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Select item 111083891.

Negative regulatory roles of ORMDL3 in the FcεRI-triggered expression of proinflammatory mediators and chemotactic response in murine mast cells

Viktor Bugajev, Ivana Halova, Lubica Draberova, Monika Bambouskova, Lucie Potuckova, Helena Draberova, Tomas Paulenda, Sergi Junyent, Petr Draber

Cell Mol Life Sci. 2016 Mar; 73(6): 1265–1285. Published online 2015 Sep 25. doi: 10.1007/s00018-015-2047-3

PMCID:: PMC11108389

Abstract Article PDF–2.3M

Select item 110743952.

Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis

Livia Demkova, Viktor Bugajev, Miroslava K. Adamcova, Ladislav Kuchar, Srdjan Grusanovic, Meritxell Alberich-Jorda, Petr Draber, Ivana Halova

Front Immunol. 2024; 15: 1376629. Published online 2024 Apr 23. doi: 10.3389/fimmu.2024.1376629

PMCID:: PMC11074395

Abstract Article PDF–4.3M

Select item 107722943.

Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis

Ryan D.R. Brown, Christopher D. Green, Cynthia Weigel, Bin Ni, Francesco S. Celi, Richard L. Proia, Sarah Spiegel

Mol Metab. 2024 Jan; 79: 101851. Published online 2023 Dec 9. doi: 10.1016/j.molmet.2023.101851

PMCID:: PMC10772294

Abstract Article PDF–4.1M

Select item 104632234.

ORMDL3‑mediated bronchial epithelial pyroptosis leads to lung inflammation in obese mice with asthma

Fan Liu, Yan Sun, Yun Zhou, Yuye Gao, Qijun Song, Jianmei Yang, Chao Xu, Guimei Li

Mol Med Rep. 2023 Oct; 28(4): 186. Published online 2023 Aug 17. doi: 10.3892/mmr.2023.13073

PMCID:: PMC10463223

Abstract Article PDF–12M

Select item 102672185.

Simultaneous reduction of all ORMDL proteins decreases the threshold of mast cell activation

Livia Demkova, Viktor Bugajev, Pavol Utekal, Ladislav Kuchar, Björn Schuster, Petr Draber, Ivana Halova

Sci Rep. 2023; 13: 9615. Published online 2023 Jun 14. doi: 10.1038/s41598-023-36344-5

PMCID:: PMC10267218

Abstract Article PDF–1.7M

Select item 101906076.

The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway

Yankun Shao, Yilin Xu, Huang Di, Xinxiu Shi, Yingying Wang, Hongyu Liu, Lina Song

IET Nanobiotechnol. 2023 May; 17(3): 182–196. Published online 2023 Jan 20. doi: 10.1049/nbt2.12113

PMCID:: PMC10190607

Abstract Article PDF–4.2M

Select item 101404917.

Ormdl3 regulation of specific ceramides is dispensable for mouse β-cell function and glucose homeostasis under obesogenic conditions

Liam D. Hurley, Hugo Lee, Gina Wade, Judith Simcox, Feyza Engin

Front Endocrinol (Lausanne) 2023; 14: 1170461. Published online 2023 Apr 14. doi: 10.3389/fendo.2023.1170461

PMCID:: PMC10140491

Abstract Article PDF–7.8M

Select item 99900768.

Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice

Briana N. James, Cynthia Weigel, Christopher D. Green, Ryan D. R. Brown, Elisa N. D. Palladino, Anuj Tharakan, Sheldon Milstien, Richard L. Proia, Rebecca K. Martin, Sarah Spiegel

FASEB J. 2023 Mar; 37(3): e22799. Published online 2023 Feb 8. doi: 10.1096/fj.202201821R

PMCID:: PMC9990076

Abstract Article PDF–12M

Select item 87624609.

Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation

Yu Song, Wenying Zan, Liping Qin, Shuang Han, Lili Ye, Molin Wang, Baichun Jiang, Pan Fang, Qiji Liu, Changshun Shao, Yaoqin Gong, Peishan Li

Mol Metab. 2022 Feb; 56: 101423. Published online 2021 Dec 22. doi: 10.1016/j.molmet.2021.101423

PMCID:: PMC8762460

Abstract Article PDF–5.5M

Select item 852704810.

Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways

Viktor Bugajev, Tomas Paulenda, Pavol Utekal, Michal Mrkacek, Ivana Halova, Ladislav Kuchar, Ondrej Kuda, Petra Vavrova, Björn Schuster, Sergio Fuentes-Liso, Lucie Potuckova, Daniel Smrz, Sara Cernohouzova, Lubica Draberova, Monika Bambouskova, Petr Draber

J Lipid Res. 2021; 62: 100121. Published online 2021 Sep 22. doi: 10.1016/j.jlr.2021.100121

PMCID:: PMC8527048

Abstract Article PDF–3.1M

Select item 793379311.

ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy–Dependent Pathway

Jia Li, Md Ashik Ullah, Hongping Jin, Yuting Liang, Lihui Lin, Juan Wang, Xia Peng, Huanjin Liao, Yanning Li, Yiqin Ge, Li Li

Front Immunol. 2021; 12: 604974. Published online 2021 Feb 19. doi: 10.3389/fimmu.2021.604974

PMCID:: PMC7933793

Abstract Article PDF–2.7M

Select item 790522412.

ORMDL2 Deficiency Potentiates the ORMDL3-Dependent Changes in Mast Cell Signaling

Viktor Bugajev, Ivana Halova, Livia Demkova, Sara Cernohouzova, Petra Vavrova, Michal Mrkacek, Pavol Utekal, Lubica Draberova, Ladislav Kuchar, Björn Schuster, Petr Draber

Front Immunol. 2020; 11: 591975. Published online 2021 Feb 11. doi: 10.3389/fimmu.2020.591975

PMCID:: PMC7905224

Abstract Article PDF–3.2M

Select item 761074913.

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

Nincy Debeuf, Assem Zhakupova, Regula Steiner, Sofie Van Gassen, Kim Deswarte, Farzaneh Fayazpour, Justine Van Moorleghem, Karl Vergote, Benjamin Pavie, Kelly Lemeire, Hamida Hammad, Thorsten Hornemann, Sophie Janssens, Bart N. Lambrecht

J Allergy Clin Immunol. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: J Allergy Clin Immunol. 2019 Dec 1; 144(6): 1648–1659.e9. Published online 2019 Jul 20. doi: 10.1016/j.jaci.2019.06.041

PMCID:: PMC7610749

Abstract Article PDF–1.9M

Select item 741599114.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 693438215.

The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice

Benjamin A Clarke, Saurav Majumder, Hongling Zhu, Y Terry Lee, Mari Kono, Cuiling Li, Caroline Khanna, Hailey Blain, Ronit Schwartz, Vienna L Huso, Colleen Byrnes, Galina Tuymetova, Teresa M Dunn, Maria L Allende, Richard L Proia

eLife. 2019; 8: e51067. Published online 2019 Dec 27. doi: 10.7554/eLife.51067

PMCID:: PMC6934382

Abstract Article PDF–2.7M

Select item 676469216.

Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock

Matthew L. Chang, Sanny Moussette, Enrique Gamero-Estevez, José Héctor Gálvez, Victoria Chiwara, Indra R. Gupta, Aimee K. Ryan, Anna K. Naumova

PLoS One. 2019; 14(9): e0223212. Published online 2019 Sep 27. doi: 10.1371/journal.pone.0223212

PMCID:: PMC6764692

Abstract Article PDF–1.9M

Select item 660528517.

Investigating the regulatory role of ORMDL3 in airway barrier dysfunction using in vivo and in vitro models

Ruixue Yang, Min Tan, Jianya Xu, Xia Zhao

Int J Mol Med. 2019 Aug; 44(2): 535–548. Published online 2019 Jun 6. doi: 10.3892/ijmm.2019.4233

PMCID:: PMC6605285

Abstract Article PDF–2.2M

Select item 629804018.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Abstract Article PDF–1.2M

Select item 621974819.

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

Konrad Aden, Florian Tran, Go Ito, Raheleh Sheibani-Tezerji, Simone Lipinski, Jan W. Kuiper, Markus Tschurtschenthaler, Svetlana Saveljeva, Joya Bhattacharyya, Robert Häsler, Kareen Bartsch, Anne Luzius, Marlene Jentzsch, Maren Falk-Paulsen, Stephanie T. Stengel, Lina Welz, Robin Schwarzer, Björn Rabe, Winfried Barchet, Stefan Krautwald, Gunther Hartmann, Manolis Pasparakis, Richard S. Blumberg, Stefan Schreiber, Arthur Kaser, Philip Rosenstiel

J Exp Med. 2018 Nov 5; 215(11): 2868–2886. doi: 10.1084/jem.20171029

PMCID:: PMC6219748

Abstract Article PDF–4.8M

Select item 542875120.

ORMDL3 is associated with airway remodeling in asthma via the ERK/MMP-9 pathway

Fei Yu, Yan Sun, Jiachen Yu, Zhen Ding, Jinrong Wang, Lanyun Zhang, Tiejing Zhang, Yun Bai, Yulin Wang

Mol Med Rep. 2017 May; 15(5): 2969–2976. Published online 2017 Mar 30. doi: 10.3892/mmr.2017.6413

PMCID:: PMC5428751

Abstract Article PDF–2.1M

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