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Select item 111711011.

Single-Cell Profiling Reveals the Impact of Genetic Alterations on the Differentiation of Inflammation-Induced Murine Colon Tumors

Ahmed H. Ghobashi, Rosie Lanzloth, Christopher A. Ladaika, Ashiq Masood, Heather M. O’Hagan

Cancers (Basel) 2024 Jun; 16(11): 2040. Published online 2024 May 28. doi: 10.3390/cancers16112040

PMCID:: PMC11171101

Abstract Article PDF–9.3M

Select item 105622522.

Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity

Peter M. K. Westcott, Francesc Muyas, Haley Hauck, Olivia C. Smith, Nathan J. Sacks, Zackery A. Ely, Alex M. Jaeger, William M. Rideout, III, Daniel Zhang, Arjun Bhutkar, Mary C. Beytagh, David A. Canner, Grissel C. Jaramillo, Roderick T. Bronson, Santiago Naranjo, Abbey Jin, J. J. Patten, Amanda M. Cruz, Sean-Luc Shanahan, Isidro Cortes-Ciriano, Tyler Jacks

Nat Genet. 2023; 55(10): 1686–1695. Published online 2023 Sep 14. doi: 10.1038/s41588-023-01499-4

PMCID:: PMC10562252

Abstract Article PDF–18M

Select item 104175103.

Acetaldehyde and defective mismatch repair increase colonic tumours in a Lynch syndrome model with Aldh1b1 inactivation

Guia Cerretelli, Ying Zhou, Mike F. Müller, David J. Adams, Mark J. Arends

Dis Model Mech. 2023 Aug 1; 16(8): dmm050240. Published online 2023 Jul 31. doi: 10.1242/dmm.050240

PMCID:: PMC10417510

Abstract Article

Select item 101842994.

Recurrent frameshift neoantigen vaccine elicits protective immunity with reduced tumor burden and improved overall survival in a Lynch syndrome mouse model

J Gebert, O Gelincik, M Oezcan-Wahlbrink, JD Marshall, A Hernandez-Sanchez, K Urban, M Long, E Cortes, E Tosti, EM Katzenmaier, Y Song, A Elsaadi, N Deng, E Vilar, V Fuchs, N Nelius, Yuan, A Ahadova, S Sei, RH Shoemaker, A Umar, L Wei, S Liu, P Bork, W Edelmann, M von Knebel Doeberitz, SM Lipkin, M Kloor

Gastroenterology. Author manuscript; available in PMC 2023 May 15.

Published in final edited form as: Gastroenterology. 2021 Oct; 161(4): 1288–1302.e13. Published online 2021 Jul 2. doi: 10.1053/j.gastro.2021.06.073

Correction in:: Gastroenterology. 2021 Oct 14

PMCID:: PMC10184299

Abstract Article PDF–1.9M

Select item 100703885.

NAD⁺ repletion with niacin counteracts cancer cachexia

Marc Beltrà, Noora Pöllänen, Claudia Fornelli, Kialiina Tonttila, Myriam Y. Hsu, Sandra Zampieri, Lucia Moletta, Samantha Corrà, Paolo E. Porporato, Riikka Kivelä, Carlo Viscomi, Marco Sandri, Juha J. Hulmi, Roberta Sartori, Eija Pirinen, Fabio Penna

Nat Commun. 2023; 14: 1849. Published online 2023 Apr 3. doi: 10.1038/s41467-023-37595-6

PMCID:: PMC10070388

Abstract Article PDF–4.6M

Select item 99436606.

Unexpected moves: a conformational change in MutSα enables high-affinity DNA mismatch binding

Susanne R Bruekner, Wietske Pieters, Alexander Fish, A Manuel Liaci, Serge Scheffers, Emily Rayner, Daphne Kaldenbach, Lisa Drost, Marleen Dekker, Sandrine van Hees-Stuivenberg, Elly Delzenne-Goette, Charlotte de Konink, Hellen Houlleberghs, Hendrikus Jan Dubbink, Abeer AlSaegh, Niels de Wind, Friedrich Förster, Hein te Riele, Titia K Sixma

Nucleic Acids Res. 2023 Feb 22; 51(3): 1173–1188. Published online 2023 Jan 30. doi: 10.1093/nar/gkad015

PMCID:: PMC9943660

Abstract Article PDF–5.2M

Select item 99158627.

