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Select item 107034191.

Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves

Rachel Queen, Moira Crosier, Lorraine Eley, Janet Kerwin, Jasmin E. Turner, Jianshi Yu, Ahlam Alqahtani, Tamilvendhan Dhanaseelan, Lynne Overman, Hannah Soetjoadi, Richard Baldock, Jonathan Coxhead, Veronika Boczonadi, Alex Laude, Simon J. Cockell, Maureen A. Kane, Steven Lisgo, Deborah J. Henderson

PLoS Genet. 2023 Nov; 19(11): e1010777. Published online 2023 Nov 27. doi: 10.1371/journal.pgen.1010777

PMCID:: PMC10703419

Abstract Article PDF–9.6M

Select item 106327462.

Role of Matrix Gla Protein in Transforming Growth Factor-β Signaling and Nonalcoholic Steatohepatitis in Mice

Simon T. Hui, Lili Gong, Chantle Swichkow, Montgomery Blencowe, Dorota Kaminska, Graciel Diamante, Calvin Pan, Meet Dalsania, Samuel W. French, Clara E. Magyar, Päivi Pajukanta, Jussi Pihlajamäki, Kristina I. Boström, Xia Yang, Aldons J. Lusis

Cell Mol Gastroenterol Hepatol. 2023; 16(6): 943–960. Published online 2023 Aug 21. doi: 10.1016/j.jcmgh.2023.08.007

PMCID:: PMC10632746

Abstract Article PDF–4.5M

Select item 106248543.

Specific heterozygous variants in MGP lead to endoplasmic reticulum stress and cause spondyloepiphyseal dysplasia

Ophélie Gourgas, Gabrielle Lemire, Alison J. Eaton, Sultanah Alshahrani, Angela L. Duker, Jingjing Li, Ricki S. Carroll, Stuart Mackenzie, Sarah M. Nikkel, Care4Rare Canada Consortium, Michael B. Bober, Kym M. Boycott, Monzur Murshed

Nat Commun. 2023; 14: 7054. Published online 2023 Nov 3. doi: 10.1038/s41467-023-41651-6

Correction in:: Nat Commun. 2024; 15: 3655.

PMCID:: PMC10624854

Abstract Article PDF–7.9M

Select item 100503984.

Matrix Gla Protein drives stemness and tumor initiation in ovarian cancer

V. Nieddu, V. Melocchi, C. Battistini, G. Franciosa, M. Lupia, C. Stellato, G. Bertalot, J. V. Olsen, N. Colombo, F. Bianchi, U. Cavallaro

Cell Death Dis. 2023 Mar; 14(3): 220. Published online 2023 Mar 28. doi: 10.1038/s41419-023-05760-w

PMCID:: PMC10050398

Abstract Article PDF–4.6M

Select item 96755565.

DIO3 protects against thyrotoxicosis-derived cranio-encephalic and cardiac congenital abnormalities

M. Elena Martinez, Ilka Pinz, Marilena Preda, Christine R. Norton, Thomas Gridley, Arturo Hernandez

JCI Insight. 2022 Nov 8; 7(21): e161214. Published online 2022 Nov 8. doi: 10.1172/jci.insight.161214

PMCID:: PMC9675556

Abstract Article PDF–3.9M

Select item 89904806.

MGP promotes CD8⁺ T cell exhaustion by activating the NF-κB pathway leading to liver metastasis of colorectal cancer

Dawei Rong, Guangshun Sun, Zhiying Zheng, Li Liu, Xiaoyuan Chen, Fan Wu, Yichao Gu, Yongjiu Dai, Weizhe Zhong, Xiaopei Hao, Chuanyong Zhang, Xiongxiong Pan, Jinhai Tang, Weiwei Tang, Xuehao Wang

Int J Biol Sci. 2022; 18(6): 2345–2361. Published online 2022 Mar 6. doi: 10.7150/ijbs.70137

PMCID:: PMC8990480

Abstract Article PDF–3.7M

Select item 89612737.

Deletion of transcription factor AP-2β from the developing murine trabecular meshwork region leads to progressive glaucomatous changes

Aftab Taiyab, Monica Akula, Japnit Dham, Paula Deschamps, Heather Sheardown, Trevor Williams, Teresa Borrás, Judith A. West-Mays

J Neurosci Res. Author manuscript; available in PMC 2022 Mar 29.

Published in final edited form as: J Neurosci Res. 2022 Feb; 100(2): 638–652. Published online 2021 Nov 25. doi: 10.1002/jnr.24982

PMCID:: PMC8961273

Abstract Article PDF–2.5M

Select item 87922388.

Matrix Gla Protein Levels are Associated with Arterial Stiffness and Incident Heart Failure with Preserved Ejection Fraction

Rajeev Malhotra, Christopher J. Nicholson, Dongyu Wang, Vijeta Bhambhani, Samantha Paniagua, Charles Slocum, Haakon H. Sigurslid, Christian L. Lino Cardenas, Rebecca Li, Sophie L. Boerboom, Yin-Ching Chen, Shih-Jen Hwang, Chen Yao, Fumito Ichinose, Donald B. Bloch, Mark E. Lindsay, Gregory D. Lewis, Jayashri R. Aragam, Udo Hoffmann, Gary F. Mitchell, Naomi M. Hamburg, Ramchandran S. Vasan, Emelia J. Benjamin, Martin G. Larson, Warren M. Zapol, Susan Cheng, Jason D. Roh, Christopher J. O’Donnell, Christopher Nguyen, Daniel Levy, Jennifer E. Ho

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2023 Feb 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2022 Feb; 42(2): e61–e73. Published online 2021 Nov 23. doi: 10.1161/ATVBAHA.121.316664

PMCID:: PMC8792238

Abstract Article PDF–741K

Select item 82655669.

