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Select item 112510551.

FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer

Nicla Lorito, Angela Subbiani, Alfredo Smiriglia, Marina Bacci, Francesca Bonechi, Laura Tronci, Elisabetta Romano, Alessia Corrado, Dario Livio Longo, Marta Iozzo, Luigi Ippolito, Giuseppina Comito, Elisa Giannoni, Icro Meattini, Alexandra Avgustinova, Paola Chiarugi, Angela Bachi, Andrea Morandi

EMBO Mol Med. 2024 Jul; 16(7): 1533–1559. Published online 2024 Jun 26. doi: 10.1038/s44321-024-00090-6

PMCID:: PMC11251055

Abstract Article PDF–9.2M

Select item 109402942.

Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2

Jingjing Zhang, Mario Ruiz, Per-Olof Bergh, Marcus Henricsson, Nena Stojanović, Ranjan Devkota, Marius Henn, Mohammad Bohlooly-Y, Abrahan Hernández-Hernández, Manfred Alsheimer, Jan Borén, Marc Pilon, Hiroki Shibuya

Nat Commun. 2024; 15: 2315. Published online 2024 Mar 14. doi: 10.1038/s41467-024-46718-6

PMCID:: PMC10940294

Abstract Article PDF–6.0M

Select item 106157423.

GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice

Hirona Yamamoto, Hyeon-Cheol Lee-Okada, Masashi Ikeda, Takumi Nakamura, Takeo Saito, Atsushi Takata, Takehiko Yokomizo, Nakao Iwata, Tadafumi Kato, Takaoki Kasahara

Mol Psychiatry. 2023; 28(7): 2848–2856. Published online 2023 Feb 21. doi: 10.1038/s41380-023-01988-2

PMCID:: PMC10615742

Abstract Article PDF–1.9M

Select item 94926974.

Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production

Keiken Ri, Hyeon-Cheol Lee-Okada, Takehiko Yokomizo

Commun Biol. 2022; 5: 1001. Published online 2022 Sep 21. doi: 10.1038/s42003-022-03972-y

PMCID:: PMC9492697

Abstract Article PDF–1014K

Select item 84792585.

High fat / high cholesterol diet does not provoke atherosclerosis in the ω3-and ω6-polyunsaturated fatty acid synthesis–inactivated Δ6-fatty acid desaturase–deficient mouse

Wilhelm Stoffel, Erika Binczek, Inga Schmidt-Soltau, Susanne Brodesser, Ina Wegner

Mol Metab. 2021 Dec; 54: 101335. Published online 2021 Sep 14. doi: 10.1016/j.molmet.2021.101335

PMCID:: PMC8479258

Abstract Article PDF–8.5M

Select item 74159916.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 71532847.

Dietary ω3-and ω6-Polyunsaturated fatty acids reconstitute fertility of Juvenile and adult Fads2-Deficient mice

Wilhelm Stoffel, Inga Schmidt-Soltau, Erika Binczek, Andreas Thomas, Mario Thevis, Ina Wegner

Mol Metab. 2020 Jun; 36: 100974. Published online 2020 Mar 17. doi: 10.1016/j.molmet.2020.100974

PMCID:: PMC7153284

Abstract Article PDF–7.0M

Select item 66720428.

Novel CB1-ligands maintain homeostasis of the endocannabinoid system in ω3- and ω6-long-chain-PUFA deficiency

Ina Hammels, Erika Binczek, Inga Schmidt-Soltau, Britta Jenke, Andreas Thomas, Matthias Vogel, Mario Thevis, Dilyana Filipova, Symeon Papadopoulos, Wilhelm Stoffel

J Lipid Res. 2019 Aug; 60(8): 1396–1409. Published online 2019 Jun 5. doi: 10.1194/jlr.M094664

PMCID:: PMC6672042

Abstract Article PDF–2.7M

Select item 63949819.

A novel polymorphism in the fatty acid desaturase 2 gene (Fads2): A possible role in the basal metabolic rate

Magdalena Czajkowska, Paweł Brzęk, Paweł Dobrzyń

PLoS One. 2019; 14(2): e0213138. Published online 2019 Feb 28. doi: 10.1371/journal.pone.0213138

PMCID:: PMC6394981

Abstract Article PDF–1.5M

Select item 629804010.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Abstract Article PDF–1.2M

Select item 624418311.

