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Select item 112342091.

Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma

Ming-Hao Xu, Yi-Min Zheng, Bu-Gang Liang, Wen-Xin Xu, Jun Cao, Pei Wang, Zi-Ying Dong, Chen-Hao Zhou, Hui-Chuan Sun, Ning Ren, Ai-Wu Ke, Ying-Hao Shen

Int J Biol Sci. 2024; 20(9): 3269–3284. Published online 2024 Jun 3. doi: 10.7150/ijbs.96031

PMCID:: PMC11234209

Abstract Article PDF–9.9M

Select item 112099352.

Antagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability

Terence Gall-Duncan, Jennifer Luo, Carla-Marie Jurkovic, Laura A. Fischer, Kyota Fujita, Amit L. Deshmukh, Rachel J. Harding, Stephanie Tran, Mustafa Mehkary, Vanessa Li, David E. Leib, Ran Chen, Hikari Tanaka, Amanda G. Mason, Dominique Lévesque, Mahreen Khan, Mortezaali Razzaghi, Tanya Prasolava, Stella Lanni, Nozomu Sato, Marie-Christine Caron, Gagan B. Panigrahi, Peixiang Wang, Rachel Lau, Arturo López Castel, Jean-Yves Masson, Lynette Tippett, Clinton Turner, Maria Spies, Albert R. La Spada, Eric I. Campos, Maurice A. Curtis, François-Michel Boisvert, Richard L.M. Faull, Beverly L. Davidson, Masayuki Nakamori, Hitoshi Okazawa, Marc S. Wold, Christopher E. Pearson

Cell. Author manuscript; available in PMC 2024 Oct 26.

Published in final edited form as: Cell. 2023 Oct 26; 186(22): 4898–4919.e25. Published online 2023 Oct 11. doi: 10.1016/j.cell.2023.09.008

PMCID:: PMC11209935

Abstract Article PDF–3.0M

Select item 111825073.

Hong xiang Hou, Li Pang, Liang Zhao, Jihong Xing

PLoS One. 2024; 19(6): e0301647. Published online 2024 Jun 17. doi: 10.1371/journal.pone.0301647

PMCID:: PMC11182507

Abstract Article PDF–4.8M

Select item 111582904.

Amphiregulin regulates the activation of ERK and Akt through epidermal growth factor receptor and HER3 signals involved in the progression of pancreatic cancer

Fusanori Yotsumoto, Tatsuya Fukami, Hiroshi Yagi, Akihiro Funakoshi, Toshiyuki Yoshizato, Masahide Kuroki, Shingo Miyamoto

Cancer Sci. 2010 Nov; 101(11): 2351–2360. Published online 2010 Jul 7. doi: 10.1111/j.1349-7006.2010.01671.x

PMCID:: PMC11158290

Abstract Article PDF–769K

Select item 111580715.

Activation of ERK1/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis

Yasunari Mizumoto, Satoru Kyo, Noriko Mori, Junko Sakaguchi, Satoshi Ohno, Yoshiko Maida, Manabu Hashimoto, Masahiro Takakura, Masaki Inoue

Cancer Sci. 2007 May; 98(5): 652–658. Published online 2007 Mar 27. doi: 10.1111/j.1349-7006.2007.00445.x

PMCID:: PMC11158071

Abstract Article PDF–278K

Select item 111317606.

CCDC134, a novel secretory protein, inhibits activation of ERK and JNK, but not p38 MAPK

J. Huang, T. Shi, T. Ma, Y. Zhang, X. Ma, Y. Lu, Q. Song, W. Liu, D. Ma, X. Qiu

Cell Mol Life Sci. 2008 Jan; 65(2): 338–349. Published online 2007 Dec 18. doi: 10.1007/s00018-007-7448-5

PMCID:: PMC11131760

Abstract Article PDF–2.1M

Select item 111157707.

Endocytosis of hepatitis C virus non-enveloped capsid-like particles induces MAPK–ERK1/2 signaling events

Konstantina Katsarou, Alexandros Α. Lavdas, Panagiota Tsitoura, Elisavet Serti, Panagiotis Markoulatos, Penelope Mavromara, Urania Georgopoulou

Cell Mol Life Sci. 2010 Jul; 67(14): 2491–2506. Published online 2010 Apr 1. doi: 10.1007/s00018-010-0351-5

PMCID:: PMC11115770

Abstract Article PDF–938K

Select item 110773718.

Ciliogenesis-associated Kinase 1 Promotes Breast Cancer Cell Proliferation and Chemoresistance via Phosphorylating ERK1

Yanling He, Xinyuan Zhang, Weijun Pan, Jiebiao Zhang, Weiliang Zhu, Jian Zhang, Jian Shi

Int J Biol Sci. 2024; 20(7): 2403–2421. Published online 2024 Apr 8. doi: 10.7150/ijbs.87442

PMCID:: PMC11077371

Abstract Article PDF–10M

Select item 110028939.

ALOX15B controls macrophage cholesterol homeostasis via lipid peroxidation, ERK1/2 and SREBP2

Yvonne Benatzy, Megan A. Palmer, Dieter Lütjohann, Rei-Ichi Ohno, Nadja Kampschulte, Nils Helge Schebb, Dominik C. Fuhrmann, Ryan G. Snodgrass, Bernhard Brüne

Redox Biol. 2024 Jun; 72: 103149. Published online 2024 Apr 3. doi: 10.1016/j.redox.2024.103149

PMCID:: PMC11002893

Abstract Article PDF–8.3M

Select item 1086758710.

