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Select item 109208921.

CRISPR/Cas9 model of prostate cancer identifies Kmt2c deficiency as a metastatic driver by Odam/Cabs1 gene cluster expression

Huiqiang Cai, Bin Zhang, Johanne Ahrenfeldt, Justin V. Joseph, Maria Riedel, Zongliang Gao, Sofie K. Thomsen, Ditte S. Christensen, Rasmus O. Bak, Henrik Hager, Mikkel H. Vendelbo, Xin Gao, Nicolai Birkbak, Martin K. Thomsen

Nat Commun. 2024; 15: 2088. Published online 2024 Mar 7. doi: 10.1038/s41467-024-46370-0

PMCID:: PMC10920892

Abstract Article PDF–6.9M

Select item 100246732.

Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer

Nikiana Simigdala, Anna Chalari, Aimilia D. Sklirou, Evangelia Chavdoula, George Papafotiou, Pelagia Melissa, Aimilia Kafalidou, Nikolaos Paschalidis, Ioannis S. Pateras, Emmanouil Athanasiadis, Dimitris Konstantopoulos, Ioannis P. Trougakos, Apostolos Klinakis

Cell Mol Life Sci. 2023 Apr; 80(4): 100. Published online 2023 Mar 18. doi: 10.1007/s00018-023-04734-7

PMCID:: PMC10024673

Abstract Article PDF–2.8M

Select item 99831713.

Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation

Ryan M. Boileau, Kevin X. Chen, Robert Blelloch

Genome Biol. 2023; 24: 41. Published online 2023 Mar 3. doi: 10.1186/s13059-023-02883-3

PMCID:: PMC9983171

Abstract Article PDF–6.9M

Select item 99694174.

KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming

Feifei Na, Xiangyu Pan, Jingyao Chen, Xuelan Chen, Manli Wang, Pengliang Chi, Liting You, Lanxin Zhang, Ailing Zhong, Lei Zhao, Siqi Dai, Mengsha Zhang, Yiyun Wang, Bo Wang, Jianan Zheng, Yuying Wang, Jing Xu, Jian Wang, Baohong Wu, Mei Chen, Hongyu Liu, Jianxin Xue, Meijuan Huang, Youling Gong, Jiang Zhu, Lin Zhou, Yan Zhang, Min Yu, Panwen Tian, Mingyu Fan, Zhenghao Lu, Zhihong Xue, Yinglan Zhao, Hanshuo Yang, Chengjian Zhao, Yuan Wang, Junhong Han, Shengyong Yang, Dan Xie, Lu Chen, Qian Zhong, Musheng Zeng, Scott W. Lowe, You Lu, Yu Liu, Yuquan Wei, Chong Chen

Nat Cancer. Author manuscript; available in PMC 2023 Feb 27.

Published in final edited form as: Nat Cancer. 2022 Jun; 3(6): 753–767. Published online 2022 Apr 21. doi: 10.1038/s43018-022-00361-6

PMCID:: PMC9969417

Abstract Article PDF–8.1M

Select item 93281465.

Circadian clock function does not require the histone methyltransferase MLL3

Matthew Baxter, Toryn Poolman, Peter Cunningham, Louise Hunter, Maria Voronkov, Gareth B. Kitchen, Laurence Goosey, Nicola Begley, Danielle Kay, Abby Hespe, Robert Maidstone, Andrew S. I. Loudon, David W. Ray

FASEB J. 2022 Jul; 36(7): e22356. Published online 2022 Jun 15. doi: 10.1096/fj.202200368R

PMCID:: PMC9328146

Abstract Article PDF–16M

Select item 89661966.

KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis

Tanja Limberger, Michaela Schlederer, Karolina Trachtová, Ines Garces de los Fayos Alonso, Jiaye Yang, Sandra Högler, Christina Sternberg, Vojtech Bystry, Jan Oppelt, Boris Tichý, Margit Schmeidl, Petra Kodajova, Anton Jäger, Heidi A. Neubauer, Monika Oberhuber, Belinda S. Schmalzbauer, Sarka Pospisilova, Helmut Dolznig, Wolfgang Wadsak, Zoran Culig, Suzanne D. Turner, Gerda Egger, Sabine Lagger, Lukas Kenner

Mol Cancer. 2022; 21: 89. Published online 2022 Mar 30. doi: 10.1186/s12943-022-01542-8

PMCID:: PMC8966196

Abstract Article PDF–3.3M

Select item 83338717.

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice

Feng Zhang, Xiong Zhao, Runmin Jiang, Yuying Wang, Xinli Wang, Yu Gu, Longyong Xu, Jing Ye, Charlie Degui Chen, Shuangping Guo, Dawei Zhang, Daqing Zhao

Front Cell Dev Biol. 2021; 9: 642931. Published online 2021 Jul 21. doi: 10.3389/fcell.2021.642931

PMCID:: PMC8333871

Abstract Article PDF–1.4M

Select item 79519518.

Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy

Ran Chen, Theresa Okeyo-Owuor, Riddhi M. Patel, Emily B. Casey, Andrew S. Cluster, Wei Yang, Jeffrey A. Magee

Cell Rep. Author manuscript; available in PMC 2021 Mar 11.

Published in final edited form as: Cell Rep. 2021 Feb 16; 34(7): 108751. doi: 10.1016/j.celrep.2021.108751

PMCID:: PMC7951951

Abstract Article PDF–2.8M

Select item 79387709.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 780145310.

The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus

Christian Huisman, Young A. Kim, Shin Jeon, Bongjin Shin, Jeonghoon Choi, Su Jeong Lim, Sung Min Youn, Younjung Park, Medha K. C., Sangsoo Kim, Soo-Kyung Lee, Seunghee Lee, Jae W. Lee

Nat Commun. 2021; 12: 256. Published online 2021 Jan 11. doi: 10.1038/s41467-020-20511-7

PMCID:: PMC7801453

Abstract Article PDF–5.6M

Select item 743104811.

MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ

Ji-Eun Lee, Young-Wook Cho, Chu-Xia Deng, Kai Ge

Mol Cell Biol. 2020 Sep; 40(17): e00209-20. Prepublished online 2020 Jun 29. Published online 2020 Aug 14. doi: 10.1128/MCB.00209-20

PMCID:: PMC7431048

Abstract Article PDF–3.8M

Select item 634489712.

H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development

Younghoon Jang, Aaron Broun, Chaochen Wang, Young-Kwon Park, Lenan Zhuang, Ji-Eun Lee, Eugene Froimchuk, Chengyu Liu, Kai Ge

Nucleic Acids Res. 2019 Jan 25; 47(2): 607–620. Published online 2018 Oct 18. doi: 10.1093/nar/gky982

PMCID:: PMC6344897

Abstract Article PDF–4.7M

Select item 628366313.

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition

John Arne Dahl, Inkyung Jung, Håvard Aanes, Gareth D. Greggains, Adeel Manaf, Mads Lerdrup, Guoqiang Li, Samantha Kuan, Bin Li, Ah Young Lee, Sebastian Preissl, Ingunn Jermstad, Mads Haugland Haugen, Rajikala Suganthan, Magnar Bjørås, Klaus Hansen, Knut Tomas Dalen, Peter Fedorcsak, Bing Ren, Arne Klungland

Nature. Author manuscript; available in PMC 2018 Dec 6.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 548–552. Published online 2016 Sep 14. doi: 10.1038/nature19360

PMCID:: PMC6283663

Abstract Article PDF–4.9M

Select item 610748014.

KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function

Kinisha Gala, Qing Li, Amit Sinha, Pedram Razavi, Madeline Dorso, Francisco Sanchez-Vega, Young Rock Chung, Ronald Hendrickson, James J. Hsieh, Michael Berger, Nikolaus Schultz, Alessandro Pastore, Omar Abdel-Wahab, Sarat Chandarlapaty

Oncogene. 2018; 37(34): 4692–4710. Published online 2018 May 14. doi: 10.1038/s41388-018-0273-5

PMCID:: PMC6107480

Abstract Article PDF–4.4M

Select item 566321615.

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

Ryan Rickels, Hans-Martin Herz, Christie C Sze, Kaixiang Cao, Marc A Morgan, Clayton K Collings, Maria Gause, Yoh-hei Takahashi, Lu Wang, Emily J Rendleman, Stacy A Marshall, Annika Krueger, Elizabeth T Bartom, Andrea Piunti, Edwin Smith, Nebiyu A Abshiru, Neil L Kelleher, Dale Dorsett, Ali Shilatifard

Nat Genet. Author manuscript; available in PMC 2017 Nov 1.

Published in final edited form as: Nat Genet. 2017 Nov; 49(11): 1647–1653. Published online 2017 Oct 2. doi: 10.1038/ng.3965

PMCID:: PMC5663216

Abstract Article PDF–1.1M

Select item 566213716.

Mll3 and Mll4 facilitate enhancer RNA synthesis and transcription from promoters independently of H3K4 monomethylation

Kristel M. Dorighi, Tomek Swigut, Telmo Henriques, Natarajan V. Bhanu, Benjamin S. Scruggs, Nataliya Nady, Christopher D. Still, II, Benjamin A. Garcia, Karen Adelman, Joanna Wysocka

Mol Cell. Author manuscript; available in PMC 2018 May 18.

Published in final edited form as: Mol Cell. 2017 May 18; 66(4): 568–576.e4. Published online 2017 May 5. doi: 10.1016/j.molcel.2017.04.018