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Items: 1 to 20 of 28

1.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
2.
Differential activity and expression of human 5β-reductase (AKR1D1) splice variants
Nathan Appanna, Hylton Gibson, Elena Gangitano, Niall J Dempster, Karen Morris, Sherly George, Anastasia Arvaniti, Laura L Gathercole, Brian Keevil, Trevor M Penning, Karl-Heinz Storbeck, Jeremy W Tomlinson, Nikolaos Nikolaou
J Mol Endocrinol. 2021 Mar; 66(3): 181–194. Published online 2021 Jan 12. doi: 10.1530/JME-20-0160
PMCID:
PMC7965358
AbstractArticlePDF–3.3M
3.
Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma
Pengfei Zhu, Ruo Feng, Xu Lu, Yuan Liao, Zhicheng Du, Wenlong Zhai, Kunlun Chen
Aging (Albany NY) 2021 Feb 15; 13(3): 4138–4156. Published online 2021 Jan 20. doi: 10.18632/aging.202380
PMCID:
PMC7906155
AbstractArticlePDF–2.3M
4.
先天性胆汁酸合成障碍2型一家系临床和遗传学分析:两个AKR1D1新突变的识别
程 映, 郭 丽, 邓 梅, 宋 元宗
Zhongguo Dang Dai Er Ke Za Zhi. 2017 Jul 25; 19(7): 734–740. Chinese. doi: 10.7499/j.issn.1008-8830.2017.07.002
PMCID:
PMC7389931
AbstractArticlePDF–2.8M
5.
AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells
Nikolaos Nikolaou, Laura L. Gathercole, Lucy Kirkwood, James E. Dunford, Beverly A. Hughes, Lorna C. Gilligan, Udo Oppermann, Trevor M. Penning, Wiebke Arlt, Leanne Hodson, Jeremy W. Tomlinson
J Steroid Biochem Mol Biol. Author manuscript; available in PMC 2020 Jul 22.
Published in final edited form as: J Steroid Biochem Mol Biol. 2019 May; 189: 218–227. Published online 2019 Feb 12. doi: 10.1016/j.jsbmb.2019.02.002
PMCID:
PMC7375835
AbstractArticlePDF–1.1M
6.
AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease
Nikolaos Nikolaou, Laura L. Gathercole, Lea Marchand, Sara Althari, Niall J. Dempster, Charlotte J. Green, Martijn van de Bunt, Catriona McNeil, Anastasia Arvaniti, Beverly A. Hughes, Bruno Sgromo, Richard S. Gillies, Hanns-Ulrich Marschall, Trevor M. Penning, John Ryan, Wiebke Arlt, Leanne Hodson, Jeremy W. Tomlinson
Metabolism. 2019 Oct; 99: 67–80. doi: 10.1016/j.metabol.2019.153947
PMCID:
PMC6744372
AbstractArticle
7.
Dysregulation of Δ4-3-oxosteroid 5β-reductase in Diabetic Patients: Implications and Mechanisms
Leila Valanejad, Mwlod Ghareeb, Stephanie Shiffka, Christina Nadolny, Yuan Chen, Liangran Guo, Ruchi Verma, Sangmin You, Fatemeh Akhlaghi, Ruitang Deng
Mol Cell Endocrinol. Author manuscript; available in PMC 2019 Jul 15.
Published in final edited form as: Mol Cell Endocrinol. 2018 Jul 15; 470: 127–141. Published online 2017 Oct 9. doi: 10.1016/j.mce.2017.10.005
PMCID:
PMC5891389
AbstractArticlePDF–923K
8.
Architecture of the human interactome defines protein communities and disease networks
Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper
Nature. Author manuscript; available in PMC 2017 Nov 17.
Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366
PMCID:
PMC5531611
AbstractArticlePDF–2.7M
9.
In-Depth Dissection of the P133R Mutation in Steroid 5β-Reductase (AKR1D1): A Molecular Basis of Bile Acid Deficiency
Mo Chen, Yi Jin, Trevor M. Penning
Biochemistry. Author manuscript; available in PMC 2016 Oct 20.
Published in final edited form as: Biochemistry. 2015 Oct 20; 54(41): 6343–6351. Published online 2015 Oct 6. doi: 10.1021/acs.biochem.5b00816
PMCID:
PMC4696769
AbstractArticlePDF–986K
10.
The BioPlex Network: A Systematic Exploration of the Human Interactome
Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2016 Jul 16.
Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043
PMCID:
PMC4617211
AbstractArticlePDF–2.2M
11.
The Rate-determining Steps of Aldo-keto Reductases (AKRs), a Study on Human Steroid 5β-Reductase (AKR1D1)
Mo Chen, Yi Jin, Trevor M. Penning
Chem Biol Interact. Author manuscript; available in PMC 2016 Jun 5.
