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Items: 1 to 20 of 190

1.
C5aR2 Deficiency Lessens C5aR1 Distribution and Expression in Neutrophils and Macrophages
Ting Zhang, Ning Ma, Jiaxing Wang, Xiaoyun Min, Linlin Wei, Ke Li
J Immunol Res. 2024; 2024: 2899154. Published online 2024 Jul 10. doi: 10.1155/2024/2899154
PMCID:
PMC11254461
AbstractArticlePDF–1.6M
2.
C5a–C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms
Akihiro Okada, Kampei Shimizu, Akitsugu Kawashima, Tomomichi Kayahara, Masahiko Itani, Hiroki Kurita, Susumu Miyamoto, Hiroharu Kataoka, Tomohiro Aoki
Sci Rep. 2024; 14: 3105. Published online 2024 Feb 7. doi: 10.1038/s41598-024-53651-7
PMCID:
PMC10850553
AbstractArticlePDF–2.8M
3.
Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer’s mouse models
Tiffany J. Petrisko, Matthew Gargus, Shu-Hui Chu, Purnika Selvan, Katrine L. Whiteson, Andrea J. Tenner
J Neuroinflammation. 2023; 20: 211. Published online 2023 Sep 19. doi: 10.1186/s12974-023-02885-9
PMCID:
PMC10507976
AbstractArticlePDF–8.3M
4.
C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps
Bruna M. Silva, Giovanni F. Gomes, Flavio P. Veras, Seppe Cambier, Gabriel V.L. Silva, Andreza U. Quadros, Diego B. Caetité, Daniele C. Nascimento, Camilla M. Silva, Juliana C. Silva, Samara Damasceno, Ayda H. Schneider, Fabio Beretta, Sabrina S. Batah, Icaro M.S. Castro, Isadora M. Paiva, Tamara Rodrigues, Ana Salina, Ronaldo Martins, Guilherme C.M. Cebinelli, Naira L. Bibo, Daniel M. Jorge, Helder I. Nakaya, Dario S. Zamboni, Luiz O. Leiria, Alexandre T. Fabro, José C. Alves-Filho, Eurico Arruda, Paulo Louzada-Junior, Renê D. Oliveira, Larissa D. Cunha, Pierre Van Mol, Lore Vanderbeke, Simon Feys, Els Wauters, Laura Brandolini, Andrea Aramini, Fernando Q. Cunha, Jörg Köhl, Marcello Allegretti, Diether Lambrechts, Joost Wauters, Paul Proost, Thiago M. Cunha
J Clin Invest. 2023 Jun 15; 133(12): e163105. Published online 2023 Jun 15. doi: 10.1172/JCI163105
PMCID:
PMC10266787
AbstractArticlePDF–18M
5.
Intracellular complement (complosome) is expressed in hematopoietic stem/progenitor cells (HSPCs) and regulates cell trafficking, metabolism and proliferation in an intracrine Nlrp3 inflammasome-dependent manner
Mariusz Z. Ratajczak, Mateusz Adamiak, Ahmed Abdelbaset-Ismail, Kamila Bujko, Arjun Thapa, Vira Chumak, Stephanie Franczak, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Magdalena Kucia
Leukemia. 2023; 37(6): 1401–1405. Published online 2023 Apr 13. doi: 10.1038/s41375-023-01894-0
PMCID:
PMC10244163
ArticlePDF–1.3M
6.
Neutrophil complement receptor signaling is required for BAFF-dependent humoral responses in mice
Arun Cumpelik, Evan Cody, Samuel Mon-Wei Yu, Emilie K. Grasset, David Dominguez-Sola, Andrea Cerutti, Peter S. Heeger
J Immunol. Author manuscript; available in PMC 2024 Jan 1.
Published in final edited form as: J Immunol. 2023 Jan 1; 210(1): 19–23. doi: 10.4049/jimmunol.2200410
PMCID:
PMC9780177
AbstractArticlePDF–1.1M
7.
Valproic acid attenuates cellular senescence in diabetic kidney disease through the inhibition of complement C5a receptors
Melinda T. Coughlan, Mark Ziemann, Adrienne Laskowski, Trent M. Woodruff, Sih Min Tan
Sci Rep. 2022; 12: 20278. Published online 2022 Nov 24. doi: 10.1038/s41598-022-24851-w
PMCID:
PMC9700697
AbstractArticlePDF–5.0M
8.