Ataxia Telangiectasia Mutated and MSH2 Control Blunt DNA End Joining in Ig Class Switch Recombination

Emily Sible, Mary Attaway, Giuseppe Fiorica, Genesis Michel, Jayanta Chaudhuri, Bao Q. Vuong

J Immunol. 2023 Feb 15; 210(4): 369–376. Published online 2023 Jan 4. doi: 10.4049/jimmunol.2200590

PMCID:: PMC9915862

Abstract Article PDF–822K

Select item 94819338.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 94252979.

FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation

Yuqing Feng, Conglei Li, Jessica A. Stewart, Philip Barbulescu, Noé Seija Desivo, Alejandro Álvarez-Quilón, Rossanna C. Pezo, Madusha L. W. Perera, Katherine Chan, Amy Hin Yan Tong, Rukshana Mohamad-Ramshan, Maribel Berru, Diana Nakib, Gavin Li, Gholam Ali Kardar, James R. Carlyle, Jason Moffat, Daniel Durocher, Javier M. Di Noia, Ashok S. Bhagwat, Alberto Martin

Nature. Author manuscript; available in PMC 2022 Aug 30.

Published in final edited form as: Nature. 2021 Dec; 600(7888): 324–328. Published online 2021 Nov 24. doi: 10.1038/s41586-021-04144-4

PMCID:: PMC9425297

Abstract Article PDF–4.9M

Select item 942158310.

Loss of MMR and TGFBR2 Increases the Susceptibility to Microbiota-Dependent Inflammation-Associated Colon Cancer

Elena Tosti, Ana S. Almeida, Tam T.T. Tran, Mariel Barbachan e Silva, Pilib Ó. Broin, Robert Dubin, Ken Chen, Amanda P. Beck, Andrew S. Mclellan, Eduardo Vilar, Aaron Golden, Paul W. O’Toole, Winfried Edelmann

Cell Mol Gastroenterol Hepatol. 2022; 14(3): 693–717. Published online 2022 Jun 7. doi: 10.1016/j.jcmgh.2022.05.010

PMCID:: PMC9421583

Abstract Article PDF–7.1M

Select item 929184311.

Ethanol‐induced formation of colorectal tumours and precursors in a mouse model of Lynch syndrome

Guia Cerretelli, Ying Zhou, Mike F Müller, David J Adams, Mark J Arends

J Pathol. 2021 Dec; 255(4): 464–474. Published online 2021 Oct 13. doi: 10.1002/path.5796

PMCID:: PMC9291843

Abstract Article PDF–19M

Select item 883246112.

DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis

Yanchuan Li, Xiaoping Xie, Zuliang Jie, Lele Zhu, Jin-Young Yang, Chun-Jung Ko, Tianxiao Gao, Antrix Jain, Sung Yun Jung, Natalia Baran, Marina Y. Konopleva, Xuhong Cheng, Shao-Cong Sun

Blood. 2021 Dec 9; 138(23): 2360–2371. doi: 10.1182/blood.2021011247

PMCID:: PMC8832461

Abstract Article

Select item 846387313.

Lactobacillus rhamnosus GG Orchestrates an Antitumor Immune Response

Joshua A. Owens, Bejan J. Saeedi, Crystal R. Naudin, Sarah Hunter-Chang, Maria E. Barbian, Richard U. Eboka, Lauren Askew, Trevor M. Darby, Brian S. Robinson, Rheinallt M. Jones

Cell Mol Gastroenterol Hepatol. 2021; 12(4): 1311–1327. Published online 2021 Jun 7. doi: 10.1016/j.jcmgh.2021.06.001

PMCID:: PMC8463873

Abstract Article PDF–6.6M

Select item 831820114.

The Transcriptomic Landscape of Mismatch Repair-Deficient Intestinal Stem Cells

Prashant V. Bommi, Charles M. Bowen, Laura Reyes-Uribe, Wenhui Wu, Hiroyuki Katayama, Pedro Rocha, Edwin R. Parra, Alejandro Francisco-Cruz, Zuhal Ozcan, Elena Tosti, Jason A. Willis, Hong Wu, Melissa W. Taggart, Jared K. Burks, Patrick M. Lynch, Winfried Edelmann, Paul Scheet, Ignacio I. Wistuba, Krishna M. Sinha, Samir M. Hanash, Eduardo Vilar

Cancer Res. Author manuscript; available in PMC 2021 Nov 15.

