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Select item 111049111.

Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer’s disease-like symptoms in animal model

Guru Krishnakumar Viswanathan, Dana Shwartz, Yelena Losev, Elad Arad, Chen Shemesh, Edward Pichinuk, Hamutal Engel, Avi Raveh, Raz Jelinek, Itzik Cooper, Fabien Gosselet, Ehud Gazit, Daniel Segal

Cell Mol Life Sci. 2020 Jul; 77(14): 2795–2813. Published online 2019 Sep 27. doi: 10.1007/s00018-019-03312-0

PMCID:: PMC11104911

Abstract Article PDF–2.7M

Select item 109017812.

Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting

Yasuo Kubota, Xiaorong Gu, Laila Terkawi, Juraj Bodo, Bartlomiej P. Przychodzen, Hussein Awada, Nakisha Williams, Carmelo Gurnari, Naomi Kawashima, Mai Aly, Arda Durmaz, Minako Mori, Ben Ponvilawan, Tariq Kewan, Waled Bahaj, Manja Meggendorfer, Babal K. Jha, Valeria Visconte, Heesun J. Rogers, Torsten Haferlach, Jaroslaw P. Maciejewski

Nat Commun. 2024; 15: 1832. Published online 2024 Feb 28. doi: 10.1038/s41467-024-46134-w

PMCID:: PMC10901781

Abstract Article PDF–3.7M

Select item 107638103.

Investigating the physiological role of S199A and S199D mutants of PHF6 protein in T-cell acute lymphoblastic leukemia

Gökçe ERDOĞAN, Osman Nidai ÖZEŞ, Alphan KÜPESİZ, Şükran Burçak YOLDAŞ

Turk J Med Sci. 2023; 53(5): 1234–1243. Published online 2023 Aug 11. doi: 10.55730/1300-0144.5689

PMCID:: PMC10763810

Abstract Article PDF–8.1M

Select item 106176734.

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J. Elledge, Michael E. Greenberg

Science. Author manuscript; available in PMC 2023 Oct 31.

Published in final edited form as: Science. 2023 Aug 25; 381(6660): eadh5021. Published online 2023 Aug 25. doi: 10.1126/science.adh5021

PMCID:: PMC10617673

Abstract Article PDF–3.6M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100401316.

PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer

Sheng Gao, Wensheng Zhang, Jingjing Ma, Xiaojian Ni

J Transl Med. 2023; 21: 220. Published online 2023 Mar 26. doi: 10.1186/s12967-023-04031-8

PMCID:: PMC10040131

Abstract Article PDF–11M

Select item 99833207.

PHF6 promotes the progression of endometrial carcinoma by increasing cancer cells growth and decreasing T‐cell infiltration

Xiaomin Wang, Aizhong Fang, Yichen Peng, Jianyu Yu, Chunna Yu, Jinxuan Xie, Yi Zheng, Lairong Song, Parker Li, Jia Li, Xun Kang, Yi Lin, Wenbin Li

J Cell Mol Med. 2023 Mar; 27(5): 609–621. Published online 2023 Feb 8. doi: 10.1111/jcmm.17638

PMCID:: PMC9983320

Abstract Article PDF–3.0M

Select item 99504478.

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma

Yu-Fei Cao, Lei Xie, Bei-Bei Tong, Man-Yu Chu, Wen-Qi Shi, Xiang Li, Jian-Zhong He, Shao-Hong Wang, Zhi-Yong Wu, Dan-Xia Deng, Ya-Qi Zheng, Zhi-Mao Li, Xiu-E Xu, Lian-Di Liao, Yin-Wei Cheng, Li-Yan Li, Li-Yan Xu, En-Min Li

Cell Death Differ. 2023 Feb; 30(2): 527–543. Published online 2022 Dec 16. doi: 10.1038/s41418-022-01104-x

PMCID:: PMC9950447

Abstract Article PDF–8.4M

Select item 99390939.

PHF6 mutation is associated with poor outcome in acute myeloid leukaemia

Kexiu Huang, Lei Wang, Yaling Zheng, Chunyan Yue, Xuedan Xu, Hongbo Chen, Rui Huang, Yuhua Li

Cancer Med. 2023 Feb; 12(3): 2795–2804. Published online 2022 Sep 29. doi: 10.1002/cam4.5173

PMCID:: PMC9939093

Abstract Article PDF–1.7M

Select item 979798810.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

Select item 977255811.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 970808612.

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers

Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy

eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676

PMCID:: PMC9708086

Abstract Article PDF–8.5M

Select item 954378513.

Further characterization of Borjeson‐Forssman‐Lehmann syndrome in females due to de novo variants in PHF6

Céline B. Gerber, Anna Fliedner, Oliver Bartsch, Siren Berland, Malin Dewenter, Marte Haug, Ian Hayes, Purificacion Marin‐Reina, Paul R. Mark, Francisco Martinez‐Castellano, Isabelle Maystadt, Deniz Karadurmus, Katharina Steindl, Antje Wiesener, Markus Zweier, Heinrich Sticht, Christiane Zweier

Clin Genet. 2022 Sep; 102(3): 182–190. Published online 2022 Jun 14. doi: 10.1111/cge.14173

PMCID:: PMC9543785

Abstract Article PDF–1.5M

Select item 948193314.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 943756315.

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk

Valentina Lukinović, Simone Hausmann, Gael S. Roth, Clement Oyeniran, Tanveer Ahmad, Ning Tsao, Joshua R. Brickner, Alexandre G. Casanova, Florent Chuffart, Ana Morales Benitez, Jessica Vayr, Rebecca Rodell, Marianne Tardif, Pascal W.T.C. Jansen, Yohann Couté, Michiel Vermeulen, Pierre Hainaut, Pawel K. Mazur, Nima Mosammaparast, Nicolas Reynoird

Cancer Discov. 2022 Sep 2; 12(9): 2158–2179. Published online 2022 Jul 12. doi: 10.1158/2159-8290.CD-21-0205

PMCID:: PMC9437563

Abstract Article PDF–9.5M

Select item 939206316.

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling

Yansheng Zhai, Xiaoyan Huang, Keren Zhang, Yuchen Huang, Yanlong Jiang, Jingwei Cui, Zhe Zhang, Cookson K. C. Chiu, Weiye Zhong, Gang Li

Nat Commun. 2022; 13: 4906. Published online 2022 Aug 20. doi: 10.1038/s41467-022-32689-z

PMCID:: PMC9392063

Abstract Article PDF–2.0M

Select item 934345517.

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis

Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi

Sci Rep. 2022; 12: 13160. Published online 2022 Aug 1. doi: 10.1038/s41598-022-16965-y

PMCID:: PMC9343455

Abstract Article PDF–3.7M

Select item 927928518.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 918515519.

Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair

Silvia Alvarez, Ana C. da Silva Almeida, Robert Albero, Mayukh Biswas, Angelica Barreto-Galvez, Thomas S. Gunning, Anam Shaikh, Tomas Aparicio, Agnieszka Wendorff, Erich Piovan, Pieter Van Vlierberghe, Steven Gygi, Jean Gautier, Advaitha Madireddy, Adolfo A. Ferrando

Blood. 2022 Jun 9; 139(23): 3418–3429. doi: 10.1182/blood.2021014103

PMCID:: PMC9185155

Abstract Article

Select item 917141120.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

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