Bacterial polyphosphates induce CXCL4 and synergize with complement anaphylatoxin C5a in lung injury
Julian Roewe, Sarah Walachowski, Arjun Sharma, Kayleigh A. Berthiaume, Christoph Reinhardt, Markus Bosmann
Front Immunol. 2022; 13: 980733. Published online 2022 Nov 3. doi: 10.3389/fimmu.2022.980733
PMCID:
PMC9669059
AbstractArticlePDF–6.6M
9.
Complement receptor C5aR1 on osteoblasts regulates osteoclastogenesis in experimental postmenopausal osteoporosis
Jasmin Maria Bülow, Nikolai Renz, Melanie Haffner-Luntzer, Verena Fischer, Astrid Schoppa, Jan Tuckermann, Jörg Köhl, Markus Huber-Lang, Anita Ignatius
Front Endocrinol (Lausanne) 2022; 13: 1016057. Published online 2022 Sep 30. doi: 10.3389/fendo.2022.1016057
PMCID:
PMC9561253
AbstractArticlePDF–5.4M
10.
Pharmacological activation of the C5a receptor leads to stimulation of the β-adrenergic receptor and alleviates cognitive impairment in a murine model of familial Alzheimer’s disease
Eleni Fella, Revekka Papacharalambous, Demos Kynigopoulos, Maria Ioannou, Rita Derua, Christiana Christodoulou, Myrto Stylianou, Christos Karaiskos, Alexia Kagiava, Gerasimou Petroula, Chryso Pierides, Maria Kyriakou, Laura Koumas, Paul Costeas, Elena Panayiotou
Front Immunol. 2022; 13: 947071. Published online 2022 Aug 26. doi: 10.3389/fimmu.2022.947071
PMCID:
PMC9462583
AbstractArticlePDF–2.1M
11.
Effects of C5a and Receptor CD88 on Glutamate and N-Methyl-D-Aspartic Acid Receptor Expression in the Mouse Model of Optic Neuromyelitis
Ling Li, Jiangwei Tang, Hongxin Wang, Jiamei Liu, Lina Zhou
Comput Math Methods Med. 2022; 2022: 4997393. Published online 2022 Apr 25. doi: 10.1155/2022/4997393
PMCID:
PMC9061005
AbstractArticlePDF–849K
12.
Folic acid-mediated fibrosis is driven by C5a receptor 1-mediated activation of kidney myeloid cells
Ranjit K. Sahu, Sandhya Xavier, Daniel Chauss, Luopin Wang, Claude Chew, Ronald Taylor, William B. Stallcup, Jennie Z. Ma, Majid Kazemian, Behdad Afzali, Jörg Köhl, Didier Portilla
Am J Physiol Renal Physiol. 2022 Jun 1; 322(6): F597–F610. Published online 2022 Apr 4. doi: 10.1152/ajprenal.00404.2021
PMCID:
PMC9054266
AbstractArticle
13.
The C5a/C5aR1 Axis Contributes to the Pathogenesis of Acute Cystitis Through Enhancement of Adhesion and Colonization of Uropathogenic E. coli
Kun-Yi Wu, Bo Cao, Chun-Xuan Wang, Xue-Ling Yang, Shu-Juan Zhao, Teng-Yue Diao, Li-Rong Lin, Guo-Xiu Zhao, Wuding Zhou, Ju-Rong Yang, Ke Li
Front Cell Infect Microbiol. 2022; 12: 824505. Published online 2022 Mar 30. doi: 10.3389/fcimb.2022.824505
PMCID:
PMC9005882
AbstractArticlePDF–22M
14.
Vascular Endothelial Cells Produce Coagulation Factors That Control Their Growth via Joint Protease-Activated Receptor and C5a Receptor 1 (CD88) Signaling
Devin Cao, Michael G. Strainic, Daniel Counihan, Shiva Sridar, Fengqi An, Wasim Hussain, Alvin H. Schmaier, Marvin Nieman, M. Edward Medof
Am J Pathol. 2022 Feb; 192(2): 361–378. doi: 10.1016/j.ajpath.2021.09.011
PMCID:
PMC8908053
AbstractArticlePDF–2.5M
15.
