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Select item 106904371.

HLA class I signal peptide polymorphism determines the level of CD94/NKG2–HLA-E-mediated regulation of effector cell responses

Zhansong Lin, Arman A. Bashirova, Mathias Viard, Lee Garner, Max Quastel, Maya Beiersdorfer, Wojciech K. Kasprzak, Marjan Akdag, Yuko Yuki, Pedro Ojeda, Sudipto Das, Thorkell Andresson, Vivek Naranbhai, Amir Horowitz, Andrew J. McMichael, Angelique Hoelzemer, Geraldine M. Gillespie, Wilfredo F. Garcia-Beltran, Mary Carrington

Nat Immunol. Author manuscript; available in PMC 2023 Dec 1.

Published in final edited form as: Nat Immunol. 2023 Jul; 24(7): 1087–1097. Published online 2023 Jun 1. doi: 10.1038/s41590-023-01523-z

PMCID:: PMC10690437

Abstract Article PDF–3.3M

Select item 106114592.

Significance of HLA-E and its two NKG2 receptors in development of complications after allogeneic transplantation of hematopoietic stem cells

Jagoda Siemaszko, Piotr Łacina, Donata Szymczak, Agnieszka Szeremet, Maciej Majcherek, Anna Czyż, Małgorzata Sobczyk-Kruszelnicka, Wojciech Fidyk, Iwona Solarska, Barbara Nasiłowska-Adamska, Patrycja Skowrońska, Maria Bieniaszewska, Agnieszka Tomaszewska, Grzegorz W. Basak, Sebastian Giebel, Tomasz Wróbel, Katarzyna Bogunia-Kubik

Front Immunol. 2023; 14: 1227897. Published online 2023 Oct 13. doi: 10.3389/fimmu.2023.1227897

PMCID:: PMC10611459

Abstract Article PDF–3.7M

Select item 103209793.

Characterization of large-scale genomic differences in the first complete human genome

Xiangyu Yang, Xuankai Wang, Yawen Zou, Shilong Zhang, Manying Xia, Lianting Fu, Mitchell R. Vollger, Nae-Chyun Chen, Dylan J. Taylor, William T. Harvey, Glennis A. Logsdon, Dan Meng, Junfeng Shi, Rajiv C. McCoy, Michael C. Schatz, Weidong Li, Evan E. Eichler, Qing Lu, Yafei Mao

Genome Biol. 2023; 24: 157. Published online 2023 Jul 4. doi: 10.1186/s13059-023-02995-w

PMCID:: PMC10320979

Abstract Article PDF–2.7M

Select item 97966214.

Diversity of NKG2C genotypes in a European population: Conserved and recombinant haplotypes in the coding, promoter, and 3′‐untranslated regions

Judit Asenjo, Manuela Moraru, Karima Al‐Akioui‐Sanz, Mireia Altadill, Aura Muntasell, Miguel López‐Botet, Carlos Vilches

HLA. 2022 Nov; 100(5): 469–478. Published online 2022 Jul 20. doi: 10.1111/tan.14734

PMCID:: PMC9796621

Abstract Article PDF–1.7M

Select item 91480695.

NKG2C+ NK Cells for Immunotherapy of Glioblastoma Multiforme

Shafiq Murad, Susanne Michen, Alexander Becker, Monika Füssel, Gabriele Schackert, Torsten Tonn, Frank Momburg, Achim Temme

Int J Mol Sci. 2022 May; 23(10): 5857. Published online 2022 May 23. doi: 10.3390/ijms23105857

PMCID:: PMC9148069

Abstract Article PDF–5.8M

Select item 89381636.

Assessment of NKG2C copy number variation in HIV-1 infection susceptibility, and considerations about the potential role of lacking receptors and virus infection

Bruno Toson, Rafael T. Michita, Maria C. T. Matte, Robson Soares, Gabriela K. S. Lawisch, Vanessa S. Mattevi, José A. B. Chies

J Hum Genet. 2022; 67(8): 475–479. Published online 2022 Mar 22. doi: 10.1038/s10038-022-01029-w

PMCID:: PMC8938163

Abstract Article PDF–397K

Select item 88558177.

