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Items: 1 to 20 of 34

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Knockdown and inhibition of hippocampal GPR17 attenuates lipopolysaccharide-induced cognitive impairment in mice
Yusheng Liang, Xu kang, Haiwang Zhang, Heng Xu, Xian Wu
J Neuroinflammation. 2023; 20: 271. Published online 2023 Nov 21. doi: 10.1186/s12974-023-02958-9
PMCID:
PMC10662506
AbstractArticlePDF–16M
3.
Intestinal Gpr17 deficiency improves glucose metabolism by promoting GLP-1 secretion
Shijun Yan, Jason M. Conley, Austin M. Reilly, Natalie D. Stull, Surabhi D. Abhyankar, Aaron C. Ericsson, Tatsuyoshi Kono, Andrei I. Molosh, Chandrashekhar A. Kubal, Carmella Evans-Molina, Hongxia Ren
Cell Rep. Author manuscript; available in PMC 2022 Apr 1.
Published in final edited form as: Cell Rep. 2022 Jan 4; 38(1): 110179. doi: 10.1016/j.celrep.2021.110179
PMCID:
PMC8972502
AbstractArticlePDF–2.7M
4.
Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin
Edward T. Wargent, Suhaib J. S. Ahmad, Qing Richard Lu, Evi Kostenis, Jonathan R. S. Arch, Claire J. Stocker
Front Endocrinol (Lausanne) 2021; 12: 698115. Published online 2021 Sep 27. doi: 10.3389/fendo.2021.698115
PMCID:
PMC8503278
AbstractArticlePDF–1.0M
5.
Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis
Stefano Raffaele, Paolo Gelosa, Elisabetta Bonfanti, Marta Lombardi, Laura Castiglioni, Mauro Cimino, Luigi Sironi, Maria P. Abbracchio, Claudia Verderio, Marta Fumagalli
Mol Ther. 2021 Apr 7; 29(4): 1439–1458. Published online 2020 Dec 10. doi: 10.1016/j.ymthe.2020.12.009
PMCID:
PMC8058432
AbstractArticlePDF–7.6M
6.
Functional genomic analyses highlight a shift in Gpr17‐regulated cellular processes in oligodendrocyte progenitor cells and underlying myelin dysregulation in the aged mouse cerebrum
Andrea D. Rivera, Francesca Pieropan, Irene Chacon‐De‐La‐Rocha, Davide Lecca, Maria P. Abbracchio, Kasum Azim, Arthur M. Butt
Aging Cell. 2021 Apr; 20(4): e13335. Published online 2021 Mar 5. doi: 10.1111/acel.13335
PMCID:
PMC8045941
AbstractArticlePDF–2.4M
7.
Robust myelination of regenerated axons induced by combined manipulations of GPR17 and microglia
Jing Wang, Xuelian He, Huyan Meng, Yi Li, Phillip Dmitriev, Feng Tian, Jessica C. Page, Richard Lu, Zhigang He
Neuron. Author manuscript; available in PMC 2021 Dec 9.
Published in final edited form as: Neuron. 2020 Dec 9; 108(5): 876–886.e4. Published online 2020 Oct 26. doi: 10.1016/j.neuron.2020.09.016
PMCID:
PMC7736523
AbstractArticlePDF–1.0M
8.
Abnormal Upregulation of GPR17 Receptor Contributes to Oligodendrocyte Dysfunction in SOD1 G93A Mice
Elisabetta Bonfanti, Tiziana Bonifacino, Stefano Raffaele, Marco Milanese, Erica Morgante, Giambattista Bonanno, Maria P. Abbracchio, Marta Fumagalli
Int J Mol Sci. 2020 Apr; 21(7): 2395. Published online 2020 Mar 31. doi: 10.3390/ijms21072395
PMCID:
PMC7177925
AbstractArticlePDF–3.7M
9.
Development of the first in vivo GPR17 ligand through an iterative drug discovery pipeline: A novel disease-modifying strategy for multiple sclerosis
Chiara Parravicini, Davide Lecca, Davide Marangon, Giusy Tindara Coppolino, Simona Daniele, Elisabetta Bonfanti, Marta Fumagalli, Luca Raveglia, Claudia Martini, Elisabetta Gianazza, Maria Letizia Trincavelli, Maria P. Abbracchio, Ivano Eberini
PLoS One. 2020; 15(4): e0231483. Published online 2020 Apr 22. doi: 10.1371/journal.pone.0231483
PMCID:
PMC7176092
AbstractArticlePDF–2.1M
10.
Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling
Krishnakali Dasgupta, Jong Uk Chung, Kesava Asam, Juhee Jeong
Dev Biol. Author manuscript; available in PMC 2020 Nov 15.