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation
Nathalie Niyonzima, Jubayer Rahman, Natalia Kunz, Erin E. West, Tilo Freiwald, Jigar V. Desai, Nicolas S. Merle, Alexandre Gidon, Bjørnar Sporsheim, Michail S. Lionakis, Kristin Evensen, Beate Lindberg, Karolina Skagen, Mona Skjelland, Parul Singh, Markus Haug, Marieta M. Ruseva, Martin Kolev, Jack Bibby, Olivia Marshall, Brett O’Brien, Nigel Deeks, Behdad Afzali, Richard J. Clark, Trent M. Woodruff, Milton Pryor, Zhi-Hong Yang, Alan T. Remaley, Tom E. Mollnes, Stephen M. Hewitt, Bingyu Yan, Majid Kazemian, Máté G. Kiss, Christoph J. Binder, Bente Halvorsen, Terje Espevik, Claudia Kemper
Sci Immunol. Author manuscript; available in PMC 2022 Jun 24.
Published in final edited form as: Sci Immunol. 2021 Dec 24; 6(66): eabf2489. Published online 2021 Dec 24. doi: 10.1126/sciimmunol.abf2489
PMCID:
PMC8902698
AbstractArticlePDF–3.9M
16.
Virulence factors perforate the pathogen-containing vacuole to signal efferocytosis
Hirotaka Hiyoshi, Bevin C. English, Vladimir E. Diaz-Ochoa, Tamding Wangdi, Lillian F. Zhang, Miako Sakaguchi, Takeshi Haneda, Renée M. Tsolis, Andreas J. Bäumler
Cell Host Microbe. Author manuscript; available in PMC 2023 Feb 9.
Published in final edited form as: Cell Host Microbe. 2022 Feb 9; 30(2): 163–170.e6. Published online 2021 Dec 23. doi: 10.1016/j.chom.2021.12.001
PMCID:
PMC8831471
AbstractArticlePDF–973K
17.
The role of complement C5a receptor in DPSC odontoblastic differentiation and in vivo reparative dentin formation
Muhammad Irfan, Ji-Hyun Kim, Hassan Marzban, David A. Reed, Anne George, Lyndon F. Cooper, Seung Chung
Int J Oral Sci. 2022; 14: 7. Published online 2022 Jan 27. doi: 10.1038/s41368-022-00158-4
PMCID:
PMC8795457
AbstractArticlePDF–3.4M
18.
Exogenous inter-α inhibitor proteins prevent cell death and improve ischemic stroke outcomes in mice
Louise D. McCullough, Meaghan Roy-O’Reilly, Yun-Ju Lai, Anthony Patrizz, Yan Xu, Juneyoung Lee, Aleah Holmes, Daniel C. Kraushaar, Anjali Chauhan, Lauren H. Sansing, Barbara S. Stonestreet, Liang Zhu, Julia Kofler, Yow-Pin Lim, Venugopal Reddy Venna
J Clin Invest. 2021 Sep 1; 131(17): e144898. Published online 2021 Sep 1. doi: 10.1172/JCI144898
PMCID:
PMC8409590
AbstractArticlePDF–9.8M
19.
Dynamic regulation of B cell Complement Signaling is Integral to Germinal Center Responses
Arun Cumpelik, David Heja, Yuan Hu, Gabriele Varano, Farideh Ordikhani, Mark P. Roberto, Zhengxiang He, Dirk Homann, Sergio A. Lira, David Dominguez-Sola, Peter S. Heeger
Nat Immunol. Author manuscript; available in PMC 2021 Nov 24.
Published in final edited form as: Nat Immunol. 2021 Jun; 22(6): 757–768. Published online 2021 May 24. doi: 10.1038/s41590-021-00926-0
PMCID:
PMC8297556
AbstractArticlePDF–4.9M
20.
The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets
Henry Nording, Lasse Baron, David Haberthür, Frederic Emschermann, Matthias Mezger, Manuela Sauter, Reinhard Sauter, Johannes Patzelt, Kai Knoepp, Anne Nording, Moritz Meusel, Roza Meyer-Saraei, Ruslan Hlushchuk, Daniel Sedding, Oliver Borst, Ingo Eitel, Christian M. Karsten, Robert Feil, Bernd Pichler, Jeanette Erdmann, Admar Verschoor, Emmanouil Chavakis, Triantafyllos Chavakis, Philipp von Hundelshausen, Jörg Köhl, Meinrad Gawaz, Harald F. Langer
Nat Commun. 2021; 12: 3352. Published online 2021 Jun 7. doi: 10.1038/s41467-021-23499-w
PMCID:
PMC8185003
AbstractArticlePDF–4.8M

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