Donor NKG2C homozygosity contributes to CMV clearance after haploidentical transplantation

Xing-Xing Yu, Qian-Nan Shang, Xue-Fei Liu, Mei He, Xu-Ying Pei, Xiao-Dong Mo, Meng Lv, Ting-Ting Han, Ming-Rui Huo, Xiao-Su Zhao, Ying-Jun Chang, Yu Wang, Xiao-Hui Zhang, Lan-Ping Xu, Kai-Yan Liu, Xiang-Yu Zhao, Xiao-Jun Huang

JCI Insight. 2022 Feb 8; 7(3): e149120. Published online 2022 Feb 8. doi: 10.1172/jci.insight.149120

PMCID:: PMC8855817

Abstract Article PDF–6.4M

Select item 87092258.

Increased Susceptibility of the CD57⁻ NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response

Anastasia I. Palamarchuk, Nadezhda A. Alekseeva, Maria A. Streltsova, Maria O. Ustiuzhanina, Polina A. Kobyzeva, Sofya A. Kust, Maria V. Grechikhina, Anna A. Boyko, Olga A. Shustova, Alexander M. Sapozhnikov, Elena I. Kovalenko

Int J Mol Sci. 2021 Dec; 22(24): 13326. Published online 2021 Dec 11. doi: 10.3390/ijms222413326

PMCID:: PMC8709225

Abstract Article PDF–3.0M

Select item 83128709.

Influence of NKG2C Genotypes on HIV Susceptibility and Viral Load Set Point

Khlood Alsulami, Naomi Bolastig, Franck P. Dupuy, Tsoarello Mabanga, Louise Gilbert, Zahra Kiani, Jean-Pierre Routy, Julie Bruneau, Réjean Thomas, Cécile Tremblay, Christos M. Tsoukas, Jason Szabo, Pierre Côté, Benoit Trottier, Roger LeBlanc, Danielle Rouleau, Nicole F. Bernard

J Virol. 2021 Aug; 95(16): e00417-21. Prepublished online 2021 Jun 2. Published online 2021 Jul 26. doi: 10.1128/JVI.00417-21

PMCID:: PMC8312870

Abstract Article PDF–1.2M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 792179911.

Surface NKG2C Identifies Differentiated αβT-Cell Clones Expanded in Peripheral Blood

Elena I. Kovalenko, Ivan V. Zvyagin, Maria A. Streltsova, Artem I. Mikelov, Sofya A. Erokhina, William G. Telford, Alexander M. Sapozhnikov, Yury B. Lebedev

Front Immunol. 2020; 11: 613882. Published online 2021 Feb 16. doi: 10.3389/fimmu.2020.613882

PMCID:: PMC7921799

Abstract Article PDF–2.5M

Select item 783566812.

Deletion of the NKG2C receptor encoding KLRC2 gene and HLA-E variants are risk factors for severe COVID-19

Hannes Vietzen, Alexander Zoufaly, Marianna Traugott, Judith Aberle, Stephan W. Aberle, Elisabeth Puchhammer-Stöckl

Genet Med. 2021 May; 23(5): 963–967. Published online 2021 Sep 5. doi: 10.1038/s41436-020-01077-7

PMCID:: PMC7835668

Abstract Article PDF–434K

Select item 735278713.

NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain

Gia-Gia T. Hò, Alexander A. Celik, Trevor Huyton, Wiebke Hiemisch, Rainer Blasczyk, Gwendolin S. Simper, Christina Bade-Doeding

Int J Mol Sci. 2020 Jun; 21(12): 4362. Published online 2020 Jun 19. doi: 10.3390/ijms21124362

PMCID:: PMC7352787

Abstract Article PDF–4.5M

Select item 705758214.

Adaptive NKG2C+ natural killer cells are related to exacerbations and nutritional abnormalities in COPD patients

Sergi Pascual-Guardia, Michelle Ataya, Isabel Ramírez-Martínez, José Yélamos, Roberto Chalela, Salomé Bellido, Miguel López-Botet, Joaquim Gea

Respir Res. 2020; 21: 63. Published online 2020 Mar 4. doi: 10.1186/s12931-020-1323-4

PMCID:: PMC7057582

Abstract Article PDF–883K

Select item 690846815.

