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Select item 67252091.

APH-1a Is the Principal Mammalian APH-1 Isoform Present in γ-Secretase Complexes during Embryonic Development

Guojun Ma, Tong Li, Donald L. Price, Philip C. Wong

J Neurosci. 2005 Jan 5; 25(1): 192–198. doi: 10.1523/JNEUROSCI.3814-04.2005

PMCID:: PMC6725209

Abstract Article PDF–351K

Select item 66728272.

Moderate Reduction of γ-Secretase Attenuates Amyloid Burden and Limits Mechanism-Based Liabilities

Tong Li, Hongjin Wen, Cory Brayton, Fiona M. Laird, Guojun Ma, Shiwen Peng, Lisa Placanica, T. C. Wu, Barbara J. Crain, Donald L. Price, Charles G. Eberhart, Philip C. Wong

J Neurosci. 2007 Oct 3; 27(40): 10849–10859. doi: 10.1523/JNEUROSCI.2152-07.2007

PMCID:: PMC6672827

Abstract Article PDF–665K

Select item 57034673.

Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin

Erdinç Dursun, Duygu Gezen-Ak

PLoS One. 2017; 12(11): e0188605. Published online 2017 Nov 27. doi: 10.1371/journal.pone.0188605

PMCID:: PMC5703467

Abstract Article PDF–9.7M

Select item 48824344.

Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior

Daniel R. Dries, Yi Zhu, Mieu M. Brooks, Diego A. Forero, Megumi Adachi, Basar Cenik, James M. West, Yu-Hong Han, Cong Yu, Jennifer Arbella, Annelie Nordin, Rolf Adolfsson, Jurgen Del-Favero, Q. Richard Lu, Patrick Callaerts, Shari G. Birnbaum, Gang Yu

J Biol Chem. 2016 May 27; 291(22): 11647–11656. Published online 2016 Mar 23. doi: 10.1074/jbc.M116.715078

PMCID:: PMC4882434

Abstract Article PDF–2.1M

Select item 45683065.

An atomic structure of human γ-secretase

Xiao-chen Bai, Chuangye Yan, Guanghui Yang, Peilong Lu, Dan Ma, Linfeng Sun, Rui Zhou, Sjors H.W. Scheres, Yigong Shi

Nature. Author manuscript; available in PMC 2016 Mar 10.

Published in final edited form as: Nature. 2015 Sep 10; 525(7568): 212–217. Published online 2015 Aug 17. doi: 10.1038/nature14892

PMCID:: PMC4568306

Abstract Article PDF–6.7M

Select item 43286476.

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

Yasuhiko Kizuka, Shinobu Kitazume, Reiko Fujinawa, Takashi Saito, Nobuhisa Iwata, Takaomi C Saido, Miyako Nakano, Yoshiki Yamaguchi, Yasuhiro Hashimoto, Matthias Staufenbiel, Hiroyuki Hatsuta, Shigeo Murayama, Hiroshi Manya, Tamao Endo, Naoyuki Taniguchi

EMBO Mol Med. 2015 Feb; 7(2): 175–189. Published online 2015 Jan 15. doi: 10.15252/emmm.201404438

PMCID:: PMC4328647

Abstract Article PDF–2.3M

Select item 42170887.

Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer’s disease

A-Ryeong Gwon, Jong-Sung Park, Thiruma V. Arumugam, Yong-Kook Kwon, Sic L. Chan, Seol-Hee Kim, Sang-Ha Baik, Sunghee Yang, Young-Kwang Yun, Yuri Choi, Saerom Kim, Sung-Chun Tang, Dong-Hoon Hyun, Aiwu Cheng, Charles E. Dann, III, Michel Bernier, Jaewon Lee, William R. Markesbery, Mark P. Mattson, Dong-Gyu Jo

Aging Cell. Author manuscript; available in PMC 2014 Nov 3.

Published in final edited form as: Aging Cell. 2012 Aug; 11(4): 559–568. Published online 2012 Apr 9. doi: 10.1111/j.1474-9726.2012.00817.x

PMCID:: PMC4217088

Abstract Article PDF–3.4M

Select item 41343238.

