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Select item 112643351.

Dynamic RNA polymerase II occupancy drives differentiation of the intestine under the direction of HNF4

Kiranmayi Vemuri, Sneha Kumar, Lei Chen, Michael P. Verzi

Cell Rep. Author manuscript; available in PMC 2024 Jul 23.

Published in final edited form as: Cell Rep. 2024 Jun 25; 43(6): 114242. Published online 2024 May 19. doi: 10.1016/j.celrep.2024.114242

PMCID:: PMC11264335

Abstract Article PDF–2.0M

Select item 111784322.

Krüppel-like Factor 10 Protects Against Metabolic Dysfunction-Associated Steatohepatitis By Regulating HNF4α-mediated Metabolic Pathways

Xiaoli Pan, Shuwei Hu, Yanyong Xu, Raja Gopoju, Yingdong Zhu, Fathima N. Cassim Bawa, Hui Wang, Jiayou Wang, Zaid Batayneh, Alyssa Clark, Yuhao Zeng, Li Lin, Xinwen Wang, Liya Yin, Yanqiao Zhang

Metabolism. Author manuscript; available in PMC 2024 Jun 14.

Published in final edited form as: Metabolism. 2024 Jun; 155: 155909. Published online 2024 Apr 4. doi: 10.1016/j.metabol.2024.155909

PMCID:: PMC11178432

Abstract Article PDF–2.4M

Select item 110558693.

A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin

Wei Gu, Xiaofeng Huang, Pratik N. P. Singh, Sanlan Li, Ying Lan, Min Deng, Lauretta A. Lacko, Jesus M. Gomez-Salinero, Shahin Rafii, Michael P. Verzi, Ramesh A. Shivdasani, Qiao Zhou

Nat Commun. 2024; 15: 3595. Published online 2024 Apr 27. doi: 10.1038/s41467-024-47738-y

PMCID:: PMC11055869

Abstract Article PDF–4.4M

Select item 109176604.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 108615185.

HNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy

Yuxing Hou, Pengxi Shi, Haiyang Du, Chenghao Zhu, Chao Tang, Linli Que, Guoqing Zhu, Li Liu, Qi Chen, Chuanfu Li, Guoqiang Shao, Yuehua Li, Jiantao Li

Cell Death Dis. 2024 Feb; 15(2): 135. Published online 2024 Feb 12. doi: 10.1038/s41419-024-06470-7

PMCID:: PMC10861518

Abstract Article PDF–6.3M

Select item 108304836.

HNF4A guides the MLL4 complex to establish and maintain H3K4me1 at gene regulatory elements

Avinash Thakur, Kwangjin Park, Rebecca Cullum, Bettina M. Fuglerud, Mina Khoshnoodi, Sibyl Drissler, Tabea L. Stephan, Jeremy Lotto, Donghwan Kim, Frank J. Gonzalez, Pamela A. Hoodless

Commun Biol. 2024; 7: 144. Published online 2024 Jan 31. doi: 10.1038/s42003-024-05835-0

PMCID:: PMC10830483

Abstract Article PDF–13M

Select item 107897427.

ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function

Yue Zhu, Qinqin Wang, Xinyu Xie, Cuihong Ma, Yuemei Qiao, Yu Zhang, Yanjun Wu, Yuan Gao, Jing Jiang, Xin Liu, Jianfeng Chen, Chen Li, Gaoxiang Ge

Cell Death Dis. 2024 Jan; 15(1): 55. Published online 2024 Jan 15. doi: 10.1038/s41419-024-06441-y

PMCID:: PMC10789742

Abstract Article PDF–8.7M

Select item 107261358.

HNF4α isoforms regulate the circadian balance between carbohydrate and lipid metabolism in the liver

Jonathan R. Deans, Poonamjot Deol, Nina Titova, Sarah H. Radi, Linh M. Vuong, Jane R. Evans, Songqin Pan, Johannes Fahrmann, Jun Yang, Bruce D. Hammock, Oliver Fiehn, Baharan Fekry, Kristin Eckel-Mahan, Frances M. Sladek

Front Endocrinol (Lausanne) 2023; 14: 1266527. Published online 2023 Dec 4. doi: 10.3389/fendo.2023.1266527

PMCID:: PMC10726135

Abstract Article PDF–7.0M

Select item 106829339.

Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis

Samira Benhamouche-Trouillet, Evan O'Loughlin, Ching-Hui Liu, William Polacheck, Julien Fitamant, Mary McKee, Nabeel El-Bardeesy, Christopher S. Chen, Andrea I. McClatchey

Development. 2018 May 1; 145(9): dev162123. Published online 2018 Apr 30. doi: 10.1242/dev.162123

PMCID:: PMC10682933

Abstract Article

Select item 1068112010.

Keratin 79 is a PPARA target that is highly expressed by liver damage

Donghwan Kim, Inwook Choi, Sang Keun Ha, Frank J. Gonzalez

Biochem Biophys Res Commun. Author manuscript; available in PMC 2023 Nov 27.

Published in final edited form as: Biochem Biophys Res Commun. 2023 Apr 2; 650: 132–136. Published online 2023 Jan 30. doi: 10.1016/j.bbrc.2023.01.071

PMCID:: PMC10681120

Abstract Article PDF–1.0M

Select item 1059805311.