Published in final edited form as: Cancer Res. 2021 May 15; 81(10): 2760–2773. Published online 2021 Mar 18. doi: 10.1158/0008-5472.CAN-20-2896

PMCID:: PMC8318201

Abstract Article PDF–2.0M

Select item 830514015.

How to Obtain a Mega-Intestine with Normal Morphology: In Silico Modelling of Postnatal Intestinal Growth in a Cd97-Transgenic Mouse

Felix Hofmann, Torsten Thalheim, Karen Rother, Marianne Quaas, Christiane Kerner, Jens Przybilla, Gabriela Aust, Joerg Galle

Int J Mol Sci. 2021 Jul; 22(14): 7345. Published online 2021 Jul 8. doi: 10.3390/ijms22147345

PMCID:: PMC8305140

Abstract Article PDF–3.2M

Select item 774652716.

The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer

Eva Pastille, Marie-Hélène Wasmer, Alexandra Adamczyk, Vivian P. Vu, Lukas F. Mager, Nhi Ngo Thi Phuong, Vittoria Palmieri, Cedric Simillion, Wiebke Hansen, Stefan Kasper, Martin Schuler, Beat Muggli, Kathy D. McCoy, Jan Buer, Inti Zlobec, Astrid M. Westendorf, Philippe Krebs

Mucosal Immunol. 2019; 12(4): 990–1003. Published online 2019 Jun 5. doi: 10.1038/s41385-019-0176-y

PMCID:: PMC7746527

Abstract Article PDF–3.5M

Select item 761215317.

Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models

Amaia Martinez-Usatorre, Ece Kadioglu, Gael Boivin, Chiara Cianciaruso, Alan Guichard, Bruno Torchia, Nadine Zangger, Sina Nassiri, Ioanna Keklikoglou, Martina Schmittnaegel, Carola H. Ries, Etienne Meylan, Michele De Palma

Sci Transl Med. Author manuscript; available in PMC 2022 Feb 11.

Published in final edited form as: Sci Transl Med. 2021 Aug 11; 13(606): eabd1616. Published online 2021 Aug 11. doi: 10.1126/scitranslmed.abd1616

PMCID:: PMC7612153

Abstract Article PDF–3.9M

Select item 745420018.

Mechanistic insight into crossing over during mouse meiosis

Shaun E. Peterson, Scott Keeney, Maria Jasin

Mol Cell. Author manuscript; available in PMC 2021 Jun 18.

Published in final edited form as: Mol Cell. 2020 Jun 18; 78(6): 1252–1263.e3. Published online 2020 May 1. doi: 10.1016/j.molcel.2020.04.009

PMCID:: PMC7454200

Abstract Article PDF–4.0M

Select item 733725519.

Proteome instability is a therapeutic vulnerability in mismatch repair deficient cancer

Daniel J McGrail, Jeannine Garnett, Jun Yin, Hui Dai, David J.H. Shih, Truong Nguyen Anh Lam, Yang Li, Chaoyang Sun, Yongsheng Li, Rosemarie Schmandt, Ji Yuan Wu, Limei Hu, Yulong Liang, Guang Peng, Eric Jonasch, David Menter, Melinda S. Yates, Scott Kopetz, Karen Lu, Russell Broaddus, Gordon B. Mills, Nidhi Sahni, Shiaw-Yih Lin

Cancer Cell. Author manuscript; available in PMC 2021 Mar 16.

Published in final edited form as: Cancer Cell. 2020 Mar 16; 37(3): 371–386.e12. Published online 2020 Feb 27. doi: 10.1016/j.ccell.2020.01.011

PMCID:: PMC7337255

Abstract Article PDF–3.5M

Select item 715645220.

Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer

Thergiory Irrazabal, Bhupesh K. Thakur, Mingsong Kang, Yann Malaise, Catherine Streutker, Erin O. Y. Wong, Julia Copeland, Robert Gryfe, David S. Guttman, William W. Navarre, Alberto Martin

Nat Commun. 2020; 11: 1802. Published online 2020 Apr 14. doi: 10.1038/s41467-020-15549-6

PMCID:: PMC7156452

Abstract Article PDF–6.9M

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