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Select item 106295591.

Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia

Shiping Zhang, Shuanglong Yi, Linfang Wang, Shuhua Li, Honglei Wang, Li Song, Jiayao Ou, Min Zhang, Ruiqi Wang, Mengxiao Wang, Yuchen Zheng, Kai Yang, Tong Liu, Margaret S. Ho

Proc Natl Acad Sci U S A. 2023 Jul 18; 120(29): e2301002120. Published online 2023 Jul 10. doi: 10.1073/pnas.2301002120

PMCID:: PMC10629559

Abstract Article PDF–6.9M

Select item 105847552.

Insights into human kidney function from the study of Drosophila

Sybille Koehler, Tobias B. Huber

Pediatr Nephrol. 2023; 38(12): 3875–3887. Published online 2023 May 12. doi: 10.1007/s00467-023-05996-w

PMCID:: PMC10584755

Abstract Article PDF–1.2M

Select item 104505803.

Milton assembles large mitochondrial clusters, mitoballs, to sustain spermatogenesis

Andy Y. Z. Li, Ying Di, Sumaera Rathore, Ason C.-Y. Chiang, Jan Jezek, Hansong Ma

Proc Natl Acad Sci U S A. 2023 Aug 22; 120(34): e2306073120. Published online 2023 Aug 14. doi: 10.1073/pnas.2306073120

PMCID:: PMC10450580

Abstract Article PDF–8.2M

Select item 98992444.

Parkinsonism mutations in DNAJC6 cause lipid defects and neurodegeneration that are rescued by Synj1

Julie Jacquemyn, Sabine Kuenen, Jef Swerts, Benjamin Pavie, Vinoy Vijayan, Ayse Kilic, Dries Chabot, Yu-Chun Wang, Nils Schoovaerts, Nikky Corthout, Patrik Verstreken

NPJ Parkinsons Dis. 2023; 9: 19. Published online 2023 Feb 4. doi: 10.1038/s41531-023-00459-3

PMCID:: PMC9899244

Abstract Article PDF–2.4M

Select item 96729665.

Parkinson disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila

Tsuyoshi Inoshita, Jun-Yi Liu, Daisuke Taniguchi, Ryota Ishii, Kahori Shiba-Fukushima, Nobutaka Hattori, Yuzuru Imai

iScience. 2022 Dec 22; 25(12): 105476. Published online 2022 Nov 2. doi: 10.1016/j.isci.2022.105476

PMCID:: PMC9672966

Abstract Article PDF–5.0M

Select item 94745456.

Mettl3-dependent m⁶A modification attenuates the brain stress response in Drosophila

Alexandra E. Perlegos, Emily J. Shields, Hui Shen, Kathy Fange Liu, Nancy M. Bonini

Nat Commun. 2022; 13: 5387. Published online 2022 Sep 14. doi: 10.1038/s41467-022-33085-3

PMCID:: PMC9474545

Abstract Article PDF–2.7M

Select item 92396807.

An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination

Oguz Kanca, Jonathan Zirin, Yanhui Hu, Burak Tepe, Debdeep Dutta, Wen-Wen Lin, Liwen Ma, Ming Ge, Zhongyuan Zuo, Lu-Ping Liu, Robert W Levis, Norbert Perrimon, Hugo J Bellen

eLife. 2022; 11: e76077. Published online 2022 Jun 20. doi: 10.7554/eLife.76077

PMCID:: PMC9239680

Abstract Article PDF–1.2M

Select item 91336538.

Auxilin regulates intestinal stem cell proliferation through EGFR

Hang Zhao, Xuejing Ren, Ruiyan Kong, Lin Shi, Zhengran Li, Runqi Wang, Rui Ma, Huiqing Zhao, Fuli Liu, Henry C. Chang, Chun-Hong Chen, Zhouhua Li

Stem Cell Reports. 2022 May 10; 17(5): 1120–1137. Published online 2022 Apr 14. doi: 10.1016/j.stemcr.2022.03.010

PMCID:: PMC9133653

Abstract Article PDF–7.1M

Select item 88989029.

Using Drosophila Nephrocytes to Understand the Formation and Maintenance of the Podocyte Slit Diaphragm

Joyce van de Leemput, Pei Wen, Zhe Han

Front Cell Dev Biol. 2022; 10: 837828. Published online 2022 Feb 21. doi: 10.3389/fcell.2022.837828

PMCID:: PMC8898902

Abstract Article PDF–1018K

Select item 866448610.

Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes

Ana López-Varea, Patricia Vega-Cuesta, Ana Ruiz-Gómez, Cristina M Ostalé, Cristina Molnar, Covadonga F Hevia, Mercedes Martín, Maria F Organista, Jesus de Celis, Joaquín Culí, Nuria Esteban, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab349. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab349

PMCID:: PMC8664486

Abstract Article PDF–3.1M

Select item 866445511.

Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing

Cristina M Ostalé, Nuria Esteban, Ana López-Varea, Jose F de Celis

G3 (Bethesda) 2021 Dec; 11(12): jkab348. Published online 2021 Oct 2. doi: 10.1093/g3journal/jkab348

PMCID:: PMC8664455

Abstract Article PDF–2.9M

Select item 850221212.

Parkinson’s disease risk genes act in glia to control neuronal α-synuclein toxicity

Abby L Olsen, Mel B Feany

Neurobiol Dis. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Neurobiol Dis. 2021 Nov; 159: 105482. Published online 2021 Aug 11. doi: 10.1016/j.nbd.2021.105482

PMCID:: PMC8502212

Abstract Article PDF–2.1M

Select item 838540213.

Predicting host dependency factors of pathogens in Drosophila melanogaster using machine learning

Olufemi Aromolaran, Thomas Beder, Eunice Adedeji, Yvonne Ajamma, Jelili Oyelade, Ezekiel Adebiyi, Rainer Koenig

Comput Struct Biotechnol J. 2021; 19: 4581–4592. Published online 2021 Aug 9. doi: 10.1016/j.csbj.2021.08.010

PMCID:: PMC8385402

Abstract Article PDF–2.2M

Select item 811171214.

Slit diaphragm maintenance requires dynamic clathrin-mediated endocytosis facilitated by AP-2, Lap, Aux and Hsc70-4 in nephrocytes

Luyao Wang, Pei Wen, Joyce van de Leemput, Zhanzheng Zhao, Zhe Han

Cell Biosci. 2021; 11: 83. Published online 2021 May 11. doi: 10.1186/s13578-021-00595-4

PMCID:: PMC8111712

Abstract Article PDF–4.8M

Select item 797983515.

A postbiotic from Aspergillus oryzae attenuates the impact of heat stress in ectothermic and endothermic organisms

J. D. Kaufman, Y. Seidler, H. R. Bailey, L. Whitacre, F. Bargo, K. Lüersen, G. Rimbach, G. M. Pighetti, I. R. Ipharraguerre, A. G. Ríus

Sci Rep. 2021; 11: 6407. Published online 2021 Mar 19. doi: 10.1038/s41598-021-85707-3

PMCID:: PMC7979835

Abstract Article PDF–1.1M

Select item 755019216.

Topology-driven protein-protein interaction network analysis detects genetic sub-networks regulating reproductive capacity

Tarun Kumar, Leo Blondel, Cassandra G Extavour

eLife. 2020; 9: e54082. Published online 2020 Sep 9. doi: 10.7554/eLife.54082

PMCID:: PMC7550192

Abstract Article PDF–2.8M

Select item 689319617.

Identification of Genes Required for Apical Protein Trafficking in Drosophila Photoreceptor Cells

Azadeh Laffafian, Ulrich Tepass

G3 (Bethesda) 2019 Dec; 9(12): 4007–4017. Published online 2019 Oct 24. doi: 10.1534/g3.119.400635

PMCID:: PMC6893196

Abstract Article PDF–2.5M

Select item 609690818.

Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals

Pierre Dourlen, Julien Chapuis, Jean-Charles Lambert

Curr Genet Med Rep. 2018; 6(3): 107–115. Published online 2018 May 29. doi: 10.1007/s40142-018-0141-1

PMCID:: PMC6096908

Abstract Article PDF–679K

Select item 594398219.

Restoring Tip60 HAT/HDAC2 Balance in the Neurodegenerative Brain Relieves Epigenetic Transcriptional Repression and Reinstates Cognition

Priyalakshmi Panikker, Song-Jun Xu, Haolin Zhang, Jessica Sarthi, Mariah Beaver, Avni Sheth, Sunya Akhter, Felice Elefant

J Neurosci. 2018 May 9; 38(19): 4569–4583. doi: 10.1523/JNEUROSCI.2840-17.2018

PMCID:: PMC5943982

Abstract Article PDF–3.9M

Select item 593136920.

A Whole Animal Platform to Advance A Clinical Kinase Inhibitor Into New Disease Space

Masahiro Sonoshita, Alex P. Scopton, Peter M-U. Ung, Matthew A. Murray, Lisa Silber, Andres Y. Maldonado, Alexander Real, Avner Schlessinger, Ross L. Cagan, Arvin C. Dar

Nat Chem Biol. Author manuscript; available in PMC 2018 Jul 22.

Published in final edited form as: Nat Chem Biol. 2018 Mar; 14(3): 291–298. Published online 2018 Jan 22. doi: 10.1038/nchembio.2556