Three-dimensional structure of human γ-secretase

Peilong Lu, Xiao-chen Bai, Dan Ma, Tian Xie, Chuangye Yan, Linfeng Sun, Guanghui Yang, Yanyu Zhao, Rui Zhou, Sjors H.W. Scheres, Yigong Shi

Nature. Author manuscript; available in PMC 2015 Feb 14.

Published in final edited form as: Nature. 2014 Aug 14; 512(7513): 166–170. Published online 2014 Jun 29. doi: 10.1038/nature13567

PMCID:: PMC4134323

Abstract Article PDF–2.6M

Select item 40665099.

Synaptic function of nicastrin in hippocampal neurons

Sang Hun Lee, Manu Sharma, Thomas C. Südhof, Jie Shen

Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24): 8973–8978. Published online 2014 Jun 2. doi: 10.1073/pnas.1408554111

PMCID:: PMC4066509

Abstract Article PDF–1.1M

Select item 337024810.

Proteomic and Metabolomic Analyses of Mitochondrial Complex I-deficient Mouse Model Generated by Spontaneous B2 Short Interspersed Nuclear Element (SINE) Insertion into NADH Dehydrogenase (Ubiquinone) Fe-S Protein 4 (Ndufs4) Gene

Dillon W. Leong, Jasper C. Komen, Chelsee A. Hewitt, Estelle Arnaud, Matthew McKenzie, Belinda Phipson, Melanie Bahlo, Adrienne Laskowski, Sarah A. Kinkel, Gayle M. Davey, William R. Heath, Anne K. Voss, René P. Zahedi, James J. Pitt, Roman Chrast, Albert Sickmann, Michael T. Ryan, Gordon K. Smyth, David R. Thorburn, Hamish S. Scott

J Biol Chem. 2012 Jun 8; 287(24): 20652–20663. Published online 2012 Apr 25. doi: 10.1074/jbc.M111.327601

PMCID:: PMC3370248

Abstract Article PDF–2.6M

Select item 327919111.

Analysis of the myosinII-responsive focal adhesion proteome reveals a role for ß-Pix in negative regulation of focal adhesion maturation

Jean-Cheng Kuo, Xuemei Han, Cheng-Te Hsiao, John R. Yates, III, Clare M. Waterman

Nat Cell Biol. Author manuscript; available in PMC 2012 Feb 14.

Published in final edited form as: Nat Cell Biol. 2011 Apr; 13(4): 383–393. Published online 2011 Mar 20. doi: 10.1038/ncb2216

PMCID:: PMC3279191

Abstract Article PDF–2.8M

Select item 325685012.

Down-regulation of the ATP-binding Cassette Transporter 2 (Abca2) Reduces Amyloid-β Production by Altering Nicastrin Maturation and Intracellular Localization

Vasiliki Michaki, Francesc X. Guix, Krist'l Vennekens, Sebastian Munck, Colin Dingwall, John B. Davis, Danyelle M. Townsend, Kenneth D. Tew, Fabian Feiguin, Bart De Strooper, Carlos G. Dotti, Tina Wahle

J Biol Chem. 2012 Jan 6; 287(2): 1100–1111. Published online 2011 Nov 15. doi: 10.1074/jbc.M111.288258

PMCID:: PMC3256850

Abstract Article PDF–2.1M

Select item 317805913.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 315769414.

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates

Gael Barthet, Junichi Shioi, Zhiping Shao, Yimin Ren, Anastasios Georgakopoulos, Nikolaos K. Robakis

FASEB J. 2011 Sep; 25(9): 2937–2946. doi: 10.1096/fj.11-183806

PMCID:: PMC3157694

Abstract Article

Select item 304543115.

Deep Sequencing of the Nicastrin Gene in Pooled DNA, the Identification of Genetic Variants That Affect Risk of Alzheimer's Disease

Michelle K. Lupton, Petroula Proitsi, Makrina Danillidou, Magda Tsolaki, Gillian Hamilton, Richard Wroe, Megan Pritchard, Kathryn Lord, Belinda M. Martin, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, Denise Harold, Paul Hollingworth, Simon Lovestone, John F. Powell

PLoS One. 2011; 6(2): e17298. Published online 2011 Feb 25. doi: 10.1371/journal.pone.0017298