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Select item 107575861.

Targeting the apelin system for the treatment of cardiovascular diseases

Fiona A Chapman, Janet J Maguire, David E Newby, Anthony P Davenport, Neeraj Dhaun

Cardiovasc Res. 2023 Dec; 119(17): 2683–2696. Published online 2023 Nov 13. doi: 10.1093/cvr/cvad171

PMCID:: PMC10757586

Abstract Article PDF–1.3M

Select item 104549952.

APLN: A potential novel biomarker for cervical cancer

Yusha Chen, Xiaoqian Lin, Jinwen Zheng, Jiancui Chen, Huifeng Xue, Xiangqin Zheng

Sci Prog. 2021 Apr-Jun; 104(2): 00368504211011341. Published online 2021 Apr 21. doi: 10.1177/00368504211011341

PMCID:: PMC10454995

Abstract Article PDF–1.6M

Select item 102131173.

Rbpj deficiency disrupts vascular remodeling via abnormal Apelin and Cdc42 activity in brain arteriovenous malformation

Subhodip Adhicary, Kayleigh Fanelli, Sera Nakisli, Brittney Ward, Isaac Pearce, Corinne M. Nielsen

Stroke. Author manuscript; available in PMC 2024 Jun 1.

Published in final edited form as: Stroke. 2023 Jun; 54(6): 1593–1605. Published online 2023 Apr 13. doi: 10.1161/STROKEAHA.122.041853

PMCID:: PMC10213117

Abstract Article PDF–1.4M

Select item 101795064.

Apelin as a Potential Regulator of Peak Athletic Performance

Roland Ligetvári, István Szokodi, Gabriella Far, Éva Csöndör, Ákos Móra, Zsolt Komka, Miklós Tóth, András Oláh, Pongrác Ács

Int J Mol Sci. 2023 May; 24(9): 8195. Published online 2023 May 3. doi: 10.3390/ijms24098195

PMCID:: PMC10179506

Abstract Article PDF–2.6M

Select item 99221965.

The Interaction of Apelin and FGFR1 Ameliorated the Kidney Fibrosis through Suppression of TGFβ-Induced Endothelial-to-Mesenchymal Transition

Rongfen Gao, Yumin Wu, Qian Yang, Liangdong Chen, Jiwei Chen, Boyong Wang, Zeming Liu, Juan Jin, Jinpeng Li, Gaosong Wu

Oxid Med Cell Longev. 2023; 2023: 5012474. Published online 2023 Feb 4. doi: 10.1155/2023/5012474

PMCID:: PMC9922196

Abstract Article PDF–3.9M

Select item 98305186.

Apelin promotes osteosarcoma metastasis by upregulating PLOD2 expression via the Hippo signaling pathway and hsa_circ_0000004/miR-1303 axis

Nguyen Thi Nha Trang, Chao-Yang Lai, Hsiao-Chi Tsai, Yuan-Li Huang, Shan-Chi Liu, Chun-Hao Tsai, Yi-Chin Fong, Huey-En Tzeng, Chih-Hsin Tang

Int J Biol Sci. 2023; 19(2): 412–425. Published online 2023 Jan 1. doi: 10.7150/ijbs.77688

PMCID:: PMC9830518

Abstract Article PDF–7.0M

Select item 97963177.

Apelin is expressed throughout the human kidney, is elevated in chronic kidney disease & associates independently with decline in kidney function

Duuamene Nyimanu, Fiona A. Chapman, Peter J. Gallacher, Rhoda E. Kuc, Thomas L. Williams, David E. Newby, Janet J. Maguire, Anthony P. Davenport, Neeraj Dhaun

Br J Clin Pharmacol. 2022 Dec; 88(12): 5295–5306. Published online 2022 Jul 19. doi: 10.1111/bcp.15446

PMCID:: PMC9796317

Abstract Article PDF–43M

Select item 97052938.

Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models

Ke Song, Xinyan Yang, Geng An, Xinyu Xia, Jiexiang Zhao, Xiaoheng Xu, Cong Wan, Tianyuan Liu, Yi Zheng, Shaofang Ren, Mei Wang, Gang Chang, Shane J. F. Cronin, Josef M. Penninger, Tao Jing, Xianghong Ou, Shuan Rao, Zhaoting Liu, Xiao-Yang Zhao

Nat Commun. 2022; 13: 7335. Published online 2022 Nov 28. doi: 10.1038/s41467-022-34990-3

PMCID:: PMC9705293

Abstract Article PDF–7.7M

Select item 96332859.

Apelin‐mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis

Yihan Zhu, Ying Yang, Hong Bu, Hong Huang, Hongyu Chen, Jingjing Ran, Liwen Qin, Yinyun Ni, Menglin Yao, Tingting Song, Mufeng Li, Yongfeng Yang, Tingting Guo, Ningning Chao, Zhiqing Liu, Weimin Li, Li Zhang

Cancer Sci. 2022 Nov; 113(11): 3722–3734. Published online 2022 Sep 10. doi: 10.1111/cas.15515

PMCID:: PMC9633285

Abstract Article PDF–12M

Select item 960053210.