Protective roles of adiponectin and molecular signatures of HNF4α and PPARα as downstream targets of adiponectin in pancreatic β cells

Toshiharu Onodera, Dae-Seok Kim, Risheng Ye, May-Yun Wang, Shiuhwei Chen, Bianca C. Field, Leon Straub, Xue-Nan Sun, Chao Li, Charlotte Lee, Megan Paredes, Clair Crewe, Shangang Zhao, Christine M. Kusminski, Ruth Gordillo, Philipp E. Scherer

Mol Metab. 2023 Dec; 78: 101821. Published online 2023 Oct 6. doi: 10.1016/j.molmet.2023.101821

PMCID:: PMC10598053

Abstract Article PDF–4.3M

Select item 1047052012.

Spontaneous episodic inflammation in the intestines of mice lacking HNF4A is driven by microbiota and associated with early life microbiota alterations

Cecelia Kelly, Jayanth Jawahar, Lauren Davey, Jeffrey I. Everitt, Joseph A. Galanko, Chelsea Anderson, Jonathan E. Avendano, Jessica R. McCann, R. Balfour Sartor, Raphael H. Valdivia, John F. Rawls

mBio. 2023 Jul-Aug; 14(4): e01504-23. Published online 2023 Aug 1. doi: 10.1128/mbio.01504-23

PMCID:: PMC10470520

Abstract Article PDF–5.6M

Select item 1031840713.

Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus

Daniel A. Michelson, Chong Zuo, Michael Verzi, Christophe Benoist, Diane Mathis

J Exp Med. 2023 Oct 2; 220(10): e20230461. Published online 2023 Jul 3. doi: 10.1084/jem.20230461

PMCID:: PMC10318407

Abstract Article PDF–6.6M

Select item 1023199414.

Transcription factor HNF4α2 promotes osteogenesis and prevents bone abnormalities in mice with renal osteodystrophy

Marta Martinez-Calle, Guillaume Courbon, Bridget Hunt-Tobey, Connor Francis, Jadeah Spindler, Xueyan Wang, Luciene M. dos Reis, Carolina S.W. Martins, Isidro B. Salusky, Hartmut Malluche, Thomas L. Nickolas, Rosa M.A. Moyses, Aline Martin, Valentin David

J Clin Invest. 2023 Jun 1; 133(11): e159928. Published online 2023 Jun 1. doi: 10.1172/JCI159928

PMCID:: PMC10231994

Abstract Article PDF–13M

Select item 1018208015.

Pharmacologic inhibition of HNF4α prevents parenteral nutrition associated cholestasis in mice

Swati Ghosh, Michael W. Devereaux, David J. Orlicky, Ronald J. Sokol

Sci Rep. 2023; 13: 7752. Published online 2023 May 12. doi: 10.1038/s41598-023-33994-3

Correction in:: Sci Rep. 2023; 13: 11673.

PMCID:: PMC10182080

Abstract Article PDF–6.6M

Select item 1013828216.

MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes

Ritwik Datta, Mohammad A. Gholampour, Christopher D. Yang, Regan Volk, Sinan Lin, Michael J. Podolsky, Thomas Arnold, Florian Rieder, Balyn W. Zaro, Michael Verzi, Richard Lehner, Nada Abumrad, Carlos O. Lizama, Kamran Atabai

Cell Rep. Author manuscript; available in PMC 2023 Apr 27.

Published in final edited form as: Cell Rep. 2023 Mar 28; 42(3): 112249. Published online 2023 Mar 15. doi: 10.1016/j.celrep.2023.112249

PMCID:: PMC10138282

Abstract Article PDF–2.5M

Select item 998443417.

General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions

Susanna Säisä-Borreill, Guillaume Davidson, Thomas Kleiber, Andréa Thevenot, Elisabeth Martin, Stanislas Mondot, Hervé Blottière, Alexandra Helleux, Gabrielle Mengus, Michelina Plateroti, Isabelle Duluc, Irwin Davidson, Jean-Noel Freund

Cell Death Differ. 2023 Mar; 30(3): 839–853. Published online 2023 Jan 13. doi: 10.1038/s41418-022-01109-6

PMCID:: PMC9984434

Abstract Article PDF–8.1M

Select item 988872518.

Hepatic ribosomal protein S6 (Rps6) insufficiency results in failed bile duct development and loss of hepatocyte viability; a ribosomopathy-like phenotype that is partially p53-dependent

Sarah A. Comerford, Elizabeth A. Hinnant, Yidong Chen, Robert E. Hammer

PLoS Genet. 2023 Jan; 19(1): e1010595. Published online 2023 Jan 19. doi: 10.1371/journal.pgen.1010595

PMCID:: PMC9888725

Abstract Article PDF–6.9M

Select item 955156719.

KRAS protein expression becomes progressively restricted during embryogenesis and in adulthood

Marie-Albane Minati, Mohamad Assi, Maxime Libert, Sabine Cordi, Frédéric Lemaigre, Patrick Jacquemin

Front Cell Dev Biol. 2022; 10: 995013. Published online 2022 Sep 27. doi: 10.3389/fcell.2022.995013

PMCID:: PMC9551567

Abstract Article PDF–5.6M

Select item 942649020.

Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression

Sage E. Foley, Michael J. Dente, Xuqiu Lei, Benjamin F. Sallis, Ethan B. Loew, Mario Meza-Segura, Katherine A. Fitzgerald, Beth A. McCormick

mBio. 2022 Jul-Aug; 13(4): e01993-22. Published online 2022 Aug 15. doi: 10.1128/mbio.01993-22

PMCID:: PMC9426490

Abstract Article PDF–2.3M

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