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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 88329732.

Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization

Cheng Chen, Lijie Gu, David J. Matye, Yung-Dai Clayton, Mohammad Nazmul Hasan, Yifeng Wang, Jacob E. Friedman, Tiangang Li

Proc Natl Acad Sci U S A. 2022 Feb 8; 119(6): e2111737119. Published online 2022 Feb 3. doi: 10.1073/pnas.2111737119

PMCID:: PMC8832973

Abstract Article PDF–2.2M

Select item 63839543.

Dual role of DMXL2 in olfactory information transmission and the first wave of spermatogenesis

Clara Gobé, Maëva Elzaiat, Nicolas Meunier, Marjolaine André, Eli Sellem, Patrice Congar, Luc Jouneau, Aurélie Allais-Bonnet, Ikrame Naciri, Bruno Passet, Eric Pailhoux, Maëlle Pannetier

PLoS Genet. 2019 Feb; 15(2): e1007909. Published online 2019 Feb 8. doi: 10.1371/journal.pgen.1007909

PMCID:: PMC6383954

Abstract Article PDF–3.2M

Select item 57856884.

Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells

Ki Beom Bae, Dong Hoon Yu, Kun Yeong Lee, Ke Yao, Joohyun Ryu, Do Young Lim, Tatyana A. Zykova, Myoung Ok Kim, Ann M. Bode, Zigang Dong

Stem Cell Reports. 2017 Dec 12; 9(6): 2050–2064. Published online 2017 Nov 16. doi: 10.1016/j.stemcr.2017.10.017

PMCID:: PMC5785688

Abstract Article PDF–4.3M

Select item 53812265.

Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function

Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang

Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626

PMCID:: PMC5381226

Abstract Article PDF–1.4M

Select item 52958216.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Abstract Article PDF–3.0M

Select item 43663547.

Both Ubiquitin Ligases FBXW8 and PARK2 Are Sequestrated into Insolubility by ATXN2 PolyQ Expansions, but Only FBXW8 Expression Is Dysregulated

Melanie Vanessa Halbach, Tanja Stehning, Ewa Damrath, Marina Jendrach, Nesli Ece Şen, A. Nazlı Başak, Georg Auburger

PLoS One. 2015; 10(3): e0121089. Published online 2015 Mar 19. doi: 10.1371/journal.pone.0121089

PMCID:: PMC4366354

Abstract Article PDF–3.6M

Select item 39010498.

Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signalling

Florian Scheufele, Benjamin Wolf, Michael Kruse, Thomas Hartmann, Justine Lempart, Susanne Mühlich, Andreas F. H. Pfeiffer, Loren J. Field, Maureen J. Charron, Zhen-Qiang Pan, Stefan Engelhardt, Antonio Sarikas

Cell Signal. Author manuscript; available in PMC 2015 Feb 1.

Published in final edited form as: Cell Signal. 2014 Feb; 26(2): 233–239. Published online 2013 Nov 9. doi: 10.1016/j.cellsig.2013.11.005

PMCID:: PMC3901049

Abstract Article PDF–684K

Select item 35349319.

mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8

Sung Jin Kim, Michael A. DeStefano, Won Jun Oh, Chang-chih Wu, Nicole M. Vega-Cotto, Monica Finlan, Dou Liu, Bing Su, Estela Jacinto

Mol Cell. Author manuscript; available in PMC 2013 Dec 28.

Published in final edited form as: Mol Cell. 2012 Dec 28; 48(6): 875–887. Published online 2012 Nov 8. doi: 10.1016/j.molcel.2012.09.029

PMCID:: PMC3534931

Abstract Article PDF–3.7M

Select item 343131110.

ATXN2-CAG42 Sequesters PABPC1 into Insolubility and Induces FBXW8 in Cerebellum of Old Ataxic Knock-In Mice

Ewa Damrath, Melanie V. Heck, Suzana Gispert, Mekhman Azizov, Joachim Nowock, Carola Seifried, Udo Rüb, Michael Walter, Georg Auburger

PLoS Genet. 2012 Aug; 8(8): e1002920. Published online 2012 Aug 30. doi: 10.1371/journal.pgen.1002920

PMCID:: PMC3431311

Abstract Article PDF–4.2M

Select item 326674211.

WD40 Repeat Propellers Define a Ubiquitin-Binding Domain that Regulates Turnover of F Box Proteins

Natasha Pashkova, Lokesh Gakhar, Stanley C. Winistorfer, Liping Yu, S. Ramaswamy, Robert C. Piper

Mol Cell. Author manuscript; available in PMC 2012 Jan 26.

Published in final edited form as: Mol Cell. 2010 Nov 12; 40(3): 433–443. doi: 10.1016/j.molcel.2010.10.018

PMCID:: PMC3266742

Abstract Article PDF–2.2M

Select item 326660012.

Genetic Reevaluation of the Role of F-Box Proteins in Cyclin D1 Degradation

Tomoharu Kanie, Ichiro Onoyama, Akinobu Matsumoto, Masanori Yamada, Hirokazu Nakatsumi, Yuki Tateishi, So Yamamura, Ryosuke Tsunematsu, Masaki Matsumoto, Keiichi I. Nakayama

Mol Cell Biol. 2012 Feb; 32(3): 590–605. doi: 10.1128/MCB.06570-11

PMCID:: PMC3266600

Abstract Article PDF–2.6M

Select item 317805913.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 309184214.

An OBSL1-Cul7^Fbxw8 Ubiquitin Ligase Signaling Mechanism Regulates Golgi Morphology and Dendrite Patterning

Nadia Litterman, Yoshiho Ikeuchi, Gilbert Gallardo, Brenda C. O'Connell, Mathew E. Sowa, Steven P. Gygi, J. Wade Harper, Azad Bonni

PLoS Biol. 2011 May; 9(5): e1001060. Published online 2011 May 10. doi: 10.1371/journal.pbio.1001060

PMCID:: PMC3091842

Abstract Article PDF–1.1M

Select item 302253415.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582