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Select item 112242691.

SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis

Surbhi Chouhan, Dhivya Sridaran, Cody Weimholt, Jingqin Luo, Tiandao Li, Myles C. Hodgson, Luana N. Santos, Samantha Le Sommer, Bin Fang, John M. Koomen, Markus Seeliger, Cheng-Kui Qu, Armelle Yart, Maria I. Kontaridis, Kiran Mahajan, Nupam P. Mahajan

Nat Commun. 2024; 15: 5629. Published online 2024 Jul 4. doi: 10.1038/s41467-024-49978-4

PMCID:: PMC11224269

Abstract Article PDF–2.1M

Select item 111363292.

How do Shp2 mutations that oppositely influence its biochemical activity result in syndromes with overlapping symptoms?

T. Edouard, A. Montagner, M. Dance, F. Conte, A. Yart, B. Parfait, M. Tauber, J. P. Salles, P. Raynal

Cell Mol Life Sci. 2007 Jul; 64(13): 1585–1590. Published online 2007 Apr 23. doi: 10.1007/s00018-007-6509-0

PMCID:: PMC11136329

Abstract Article PDF–123K

Select item 109702863.

Spectrum of Mutations in PTPN11 in Russian Cohort

Anna Orlova, Daria Guseva, Nina Demina, Aleksander Polyakov, Oksana Ryzhkova

Genes (Basel) 2024 Mar; 15(3): 345. Published online 2024 Mar 7. doi: 10.3390/genes15030345

PMCID:: PMC10970286

Abstract Article PDF–942K

Select item 109385174.

Clinical Variability in a Family with Noonan Syndrome with a Homozygous PTPN11 Gene Variant in Two Individuals

Ruken Yıldırım, Edip Ünal, Şervan Özalkak, Akçahan Akalın, Ayça Aykut, Nevzat Yılmaz

J Clin Res Pediatr Endocrinol. 2024 Mar; 16(1): 76–83. Published online 2024 Mar 11. doi: 10.4274/jcrpe.galenos.2023.2023-5-16

PMCID:: PMC10938517

Abstract Article PDF–503K

Select item 107814825.

M-CSF secreted by gastric cancer cells exacerbates the progression of gastric cancer by increasing the expression of SHP2 in tumor-associated macrophages

Shaohua Zhang, Dongfei Ren, Huiyu Hou, Li Yao, Hufang Yuan

Aging (Albany NY) 2023 Dec 31; 15(24): 15525–15534. Published online 2023 Dec 29. doi: 10.18632/aging.205390

PMCID:: PMC10781482

Abstract Article PDF–906K

Select item 107269036.

The clinical features and prognostic implications of PTPN11 mutation in adult patients with acute myeloid leukemia in China

Jinjun Yang, Lei Zhao, Yu Wu, Ting Niu, Yuping Gong, Xinchuan Chen, Xiaoou Huang, Jiazhuo Liu, Yang Dai, Hongbing Ma

Cancer Med. 2023 Dec; 12(23): 21111–21117. Published online 2023 Nov 8. doi: 10.1002/cam4.6669

PMCID:: PMC10726903

Abstract Article PDF–1.2M

Select item 106415247.

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis

Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley

J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295

PMCID:: PMC10641524

Abstract Article PDF–3.8M

Select item 106374678.

Fgf2 and Ptpn11 play a role in cerebral injury caused by sevoflurane anesthesia

Lin Zhang, Lingyan Xu

Medicine (Baltimore) 2023 Nov 10; 102(45): e36108. Published online 2023 Nov 10. doi: 10.1097/MD.0000000000036108

PMCID:: PMC10637467

Abstract Article PDF–1.3M

Select item 106029179.

PTPN11 Mosaicism Causes a Spectrum of Pigmentary and Vascular Neurocutaneous Disorders and Predisposes to Melanoma

Satyamaanasa Polubothu, Nicole Bender, Siobhan Muthiah, Davide Zecchin, Charalambos Demetriou, Sara Barberan Martin, Sony Malhotra, Jana Travnickova, Zhiqiang Zeng, Markus Böhm, Sebastien Barbarot, Catherine Cottrell, Olivia Davies, Eulalia Baselga, Nigel P. Burrows, Virginie Carmignac, Joey Santiago Diaz, Christine Fink, Holger A. Haenssle, Rudolf Happle, Mark Harland, Jacquelyn Majerowski, Pierre Vabres, Marie Vincent, Julia A. Newton-Bishop, D. Tim Bishop, Dawn Siegel, E. Elizabeth Patton, Maya Topf, Neil Rajan, Beth Drolet, Veronica A. Kinsler

J Invest Dermatol. 2023 Jun; 143(6): 1042–1051.e3. doi: 10.1016/j.jid.2022.09.661

PMCID:: PMC10602917

Abstract Article PDF–2.8M

Select item 1040899110.

MUC1-C IS NECESSARY FOR SHP2 ACTIVATION AND BRAF INHIBITOR RESISTANCE IN BRAF(V600E) MUTANT COLORECTAL CANCER

Yoshihiro Morimoto, Nami Yamashita, Haruka Hirose, Atsushi Fushimi, Naoki Haratake, Tatsuaki Daimon, Atrayee Bhattacharya, Rehan Ahmad, Yozo Suzuki, Hidekazu Takahashi, Donald W. Kufe

Cancer Lett. Author manuscript; available in PMC 2024 Apr 10.

Published in final edited form as: Cancer Lett. 2023 Apr 10; 559: 216116. Published online 2023 Mar 5. doi: 10.1016/j.canlet.2023.216116

PMCID:: PMC10408991

Abstract Article PDF–2.8M

Select item 1035321711.

LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection

Yuantao Li, Jingjing Guo, Haixia Zhang, Zhidan Li, Yushan Ren, Yuzhu Jiang, Xianbing Liu, Xuemei Hu

Parasit Vectors. 2023; 16: 237. Published online 2023 Jul 17. doi: 10.1186/s13071-023-05856-4

PMCID:: PMC10353217

Abstract Article PDF–4.9M

Select item 1032325212.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

Beverley Wilson, Chloe Flett, Jakub Gemperle, Craig Lawless, Matthew Hartshorn, Eleanor Hinde, Tess Harrison, Megan Chastney, Sarah Taylor, Jennifer Allen, Jim C. Norman, Thomas Zacharchenko, Patrick T. Caswell

J Cell Sci. 2023 Jun 15; 136(12): jcs260468. Published online 2023 Jun 23. doi: 10.1242/jcs.260468

PMCID:: PMC10323252

Abstract Article

Select item 1023742213.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1017534414.

Ganglioglioma with adverse clinical outcome and atypical histopathological features were defined by alterations in PTPN11/KRAS/NF1 and other RAS-/MAP-Kinase pathway genes

Lucas Hoffmann, Roland Coras, Katja Kobow, Javier A. López-Rivera, Dennis Lal, Costin Leu, Imad Najm, Peter Nürnberg, Jochen Herms, Patrick N. Harter, Christian G. Bien, Thilo Kalbhenn, Markus Müller, Tom Pieper, Till Hartlieb, Manfred Kudernatsch, Hajo Hamer, Sebastian Brandner, Karl Rössler, Ingmar Blümcke, Samir Jabari

Acta Neuropathol. 2023; 145(6): 815–827. Published online 2023 Mar 27. doi: 10.1007/s00401-023-02561-5

Correction in:: Acta Neuropathol. 2023; 145(6): 851–855.

PMCID:: PMC10175344

Abstract Article PDF–3.7M

Select item 1014079515.

Shp2 Deficiency in Kupffer Cells and Hepatocytes Aggravates Hepatocarcinogenesis by Recruiting Non-Kupffer Macrophages

Li Du, Yichun Ji, Bing Xin, Jiemeng Zhang, Li-Chun Lu, Christopher K. Glass, Gen-Sheng Feng

Cell Mol Gastroenterol Hepatol. 2023; 15(6): 1351–1369. Published online 2023 Feb 23. doi: 10.1016/j.jcmgh.2023.02.011

PMCID:: PMC10140795

Abstract Article PDF–7.5M

Select item 1012414016.

Potential clinical use of azacitidine and MEK inhibitor combination therapy in PTPN11-mutated juvenile myelomonocytic leukemia

Santhosh Kumar Pasupuleti, Karen Chao, Baskar Ramdas, Rahul Kanumuri, Lakshmi Reddy Palam, Sheng Liu, Jun Wan, Colleen Annesley, Mignon L. Loh, Elliot Stieglitz, Michael J. Burke, Reuben Kapur

Mol Ther. 2023 Apr 5; 31(4): 986–1001. Published online 2023 Feb 3. doi: 10.1016/j.ymthe.2023.01.030

PMCID:: PMC10124140

Abstract Article PDF–5.8M

Select item 1009977417.

Germline selection of PTPN11 (HGNC:9644) variants make a major contribution to both Noonan syndrome's high birth rate and the transmission of sporadic cancer variants resulting in fetal abnormality

Jordan Eboreime, Soo‐Kyung Choi, Song‐Ro Yoon, Anastasiia Sadybekov, Vsevolod Katritch, Peter Calabrese, Norman Arnheim

Hum Mutat. 2022 Dec; 43(12): 2205–2221. Published online 2022 Nov 24. doi: 10.1002/humu.24493

PMCID:: PMC10099774

Abstract Article PDF–1.5M

Select item 998681718.

METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m⁶A homeostasis

Zhan‐Cheng Zeng, Qi Pan, Yu‐Meng Sun, Heng‐Jing Huang, Xiao‐Tong Chen, Tian‐Qi Chen, Bo He, Hua Ye, Shun‐Xin Zhu, Ke‐Jia Pu, Ke Fang, Wei Huang, Yue‐Qin Chen, Wen‐Tao Wang

EMBO Rep. 2023 Mar; 24(3): e55762. Published online 2023 Jan 4. doi: 10.15252/embr.202255762

PMCID:: PMC9986817

Abstract Article PDF–3.5M

Select item 992794619.

SHP2 deneddylation mediates tumor immunosuppression in colon cancer via the CD47/SIRPα axis

Yiqing Li, Hui Zhou, Pan Liu, Dandan Lv, Yichun Shi, Bufu Tang, Jiaqi Xu, Tingting Zhong, Wangting Xu, Jie Zhang, Jianying Zhou, Kejing Ying, Yongchao Zhao, Yi Sun, Zhinong Jiang, Hongqiang Cheng, Xue Zhang, Yuehai Ke

J Clin Invest. 2023 Feb 15; 133(4): e162870. Published online 2023 Feb 15. doi: 10.1172/JCI162870

PMCID:: PMC9927946

Abstract Article PDF–28M

Select item 973798420.

A novel stop-gain pathogenic variant in FLT4 and a nonsynonymous pathogenic variant in PTPN11 associated with congenital heart defects

Avisa Tabib, Taravat Talebi, Serwa Ghasemi, Maryam Pourirahim, Niloofar Naderi, Majid Maleki, Samira Kalayinia

Eur J Med Res. 2022; 27: 286. Published online 2022 Dec 10. doi: 10.1186/s40001-022-00920-8

PMCID:: PMC9737984

Abstract Article PDF–2.3M

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