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Select item 111094831.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 105658762.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 105166273.

The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair

Lingyu Qiu, Wenchao Xu, Xiaopeng Lu, Feng Chen, Yongcan Chen, Yuan Tian, Qian Zhu, Xiangyu Liu, Yongqing Wang, Xin-Hai Pei, Xingzhi Xu, Jun Zhang, Wei-Guo Zhu

Nucleic Acids Res. 2023 Sep 22; 51(17): 9166–9182. Published online 2023 Jul 28. doi: 10.1093/nar/gkad631

PMCID:: PMC10516627

Abstract Article PDF–2.5M

Select item 104133574.

UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair

Seong-Ok Lee, Jessica L. Kelliher, Wan Song, Kyle Tengler, Aradhan Sarkar, Eloise Dray, Justin W.C. Leung

J Biol Chem. 2023 Aug; 299(8): 105043. Published online 2023 Jul 13. doi: 10.1016/j.jbc.2023.105043

PMCID:: PMC10413357

Abstract Article PDF–4.0M

Select item 100909635.

Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-κB Activation in Lupus Nephritis

Luxi Zou, Ling Sun, Ruixue Hua, Yu Wu, Linlin Sun, Ting Chen

J Innate Immun. 2023 Jan-Dec; 15(1): 428–441. Published online 2023 Mar 21. doi: 10.1159/000527624

PMCID:: PMC10090963

Abstract Article PDF–1.4M

Select item 99205196.

Emerging Roles of RNF168 in Tumor Progression

Tianyuan Xie, Hai Qin, Zhengdong Yuan, Yiwen Zhang, Xiaoman Li, Lufeng Zheng

Molecules. 2023 Feb; 28(3): 1417. Published online 2023 Feb 2. doi: 10.3390/molecules28031417

PMCID:: PMC9920519

Abstract Article PDF–1.7M

Select item 98811367.

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke

Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188

PMCID:: PMC9881136

Abstract Article PDF–4.4M

Select item 97979888.

TBK1 posphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1

Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel

J Cell Biol. 2023 Feb 6; 222(2): e202108144. Published online 2022 Dec 27. doi: 10.1083/jcb.202108144

PMCID:: PMC9797988

Abstract Article PDF–6.9M

Select item 95403459.

The in vivo Interaction Landscape of Histones H3.1 and H3.3

Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins

Mol Cell Proteomics. 2022 Oct; 21(10): 100411. Published online 2022 Sep 9. doi: 10.1016/j.mcpro.2022.100411

PMCID:: PMC9540345

Abstract Article PDF–3.9M

Select item 888257510.

Defective repair of topoisomerase I induced chromosomal damage in Huntington’s disease

Nelma M. Palminha, Cleide Dos Santos Souza, Jon Griffin, Chunyan Liao, Laura Ferraiuolo, Sherif F. El-Khamisy

Cell Mol Life Sci. 2022 Mar; 79(3): 160. Published online 2022 Feb 28. doi: 10.1007/s00018-022-04204-6

PMCID:: PMC8882575

Abstract Article PDF–2.0M

Select item 848688811.

New answers to the old RIDDLE: RNF168 and the DNA damage response pathway

Jessica Kelliher, Gargi Ghosal, Justin Wai Chung Leung

FEBS J. Author manuscript; available in PMC 2023 May 1.

Published in final edited form as: FEBS J. 2022 May; 289(9): 2467–2480. Published online 2021 Apr 16. doi: 10.1111/febs.15857

PMCID:: PMC8486888

Abstract Article PDF–1.2M

Select item 840959112.

Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response

Kishu Ranjan, Matija Hedl, Saloni Sinha, Xuchen Zhang, Clara Abraham

J Clin Invest. 2021 Sep 1; 131(17): e145472. Published online 2021 Sep 1. doi: 10.1172/JCI145472

PMCID:: PMC8409591

Abstract Article PDF–18M

Select item 837396113.

RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage

John J. Krais, Yifan Wang, Pooja Patel, Jayati Basu, Andrea J. Bernhardy, Neil Johnson

Nat Commun. 2021; 12: 5016. Published online 2021 Aug 18. doi: 10.1038/s41467-021-25346-4

PMCID:: PMC8373961

Abstract Article PDF–4.1M

Select item 824203214.

Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance

Qinglei Hang, Liyong Zeng, Li Wang, Litong Nie, Fan Yao, Hongqi Teng, Yalan Deng, Shannon Yap, Yutong Sun, Steven J. Frank, Junjie Chen, Li Ma

Nat Commun. 2021; 12: 4033. Published online 2021 Jun 29. doi: 10.1038/s41467-021-24298-z

PMCID:: PMC8242032

Abstract Article PDF–4.8M

Select item 810809315.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary

Cell. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050

PMCID:: PMC8108093

Abstract Article PDF–3.5M

Select item 801772016.

SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

Ukhyun Jo, Yasuhisa Murai, Sirisha Chakka, Lu Chen, Ken Cheng, Junko Murai, Liton Kumar Saha, Lisa M. Miller Jenkins, Yves Pommier

Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2015654118. Published online 2021 Feb 3. doi: 10.1073/pnas.2015654118

PMCID:: PMC8017720

Abstract Article PDF–1.9M

Select item 795030317.

RNF168 is highly expressed in esophageal squamous cell carcinoma and contributes to the malignant behaviors in association with the Wnt/β-catenin signaling pathway

Yunjiu Gou, Dacheng Jin, Shengliang He, Songchen Han, Qizhou Bai

Aging (Albany NY) 2021 Feb 28; 13(4): 5403–5414. Published online 2021 Jan 25. doi: 10.18632/aging.202471

PMCID:: PMC7950303

Abstract Article PDF–1.5M

Select item 784322818.

RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors

Parasvi S. Patel, Karan Joshua Abraham, Kiran Kumar Naidu Guturi, Marie-Jo Halaby, Zahra Khan, Luis Palomero, Brandon Ho, Shili Duan, Jonathan St-Germain, Arash Algouneh, Francesca Mateo, Samah El Ghamrasni, Haithem Barbour, Daniel R. Barnes, Jonathan Beesley, Otto Sanchez, Hal K. Berman, Grant W. Brown, El Bachir Affar, Georgia Chenevix-Trench, Antonis C. Antoniou, Cheryl H. Arrowsmith, Brian Raught, Miquel Angel Pujana, Karim Mekhail, Anne Hakem, Razqallah Hakem

J Clin Invest. 2021 Feb 1; 131(3): e140105. Published online 2021 Feb 1. doi: 10.1172/JCI140105

PMCID:: PMC7843228

Abstract Article PDF–8.1M

Select item 765566419.

Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response

Franziska Walser, Monique P.C. Mulder, Benoît Bragantini, Sibylle Burger, Tatiana Gubser, Marco Gatti, Maria Victoria Botuyan, Alessandra Villa, Matthias Altmeyer, Dario Neri, Huib Ovaa, Georges Mer, Lorenza Penengo

Mol Cell. Author manuscript; available in PMC 2021 Nov 5.

Published in final edited form as: Mol Cell. 2020 Nov 5; 80(3): 423–436.e9. Published online 2020 Oct 5. doi: 10.1016/j.molcel.2020.09.017

PMCID:: PMC7655664

Abstract Article PDF–2.5M

Select item 730600520.

Synthetic lethal and resistance interactions with BET bromodomain inhibitors in triple-negative breast cancer

Shaokun Shu, Hua-Jun Wu, Jennifer Y. Ge, Rhamy Zeid, Isaac S. Harris, Bojana Jovanović, Katherine Murphy, Binbin Wang, Xintao Qiu, Jennifer E. Endress, Jaime Reyes, Klothilda Lim, Alba Font-Tello, Sudeepa Syamala, Tengfei Xiao, Chandra Sekhar Reddy Chilamakuri, Evangelia K. Papachristou, Clive D’Santos, Jayati Anand, Kunihiko Hinohara, Wei Li, Thomas O. McDonald, Adrienne Luoma, Rebecca J. Modiste, Quang-De Nguyen, Brittany Michel, Paloma Cejas, Cigall Kadoch, Jacob D. Jaffe, Kai W. Wucherpfennig, Jun Qi, X. Shirley Liu, Henry Long, Myles Brown, Jason S. Carroll, Joan S. Brugge, James Bradner, Franziska Michor, Kornelia Polyak

Mol Cell. Author manuscript; available in PMC 2021 Jun 18.

Published in final edited form as: Mol Cell. 2020 Jun 18; 78(6): 1096–1113.e8. Published online 2020 May 15. doi: 10.1016/j.molcel.2020.04.027

PMCID:: PMC7306005

Abstract Article PDF–3.2M

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