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Select item 112511671.

MCM8 interacts with DDX5 to promote R-loop resolution

Canxin Wen, Lili Cao, Shuhan Wang, Weiwei Xu, Yongze Yu, Simin Zhao, Fan Yang, Zi-Jiang Chen, Shidou Zhao, Yajuan Yang, Yingying Qin

EMBO J. 2024 Jul; 43(14): 3044–3071. Published online 2024 Jun 10. doi: 10.1038/s44318-024-00134-0

PMCID:: PMC11251167

Abstract Article PDF–8.7M

Select item 105997412.

Reduction of double-strand DNA break repair exacerbates vascular aging

Samuel I. Bloom, Jordan R. Tucker, Daniel R. Machin, Hossein Abdeahad, AdeLola O. Adeyemo, Tyler G. Thomas, R. Colton Bramwell, Lisa A. Lesniewski, Anthony J. Donato

Aging (Albany NY) 2023 Oct 15; 15(19): 9913–9947. Published online 2023 Oct 2. doi: 10.18632/aging.205066

PMCID:: PMC10599741

Abstract Article PDF–1.3M

Select item 102834183.

ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4

Hao Wu, Qian Liu, Xinyi Shan, Weihua Gao, Quan Chen

Autophagy. 2023; 19(7): 2062–2077. Published online 2023 Feb 8. doi: 10.1080/15548627.2023.2170960

PMCID:: PMC10283418

Abstract Article PDF–5.7M

Select item 100932694.

Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance

Andrea Kuzelova, Naoko Dupacova, Barbora Antosova, Sweetu Susan Sunny, Zbynek Kozmik, Jr., Jan Paces, Arthur I. Skoultchi, Tomas Stopka, Zbynek Kozmik

Cells. 2023 Apr; 12(7): 1035. Published online 2023 Mar 28. doi: 10.3390/cells12071035

PMCID:: PMC10093269

Abstract Article PDF–21M

Select item 100232145.

ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen

Rifat Ara Najnin, Md Rasel Al Mahmud, Md Maminur Rahman, Shunichi Takeda, Hiroyuki Sasanuma, Hisashi Tanaka, Yasuhiro Murakawa, Naoto Shimizu, Salma Akter, Masatoshi Takagi, Takuro Sunada, Shusuke Akamatsu, Gang He, Junji Itou, Masakazu Toi, Mary Miyaji, Kimiko M. Tsutsui, Scott Keeney, Shintaro Yamada

Cell Rep. Author manuscript; available in PMC 2023 Mar 17.

Published in final edited form as: Cell Rep. 2023 Jan 31; 42(1): 111909. Published online 2022 Dec 30. doi: 10.1016/j.celrep.2022.111909

PMCID:: PMC10023214

Abstract Article PDF–1.8M

Select item 97914546.

Selective ablation of P53 in pancreatic beta cells fails to ameliorate glucose metabolism in genetic, dietary and pharmacological models of diabetes mellitus

Celina Uhlemeyer, Nadine Müller, Michael Rieck, Jennifer Kuboth, Caroline Schlegel, Kerstin Grieß, Tim Florian Dorweiler, Sonja Heiduschka, Jürgen Eckel, Michael Roden, Eckhard Lammert, Markus Stoffel, Bengt-Frederik Belgardt

Mol Metab. 2023 Jan; 67: 101650. Published online 2022 Dec 5. doi: 10.1016/j.molmet.2022.101650

PMCID:: PMC9791454

Abstract Article PDF–3.1M

Select item 97006007.

ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response

Amrita Sule, Sarah E. Golding, Syed F. Ahmad, James Watson, Mostafa H. Ahmed, Glen E. Kellogg, Tytus Bernas, Sean Koebley, Jason C. Reed, Lawrence F. Povirk, Kristoffer Valerie

Cell Mol Life Sci. 2022; 79(12): 603. Published online 2022 Nov 24. doi: 10.1007/s00018-022-04550-5

PMCID:: PMC9700600

Abstract Article PDF–3.6M

Select item 96039988.

Kidney Cyst Lining Epithelial Cells Are Resistant to Low-Dose Cisplatin-Induced DNA Damage in a Preclinical Model of Autosomal Dominant Polycystic Kidney Disease

Sayanthooran Saravanabavan, Gopala K. Rangan

Int J Mol Sci. 2022 Oct; 23(20): 12547. Published online 2022 Oct 19. doi: 10.3390/ijms232012547

PMCID:: PMC9603998

Abstract Article PDF–5.0M

Select item 95449569.

MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice

Samina Kazi, Julio M. Castañeda, Audrey Savolainen, Yiding Xu, Ning Liu, Huanyu Qiao, Ramiro Ramirez‐Solis, Kaori Nozawa, Zhifeng Yu, Martin M. Matzuk, Renata Prunskaite‐Hyyryläinen

FASEB J. 2022 Sep; 36(9): e22479. Published online 2022 Aug 3. doi: 10.1096/fj.202101168RR

PMCID:: PMC9544956

Abstract Article PDF–9.8M

Select item 930507710.

FATC domain deletion compromises ATM protein stability, lymphocyte development, and promotes lymphomagenesis

Maja Milanovic, Zhengping Shao, Verna M. Estes, Xiaobin S. Wang, Demis Menolfi, Xiaohui Lin, Brian J. Lee, Jun Xu, Olivia M. Cupo, Dong Wang, Shan Zha

J Immunol. Author manuscript; available in PMC 2022 Jul 22.