Published in final edited form as: Dev Biol. 2019 Nov 15; 455(2): 434–448. Published online 2019 Jul 24. doi: 10.1016/j.ydbio.2019.07.015
PMCID:
PMC6842427
AbstractArticlePDF–6.1M
11.
Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding
Austin M. Reilly, Shudi Zhou, Sunil K. Panigrahi, Shijun Yan, Jason M. Conley, Patrick L. Sheets, Sharon L. Wardlaw, Hongxia Ren
Nutr Diabetes. 2019; 9: 29. Published online 2019 Oct 14. doi: 10.1038/s41387-019-0096-7
PMCID:
PMC6791877
AbstractArticlePDF–1.5M
12.
Sox10 Cooperates with the Mediator Subunit 12 during Terminal Differentiation of Myelinating Glia
Michael R. Vogl, Simone Reiprich, Melanie Küspert, Thomas Kosian, Heinrich Schrewe, Klaus-Armin Nave, Michael Wegner
J Neurosci. 2013 Apr 10; 33(15): 6679–6690. doi: 10.1523/JNEUROSCI.5178-12.2013
PMCID:
PMC6619079
AbstractArticlePDF–2.3M
13.
Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination
Zhimin Ou, Yuxia Sun, Li Lin, Nachun You, Xue Liu, Hongchao Li, Yanchen Ma, Lei Cao, Ying Han, Min Liu, Yaqi Deng, Luming Yao, Q. Richard Lu, Ying Chen
J Neurosci. 2016 Oct 12; 36(41): 10560–10573. doi: 10.1523/JNEUROSCI.0898-16.2016
PMCID:
PMC6601930
AbstractArticlePDF–5.1M
14.
Differential local tissue permissiveness influences the final fate of GPR17‐expressing oligodendrocyte precursors in two distinct models of demyelination
Giusy T. Coppolino, Davide Marangon, Camilla Negri, Gianluca Menichetti, Marta Fumagalli, Paolo Gelosa, Leda Dimou, Roberto Furlan, Davide Lecca, Maria P. Abbracchio
Glia. 2018 May; 66(5): 1118–1130. Published online 2018 Feb 9. doi: 10.1002/glia.23305
PMCID:
PMC5900886
AbstractArticlePDF–1.9M
15.
G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Differentiation in Response to Lysolecithin-Induced Demyelination
Changqing Lu, Lihua Dong, Hui Zhou, Qianmei Li, Guojiao Huang, Shu jun Bai, Linchuan Liao
Sci Rep. 2018; 8: 4502. Published online 2018 Mar 14. doi: 10.1038/s41598-018-22452-0
PMCID:
PMC5852120
AbstractArticlePDF–8.3M
16.
The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke
Elisabetta Bonfanti, Paolo Gelosa, Marta Fumagalli, Leda Dimou, Francesca Viganò, Elena Tremoli, Mauro Cimino, Luigi Sironi, Maria P Abbracchio
Cell Death Dis. 2017 Jun; 8(6): e2871. Published online 2017 Jun 8. doi: 10.1038/cddis.2017.256
PMCID:
PMC5520912
AbstractArticlePDF–8.1M
17.
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray
Nature. Author manuscript; available in PMC 2017 Mar 14.
Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356
Correction in:
Nature. 2017 Nov 16; 551(7680): 398.
PMCID:
PMC5295821
AbstractArticlePDF–3.0M
18.
The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules
Katharina Simon, Stephanie Hennen, Nicole Merten, Stefanie Blättermann, Michel Gillard, Evi Kostenis, Jesus Gomeza
J Biol Chem. 2016 Jan 8; 291(2): 705–718. Published online 2015 Nov 30. doi: 10.1074/jbc.M115.683953
PMCID:
PMC4705391
AbstractArticlePDF–3.5M
19.
Gpr17 in AgRP Neurons Regulates Feeding and Sensitivity to Insulin and Leptin
Hongxia Ren, Joshua R. Cook, Ning Kon, Domenico Accili
Diabetes. 2015 Nov; 64(11): 3670–3679. Published online 2015 Jul 15. doi: 10.2337/db15-0390
PMCID:
PMC4613971
AbstractArticlePDF–1.8M
20.
GPR17 gene disruption does not alter food intake or glucose homeostasis in mice
Jason Mastaitis, Soo Min, Ralf Elvert, Aimo Kannt, Yurong Xin, Francisca Ochoa, Nicholas W. Gale, David M. Valenzuela, Andrew J. Murphy, George D. Yancopoulos, Jesper Gromada
Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6): 1845–1849. Published online 2015 Jan 26. doi: 10.1073/pnas.1424968112
PMCID:
PMC4330737
AbstractArticlePDF–858K

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