1756. Published online 2019 Apr 5. doi: 10.1080/15548627.2019.1596475

PMCID:: PMC6735675

Abstract Article PDF–6.5M

Select item 659397016.

Haploinsufficiency of UNC13D increases the risk of lymphoma

Alexandra Löfstedt, Clas Ahlm, Bianca Tesi, Ingvar A. Bergdahl, Magnus Nordenskjöld, Yenan T. Bryceson, Jan‐Inge Henter, Marie Meeths

Cancer. 2019 Jun 1; 125(11): 1848–1854. Published online 2019 Feb 13. doi: 10.1002/cncr.32011

PMCID:: PMC6593970

Abstract Article PDF–172K

Select item 655431417.

Defective Zn²⁺ homeostasis in mouse and human platelets with α- and δ-storage pool diseases

Sanjeev Kiran Gotru, Johanna P. van Geffen, Magdolna Nagy, Elmina Mammadova-Bach, Julia Eilenberger, Julia Volz, Georgi Manukjan, Harald Schulze, Leonard Wagner, Stefan Eber, Christian Schambeck, Carsten Deppermann, Sanne Brouns, Paquita Nurden, Andreas Greinacher, Ulrich Sachs, Bernhard Nieswandt, Heike M. Hermanns, Johan W. M. Heemskerk, Attila Braun

Sci Rep. 2019; 9: 8333. Published online 2019 Jun 6. doi: 10.1038/s41598-019-44751-w

PMCID:: PMC6554314

Abstract Article PDF–1.1M

Select item 608093718.

A Ca²⁺-stimulated exosome release pathway in cancer cells is regulated by Munc13-4

Scott W. Messenger, Sang Su Woo, Zhongze Sun, Thomas F.J. Martin

J Cell Biol. 2018 Aug 6; 217(8): 2877–2890. doi: 10.1083/jcb.201710132

Correction in:: J Cell Biol. 2019 Apr 1; 218(4): 1423.

PMCID:: PMC6080937

Abstract Article PDF–2.1M

Select item 596318719.

Identification of a novel nonsense mutation in the UNC13D gene from a patient with hemophagocytic lymphohistiocytosis: a case report

Xijiang Hu, Dongling Liu, Xiwen Jiang, Bo Gao, Changying Chen

BMC Med Genet. 2018; 19: 82. Published online 2018 May 21. doi: 10.1186/s12881-018-0600-2

PMCID:: PMC5963187

Abstract Article PDF–1.3M

Select item 546961120.

A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel–Palade body exocytosis in endothelial cells

Tarek Chehab, Nina Criado Santos, Anna Holthenrich, Sophia N. Koerdt, Jennifer Disse, Christian Schuberth, Ali Reza Nazmi, Maaike Neeft, Henriette Koch, Kwun Nok M. Man, Sonja M. Wojcik, Thomas F. J. Martin, Peter van der Sluijs, Nils Brose, Volker Gerke

Mol Biol Cell. 2017 Jun 15; 28(12): 1688–1700. doi: 10.1091/mbc.E17-02-0128

PMCID:: PMC5469611

Abstract Article PDF–3.6M

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