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells

Sunyuan Zhang, Nicholas A. Williamson, Marie A. Bogoyevitch

Sci Data. 2018; 5: 180262. Published online 2018 Nov 20. doi: 10.1038/sdata.2018.262

PMCID:: PMC6244183

Abstract Article PDF–753K

Select item 508786712.

Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio

Hang Su, Dan Zhou, Yuan-Xiang Pan, Xingguo Wang, Manabu T. Nakamura

J Lipid Res. 2016 Nov; 57(11): 1995–2004. Published online 2016 Oct 27. doi: 10.1194/jlr.M064956

PMCID:: PMC5087867

Abstract Article PDF–913K

Select item 508140613.

Lsd1 Ablation Triggers Metabolic Reprogramming of Brown Adipose Tissue

Delphine Duteil, Milica Tosic, Franziska Lausecker, Hatice Z. Nenseth, Judith M. Müller, Sylvia Urban, Dominica Willmann, Kerstin Petroll, Nadia Messaddeq, Laura Arrigoni, Thomas Manke, Jan-Wilhelm Kornfeld, Jens C. Brüning, Vyacheslav Zagoriy, Michael Meret, Jörn Dengjel, Toufike Kanouni, Roland Schüle

Cell Rep. 2016 Oct 18; 17(4): 1008–1021. Published online 2016 Oct 18. doi: 10.1016/j.celrep.2016.09.053

PMCID:: PMC5081406

Abstract Article

Select item 430345514.

Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency

Wilhelm Stoffel, Ina Hammels, Britta Jenke, Erika Binczek, Inga Schmidt-Soltau, Susanne Brodesser, Margarete Odenthal, Mario Thevis

EMBO Rep. 2014 Jan; 15(1): 110–120. Published online 2013 Dec 30. doi: 10.1002/embr.201338041

PMCID:: PMC4303455

Abstract Article PDF–3.0M

Select item 414181915.

Cartilage-Specific Ablation of Site-1 Protease in Mice Results in the Endoplasmic Reticulum Entrapment of Type IIB Procollagen and Down-Regulation of Cholesterol and Lipid Homeostasis

Debabrata Patra, Elizabeth DeLassus, Guosheng Liang, Linda J. Sandell

PLoS One. 2014; 9(8): e105674. Published online 2014 Aug 22. doi: 10.1371/journal.pone.0105674

PMCID:: PMC4141819

Abstract Article PDF–21M

Select item 369492616.

FADS2 Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain

Thais S. Rizzi, Sophie van der Sluis, Catherine Derom, Evert Thiery, Ronald E. van Kesteren, Nele Jacobs, Sofie Van Gestel, Robert Vlietinck, Matthijs Verhage, Peter Heutink, Danielle Posthuma

PLoS One. 2013; 8(6): e68000. Published online 2013 Jun 27. doi: 10.1371/journal.pone.0068000

PMCID:: PMC3694926

Abstract Article PDF–506K

Select item 356837217.

Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration

Stephen Lumayag, Caroline E. Haldin, Nicola J. Corbett, Karl J. Wahlin, Colleen Cowan, Sanja Turturro, Peter E. Larsen, Beatrix Kovacs, P. Dane Witmer, David Valle, Donald J. Zack, Daniel A. Nicholson, Shunbin Xu

Proc Natl Acad Sci U S A. 2013 Feb 5; 110(6): E507–E516. Published online 2013 Jan 22. doi: 10.1073/pnas.1212655110

PMCID:: PMC3568372

Abstract Article PDF–2.1M

Select item 348042118.

Inhibiting Delta-6 Desaturase Activity Suppresses Tumor Growth in Mice

Chengwei He, Xiying Qu, Jianbo Wan, Rong Rong, Lili Huang, Chun Cai, Keyuan Zhou, Yan Gu, Steven Y. Qian, Jing X. Kang

PLoS One. 2012; 7(10): e47567. Published online 2012 Oct 24. doi: 10.1371/journal.pone.0047567

PMCID:: PMC3480421

Abstract Article PDF–442K

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 280323820.

Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice

Manuel Roqueta-Rivera, Chad K. Stroud, Wanda M. Haschek, Sandeep J. Akare, Mariangela Segre, Richard S. Brush, Martin-Paul Agbaga, Robert E. Anderson, Rex A. Hess, Manabu T. Nakamura

J Lipid Res. 2010 Feb; 51(2): 360–367. doi: 10.1194/jlr.M001180

PMCID:: PMC2803238

Abstract Article PDF–1.2M

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