PMC Links for GEO Profiles (Select 63862473) - PMC

Select item 69651441.

Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress

Kai Wang, Chuanjiang Li, Xinxin Lin, Hang Sun, Ruijuan Xu, Qingping Li, Yiran Wei, Yiyi Li, Jianping Qian, Cuiting Liu, Qifan Zhang, Sheng Yu, Zhonglin Cui, Xixin Huang, Bili Zhu, Jie Zhou, Cungui Mao

Cell Death Dis. 2020 Jan; 11(1): 28. Published online 2020 Jan 16. doi: 10.1038/s41419-019-2214-9

Correction in:: Cell Death Dis. 2020 Mar; 11(3): 191.

PMCID:: PMC6965144

Abstract Article PDF–5.3M

Select item 63033882.

Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy

Ieva Vasiliauskaité-Brooks, Robert D. Healey, Pascal Rochaix, Julie Saint-Paul, Rémy Sounier, Claire Grison, Thierry Waltrich-Augusto, Mathieu Fortier, François Hoh, Essa M. Saied, Christoph Arenz, Shibom Basu, Cédric Leyrat, Sébastien Granier

Nat Commun. 2018; 9: 5437. Published online 2018 Dec 21. doi: 10.1038/s41467-018-07864-w

PMCID:: PMC6303388

Abstract Article PDF–5.1M

Select item 50689173.

Deficiency of the alkaline ceramidase ACER3 manifests in early childhood by progressive leukodystrophy

Simon Edvardson, Jae Kyo Yi, Chaim Jalas, Ruijuan Xu, Bryn D Webb, Justin Snider, Anastasia Fedick, Elisheva Kleinman, Nathan R Treff, Cungui Mao, Orly Elpeleg

J Med Genet. Author manuscript; available in PMC 2016 Oct 18.

Published in final edited form as: J Med Genet. 2016 Jun; 53(6): 389–396. Published online 2016 Jan 20. doi: 10.1136/jmedgenet-2015-103457

PMCID:: PMC5068917

Abstract Article PDF–644K

Select item 48239374.

Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system

K Wang, R Xu, A J Snider, J Schrandt, Y Li, A B Bialkowska, M Li, J Zhou, Y A Hannun, L M Obeid, V W Yang, C Mao

Cell Death Dis. 2016 Mar; 7(3): e2124. Published online 2016 Mar 3. doi: 10.1038/cddis.2016.36

PMCID:: PMC4823937

Abstract Article PDF–4.2M

Select item 46087635.

Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain

Kai Wang, Ruijuan Xu, Jennifer Schrandt, Prithvi Shah, Yong Z. Gong, Chet Preston, Louis Wang, Jae Kyo Yi, Chih-Li Lin, Wei Sun, Demetri D. Spyropoulos, Soyoung Rhee, Mingsong Li, Jie Zhou, Shaoyu Ge, Guofeng Zhang, Ashley J. Snider, Yusuf A. Hannun, Lina M. Obeid, Cungui Mao

PLoS Genet. 2015 Oct; 11(10): e1005591. Published online 2015 Oct 16. doi: 10.1371/journal.pgen.1005591