The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone Sensitivity in the Fetal Brain

Maria Elena Martinez, Arturo Hernandez

Front Neurosci. 2021; 15: 703730. Published online 2021 Jun 29. doi: 10.3389/fnins.2021.703730

PMCID:: PMC8265566

Abstract Article PDF–8.3M

Select item 826227410.

Shifting osteogenesis in vascular calcification

Jiayi Yao, Xiuju Wu, Xiaojing Qiao, Daoqin Zhang, Li Zhang, Jocelyn A. Ma, Xinjiang Cai, Kristina I. Boström, Yucheng Yao

JCI Insight. 2021 May 24; 6(10): e143023. Published online 2021 May 24. doi: 10.1172/jci.insight.143023

PMCID:: PMC8262274

Abstract Article PDF–1.5M

Select item 776905011.

Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function

John DeSisto, Rebecca O’Rourke, Hannah E. Jones, Bradley Pawlikowski, Alexandra D. Malek, Stephanie Bonney, Fabien Guimiot, Kenneth L. Jones, Julie A. Siegenthaler

Dev Cell. Author manuscript; available in PMC 2021 Jul 6.

Published in final edited form as: Dev Cell. 2020 Jul 6; 54(1): 43–59.e4. doi: 10.1016/j.devcel.2020.06.009

PMCID:: PMC7769050

Abstract Article PDF–2.6M

Select item 759654512.

Generation of a Matrix Gla (Mgp) floxed mouse, followed by conditional knockout, uncovers a new Mgp function in the eye

Teresa Borrás, Dale O. Cowley, Priyadarsini Asokan, Kumar Pandya

Sci Rep. 2020; 10: 18583. Published online 2020 Oct 29. doi: 10.1038/s41598-020-75031-7

PMCID:: PMC7596545

Abstract Article PDF–3.1M

Select item 736849413.

The sperm associated antigen 6 interactome and its role in spermatogenesis

Yunhao Liu, Ling Zhang, Wei Li, Yuhong Li, Junpin Liu, Shiyang Zhang, Guanglun Pin, Shizhen Song, Pierre F Ray, Christophe Arnoult, Chunghee Cho, Balbina Garcia-Reyes, Uwe Knippschild, Jerome F. Strauss, III, Zhibing Zhang

Reproduction. Author manuscript; available in PMC 2020 Jul 18.

Published in final edited form as: Reproduction. 2019 Aug; 158(2): 181–197. doi: 10.1530/REP-18-0522

PMCID:: PMC7368494

Abstract Article PDF–1.8M

Select item 714780914.

Skip is essential for Notch signaling to induce Sox2 in cerebral arteriovenous malformations

Daoqin Zhang, Xiaojing Qiao, Lumin Wang, Li Zhang, Jiayi Yao, Xiuju Wu, Tongtong Yu, Kristina I. Boström, Yucheng Yao

Cell Signal. Author manuscript; available in PMC 2020 Apr 10.

Published in final edited form as: Cell Signal. 2020 Apr; 68: 109537. Published online 2020 Jan 10. doi: 10.1016/j.cellsig.2020.109537

PMCID:: PMC7147809

Abstract Article PDF–984K

Select item 699984415.

Matrix Gla protein regulates adipogenesis and is serum marker of visceral adiposity

Chaomin Li, Jing Li, Fang He, Kun Li, Xu Li, Yan Zhang

Adipocyte. 2020; 9(1): 68–76. Published online 2020 Jan 31. doi: 10.1080/21623945.2020.1721692

PMCID:: PMC6999844

Abstract Article PDF–1.1M

Select item 685857516.

HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype

Rajeev Malhotra, Andreas C. Mauer, Christian L. Lino Cardenas, Xiuqing Guo, Jie Yao, Xiaoling Zhang, Florian Wunderer, Albert V. Smith, Quenna Wong, Sonali Pechlivanis, Shih-Jen Hwang, Judy Wang, Lingyi Lu, Christopher J. Nicholson, Georgia Shelton, Mary D. Buswell, Hanna J. Barnes, Haakon H. Sigurslid, Charles Slocum, Caitlin O’Rourke, David K. Rhee, Aranya Bagchi, Sagar U. Nigwekar, Emmanuel S. Buys, Catherine Y. Campbell, Tamara Harris, Matthew Budoff, Michael H. Criqui, Jerome I. Rotter, Andrew D. Johnson, Ci Song, Nora Franceschini, Stephanie Debette, Udo Hoffmann, Hagen Kälsch, Markus M. Nöthen, Sigurdur Sigurdsson, Barry I. Freedman, Donald W. Bowden, Karl-Heinz Jöckel, Susanne Moebus, Raimund Erbel, Mary F. Feitosa, Vilmundur Gudnason, George Thanassoulis, Warren M. Zapol, Mark E. Lindsay, Donald B. Bloch, Wendy S. Post, Christopher J. O’Donnell

Nat Genet. Author manuscript; available in PMC 2020 Apr 28.

Published in final edited form as: Nat Genet. 2019 Nov; 51(11): 1580–1587. Published online 2019 Oct 28. doi: 10.1038/s41588-019-0514-8