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Items: 1 to 20 of 287

1.
Circadian regulation of MGMT expression and promoter methylation underlies daily rhythms in TMZ sensitivity in glioblastoma
Maria F. Gonzalez-Aponte, Anna R. Damato, Laura Lucía Trebucq, Tatiana Simon, Sandra P. Cárdenas-García, Kevin Cho, Gary J. Patti, Diego A. Golombek, Juan José Chiesa, Joshua B. Rubin, Erik D. Herzog
J Neurooncol. Author manuscript; available in PMC 2024 Aug 6.
Published in final edited form as: J Neurooncol. 2024 Feb; 166(3): 419–430. Published online 2024 Jan 26. doi: 10.1007/s11060-023-04535-9
PMCID:
PMC11301575
AbstractArticlePDF–955K
2.
Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non‐small‐cell lung cancer
Min Kim, Hyo‐Gyoung Kang, Shin Yup Lee, Hyung Cheol Lee, Eung Bae Lee, Yi Young Choi, Won Kee Lee, Sukki Cho, Guang Jin, Hyo‐Sung Jheon, Ji Woong Son, Myung‐Hoon Lee, Deuk Kju Jung, Seung Ick Cha, Chang Ho Kim, Young Mo Kang, Sin Kam, Tae Hoon Jung, Sanghoon Jheon, Jae Yong Park
Cancer Sci. 2010 Nov; 101(11): 2436–2442. Published online 2010 Jul 31. doi: 10.1111/j.1349-7006.2010.01699.x
PMCID:
PMC11159840
AbstractArticlePDF–209K
3.
MiR‐195, miR‐196b, miR‐181c, miR‐21 expression levels and O‐6‐methylguanine‐DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patients
Radek Lakomy, Jiri Sana, Simona Hankeova, Pavel Fadrus, Leos Kren, Eva Lzicarova, Marek Svoboda, Hana Dolezelova, Martin Smrcka, Rostislav Vyzula, Jaroslav Michalek, Marian Hajduch, Ondrej Slaby
Cancer Sci. 2011 Dec; 102(12): 2186–2190. Published online 2011 Oct 12. doi: 10.1111/j.1349-7006.2011.02092.x
PMCID:
PMC11158343
AbstractArticlePDF–216K
4.
Constitutional BRCA1 and MGMT Methylation Are Significant Risk Factors for Triple-Negative Breast Cancer and High-Grade Serous Ovarian Cancer in Saudi Women
Nisreen Al-Moghrabi, Maram Al-Showimi, Amal Alqahtani, Osama Almalik, Hamed Alhusaini, Ghdah Almalki, Ajawhara Saad, Elaf Alsunayi
Int J Mol Sci. 2024 Mar; 25(6): 3108. Published online 2024 Mar 7. doi: 10.3390/ijms25063108
PMCID:
PMC10970267
AbstractArticlePDF–1.0M
5.
Proteomic and metabolomic analyses illustrate the mechanisms of expression of the O6‐methylguanine‐DNA methyltransferase gene in glioblastoma
Xi Chen, Jinli Sun, Yukui Li, Weichao Jiang, Zhangyu Li, Jianyao Mao, Liwei Zhou, Sifang Chen, Guowei Tan
CNS Neurosci Ther. 2024 Feb; 30(2): e14415. Published online 2023 Aug 28. doi: 10.1111/cns.14415
PMCID:
PMC10848106
AbstractArticlePDF–14M
6.
Glioblastoma with high O6-methyl-guanine DNA methyltransferase expression are more immunologically active than tumors with low MGMT expression
Yoshihiro Kushihara, Shota Tanaka, Yukari Kobayashi, Koji Nagaoka, Miyu Kikuchi, Takahide Nejo, Erika Yamazawa, Shohei Nambu, Kazuha Kugasawa, Hirokazu Takami, Shunsaku Takayanagi, Nobuhito Saito, Kazuhiro Kakimi
Front Immunol. 2024; 15: 1328375. Published online 2024 Jan 15. doi: 10.3389/fimmu.2024.1328375
PMCID:
PMC10824125
AbstractArticlePDF–6.4M
7.
Preferential MGMT hypermethylation in SDH-deficient wild-type GIST
Olivier T Giger, Rogier ten Hoopen, David Shorthouse, Shukri Abdullahi, Venkata Ramesh Bulusu, Saili Jadhav, Eamonn R Maher, Ruth T Casey
J Clin Pathol. 2024 Jan; 77(1): 34–39. Published online 2022 Oct 5. doi: 10.1136/jcp-2022-208462
PMCID:
PMC10804026
AbstractArticlePDF–458K
8.