Published in final edited form as: J Immunol. 2021 Mar 15; 206(6): 1228–1239. Published online 2021 Feb 3. doi: 10.4049/jimmunol.2000967

PMCID:: PMC9305077

Abstract Article PDF–3.8M

Select item 924009211.

SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination

Estelle Vincendeau, Wenming Wei, Xuefei Zhang, Cyril Planchais, Wei Yu, Hélène Lenden-Hasse, Thomas Cokelaer, Juliana Pipoli da Fonseca, Hugo Mouquet, David J. Adams, Frederick W. Alt, Stephen P. Jackson, Gabriel Balmus, Chloé Lescale, Ludovic Deriano

Nat Commun. 2022; 13: 3707. Published online 2022 Jun 28. doi: 10.1038/s41467-022-31287-3

PMCID:: PMC9240092

Abstract Article PDF–3.7M

Select item 897411112.

Ataxia-televangelist mutated (ATM)/ ATR serine/threonine kinase (ATR)-mediated RAD51 recombinase (RAD51) promotes osteogenic differentiation and inhibits osteoclastogenesis in osteoporosis

Minli Qiu, Liudan Tu, Minjing Zhao, Mingcan Yang, Jun Qi, Ya Xie, Jieruo Gu

Bioengineered. 2022; 13(2): 4201–4211. Published online 2022 Feb 17. doi: 10.1080/21655979.2022.2026729

PMCID:: PMC8974111

Abstract Article PDF–2.6M

Select item 878603713.

Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation

Amit Kulkarni, Kumuda C. Das

Am J Physiol Lung Cell Mol Physiol. Author manuscript; available in PMC 2022 Jan 24.

Published in final edited form as: Am J Physiol Lung Cell Mol Physiol. 2008 May; 294(5): L998–L1006. Published online 2008 Mar 14. doi: 10.1152/ajplung.00004.2008

PMCID:: PMC8786037

Abstract Article PDF–1.8M

Select item 863544614.

Heart neurons use clock genes to control myocyte proliferation

Emmanouil Tampakakis, Harshi Gangrade, Stephanie Glavaris, Myo Htet, Sean Murphy, Brian Leei Lin, Ting Liu, Amir Saberi, Matthew Miyamoto, William Kowalski, Yoh-Suke Mukouyama, Gabsang Lee, Liliana Minichiello, Chulan Kwon

Sci Adv. 2021 Dec; 7(49): eabh4181. Published online 2021 Dec 1. doi: 10.1126/sciadv.abh4181

PMCID:: PMC8635446

Abstract Article PDF–6.2M

Select item 861683715.

De novo deletions and duplications at recombination hotspots in mouse germlines

Agnieszka Lukaszewicz, Julian Lange, Scott Keeney, Maria Jasin

Cell. Author manuscript; available in PMC 2022 Nov 24.

Published in final edited form as: Cell. 2021 Nov 24; 184(24): 5970–5984.e18. Published online 2021 Nov 17. doi: 10.1016/j.cell.2021.10.025

PMCID:: PMC8616837

Abstract Article PDF–2.6M

Select item 860166216.

A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation

Harvey Perez, May F Abdallah, Jose I Chavira, Angelina S Norris, Martin T Egeland, Karen L Vo, Callan L Buechsenschuetz, Valentina Sanghez, Jeannie L Kim, Molly Pind, Kotoka Nakamura, Geoffrey G Hicks, Richard A Gatti, Joaquin Madrenas, Michelina Iacovino, Peter J McKinnon, Paul J Mathews

eLife. 2021; 10: e64695. Published online 2021 Nov 1. doi: 10.7554/eLife.64695

PMCID:: PMC8601662

Abstract Article PDF–11M

Select item 858014817.

DNA Repair Inhibition Leads to Active Export of Repetitive Sequences to the Cytoplasm Triggering an Inflammatory Response

Xuan Song, Jacqueline T. M. Aw, Fulin Ma, Ming Fung Cheung, Danny Leung, Karl Herrup

J Neurosci. 2021 Nov 10; 41(45): 9286–9307. doi: 10.1523/JNEUROSCI.0845-21.2021

PMCID:: PMC8580148

Abstract Article PDF–8.8M

Select item 856411718.

Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons

Remi Akagawa, Yo-ichi Nabeshima, Takeshi Kawauchi

Front Cell Dev Biol. 2021; 9: 753175. Published online 2021 Oct 20. doi: 10.3389/fcell.2021.753175

PMCID:: PMC8564117

Abstract Article PDF–2.2M

Select item 851641219.

An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development

Benoit Roch, Vincent Abramowski, Olivier Etienne, Stefania Musilli, Pierre David, Jean-Baptiste Charbonnier, Isabelle Callebaut, François D Boussin, Jean-Pierre de Villartay

eLife. 2021; 10: e69353. Published online 2021 Sep 14. doi: 10.7554/eLife.69353

PMCID:: PMC8516412

Abstract Article PDF–10M

Select item 838671120.

ATM loss disrupts the autophagy-lysosomal pathway

Aifang Cheng, Kai-Hei Tse, Hei-Man Chow, Yunqiao Gan, Xuan Song, Fulin Ma, Yi Xuan Yvonne Qian, Weiyi She, Karl Herrup

Autophagy. 2021; 17(8): 1998–2010. Published online 2020 Aug 14. doi: 10.1080/15548627.2020.1805860

PMCID:: PMC8386711

Abstract Article PDF–7.2M

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