Apelin Promotes Prostate Cancer Metastasis by Downregulating TIMP2 via Increases in miR-106a-5p Expression

Tien-Huang Lin, Sunny Li-Yun Chang, Pham Minh Khanh, Nguyen Thi Nha Trang, Shan-Chi Liu, Hsiao-Chi Tsai, An-Chen Chang, Jo-Yu Lin, Po-Chun Chen, Ju-Fang Liu, Jeng-Hung Guo, Chun-Lin Liu, Hsi-Chin Wu, Chih-Hsin Tang

Cells. 2022 Oct; 11(20): 3285. Published online 2022 Oct 19. doi: 10.3390/cells11203285

PMCID:: PMC9600532

Abstract Article PDF–6.0M

Select item 957335811.

Apelin-13 and Asprosin in Adolescents with Anorexia Nervosa and Their Association with Psychometric and Metabolic Variables

Katarzyna Jowik, Monika Dmitrzak-Węglarz, Natalia Pytlińska, Anna Jasińska-Mikołajczyk, Agnieszka Słopień, Marta Tyszkiewicz-Nwafor

Nutrients. 2022 Oct; 14(19): 4022. Published online 2022 Sep 28. doi: 10.3390/nu14194022

PMCID:: PMC9573358

Abstract Article PDF–605K

Select item 952664812.

High APLN Expression Predicts Poor Prognosis for Glioma Patients

Shuangyu Lv, Yang An, Huan Dong, Longxiang Xie, Hong Zheng, Xiaoxia Cheng, Lei Zhang, Tieshan Teng, Qiang Wang, Zhongyi Yan, Xiangqian Guo

Oxid Med Cell Longev. 2022; 2022: 8393336. Published online 2022 Sep 22. doi: 10.1155/2022/8393336

PMCID:: PMC9526648

Abstract Article PDF–3.0M

Select item 950350013.

Upregulated Apelin Signaling in Pancreatic Cancer Activates Oncogenic Signaling Pathways to Promote Tumor Development

Carline Chaves-Almagro, Johanna Auriau, Alizée Dortignac, Pascal Clerc, Hubert Lulka, Simon Deleruyelle, Fabrice Projetti, Jessica Nakhlé, Audrey Frances, Judit Berta, Véronique Gigoux, Daniel Fourmy, Marlène Dufresne, Anne Gomez-Brouchet, Julie Guillermet-Guibert, Pierre Cordelier, Bernard Knibiehler, Ralf Jockers, Philippe Valet, Yves Audigier, Bernard Masri

Int J Mol Sci. 2022 Sep; 23(18): 10600. Published online 2022 Sep 13. doi: 10.3390/ijms231810600

PMCID:: PMC9503500

Abstract Article PDF–37M

Select item 942286314.

Inhibition of APLN suppresses cell proliferation and migration and promotes cell apoptosis in esophageal cancer cells in vitro, through activating PI3K/mTOR signaling pathway

Yuhan Wang, Gang Wang, Xiaojun Liu, Dong Yun, Qing Cui, Xiaoting Wu, Wenfeng Lu, Xiwen Yang, Ming Zhang

Eur J Histochem. 2022 Jun 21; 66(3): 3336. Published online 2022 Aug 3. doi: 10.4081/ejh.2022.3336

PMCID:: PMC9422863

Abstract Article PDF–1.1M

Select item 934278115.

Apelin and its ratio to lipid factors are associated with cardiovascular diseases: A systematic review and meta-analysis

Hamed Akbari, Mahnaz Hosseini-Bensenjan, Sarvenaz Salahi, Fatemeh Moazzen, Hamid Aria, Alireza Manafi, Saeed Hosseini, Maryam Niknam, Gholamreza Asadikaram

PLoS One. 2022; 17(8): e0271899. Published online 2022 Aug 1. doi: 10.1371/journal.pone.0271899

PMCID:: PMC9342781

Abstract Article PDF–1.2M

Select item 929470716.

Apelin Association with Hepatic Fibrosis and Esophageal Varices in Patients with Chronic Hepatitis C Virus

Lamyaa Abdellatif Soliman, Rania A. Zayed, Dalia Omran, Fadwa Said, Samar Kamal Darweesh, Doaa Mohamed Ghaith, Rasha Eletreby, Mahmoud Salama Barakat, Mahmoud M. Bendary, Doaa Zakaria Zaky, Eman Amer, Iman Rifaat Elmahgoub

Am J Trop Med Hyg. 2022 Jul; 107(1): 190–197. Published online 2022 Jun 13. doi: 10.4269/ajtmh.21-0085