Cognitive functioning is prognostic in patients with IDH1-wild type and MGMT-unmethylated high-grade gliomas
Uroš Smrdel, Andreja Cirila Škufca Smrdel, Anja Podlesek, Marija Skoblar Vidmar, Gregor Kos, Jana Markovic, Jana Jereb, Jana Knific, Tina Rus
Croat Med J. 2023 Dec; 64(6): 383–390. doi: 10.3325/cmj.2023.64.383
PMCID:
PMC10797236
AbstractArticlePDF–373K
9.
Pyrosequencing Analysis of O-6-Methylguanine-DNA Methyltransferase Methylation at Different Cut-Offs of Positivity Associated with Treatment Response and Disease-Specific Survival in Isocitrate Dehydrogenase-Wildtype Grade 4 Glioblastoma
Fábio França Vieira e Silva, Marina Di Domenico, Vito Carlo Alberto Caponio, Mario Pérez-Sayáns, Gisela Cristina Vianna Camolesi, Laura Isabel Rojo-Álvarez, Andrea Ballini, Abel García-García, María Elena Padín-Iruegas, Jose Manuel Suaréz-Peñaranda
Int J Mol Sci. 2024 Jan; 25(1): 612. Published online 2024 Jan 3. doi: 10.3390/ijms25010612
PMCID:
PMC10779484
AbstractArticlePDF–1.9M
10.
Mass Spectrometric Analysis of the Active Site Tryptic Peptide of Recombinant O6-Methylguanine-DNA Methyltransferase Following Incubation with Human Colorectal DNA Reveals the Presence of an O6-Alkylguanine Adductome
Rasha Abdelhady, Pattama Senthong, Claire E. Eyers, Onrapak Reamtong, Elizabeth Cowley, Luca Cannizzaro, Joanna Stimpson, Kathleen Cain, Oliver J. Wilkinson, Nicholas H. Williams, Perdita E. Barran, Geoffrey P. Margison, David M. Williams, Andrew C. Povey
Chem Res Toxicol. 2023 Dec 18; 36(12): 1921–1929. Published online 2023 Nov 20. doi: 10.1021/acs.chemrestox.3c00207
PMCID:
PMC10731659
AbstractArticlePDF–3.4M
11.
Variant allelic frequencies of driver mutations can identify gliomas with potentially false-negative MGMT promoter methylation results
Matthew McCord, Pouya Jamshidi, Vineeth Thirunavu, Lucas Santana-Santos, Erica Vormittag-Nocito, David Dittman, Stephanie Parker, Joseph Baczkowski, Lawrence Jennings, Jordain Walshon, Kathleen McCortney, Kristyn Galbraith, Hui Zhang, Rimas V. Lukas, Roger Stupp, Karan Dixit, Priya Kumthekar, Amy B. Heimberger, Matija Snuderl, Craig Horbinski
Acta Neuropathol Commun. 2023; 11: 175. Published online 2023 Nov 2. doi: 10.1186/s40478-023-01680-0
PMCID:
PMC10623846
AbstractArticlePDF–2.3M
12.
ERCC1 and MGMT Methylation as a Predictive Marker of Relapse and FOLFOX Response in Colorectal Cancer Patients from South Tunisia
Dhouha Jamai, Raja Gargouri, Boulbaba Selmi, Abdelmajid Khabir
Genes (Basel) 2023 Jul; 14(7): 1467. Published online 2023 Jul 19. doi: 10.3390/genes14071467
PMCID:
PMC10379058
AbstractArticlePDF–1.3M
13.
Treatment benefit in patients aged 80 years or older with biopsy-proven and non-resected glioblastoma is dependent on MGMT promoter methylation status
Jonathan Weller, Sophie Katzendobler, Sebastian Niedermeyer, Patrick N. Harter, Jochen Herms, Christoph Trumm, Maximilian Niyazi, Niklas Thon, Joerg-Christian Tonn, Veit M. Stoecklein
J Neurooncol. 2023; 163(2): 407–415. Published online 2023 Jun 8. doi: 10.1007/s11060-023-04362-y
PMCID:
PMC10322768
AbstractArticlePDF–1.3M
14.
