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Select item 74594101.

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models

Ramanath Narayana Hegde, Anass Chiki, Lara Petricca, Paola Martufi, Nicolas Arbez, Laurent Mouchiroud, Johan Auwerx, Christian Landles, Gillian P Bates, Malvindar K Singh‐Bains, Mike Dragunow, Maurice A Curtis, Richard LM Faull, Christopher A Ross, Andrea Caricasole, Hilal A Lashuel

EMBO J. 2020 Sep 1; 39(17): e104671. Published online 2020 Aug 5. doi: 10.15252/embj.2020104671

PMCID:: PMC7459410

Abstract Article PDF–3.0M

Select item 67927272.

Interaction of Huntingtin-Associated Protein with Dynactin P150^Glued

Shi-Hua Li, Claire-Anne Gutekunst, Steven M. Hersch, Xiao-Jiang Li

J Neurosci. 1998 Feb 15; 18(4): 1261–1269. doi: 10.1523/JNEUROSCI.18-04-01261.1998

PMCID:: PMC6792727

Abstract Article PDF–357K

Select item 67629123.

Neurons Lacking Huntingtin Differentially Colonize Brain and Survive in Chimeric Mice

Anton Reiner, Nobel Del Mar, Christopher A. Meade, Huaitao Yang, Ioannis Dragatsis, Scott Zeitlin, Daniel Goldowitz

J Neurosci. 2001 Oct 1; 21(19): 7608–7619. doi: 10.1523/JNEUROSCI.21-19-07608.2001

PMCID:: PMC6762912

Abstract Article PDF–2.6M

Select item 67580874.

Early Motor Dysfunction and Striosomal Distribution of Huntingtin Microaggregates in Huntington's Disease Knock-In Mice

Liliana B. Menalled, Jessica D. Sison, Ying Wu, Melisa Olivieri, Xiao-Jiang Li, He Li, Scott Zeitlin, Marie-Françoise Chesselet

J Neurosci. 2002 Sep 15; 22(18): 8266–8276. doi: 10.1523/JNEUROSCI.22-18-08266.2002

PMCID:: PMC6758087

Abstract Article PDF–663K

Select item 66729125.

The Induction Levels of Heat Shock Protein 70 Differentiate the Vulnerabilities to Mutant Huntingtin among Neuronal Subtypes

Kazuhiko Tagawa, Shigeki Marubuchi, Mei-Ling Qi, Yasushi Enokido, Takuya Tamura, Reina Inagaki, Miho Murata, Ichiro Kanazawa, Erich E. Wanker, Hitoshi Okazawa

J Neurosci. 2007 Jan 24; 27(4): 868–880. doi: 10.1523/JNEUROSCI.4522-06.2007

PMCID:: PMC6672912

Abstract Article PDF–836K

Select item 66723196.

Brain-Derived Neurotrophic Factor Restores Synaptic Plasticity in a Knock-In Mouse Model of Huntington's Disease

Gary Lynch, Eniko A. Kramar, Christopher S. Rex, Yousheng Jia, Danielle Chappas, Christine M. Gall, Danielle A. Simmons

J Neurosci. 2007 Apr 18; 27(16): 4424–4434. doi: 10.1523/JNEUROSCI.5113-06.2007

PMCID:: PMC6672319

Abstract Article PDF–723K

Select item 66722107.

Longitudinal Evaluation of the Hdh^(CAG)150 Knock-In Murine Model of Huntington's Disease

Mary Y. Heng, Sara J. Tallaksen-Greene, Peter J. Detloff, Roger L. Albin

J Neurosci. 2007 Aug 22; 27(34): 8989–8998. doi: 10.1523/JNEUROSCI.1830-07.2007

PMCID:: PMC6672210

Abstract Article PDF–442K

Select item 65788898.

Expression of Normal and Mutant Huntingtin in the Developing Brain

Pradeep G. Bhide, Michelle Day, Ellen Sapp, Cordula Schwarz, Ami Sheth, Johnny Kim, Anne B. Young, John Penney, Jeffrey Golden, Neil Aronin, Marian DiFiglia

J Neurosci. 1996 Sep 1; 16(17): 5523–5535. doi: 10.1523/JNEUROSCI.16-17-05523.1996

PMCID:: PMC6578889

Abstract Article PDF–2.2M

Select item 62901549.

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting

Sean M. DeGuire, Francesco S. Ruggeri, Mohamed-Bilal Fares, Anass Chiki, Urszula Cendrowska, Giovanni Dietler, Hilal A. Lashuel

J Biol Chem. 2018 Nov 30; 293(48): 18540–18558. Published online 2018 Sep 5. doi: 10.1074/jbc.RA118.004621

PMCID:: PMC6290154

Abstract Article PDF–5.0M

Select item 617760110.

Heat shock promotes inclusion body formation of mutant huntingtin (mHtt) and alleviates mHtt-induced transcription factor dysfunction

Justin Y. Chen, Miloni Parekh, Hadear Seliman, Dariya Bakshinskaya, Wei Dai, Kelvin Kwan, Kuang Yu Chen, Alice Y. C. Liu

J Biol Chem. 2018 Oct 5; 293(40): 15581–15593. Published online 2018 Aug 24. doi: 10.1074/jbc.RA118.002933

PMCID:: PMC6177601

Abstract Article PDF–3.4M

Select item 580290711.

BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates

Giuseppe Manfré, Arianna Novati, Ilaria Faccini, Andrea C. Rossetti, Kari Bosch, Raffaella Molteni, Marco A. Riva, Johanneke E. Van der Harst, Huu Phuc Nguyen, Judith R. Homberg

PLoS One. 2018; 13(2): e0192289. Published online 2018 Feb 7. doi: 10.1371/journal.pone.0192289

PMCID:: PMC5802907

Abstract Article PDF–6.1M

Select item 559798112.

Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway

Katarina Trajkovic, Hyunkyung Jeong, Dimitri Krainc

J Neurosci. 2017 Sep 13; 37(37): 9000–9012. doi: 10.1523/JNEUROSCI.0118-17.2017

PMCID:: PMC5597981

Abstract Article PDF–3.3M

Select item 542668213.

Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation

Haifei Xu, Juan Ji An, Baoji Xu

PLoS One. 2017; 12(5): e0177610. Published online 2017 May 11. doi: 10.1371/journal.pone.0177610

PMCID:: PMC5426682

Abstract Article PDF–16M

Select item 536514314.

Intrinsically disordered proteins as molecular shields

Sohini Chakrabortee, Rashmi Tripathi, Matthew Watson, Gabriele S. Kaminski Schierle, Davy P. Kurniawan, Clemens F. Kaminski, Michael J. Wise, Alan Tunnacliffe

Mol Biosyst. Author manuscript; available in PMC 2017 Mar 24.

Published in final edited form as: Mol Biosyst. 2012 Jan; 8(1): 210–219. Published online 2011 Sep 9. doi: 10.1039/c1mb05263b

PMCID:: PMC5365143

Abstract Article PDF–1.3M

Select item 513539215.

Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract

Koning Shen, Barbara Calamini, Jonathan A Fauerbach, Boxue Ma, Sarah H Shahmoradian, Ivana L Serrano Lachapel, Wah Chiu, Donald C Lo, Judith Frydman

eLife. 2016; 5: e18065. Published online 2016 Oct 18. doi: 10.7554/eLife.18065

PMCID:: PMC5135392

Abstract Article PDF–5.3M

Select item 489463616.

Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer

Bankanidhi Sahoo, Irene Arduini, Kenneth W. Drombosky, Ravindra Kodali, Laurie H. Sanders, J. Timothy Greenamyre, Ronald Wetzel

PLoS One. 2016; 11(6): e0155747. Published online 2016 Jun 6. doi: 10.1371/journal.pone.0155747

PMCID:: PMC4894636

Abstract Article PDF–2.3M

Select item 469615217.

siRNA screen identifies QPCT as a druggable target for Huntington’s disease

Maria Jimenez-Sanchez, Wun Lam, Michael Hannus, Birte Sönnichsen, Sara Imarisio, Angeleen Fleming, Alessia Tarditi, Fiona Menzies, Teresa Ed Dami, Catherine Xu, Eduardo Gonzalez-Couto, Giulia Lazzeroni, Freddy Heitz, Daniela Diamanti, Luisa Massai, Venkata P. Satagopam, Guido Marconi, Chiara Caramelli, Arianna Nencini, Matteo Andreini, Gian Luca Sardone, Nicola P. Caradonna, Valentina Porcari, Carla Scali, Reinhard Schneider, Giuseppe Pollio, Cahir J. O’Kane, Andrea Caricasole, David C. Rubinsztein

Nat Chem Biol. Author manuscript; available in PMC 2015 Dec 30.

Published in final edited form as: Nat Chem Biol. 2015 May; 11(5): 347–354. Published online 2015 Apr 6. doi: 10.1038/nchembio.1790

PMCID:: PMC4696152

Abstract Article PDF–2.4M

Select item 437277418.

A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity

Yuwei Yao, Xiaotian Cui, Ismael Al-Ramahi, Xiaoli Sun, Bo Li, Jiapeng Hou, Marian Difiglia, James Palacino, Zhi-Ying Wu, Lixiang Ma, Juan Botas, Boxun Lu

eLife. 2015; 4: e05449. Published online 2015 Mar 4. doi: 10.7554/eLife.05449

PMCID:: PMC4372774

Abstract Article PDF–4.5M

Select item 434487319.

Huntingtin Functions as a Scaffold for Selective Macroautophagy

Yan-Ning Rui, Zhen Xu, Bindi Patel, Zhihua Chen, Dongsheng Chen, Antonio Tito, Gabriela David, Yamin Sun, Erin F. Stimming, Hugo Bellen, Ana Maria Cuervo, Sheng Zhang

Nat Cell Biol. Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: Nat Cell Biol. 2015 Mar; 17(3): 262–275. Published online 2015 Feb 16. doi: 10.1038/ncb3101

PMCID:: PMC4344873

Abstract Article PDF–2.8M

Select item 413760220.

Transgenic Rat Model of Huntington's Disease: A Histopathological Study and Correlations with Neurodegenerative Process in the Brain of HD Patients

Yvona Mazurová, Miroslava Anderova, Ivana Němečková, Aleš Bezrouk

Biomed Res Int. 2014; 2014: 291531. Published online 2014 Aug 3. doi: 10.1155/2014/291531

PMCID:: PMC4137602

Abstract Article PDF–6.2M

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