Phenotypic and Functional Analysis of Human NK Cell Subpopulations According to the Expression of FcεRIγ and NKG2C

Kyung Hwan Kim, Hee Tae Yu, Ilwoong Hwang, Sungha Park, Su-Hyung Park, Sungjin Kim, Eui-Cheol Shin

Front Immunol. 2019; 10: 2865. Published online 2019 Dec 6. doi: 10.3389/fimmu.2019.02865

PMCID:: PMC6908468

Abstract Article PDF–1.9M

Select item 620626716.

Donor NKG2C Copy Number: An Independent Predictor for CMV Reactivation After Double Cord Blood Transplantation

Kai Cao, David Marin, Takuye Sekine, Gabriela Rondon, Weicheng Zhao, Nathaniel T. Smith, May Daher, Qing Wang, Li Li, Rima M. Saliba, Ravi Pingali, Uday Popat, Chitra Hosing, Amanda Olson, Betul Oran, Rafet Basar, Rohtesh S. Mehta, Richard Champlin, Elizabeth J. Shpall, Katayoun Rezvani

Front Immunol. 2018; 9: 2444. Published online 2018 Oct 23. doi: 10.3389/fimmu.2018.02444

PMCID:: PMC6206267

Abstract Article PDF–377K

Select item 494748417.

Differential frequency of NKG2C/KLRC2 deletion in distinct African populations and susceptibility to Trachoma: a new method for imputation of KLRC2 genotypes from SNP genotyping data

Adriana Goncalves, Pateh Makalo, Hassan Joof, Sarah Burr, Athumani Ramadhani, Patrick Massae, Aiweda Malisa, Tara Mtuy, Tamsyn Derrick, Anna R. Last, Meno Nabicassa, Eunice Cassama, Joanna Houghton, Christine D. Palmer, Harry Pickering, Matthew J. Burton, David C. W. Mabey, Robin L. Bailey, Martin R. Goodier, Martin J. Holland, Chrissy h. Roberts

Hum Genet. 2016; 135: 939–951. Published online 2016 Jun 16. doi: 10.1007/s00439-016-1694-2

PMCID:: PMC4947484

Abstract Article PDF–691K

Select item 485856518.

Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans

Lisa L. Liu, Johannes Landskron, Eivind H. Ask, Monika Enqvist, Ebba Sohlberg, James A. Traherne, Quirin Hammer, Jodie P. Goodridge, Stella Larsson, Jyothi Jayaraman, Vincent Y.S. Oei, Marie Schaffer, Kjetil Taskén, Hans-Gustaf Ljunggren, Chiara Romagnani, John Trowsdale, Karl-Johan Malmberg, Vivien Béziat

Cell Rep. 2016 May 3; 15(5): 1088–1099. Published online 2016 Apr 21. doi: 10.1016/j.celrep.2016.04.005

PMCID:: PMC4858565

Abstract Article PDF–3.9M

Select item 420695319.

Rapid NK cell differentiation in a population with near-universal human cytomegalovirus infection is attenuated by NKG2C deletions

Martin R. Goodier, Matthew J. White, Alansana Darboe, Carolyn M. Nielsen, Adriana Goncalves, Christian Bottomley, Sophie E. Moore, Eleanor M. Riley

Blood. 2014 Oct 2; 124(14): 2213–2222. Prepublished online 2014 Aug 22. doi: 10.1182/blood-2014-05-576124

PMCID:: PMC4206953

Abstract Article

Select item 401352720.

NKG2C^hiCD57⁺ Natural Killer cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus

Deborah W. Hendricks, Henry H. Balfour, Jr., Samantha K. Dunmire, David O. Schmeling, Kristin A. Hogquist, Lewis L. Lanier

J Immunol. Author manuscript; available in PMC 2015 May 15.

Published in final edited form as: J Immunol. 2014 May 15; 192(10): 4492–4496. Published online 2014 Apr 16. doi: 10.4049/jimmunol.1303211

PMCID:: PMC4013527

Abstract Article PDF–536K

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