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Items: 1 to 20 of 139

1.
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability
YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek
Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x
PMCID:
PMC11148184
AbstractArticlePDF–8.1M
2.
NRF2 promotes radiation resistance by cooperating with TOPBP1 to activate the ATR-CHK1 signaling pathway
Xiaohui Sun, Mingxin Dong, Jiale Li, Yuxiao Sun, Yu Gao, Yan Wang, Liqing Du, Yang Liu, Kaihua Ji, Ningning He, Jinhan Wang, Manman Zhang, Huijuan Song, Chang Xu, Qiang Liu
Theranostics. 2024; 14(2): 681–698. Published online 2024 Jan 1. doi: 10.7150/thno.88899
PMCID:
PMC10758056
AbstractArticlePDF–10M
3.
Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function
Apurva T. Prabhakar, Claire D. James, Christian T. Fontan, Raymonde Otoa, Xu Wang, Molly L. Bristol, Calvin Yeager, Ronald D. Hill, Aanchal Dubey, Shwu-Yuan Wu, Cheng-Ming Chiang, Iain M. Morgan
J Virol. 2023 Oct; 97(10): e00782-23. Published online 2023 Sep 15. doi: 10.1128/jvi.00782-23
PMCID:
PMC10617519
AbstractArticlePDF–2.7M
4.
Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates
Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert
Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644
PMCID:
PMC10565876
AbstractArticlePDF–3.7M
5.
Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis
Camille Gelot, Marton Tibor Kovacs, Simona Miron, Emilie Mylne, Alexis Haan, Liza Boeffard-Dosierre, Rania Ghouil, Tatiana Popova, Florent Dingli, Damarys Loew, Josée Guirouilh-Barbat, Elaine Del Nery, Sophie Zinn-Justin, Raphael Ceccaldi
Nature. 2023; 621(7978): 415–422. Published online 2023 Sep 6. doi: 10.1038/s41586-023-06506-6
Correction in:
Nature. 2024; 626(7999): E13.
PMCID:
PMC10499603
AbstractArticlePDF–13M
6.
Mitotic tethering enables inheritance of shattered micronuclear chromosomes
Prasad Trivedi, Christopher D. Steele, Franco K. C. Au, Ludmil B. Alexandrov, Don W. Cleveland
Nature. Author manuscript; available in PMC 2023 Dec 14.
Published in final edited form as: Nature. 2023 Jun; 618(7967): 1049–1056. Published online 2023 Jun 14. doi: 10.1038/s41586-023-06216-z
PMCID:
PMC10424572
AbstractArticlePDF–5.9M
7.
Mitotic clustering of pulverized chromosomes from micronuclei
Yu-Fen Lin, Qing Hu, Alice Mazzagatti, Jose Espejo Valle-Inclán, Elizabeth G. Maurais, Rashmi Dahiya, Alison Guyer, Jacob T. Sanders, Justin L. Engel, Giaochau Nguyen, Daniel Bronder, Samuel F. Bakhoum, Isidro Cortés-Ciriano, Peter Ly
Nature. 2023; 618(7967): 1041–1048. Published online 2023 May 10. doi: 10.1038/s41586-023-05974-0
PMCID:
PMC10307639
AbstractArticlePDF–10M
8.
Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification
Camila M. Aprosoff, Boris J.A. Dyakov, Vivian H.W. Cheung, Cassandra J. Wong, Mikaela Palandra, Anne-Claude Gingras, Haley D.M. Wyatt
J Proteome Res. 2023 Jun 2; 22(6): 1660–1681. Published online 2023 Apr 18. doi: 10.1021/acs.jproteome.2c00706
PMCID:
PMC10243116
AbstractArticlePDF–13M
9.
A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor
Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth
Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.
Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841
PMCID:
PMC9769698
AbstractArticlePDF–2.7M
10.
Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy
Yan Zhao, Xinping Huang, Dan Zhu, Min Wei, Jiechen Luo, Shuyu Yu, Yonglu Tian, Xiaofeng Zheng
Cell Death Differ. 2022 Dec; 29(12): 2531–2544. Published online 2022 Jun 29. doi: 10.1038/s41418-022-01036-6
PMCID:
PMC9751275
AbstractArticlePDF–6.6M
11.
The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers
Martina Oravcová, Minghua Nie, Nicola Zilio, Shintaro Maeda, Yasaman Jami-Alahmadi, Eros Lazzerini-Denchi, James A Wohlschlegel, Helle D Ulrich, Takanori Otomo, Michael N Boddy
eLife. 2022; 11: e79676. Published online 2022 Nov 14. doi: 10.7554/eLife.79676
PMCID:
PMC9708086
AbstractArticlePDF–8.5M
12.
The in vivo Interaction Landscape of Histones H3.1 and H3.3
Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins
Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411
PMCID:
PMC9540345
AbstractArticlePDF–3.9M
13.
FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
Hua Jiang, Weixiang Bian, Yue Sui, Huanle Li, Han Zhao, Wenqi Wang, Xu Li
Sci Adv. 2022 Sep; 8(38): eabq4831. Published online 2022 Sep 21. doi: 10.1126/sciadv.abq4831
PMCID:
PMC9491713
AbstractArticlePDF–12M
14.
Interaction with TopBP1 Is Required for Human Papillomavirus 16 E2 Plasmid Segregation/Retention Function during Mitosis
Apurva T. Prabhakar, Claire D. James, Dipon Das, Christian T. Fontan, Raymonde Otoa, Xu Wang, Molly L. Bristol, Iain M. Morgan
J Virol. 2022 Aug; 96(16): e00830-22. Published online 2022 Jul 26. doi: 10.1128/jvi.00830-22
PMCID:
PMC9400484
AbstractArticlePDF–4.2M
15.
The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis
Natalie Vaughan, Nico Scholz, Catherine Lindon, Julien D. F. Licchesi
Sci Rep. 2022; 12: 13160. Published online 2022 Aug 1. doi: 10.1038/s41598-022-16965-y
PMCID:
PMC9343455
AbstractArticlePDF–3.7M
16.
The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis
Mara De Marco Zompit, Mònica Torres Esteban, Clémence Mooser, Salomé Adam, Silvia Emma Rossi, Alain Jeanrenaud, Pia-Amata Leimbacher, Daniel Fink, Ann-Marie K. Shorrocks, Andrew N. Blackford, Daniel Durocher, Manuel Stucki
Nat Commun. 2022; 13: 4143. Published online 2022 Jul 16. doi: 10.1038/s41467-022-31865-5
PMCID:
PMC9288427
AbstractArticlePDF–11M
17.
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery
Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili
Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z
PMCID:
PMC9279285
AbstractArticlePDF–2.5M
18.
Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors
Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen
Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638
PMCID:
PMC9106303
AbstractArticlePDF–918K
19.
Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis
Fenglong Jiao, Clinton Yu, Andrew Wheat, Xiaorong Wang, Scott D. Rychnovsky, Lan Huang
Anal Chem. Author manuscript; available in PMC 2022 Apr 30.
Published in final edited form as: Anal Chem. 2022 Mar 15; 94(10): 4236–4242. Published online 2022 Mar 2. doi: 10.1021/acs.analchem.1c04485
PMCID:
PMC9056026
AbstractArticlePDF–1.0M
20.
CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle
Apurva T. Prabhakar, Claire D. James, Dipon Das, Raymonde Otoa, Matthew Day, John Burgner, Christian T. Fontan, Xu Wang, Sarah H. Glass, Andreas Wieland, Mary M. Donaldson, Molly L. Bristol, Renfeng Li, Anthony W. Oliver, Laurence H. Pearl, Brian O. Smith, Iain M. Morgan
mBio. 2021 Sep-Oct; 12(5): e01163-21. Published online 2021 Sep 21. doi: 10.1128/mBio.01163-21
PMCID:
PMC8546539
AbstractArticlePDF–3.6M

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