LncNFYB promotes the proliferation of rheumatoid arthritis fibroblast-like synoviocytes via LncNFYB/ANXA2/ERK1/2 axis

Shibai Xiao, Qingqing Ouyang, Yi Feng, Xiaoxi Lu, Yipeng Han, Hao Ren, Qin Huang, Jinjun Zhao, Changhong Xiao, Min Yang

J Biol Chem. 2024 Feb; 300(2): 105591. Published online 2023 Dec 21. doi: 10.1016/j.jbc.2023.105591

PMCID:: PMC10867587

Abstract Article PDF–5.7M

Select item 1073990211.

Mir-142-3P regulates MAPK protein family by inhibiting 14-3-3η to enhance bone marrow mesenchymal stem cells osteogenesis

Ya-qian Liu, Yue-chen Xu, Zong-wen Shuai

Sci Rep. 2023; 13: 22862. Published online 2023 Dec 21. doi: 10.1038/s41598-023-48950-4

PMCID:: PMC10739902

Abstract Article PDF–1.8M

Select item 1061235712.

The complex impact of cancer-related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants

Maria Petrosino, Leonore Novak, Alessandra Pasquo, Paola Turina, Emidio Capriotti, Velia Minicozzi, Valerio Consalvi, Roberta Chiaraluce

Hum Genomics. 2023; 17: 95. Published online 2023 Oct 27. doi: 10.1186/s40246-023-00544-x

PMCID:: PMC10612357

Abstract Article PDF–4.7M

Select item 1059472713.

Nuclear respiratory factor 1 drives hepatocellular carcinoma progression by activating LPCAT1-ERK1/2-CREB axis

Ran Liu, Chuanzheng Yin, Peng Zhao, Bing Guo, Wenbo Ke, Xichuan Zheng, Dawei Xie, Yaofeng Wang, Gengqiao Wang, Yinzhao Jia, Yang Gao, Wenjun Hu, Gang Logan Liu, Zifang Song

Biol Direct. 2023; 18: 67. Published online 2023 Oct 24. doi: 10.1186/s13062-023-00428-z

PMCID:: PMC10594727

Abstract Article PDF–15M

Select item 1045872214.

A conserved arginine within the αC-helix of Erk1/2 is a latch of autoactivation and of oncogenic capabilities

Nadine Soudah, Alexey Baskin, Karin Smorodinsky-Atias, Jonah Beenstock, Yifat Ganon, Ruchama Hayouka, Mohammed Aboraya, Oded Livnah, Ronit Ilouz, David Engelberg

J Biol Chem. 2023 Sep; 299(9): 105072. Published online 2023 Jul 18. doi: 10.1016/j.jbc.2023.105072

PMCID:: PMC10458722

Abstract Article PDF–4.2M

Select item 1031806915.

TRIM22 promotes the proliferation of glioblastoma cells by activating MAPK signaling and accelerating the degradation of Raf-1

Xiaowei Fei, Ya-nan Dou, Kai Sun, Jialiang Wei, Qingdong Guo, Li Wang, Xiuquan Wu, Weihao Lv, Xiaofan Jiang, Zhou Fei

Exp Mol Med. 2023 Jun; 55(6): 1203–1217. Published online 2023 Jun 1. doi: 10.1038/s12276-023-01007-y

PMCID:: PMC10318069

Abstract Article PDF–7.6M

Select item 1027991316.

AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity

Mario Ruiz, Ranjan Devkota, Delaney Kaper, Hanna Ruhanen, Kiran Busayavalasa, Uroš Radović, Marcus Henricsson, Reijo Käkelä, Jan Borén, Marc Pilon

J Biol Chem. 2023 Jun; 299(6): 104799. Published online 2023 May 8. doi: 10.1016/j.jbc.2023.104799

PMCID:: PMC10279913

Abstract Article PDF–4.1M

Select item 1023742217.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1020218318.

SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage

Fengli Wang, Lingjuan Wang, Shiming Gan, Shenglei Feng, Sijin Ouyang, Xiaoli Wang, Shuiqiao Yuan

Research (Wash D C) 2023; 6: 0091. Published online 2023 Apr 12. doi: 10.34133/research.0091

PMCID:: PMC10202183

Abstract Article PDF–18M

Select item 1019907919.

ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy

Xiangling Xiao, Jie Shi, Chuan He, Xia Bu, Yishuang Sun, Minling Gao, Bolin Xiang, Wenjun Xiong, Panpan Dai, Qi Mao, Xixin Xing, Yingmeng Yao, Haisheng Yu, Gaoshan Xu, Siqi Li, Yan Ren, Baoxiang Chen, Congqing Jiang, Geng Meng, Yu-Ru Lee, Wenyi Wei, Gordon J. Freeman, Conghua Xie, Jinfang Zhang

Nat Commun. 2023; 14: 2859. Published online 2023 May 19. doi: 10.1038/s41467-023-38605-3

PMCID:: PMC10199079

Abstract Article PDF–3.3M

Select item 1018849220.

GDE7 produces cyclic phosphatidic acid in the ER lumen functioning as a lysophospholipid mediator

Keisuke Kitakaze, Hanif Ali, Raiki Kimoto, Yasuhiro Takenouchi, Hironobu Ishimaru, Atsushi Yamashita, Natsuo Ueda, Tamotsu Tanaka, Yasuo Okamoto, Kazuhito Tsuboi

Commun Biol. 2023; 6: 524. Published online 2023 May 16. doi: 10.1038/s42003-023-04900-4

PMCID:: PMC10188492

Abstract Article PDF–2.2M

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