Association between MGMT Enhancer Methylation and MGMT Promoter Methylation, MGMT Protein Expression, and Overall Survival in Glioblastoma
Katja Zappe, Katharina Pühringer, Simon Pflug, Daniel Berger, Andreas Böhm, Sabine Spiegl-Kreinecker, Margit Cichna-Markl
Cells. 2023 Jun; 12(12): 1639. Published online 2023 Jun 15. doi: 10.3390/cells12121639
PMCID:
PMC10297309
AbstractArticlePDF–8.0M
15.
Association of MGMT Promoter Methylation With Survival in Low-grade and Anaplastic Gliomas After Alkylating Chemotherapy
Connor J. Kinslow, Ann Mercurio, Prashanth Kumar, Ali I. Rae, Markus D. Siegelin, Jack Grinband, Kekoa Taparra, Pavan S. Upadhyayula, Guy M. McKhann, Michael B. Sisti, Jeffrey N. Bruce, Peter D. Canoll, Fabio M. Iwamoto, Lisa A. Kachnic, James B. Yu, Simon K. Cheng, Tony J. C. Wang
JAMA Oncol. 2023 Jul; 9(7): 919–927. Published online 2023 May 18. doi: 10.1001/jamaoncol.2023.0990
Correction in:
JAMA Oncol. 2023 Jul; 9(7): 1009.
PMCID:
PMC10196932
AbstractArticle
16.
MGMT is frequently inactivated in pancreatic NET-G2 and is associated with the therapeutic activity of STZ-based regimens
Kohei Yagi, Hiroaki Ono, Atsushi Kudo, Yuko Kinowaki, Daisuke Asano, Shuichi Watanabe, Yoshiya Ishikawa, Hiroki Ueda, Keiichi Akahoshi, Shinji Tanaka, Minoru Tanabe
Sci Rep. 2023; 13: 7535. Published online 2023 May 9. doi: 10.1038/s41598-023-34666-y
PMCID:
PMC10170117
AbstractArticlePDF–1.8M
17.
Influence of MMR, MGMT Promotor Methylation and Protein Expression on Overall and Progression-Free Survival in Primary Glioblastoma Patients Treated with Temozolomide
Konstantin R. Brawanski, Susanne Sprung, Christian F. Freyschlag, Romana Hoeftberger, Thomas Ströbel, Johannes Haybaeck, Claudius Thomé, Claudia Manzl, Anna M. Birkl-Toeglhofer
Int J Mol Sci. 2023 Apr; 24(7): 6184. Published online 2023 Mar 24. doi: 10.3390/ijms24076184
PMCID:
PMC10094528
AbstractArticlePDF–2.0M
18.
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain
Lisa Marie Weber, Yulin Jia, Bastian Stielow, Stephen S Gisselbrecht, Yinghua Cao, Yanpeng Ren, Iris Rohner, Jessica King, Elisabeth Rothman, Sabrina Fischer, Clara Simon, Ignasi Forné, Andrea Nist, Thorsten Stiewe, Martha L Bulyk, Zhanxin Wang, Robert Liefke
Nucleic Acids Res. 2023 Jan 25; 51(2): 574–594. Published online 2022 Dec 20. doi: 10.1093/nar/gkac1188
PMCID:
PMC9881136
AbstractArticlePDF–4.4M
19.
ProNGF Expression and Targeting in Glioblastoma Multiforme
Mark Marsland, Amiee Dowdell, Sam Faulkner, Phillip Jobling, Robert A. Rush, Craig Gedye, James Lynam, Cassandra P. Griffin, Mark Baker, Joanne Marsland, Chen Chen Jiang, Hubert Hondermarck
Int J Mol Sci. 2023 Jan; 24(2): 1616. Published online 2023 Jan 13. doi: 10.3390/ijms24021616
PMCID:
PMC9863529
AbstractArticlePDF–4.2M
20.
The Significance of MGMT Promoter Methylation Status in Diffuse Glioma
Nikola Jovanović, Milica Lazarević, Vladimir J. Cvetković, Vesna Nikolov, Jelena Kostić Perić, Milena Ugrin, Sonja Pavlović, Tatjana Mitrović
Int J Mol Sci. 2022 Nov; 23(21): 13034. Published online 2022 Oct 27. doi: 10.3390/ijms232113034
PMCID:
PMC9654114
AbstractArticlePDF–2.8M

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