Published in final edited form as: Chem Biol Interact. 2015 Jun 5; 234: 360–365. Published online 2014 Dec 11. doi: 10.1016/j.cbi.2014.12.004
PMCID:
PMC4414691
AbstractArticlePDF–910K
12.
Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis
Yi Jin, Mo Chen, Trevor M. Penning
Biochem J. Author manuscript; available in PMC 2015 Aug 15.
Published in final edited form as: Biochem J. 2014 Aug 15; 462(1): 163–171. doi: 10.1042/BJ20140220
PMCID:
PMC4163838
AbstractArticlePDF–961K
13.
Genetic Variation in Aldo-Keto Reductase 1D1 (AKR1D1) Affects the Expression and Activity of Multiple Cytochrome P450s
Amarjit S. Chaudhry, Ranjit K. Thirumaran, Kazuto Yasuda, Xia Yang, Yiping Fan, Stephen C. Strom, Erin G. Schuetz
Drug Metab Dispos. 2013 Aug; 41(8): 1538–1547. Published online 2013 Aug. doi: 10.1124/dmd.113.051672
Correction in:
Drug Metab Dispos. 2014 May; 42(5): 917.
PMCID:
PMC4162005
AbstractArticlePDF–906K
14.
An atlas of genetic influences on human blood metabolites
So-Youn Shin, Eric B. Fauman, Ann-Kristin Petersen, Jan Krumsiek, Rita Santos, Jie Huang, Matthias Arnold, Idil Erte, Vincenzo Forgetta, Tsun-Po Yang, Klaudia Walter, Cristina Menni, Lu Chen, Louella Vasquez, Ana M. Valdes, Craig L. Hyde, Vicky Wang, Daniel Ziemek, Phoebe Roberts, Li Xi, Elin Grundberg, The Multiple Tissue Human Expression Resource (MuTHER) Consortium, Melanie Waldenberger, J. Brent Richards, Robert P. Mohney, Michael V. Milburn, Sally L. John, Jeff Trimmer, Fabian J. Theis, John P. Overington, Karsten Suhre, M. Julia Brosnan, Christian Gieger, Gabi Kastenmüller, Tim D Spector, Nicole Soranzo
Nat Genet. Author manuscript; available in PMC 2014 Dec 1.
Published in final edited form as: Nat Genet. 2014 Jun; 46(6): 543–550. Published online 2014 May 11. doi: 10.1038/ng.2982
PMCID:
PMC4064254
AbstractArticlePDF–2.4M
15.
5β-Reduced Steroids and Human Δ4-3-Ketosteroid 5β-Reductase (AKR1D1)
Mo Chen, Trevor M. Penning
Steroids. Author manuscript; available in PMC 2015 May 1.
Published in final edited form as: Steroids. 2014 May; 83: 17–26. Published online 2014 Feb 8. doi: 10.1016/j.steroids.2014.01.013
PMCID:
PMC3971473
AbstractArticlePDF–2.6M
16.
Role of Aldo-Keto Reductase Family 1 (AKR1) Enzymes in Human Steroid Metabolism
Tea Lanišnik Rižner, Trevor M. Penning
Steroids. Author manuscript; available in PMC 2015 Jan 1.
Published in final edited form as: Steroids. 2014 Jan; 79: 10.1016/j.steroids.2013.10.012. Published online 2013 Nov 1. doi: 10.1016/j.steroids.2013.10.012
PMCID:
PMC3870468
AbstractArticlePDF–1.3M
17.
A combination of mutations in AKR1D1 and SKIV2L in a family with severe infantile liver disease
Neil V Morgan, Jane L Hartley, Kenneth DR Setchell, Michael A Simpson, Rachel Brown, Louise Tee, Sian Kirkham, Shanaz Pasha, Richard C Trembath, Eamonn R Maher, Paul Gissen, Deirdre A Kelly
Orphanet J Rare Dis. 2013; 8: 74. Published online 2013 May 16. doi: 10.1186/1750-1172-8-74
PMCID:
PMC3659031
AbstractArticlePDF–344K
18.
Genome-wide association of mood-incongruent psychotic bipolar disorder
F S Goes, M L Hamshere, F Seifuddin, M Pirooznia, P Belmonte-Mahon, R Breuer, T Schulze, M Nöthen, S Cichon, M Rietschel, P Holmans, P P Zandi, Bipolar Genome Study (BiGS), N Craddock, J B Potash
Transl Psychiatry. 2012 Oct; 2(10): e180. Published online 2012 Oct 23. doi: 10.1038/tp.2012.106
PMCID:
PMC3565814
AbstractArticlePDF–489K
19.
Conversion of Human Steroid 5β-Reductase (AKR1D1) into 3β-Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING
Mo Chen, Jason E. Drury, David W. Christianson, Trevor M. Penning
J Biol Chem. 2012 May 11; 287(20): 16609–16622. Published online 2012 Mar 20. doi: 10.1074/jbc.M111.338780
PMCID:
PMC3351325
AbstractArticlePDF–2.6M
20.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M

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